{"id":"https://openalex.org/W4375866735","doi":"https://doi.org/10.1016/j.prp.2023.154510","title":"The role of miRNAs in laryngeal cancer pathogenesis and therapeutic resistance \u2013 A focus on signaling pathways interplay","display_name":"The role of miRNAs in laryngeal cancer pathogenesis and therapeutic resistance \u2013 A focus on signaling pathways interplay","publication_year":2023,"publication_date":"2023-05-08","ids":{"openalex":"https://openalex.org/W4375866735","doi":"https://doi.org/10.1016/j.prp.2023.154510","pmid":"https://pubmed.ncbi.nlm.nih.gov/37167812"},"language":"en","primary_location":{"id":"doi:10.1016/j.prp.2023.154510","doi":"https://doi.org/10.1016/j.prp.2023.154510","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.prp.2023.154510","pdf_url":null,"source":{"id":"https://openalex.org/S73101346","display_name":"Pathology - Research and Practice","issn_l":"0344-0338","issn":["0344-0338","1618-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology - Research and Practice","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068467976","display_name":"Maghawry Hegazy","orcid":"https://orcid.org/0000-0001-7629-4269","observed_orcids":["https://orcid.org/0000-0001-7629-4269"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Maghawry Hegazy","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021759842","display_name":"Mohamed A. Elkady","orcid":"https://orcid.org/0000-0002-6475-6937","observed_orcids":["https://orcid.org/0000-0002-6475-6937"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed A. Elkady","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062979511","display_name":"Amr Mohamed Yehia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amr Mohamed Yehia","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027390894","display_name":"Elsayed G.E. Elsakka","orcid":"https://orcid.org/0000-0001-7065-5553","observed_orcids":["https://orcid.org/0000-0001-7065-5553"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Elsayed G.E. Elsakka","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000718272","display_name":"Ahmed I. Abulsoud","orcid":"https://orcid.org/0000-0002-7876-3425","observed_orcids":["https://orcid.org/0000-0002-7876-3425"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed I. Abulsoud","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt","Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt","institution_ids":["https://openalex.org/I184834183","https://openalex.org/I3130228804"]},{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067288458","display_name":"Nourhan M. Abdelmaksoud","orcid":"https://orcid.org/0000-0002-9142-3281","observed_orcids":["https://orcid.org/0000-0002-9142-3281"]},"institutions":[{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nourhan M. Abdelmaksoud","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050403847","display_name":"Ahmed Elshafei","orcid":"https://orcid.org/0000-0003-3759-0318","observed_orcids":["https://orcid.org/0000-0003-3759-0318"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Elshafei","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007687359","display_name":"Tamer M. Abdelghany","orcid":"https://orcid.org/0000-0002-2568-9356","observed_orcids":["https://orcid.org/0000-0002-2568-9356"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I3130228804","display_name":"Heliopolis University","ror":"https://ror.org/02tme6r37","country_code":"EG","type":"education","lineage":["https://openalex.org/I3130228804"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Tamer M. Abdelghany","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt","Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt","Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt","institution_ids":["https://openalex.org/I184834183","https://openalex.org/I3130228804"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt","institution_ids":["https://openalex.org/I3130228804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075906772","display_name":"Samy Y. Elkhawaga","orcid":"https://orcid.org/0000-0002-4295-4393","observed_orcids":["https://orcid.org/0000-0002-4295-4393"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Samy Y. Elkhawaga","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041373551","display_name":"Ahmed Ismail","orcid":"https://orcid.org/0000-0002-7982-7718","observed_orcids":["https://orcid.org/0000-0002-7982-7718"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Ismail","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060248513","display_name":"Mahmoud Mohamed Mokhtar","orcid":"https://orcid.org/0000-0001-6862-5662","observed_orcids":["https://orcid.org/0000-0001-6862-5662"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mahmoud Mohamed Mokhtar","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075447277","display_name":"Hesham A. El\u2010Mahdy","orcid":"https://orcid.org/0000-0003-4074-8569","observed_orcids":["https://orcid.org/0000-0003-4074-8569","https://orcid.org/0000-0002-4274-0301"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Hesham A. El-Mahdy","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt. Electronic address: heshamabbas@azhar.edu.eg","Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt. Electronic address: heshamabbas@azhar.edu.eg","institution_ids":["https://openalex.org/I184834183"]},{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035913177","display_name":"Ahmed Soliman Doghish","orcid":"https://orcid.org/0000-0002-0136-7096","observed_orcids":["https://orcid.org/0000-0002-0136-7096"]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]},{"id":"https://openalex.org/I4210151980","display_name":"Badr University in Cairo","ror":"https://ror.org/04tbvjc27","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210151980"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ahmed S. Doghish","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg","Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt","Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt. Electronic address: ahmed_doghish@azhar.edu.eg","institution_ids":["https://openalex.org/I184834183","https://openalex.org/I4210151980"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt","institution_ids":["https://openalex.org/I4210151980"]},{"raw_affiliation_string":"Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035913177","https://openalex.org/A5075447277"],"corresponding_institution_ids":["https://openalex.org/I184834183","https://openalex.org/I4210151980"],"apc_list":{"value":2570,"currency":"USD","value_usd":2570},"apc_paid":null,"fwci":1.4858,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.84322508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"246","issue":null,"first_page":"154510","last_page":"154510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.8930000066757202},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8029999732971191},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.9169999957084656},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7459999918937683},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9160000085830688},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.800000011920929},{"id":"https://openalex.org/keywords/egf-signaling","display_name":"EGF signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9419999718666077},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/apoptosis-evasion","display_name":"apoptosis evasion","score":0.9829999804496765},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.7799999713897705},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6259999871253967},{"id":"https://openalex.org/keywords/diagnosis-and-prognosis","display_name":"diagnosis and prognosis","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7772919535636902},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6874171495437622},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6245214343070984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.574479877948761},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5304001569747925},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5267859101295471},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5118016600608826},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4583645761013031},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4538589119911194},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.419842392206192},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4186205565929413},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3876396417617798},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20246338844299316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1740177571773529},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10402730107307434}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.prp.2023.154510","doi":"https://doi.org/10.1016/j.prp.2023.154510","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.prp.2023.154510","pdf_url":null,"source":{"id":"https://openalex.org/S73101346","display_name":"Pathology - Research and Practice","issn_l":"0344-0338","issn":["0344-0338","1618-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology - Research and Practice","raw_type":"journal-article"},{"id":"pmid:37167812","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37167812","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology, research and practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":251,"referenced_works":["https://openalex.org/W197586987","https://openalex.org/W282221905","https://openalex.org/W567363334","https://openalex.org/W1527599612","https://openalex.org/W1828642547","https://openalex.org/W1942614232","https://openalex.org/W1944738757","https://openalex.org/W1972989638","https://openalex.org/W1973076878","https://openalex.org/W1973465457","https://openalex.org/W1975700946","https://openalex.org/W1986915398","https://openalex.org/W2000798911","https://openalex.org/W2010454119","https://openalex.org/W2019128602","https://openalex.org/W2021227510","https://openalex.org/W2024769280","https://openalex.org/W2028354654","https://openalex.org/W2029805440","https://openalex.org/W2033583131","https://openalex.org/W2039232562","https://openalex.org/W2044500931","https://openalex.org/W2045126262","https://openalex.org/W2049852036","https://openalex.org/W2054413411","https://openalex.org/W2060088882","https://openalex.org/W2061943812","https://openalex.org/W2063880557","https://openalex.org/W2065814242","https://openalex.org/W2066922844","https://openalex.org/W2070032322","https://openalex.org/W2072155079","https://openalex.org/W2078535993","https://openalex.org/W2083966895","https://openalex.org/W2092767792","https://openalex.org/W2099034193","https://openalex.org/W2106320300","https://openalex.org/W2107248616","https://openalex.org/W2109227959","https://openalex.org/W2115797469","https://openalex.org/W2117784705","https://openalex.org/W2119015197","https://openalex.org/W2124684616","https://openalex.org/W2128034264","https://openalex.org/W2131266592","https://openalex.org/W2135810600","https://openalex.org/W2136991248","https://openalex.org/W2143677057","https://openalex.org/W2144958510","https://openalex.org/W2155412493","https://openalex.org/W2176847520","https://openalex.org/W2181456842","https://openalex.org/W2187601106","https://openalex.org/W2206080624","https://openalex.org/W2214080543","https://openalex.org/W2242147159","https://openalex.org/W2253183496","https://openalex.org/W2265177338","https://openalex.org/W2269377383","https://openalex.org/W2276137469","https://openalex.org/W2302029001","https://openalex.org/W2336781799","https://openalex.org/W2337651052","https://openalex.org/W2341919182","https://openalex.org/W2413618440","https://openalex.org/W2434206469","https://openalex.org/W2437469184","https://openalex.org/W2465803133","https://openalex.org/W2509430588","https://openalex.org/W2512350109","https://openalex.org/W2538373487","https://openalex.org/W2554348971","https://openalex.org/W2557888310","https://openalex.org/W2563308020","https://openalex.org/W2587253720","https://openalex.org/W2597921386","https://openalex.org/W2611999725","https://openalex.org/W2615103832","https://openalex.org/W2736052270","https://openalex.org/W2751472497","https://openalex.org/W2751989228","https://openalex.org/W2753030235","https://openalex.org/W2780904926","https://openalex.org/W2802345478","https://openalex.org/W2804864274","https://openalex.org/W2808037927","https://openalex.org/W2808759520","https://openalex.org/W2809797501","https://openalex.org/W2850822830","https://openalex.org/W2885022472","https://openalex.org/W2893427972","https://openalex.org/W2902122770","https://openalex.org/W2902336356","https://openalex.org/W2902931641","https://openalex.org/W2912476769","https://openalex.org/W2914301546","https://openalex.org/W2914775578","https://openalex.org/W2921971396","https://openalex.org/W2943110603","https://openalex.org/W2943588102","https://openalex.org/W2947184164","https://openalex.org/W2947867268","https://openalex.org/W2950383576","https://openalex.org/W2952477354","https://openalex.org/W2965332892","https://openalex.org/W2974184195","https://openalex.org/W2975046624","https://openalex.org/W2978897986","https://openalex.org/W2980840222","https://openalex.org/W2980849622","https://openalex.org/W2987782924","https://openalex.org/W2990992250","https://openalex.org/W2992865818","https://openalex.org/W2995514254","https://openalex.org/W2996238888","https://openalex.org/W2997389342","https://openalex.org/W3003783648","https://openalex.org/W3004477336","https://openalex.org/W3005855303","https://openalex.org/W3006447992","https://openalex.org/W3007265855","https://openalex.org/W3008195952","https://openalex.org/W3011532101","https://openalex.org/W3011767868","https://openalex.org/W3014681297","https://openalex.org/W3014842218","https://openalex.org/W3016284863","https://openalex.org/W3019679901","https://openalex.org/W3023396451","https://openalex.org/W3024414049","https://openalex.org/W3026346415","https://openalex.org/W3027067016","https://openalex.org/W3030918339","https://openalex.org/W3033608610","https://openalex.org/W3036199515","https://openalex.org/W3037536021","https://openalex.org/W3043967690","https://openalex.org/W3082340133","https://openalex.org/W3090959428","https://openalex.org/W3094813659","https://openalex.org/W3109332841","https://openalex.org/W3109896124","https://openalex.org/W3112898563","https://openalex.org/W3117361730","https://openalex.org/W3121113140","https://openalex.org/W3126542171","https://openalex.org/W3132027627","https://openalex.org/W3151462050","https://openalex.org/W3154173888","https://openalex.org/W3157903393","https://openalex.org/W3157972907","https://openalex.org/W3160400610","https://openalex.org/W3175226701","https://openalex.org/W3178809923","https://openalex.org/W3184734789","https://openalex.org/W3193267947","https://openalex.org/W3193918140","https://openalex.org/W3198149563","https://openalex.org/W3200083940","https://openalex.org/W3201001961","https://openalex.org/W3202030968","https://openalex.org/W3203789682","https://openalex.org/W3205347996","https://openalex.org/W3207143191","https://openalex.org/W3213663371","https://openalex.org/W3215827337","https://openalex.org/W3216146155","https://openalex.org/W4200291296","https://openalex.org/W4200563401","https://openalex.org/W4200625470","https://openalex.org/W4205185259","https://openalex.org/W4205241485","https://openalex.org/W4210895637","https://openalex.org/W4210984898","https://openalex.org/W4211075026","https://openalex.org/W4212974698","https://openalex.org/W4220790638","https://openalex.org/W4223491865","https://openalex.org/W4223598652","https://openalex.org/W4225137939","https://openalex.org/W4226224051","https://openalex.org/W4237011200","https://openalex.org/W4281739780","https://openalex.org/W4282965879","https://openalex.org/W4283277326","https://openalex.org/W4283590904","https://openalex.org/W4284967152","https://openalex.org/W4284973855","https://openalex.org/W4286564645","https://openalex.org/W4288058528","https://openalex.org/W4288068990","https://openalex.org/W4288736947","https://openalex.org/W4289986017","https://openalex.org/W4291397514","https://openalex.org/W4291926523","https://openalex.org/W4292386292","https://openalex.org/W4293014387","https://openalex.org/W4293473313","https://openalex.org/W4297238866","https://openalex.org/W4297473313","https://openalex.org/W4303446291","https://openalex.org/W4304689447","https://openalex.org/W4306153573","https://openalex.org/W4306884942","https://openalex.org/W4307342901","https://openalex.org/W4308035976","https://openalex.org/W4308074152","https://openalex.org/W4308450276","https://openalex.org/W4309514923","https://openalex.org/W4309565145","https://openalex.org/W4312113725","https://openalex.org/W4312118694","https://openalex.org/W4312125669","https://openalex.org/W4312140777","https://openalex.org/W4312175198","https://openalex.org/W4313260930","https://openalex.org/W4313627347","https://openalex.org/W4315477042","https://openalex.org/W4316368853","https://openalex.org/W4317433998","https://openalex.org/W4317528644","https://openalex.org/W4319335720","https://openalex.org/W4319869359","https://openalex.org/W4320717656","https://openalex.org/W4321611427","https://openalex.org/W4322487511","https://openalex.org/W4323928834","https://openalex.org/W4360874514","https://openalex.org/W4360939541","https://openalex.org/W4362560815","https://openalex.org/W4362634292","https://openalex.org/W4362640205","https://openalex.org/W4362671323","https://openalex.org/W4362672592","https://openalex.org/W4362673165","https://openalex.org/W4363650024","https://openalex.org/W4365517364","https://openalex.org/W6615978225","https://openalex.org/W6638999561","https://openalex.org/W6690019305","https://openalex.org/W6691739449","https://openalex.org/W6693103928","https://openalex.org/W6694992219","https://openalex.org/W6703224911","https://openalex.org/W6716212299","https://openalex.org/W6756159905","https://openalex.org/W6756814757","https://openalex.org/W6782353949","https://openalex.org/W6797541320","https://openalex.org/W6801571586","https://openalex.org/W6810849934"],"related_works":["https://openalex.org/W2118016057","https://openalex.org/W4288736947","https://openalex.org/W7098057665","https://openalex.org/W2465803133","https://openalex.org/W2353894536","https://openalex.org/W2785131364","https://openalex.org/W2370939376","https://openalex.org/W2898360692","https://openalex.org/W2607953254","https://openalex.org/W3027067016"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":31}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-05-10T00:00:00"}
