{"id":"https://openalex.org/W4375860366","doi":"https://doi.org/10.51248/.v43i02.2089","title":"To unravel the role of TCF7L2 (Transcription Factor 7 like 2) variants in type 2 diabetes mellitus","display_name":"To unravel the role of TCF7L2 (Transcription Factor 7 like 2) variants in type 2 diabetes mellitus","publication_year":2023,"publication_date":"2023-05-04","ids":{"openalex":"https://openalex.org/W4375860366","doi":"https://doi.org/10.51248/.v43i02.2089"},"language":"en","primary_location":{"id":"doi:10.51248/.v43i02.2089","doi":"https://doi.org/10.51248/.v43i02.2089","is_oa":true,"landing_page_url":"https://doi.org/10.51248/.v43i02.2089","pdf_url":"https://biomedicineonline.org/index.php/home/article/download/2089/825","source":{"id":"https://openalex.org/S2755993601","display_name":"Biomedicine","issn_l":"0970-2067","issn":["0970-2067"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4360969456","host_organization_name":"Indian Association of Biomedical Scientists","host_organization_lineage":["https://openalex.org/P4360969456"],"host_organization_lineage_names":["Indian Association of Biomedical Scientists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://biomedicineonline.org/index.php/home/article/download/2089/825","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059357921","display_name":"Shubhra Chowdhry","orcid":"https://orcid.org/0000-0002-6534-1688","observed_orcids":["https://orcid.org/0000-0002-6534-1688"]},"institutions":[{"id":"https://openalex.org/I189949046","display_name":"Integral University","ror":"https://ror.org/039zd5s34","country_code":"IN","type":"education","lineage":["https://openalex.org/I189949046"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubhra Chowdhry","raw_affiliation_strings":["Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India","institution_ids":["https://openalex.org/I189949046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021191132","display_name":"Gyanendra Kumar Sonkar","orcid":"https://orcid.org/0000-0002-0813-5466","observed_orcids":["https://orcid.org/0000-0002-0813-5466"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gyanendra Kumar Sonkar","raw_affiliation_strings":["Department of Biochemistry, King George's Medical University, Lucknow, 226003, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, King George's Medical University, Lucknow, 226003, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103176458","display_name":"Priyanka Thapa Manger","orcid":"https://orcid.org/0000-0003-3401-9271","observed_orcids":["https://orcid.org/0000-0003-3401-9271"]},"institutions":[{"id":"https://openalex.org/I189949046","display_name":"Integral University","ror":"https://ror.org/039zd5s34","country_code":"IN","type":"education","lineage":["https://openalex.org/I189949046"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Thapa Manger","raw_affiliation_strings":["Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India","institution_ids":["https://openalex.org/I189949046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032743403","display_name":"Mohammad Mustufa Khan","orcid":"https://orcid.org/0000-0001-8831-7026","observed_orcids":["https://orcid.org/0000-0001-8831-7026"]},"institutions":[{"id":"https://openalex.org/I189949046","display_name":"Integral University","ror":"https://ror.org/039zd5s34","country_code":"IN","type":"education","lineage":["https://openalex.org/I189949046"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohammad Mustufa Khan","raw_affiliation_strings":["Department of Basic Medical Sciences, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India","institution_ids":["https://openalex.org/I189949046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067756801","display_name":"Roshan Alam","orcid":"https://orcid.org/0000-0003-1944-8924","observed_orcids":["https://orcid.org/0000-0003-1944-8924"]},"institutions":[{"id":"https://openalex.org/I189949046","display_name":"Integral University","ror":"https://ror.org/039zd5s34","country_code":"IN","type":"education","lineage":["https://openalex.org/I189949046"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Roshan Alam","raw_affiliation_strings":["Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India","institution_ids":["https://openalex.org/I189949046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040721530","display_name":"Saba Khan","orcid":"https://orcid.org/0000-0002-6140-8152","observed_orcids":["https://orcid.org/0000-0002-6140-8152"]},"institutions":[{"id":"https://openalex.org/I189949046","display_name":"Integral University","ror":"https://ror.org/039zd5s34","country_code":"IN","type":"education","lineage":["https://openalex.org/I189949046"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saba Khan","raw_affiliation_strings":["Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Integral Institute of Medical Sciences & Research, Integral University, Lucknow, 226026, Uttar Pradesh, India","institution_ids":["https://openalex.org/I189949046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1187,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.31544751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"43","issue":"02","first_page":"535","last_page":"540"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.1251000016927719,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tcf7l2","display_name":"TCF7L2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.722000002861023},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.6949999928474426},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8019999861717224},{"id":"https://openalex.org/keywords/wnt-signalling-pathway","display_name":"Wnt signalling pathway","score":0.8389999866485596},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/blood-glucose-regulation","display_name":"blood glucose regulation","score":0.703000009059906},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5680000185966492},{"id":"https://openalex.org/keywords/indian-tribes","display_name":"Indian tribes","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C39263347","wikidata":"https://www.wikidata.org/wiki/Q14913892","display_name":"TCF7L2","level":5,"score":0.9840201139450073},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7079207897186279},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.6108976602554321},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.565918505191803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5126273036003113},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5102179050445557},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.49485987424850464},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4924341142177582},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4675658345222473},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.43855977058410645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3669968843460083},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34509560465812683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.333914190530777},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.328465074300766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3131709098815918},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.307409405708313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3011651039123535},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.06944310665130615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.51248/.v43i02.2089","doi":"https://doi.org/10.51248/.v43i02.2089","is_oa":true,"landing_page_url":"https://doi.org/10.51248/.v43i02.2089","pdf_url":"https://biomedicineonline.org/index.php/home/article/download/2089/825","source":{"id":"https://openalex.org/S2755993601","display_name":"Biomedicine","issn_l":"0970-2067","issn":["0970-2067"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4360969456","host_organization_name":"Indian Association of Biomedical Scientists","host_organization_lineage":["https://openalex.org/P4360969456"],"host_organization_lineage_names":["Indian Association of Biomedical Scientists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.51248/.v43i02.2089","doi":"https://doi.org/10.51248/.v43i02.2089","is_oa":true,"landing_page_url":"https://doi.org/10.51248/.v43i02.2089","pdf_url":"https://biomedicineonline.org/index.php/home/article/download/2089/825","source":{"id":"https://openalex.org/S2755993601","display_name":"Biomedicine","issn_l":"0970-2067","issn":["0970-2067"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4360969456","host_organization_name":"Indian Association of Biomedical Scientists","host_organization_lineage":["https://openalex.org/P4360969456"],"host_organization_lineage_names":["Indian Association of Biomedical Scientists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4375860366.pdf","grobid_xml":"https://content.openalex.org/works/W4375860366.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W264671013","https://openalex.org/W1504655784","https://openalex.org/W1511545125","https://openalex.org/W1523913993","https://openalex.org/W1573925283","https://openalex.org/W1963510918","https://openalex.org/W1965141016","https://openalex.org/W2028521239","https://openalex.org/W2042887667","https://openalex.org/W2102743706","https://openalex.org/W2157044641","https://openalex.org/W2165781463","https://openalex.org/W2168893898","https://openalex.org/W2409172672","https://openalex.org/W2519031788","https://openalex.org/W2520632143","https://openalex.org/W2772059359","https://openalex.org/W2806850297","https://openalex.org/W6608507298","https://openalex.org/W6769123712","https://openalex.org/W6982149987","https://openalex.org/W7074079697"],"related_works":["https://openalex.org/W1962785595","https://openalex.org/W3213611487","https://openalex.org/W3030289894","https://openalex.org/W2358739424","https://openalex.org/W2010876773","https://openalex.org/W2106689948","https://openalex.org/W4414916771","https://openalex.org/W232391152","https://openalex.org/W3216543178","https://openalex.org/W2154486810"],"abstract_inverted_index":{"Predisposition":[0],"to":[1,5,34,59,83,112,129,145,181],"diabetes":[2],"is":[3,12,24,106],"attributed":[4],"a":[6,51,98,118,120,148,188],"large":[7],"number":[8],"of":[9,14,140,161,166,173,190],"genes.":[10],"TCF7L2":[11,37,54,67,88,156],"one":[13],"the":[15,90,138,155,159,171,185,191],"most":[16],"significant":[17,167],"candidate":[18],"genes":[19],"among":[20],"them,":[21],"and":[22,29,57,95,183],"it":[23],"crucial":[25],"for":[26,80,101,108],"beta-cell":[27],"activity":[28],"blood":[30],"glucose":[31],"regulation.":[32],"According":[33],"previous":[35],"research,":[36],"has":[38],"been":[39],"implicated":[40],"in":[41,43,66,122],"T2DM":[42,146,162],"various":[44],"Indian":[45],"tribes.":[46],"Many":[47],"studies":[48],"have":[49,134],"discovered":[50],"link":[52],"between":[53],"gene":[55,157,192],"variations":[56],"vulnerability":[58],"T2DM.":[60],"These":[61],"results":[62],"suggest":[63],"that":[64,177],"changes":[65],"expression":[68],"are":[69],"not":[70],"only":[71],"associated":[72],"with":[73,78],"insulin":[74,141],"resistance":[75],"but":[76],"also":[77],"risk":[79],"genotypes":[81],"connected":[82],"poor":[84],"beta":[85,102],"cell":[86],"activity.":[87],"drives":[89],"conventional":[91],"Wnt":[92,104],"signalling":[93,105],"pathway":[94],"functions":[96],"as":[97,147,169,187],"nuclear":[99],"ligand":[100],"catenin.":[103],"necessary":[107],"intestinal":[109],"endocrine":[110],"L-cells":[111],"emit":[113],"GLP-1":[114,128],"(glucagon-like":[115],"peptide-1).":[116],"As":[117],"result,":[119],"blockage":[121],"this":[123],"route":[124],"would":[125],"cause":[126],"less":[127],"be":[130,165,179],"released,":[131],"which":[132,154],"might":[133],"an":[135],"impact":[136],"on":[137],"release":[139],"after":[142],"meals":[143],"contributing":[144],"result.":[149],"The":[150],"molecular":[151],"processes":[152],"through":[153],"increases":[158],"susceptibility":[160],"will":[163,170],"therefore":[164],"interest,":[168],"identification":[172],"possible":[174],"therapeutic":[175],"targets":[176],"may":[178],"employed":[180],"treat":[182],"prevent":[184],"illness":[186],"result":[189],"variations.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-05-10T00:00:00"}