{"id":"https://openalex.org/W4375855680","doi":"https://doi.org/10.1186/s12989-023-00522-0","title":"An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma","display_name":"An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma","publication_year":2023,"publication_date":"2023-05-07","ids":{"openalex":"https://openalex.org/W4375855680","doi":"https://doi.org/10.1186/s12989-023-00522-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37150820","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10165766"},"language":"en","primary_location":{"id":"doi:10.1186/s12989-023-00522-0","doi":"https://doi.org/10.1186/s12989-023-00522-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-023-00522-0","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-023-00522-0","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-023-00522-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048314790","display_name":"Maya-Liliana Avramescu","orcid":"https://orcid.org/0000-0002-7004-8662","observed_orcids":["https://orcid.org/0000-0002-7004-8662"]},"institutions":[{"id":"https://openalex.org/I4405286786","display_name":"Institute for Planetary Materials, Okayama University","ror":"https://ror.org/033dc9a60","country_code":"JP","type":"facility","lineage":["https://openalex.org/I163770644","https://openalex.org/I4405286786"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maya-Liliana Avramescu","raw_affiliation_strings":["The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan","institution_ids":["https://openalex.org/I4405286786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048306452","display_name":"Christian Potiszil","orcid":"https://orcid.org/0000-0001-9420-4220","observed_orcids":["https://orcid.org/0000-0001-9420-4220"]},"institutions":[{"id":"https://openalex.org/I4405286786","display_name":"Institute for Planetary Materials, Okayama University","ror":"https://ror.org/033dc9a60","country_code":"JP","type":"facility","lineage":["https://openalex.org/I163770644","https://openalex.org/I4405286786"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Christian Potiszil","raw_affiliation_strings":["The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan","institution_ids":["https://openalex.org/I4405286786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085880221","display_name":"Takuya Kunihiro","orcid":"https://orcid.org/0000-0001-5605-1227","observed_orcids":["https://orcid.org/0000-0001-5605-1227"]},"institutions":[{"id":"https://openalex.org/I4405286786","display_name":"Institute for Planetary Materials, Okayama University","ror":"https://ror.org/033dc9a60","country_code":"JP","type":"facility","lineage":["https://openalex.org/I163770644","https://openalex.org/I4405286786"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tak Kunihiro","raw_affiliation_strings":["The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan","institution_ids":["https://openalex.org/I4405286786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001765159","display_name":"Kazunori Okabe","orcid":"https://orcid.org/0000-0001-5024-0764","observed_orcids":["https://orcid.org/0000-0001-5024-0764"]},"institutions":[{"id":"https://openalex.org/I4210134628","display_name":"Berurando General Hospital","ror":"https://ror.org/03mz46a79","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210134628"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Okabe","raw_affiliation_strings":["Bell Land General Hospital, 500-3 Higashiyama, Sakai, Osaka, 599-8247, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bell Land General Hospital, 500-3 Higashiyama, Sakai, Osaka, 599-8247, Japan","institution_ids":["https://openalex.org/I4210134628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029814244","display_name":"Eizo Nakamura","orcid":"https://orcid.org/0000-0003-4399-9443","observed_orcids":["https://orcid.org/0000-0003-4399-9443"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4405286786","display_name":"Institute for Planetary Materials, Okayama University","ror":"https://ror.org/033dc9a60","country_code":"JP","type":"facility","lineage":["https://openalex.org/I163770644","https://openalex.org/I4405286786"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Eizo Nakamura","raw_affiliation_strings":["Advanced Science Research Center, Okayama University, Tsushima, Okayama, 700-8530, Japan. eizonak@gmail.com","The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan. eizonak@gmail.com"],"raw_orcid":"https://orcid.org/0000-0003-4399-9443","affiliations":[{"raw_affiliation_string":"Advanced Science Research Center, Okayama University, Tsushima, Okayama, 700-8530, Japan. eizonak@gmail.com","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University, Misasa, Tottori, 682-0193, Japan. eizonak@gmail.com","institution_ids":["https://openalex.org/I163770644","https://openalex.org/I4405286786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029814244"],"corresponding_institution_ids":["https://openalex.org/I163770644","https://openalex.org/I4405286786"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":2.4542,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.89733363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"19","last_page":"19"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14168","display_name":"Occupational Health and Global Justice","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-mesothelioma","display_name":"malignant mesothelioma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/asbestos-fibers","display_name":"asbestos fibers","score":0.7990000247955322},{"id":"https://openalex.org/keywords/ferrihydrite","display_name":"ferrihydrite","score":0.902999997138977},{"id":"https://openalex.org/keywords/frustrated-phagocytosis","display_name":"frustrated phagocytosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cigarette-smoke","display_name":"cigarette smoke","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.5789999961853027},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.796999990940094},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C510490043","wikidata":"https://www.wikidata.org/wiki/Q104085","display_name":"Asbestos","level":2,"score":0.7520892024040222},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.580367386341095},{"id":"https://openalex.org/C2780191927","wikidata":"https://www.wikidata.org/wiki/Q2250996","display_name":"Ferrihydrite","level":3,"score":0.5124130845069885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.42548006772994995},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33292242884635925},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2852255702018738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2653461992740631},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.143461674451828},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000086002","descriptor_name":"Mesothelioma, Malignant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001194","descriptor_name":"Asbestos","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001194","descriptor_name":"Asbestos","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005290","descriptor_name":"Ferric Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12989-023-00522-0","doi":"https://doi.org/10.1186/s12989-023-00522-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-023-00522-0","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-023-00522-0","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10165766","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10165766","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10165766/pdf/12989_2023_Article_522.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Part Fibre Toxicol","raw_type":"Text"},{"id":"pmid:37150820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37150820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and fibre toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0005843825","doi":null,"is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/65293","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/6/65293/20230602150454494584/fulltext.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal article"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:65293","doi":null,"is_oa":false,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/65293","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:52fc96bf617643e6af1b7b96d8754002","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/52fc96bf617643e6af1b7b96d8754002","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12989-023-00522-0","doi":"https://doi.org/10.1186/s12989-023-00522-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-023-00522-0","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-023-00522-0","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4375855680.pdf","grobid_xml":"https://content.openalex.org/works/W4375855680.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W40952936","https://openalex.org/W278359189","https://openalex.org/W1598888463","https://openalex.org/W1977853376","https://openalex.org/W1988177109","https://openalex.org/W1989001541","https://openalex.org/W1994213943","https://openalex.org/W1998184337","https://openalex.org/W2006313999","https://openalex.org/W2010133530","https://openalex.org/W2016700343","https://openalex.org/W2030140921","https://openalex.org/W2030451506","https://openalex.org/W2044353844","https://openalex.org/W2053019542","https://openalex.org/W2059065982","https://openalex.org/W2066011638","https://openalex.org/W2127236625","https://openalex.org/W2143956455","https://openalex.org/W2163458761","https://openalex.org/W2167083020","https://openalex.org/W2244784826","https://openalex.org/W2404280394","https://openalex.org/W2518727055","https://openalex.org/W2561916519","https://openalex.org/W2597428042","https://openalex.org/W2885244866","https://openalex.org/W2896335047","https://openalex.org/W2913793261","https://openalex.org/W2931343844","https://openalex.org/W2961268319","https://openalex.org/W2979787190","https://openalex.org/W4206443925"],"related_works":["https://openalex.org/W6958679483","https://openalex.org/W7110836984","https://openalex.org/W6902073053","https://openalex.org/W6920974860","https://openalex.org/W6939852810","https://openalex.org/W2168763813","https://openalex.org/W4365484860","https://openalex.org/W1994213943","https://openalex.org/W2037888680","https://openalex.org/W2189099566"],"abstract_inverted_index":{"BACKGROUND:":[0],"Asbestos":[1],"is":[2,16],"a":[3,159,175,290],"fibrous":[4],"mineral":[5],"that":[6,258,329,336],"was":[7,333],"widely":[8],"used":[9],"in":[10,174,202,249,255,280,324],"the":[11,36,40,53,65,73,91,96,145,148,152,180,184,189,263,295,317,325,330,341,345],"past.":[12],"However,":[13,286],"asbestos":[14,37,172,264],"inhalation":[15],"associated":[17,56],"with":[18,57,138,171,211],"an":[19,31,46],"aggressive":[20],"type":[21],"of":[22,68,78,93,100,106,125,130,133,147,158,191,204,243,266,319,347],"cancer":[23],"known":[24],"as":[25],"malignant":[26],"mesothelioma":[27],"(MM).":[28],"After":[29],"inhalation,":[30],"iron-rich":[32],"coat":[33,41],"forms":[34],"around":[35],"fibres,":[38],"together":[39],"and":[42,84,98,103,118,150,208,234,245,268,276,283,312,335],"fibre":[43],"are":[44,52,87,157],"termed":[45],"\"asbestos":[47],"ferruginous":[48],"body\"":[49],"(AFB).":[50],"AFBs":[51,80,107,124,149,185,198,237,242,288,326],"main":[54,342],"features":[55,141],"asbestos-induced":[58],"MM.":[59,348],"Whilst":[60],"several":[61],"studies":[62],"have":[63,71,232],"investigated":[64],"external":[66],"morphology":[67],"AFBs,":[69],"none":[70],"characterised":[72],"internal":[74],"morphology.":[75],"Here,":[76],"cross-sections":[77],"multiple":[79],"from":[81,168,188,306],"two":[82,85],"smokers":[83,228,244,267],"non-smokers":[86,246,269],"compared":[88,298],"to":[89,162,231,273,299,303],"investigate":[90],"effects":[92],"smoking":[94],"on":[95,144],"onset":[97,346],"growth":[99],"AFBs.":[101,315],"Morphological":[102],"chemical":[104],"observations":[105],"were":[108,128,199,229,270],"undertaken":[109],"by":[110],"transmission":[111],"electron":[112],"microscopy,":[113],"energy":[114],"dispersive":[115],"x-ray":[116],"spectroscopy":[117],"selected":[119],"area":[120],"diffraction.":[121],"RESULTS:":[122],"The":[123,154,197,241],"all":[126],"patients":[127],"composed":[129],"concentric":[131],"layers":[132,213],"2-line":[134],"or":[135],"6-line":[136],"ferrihydrite,":[137],"small":[139],"spherical":[140,155,181],"being":[142],"observed":[143],"outside":[146],"within":[151,166,294],"cross-sections.":[153],"components":[156,182],"similar":[160],"size":[161],"Fe-rich":[163,192,314],"inclusions":[164,193],"found":[165,230],"macrophages":[167],"mice":[169],"injected":[170],"fibres":[173,265],"previous":[176],"study.":[177],"As":[178],"such,":[179],"composing":[183],"may":[186,327,338],"result":[187],"deposition":[190],"during":[194],"frustrated":[195,274],"phagocytosis.":[196],"also":[200],"variable":[201],"terms":[203],"their":[205,250],"Fe,":[206],"P":[207],"Ca":[209],"abundances,":[210],"some":[212],"recording":[214],"higher":[215],"Fe":[216,223,281,304,322],"concentrations":[217,224],"(dense":[218],"layers),":[219],"whilst":[220],"others":[221],"lower":[222],"(porous":[225],"layers).":[226],"Furthermore,":[227],"smaller":[233,311],"overall":[235],"denser":[236],"than":[238],"non-smokers.":[239],"CONCLUSIONS:":[240],"show":[247],"differences":[248],"morphology,":[251],"indicating":[252],"they":[253],"grew":[254],"lung":[256,296],"environments":[257],"experienced":[259,289],"disparate":[260],"conditions.":[261],"Both":[262],"likely":[271,301],"subjected":[272],"phagocytosis":[275],"accreted":[277],"mucopolysaccharides,":[278],"resulting":[279],"accumulation":[282],"AFB":[284],"formation.":[285],"smokers'":[287],"more":[291,313],"uniform":[292],"Fe-supply":[293],"environment":[297],"non-smokers,":[300],"due":[302],"complexation":[305],"cigarette":[307],"smoke,":[308],"yielding":[309],"denser,":[310],"Moreover,":[316],"lack":[318],"any":[320],"non-ferrihydrite":[321],"phases":[323],"indicate":[328],"ferritin":[331],"shell":[332],"intact,":[334],"ROS":[337],"not":[339],"be":[340],"driver":[343],"for":[344]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-05-10T00:00:00"}