{"id":"https://openalex.org/W4372049985","doi":"https://doi.org/10.55920/ijcimr.2023.04.001135","title":"A Case of Autoimmune Hypophysitis Induced by Ipilimumab/Nivolumab Combination Therapy for Metastatic Melanoma","display_name":"A Case of Autoimmune Hypophysitis Induced by Ipilimumab/Nivolumab Combination Therapy for Metastatic Melanoma","publication_year":2023,"publication_date":"2023-01-11","ids":{"openalex":"https://openalex.org/W4372049985","doi":"https://doi.org/10.55920/ijcimr.2023.04.001135"},"language":"en","primary_location":{"id":"doi:10.55920/ijcimr.2023.04.001135","doi":"https://doi.org/10.55920/ijcimr.2023.04.001135","is_oa":true,"landing_page_url":"http://dx.doi.org/10.55920/ijcimr.2023.04.001135","pdf_url":"https://ijcimr.org/articles/IJCIMR-V4-1134.pdf","source":{"id":"https://openalex.org/S4387279941","display_name":"International Journal of Clinical Images and Medical Reviews","issn_l":"2771-6309","issn":["2771-6309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Images and Medical Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ijcimr.org/articles/IJCIMR-V4-1134.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074569866","display_name":"Cheuk Cheung Derek Leung","orcid":"https://orcid.org/0000-0001-7590-9997","observed_orcids":["https://orcid.org/0000-0001-7590-9997"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cheuk Cheung Derek Leung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074569866"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07769029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1404999941587448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hypophysitis","display_name":"autoimmune hypophysitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ipilimumab","display_name":"ipilimumab","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":1.0},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7250000238418579},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8289999961853027},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/online-examinations","display_name":"online examinations","score":0.6800000071525574},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8550000190734863},{"id":"https://openalex.org/keywords/obstetrics-and-gynecology-training","display_name":"obstetrics and gynecology training","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.9622623324394226},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.9574583768844604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8305186033248901},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.7943084836006165},{"id":"https://openalex.org/C2780194577","wikidata":"https://www.wikidata.org/wiki/Q4120169","display_name":"Hypophysitis","level":4,"score":0.6602329015731812},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6312376260757446},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4490377604961395},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4047158360481262},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4026070237159729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33568698167800903},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2862882912158966},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1933116614818573},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.0662229061126709},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55920/ijcimr.2023.04.001135","doi":"https://doi.org/10.55920/ijcimr.2023.04.001135","is_oa":true,"landing_page_url":"http://dx.doi.org/10.55920/ijcimr.2023.04.001135","pdf_url":"https://ijcimr.org/articles/IJCIMR-V4-1134.pdf","source":{"id":"https://openalex.org/S4387279941","display_name":"International Journal of Clinical Images and Medical Reviews","issn_l":"2771-6309","issn":["2771-6309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Images and Medical Reviews","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55920/ijcimr.2023.04.001135","doi":"https://doi.org/10.55920/ijcimr.2023.04.001135","is_oa":true,"landing_page_url":"http://dx.doi.org/10.55920/ijcimr.2023.04.001135","pdf_url":"https://ijcimr.org/articles/IJCIMR-V4-1134.pdf","source":{"id":"https://openalex.org/S4387279941","display_name":"International Journal of Clinical Images and Medical Reviews","issn_l":"2771-6309","issn":["2771-6309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Clinical Images and Medical Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4372049985.pdf","grobid_xml":"https://content.openalex.org/works/W4372049985.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W128146172","https://openalex.org/W1967256784","https://openalex.org/W3023581208","https://openalex.org/W3025972517","https://openalex.org/W3028616857","https://openalex.org/W3029267276","https://openalex.org/W3033463684","https://openalex.org/W3034040023","https://openalex.org/W3037536010","https://openalex.org/W3044407403","https://openalex.org/W3049547760","https://openalex.org/W3090701918","https://openalex.org/W3108667536","https://openalex.org/W3114541945","https://openalex.org/W3118613563","https://openalex.org/W4251700900","https://openalex.org/W4288400169","https://openalex.org/W6903569122"],"related_works":["https://openalex.org/W4292385796","https://openalex.org/W3196809896","https://openalex.org/W4319752883","https://openalex.org/W7216955806","https://openalex.org/W3164577485","https://openalex.org/W3041523390","https://openalex.org/W3126399656","https://openalex.org/W3089391679","https://openalex.org/W4226187062","https://openalex.org/W4402326671"],"abstract_inverted_index":{"Ipilimumab":[0],"and":[1,29,68,110,135,145,150,180,207,233,247],"Nivolumab":[2],"are":[3,18],"immune":[4,112,200],"checkpoint":[5,113,201],"inhibitors":[6],"used":[7],"to":[8,14,49,107,132,164],"treat":[9,111],"patients":[10],"with":[11,21,63,152,172,178,188],"advanced":[12],"melanoma":[13,175],"improve":[15],"survival.However,":[16],"they":[17],"commonly":[19],"associated":[20],"immune-related":[22],"adverse":[23],"events,":[24],"including":[25],"endocrinopathies,":[26],"colitis,":[27],"dermatitis,":[28],"hepatitis.Here,":[30],"we":[31],"report":[32,102],"a":[33,64,81,105,153,218,224],"case":[34,101],"of":[35,61,97,157,176,191,230,242],"Autoimmune":[36],"hypophysitis":[37,58,98,116],"Induced":[38,115],"by":[39,80,223],"ipilimumab/nivolumab":[40],"Combination":[41],"Therapy,":[42],"which":[43,258],"is":[44,147],"an":[45,69,148,199,234],"increasingly":[46],"recognised":[47],"phenomenon.Prior":[48],"symptom":[50],"onset,":[51],"the":[52,95,119,133],"patient's":[53],"hormonal":[54,121],"profile":[55],"already":[56],"suggested":[57],"following":[59],"initiation":[60],"ipilimumab/nivolumab,":[62],"low":[65,90,225],"thyroxine":[66,227],"level":[67,84,229,241,255],"inappropriately":[70,235],"normal":[71,86,236,261],"thyroid":[72,210,237],"stimulating":[73,238],"hormone":[74,239],"level.The":[75],"clinician":[76],"was":[77,99,170,186,256,259],"falsely":[78],"reassured":[79],"morning":[82],"cortisol":[83,254],"within":[85,260],"range,":[87],"without":[88],"performing":[89],"dose":[91],"short":[92],"synacthen":[93],"test.Therefore,":[94],"diagnosis":[96],"delayed.This":[100],"serves":[103],"as":[104,118],"reminder":[106],"suspect,":[108],"diagnose,":[109],"inhibitor":[114,202],"promptly,":[117],"resulting":[120],"insufficiency":[122],"can":[123],"be":[124],"life-threatening.":[125],"Case":[126],"historyAn":[127],"83-year-old":[128],"Chinese":[129],"gentleman":[130],"presented":[131],"Accident":[134],"Emergency":[136],"department":[137],"in":[138,160,166,214],"July":[139],"2021":[140,216],"for":[141],"severe":[142],"non-vertigo":[143],"dizziness":[144],"fatigue.He":[146],"ex-smoker":[149],"ex-drinker,":[151],"past":[154],"medical":[155],"history":[156],"pulmonary":[158],"tuberculosis":[159],"2009.10":[161],"months":[162],"prior":[163],"presentation,":[165],"September":[167],"2020,":[168],"he":[169],"diagnosed":[171],"BRAF-negative":[173],"metastatic":[174],"scrotum":[177],"groin":[179],"external":[181],"iliac":[182],"lymph":[183],"node":[184],"metastasis.He":[185],"treated":[187],"4":[189,197],"cycles":[190],"intravenous":[192],"(IV)":[193],"nivolumab":[194],"480mg":[195],"every":[196],"weeks,":[198],"(ICPi),":[203],"between":[204],"November":[205],"2020":[206],"February":[208],"2021.Routine":[209],"function":[211],"tests":[212],"(TFTs)":[213],"January":[215],"showed":[217],"secondary":[219],"hypothyroid":[220],"pattern,":[221],"evidenced":[222],"free":[226],"(FT4)":[228],"10.8":[231],"pmol/L":[232],"(TSH)":[240],"3.28":[243],"mIU/L.(Table":[244],"1)":[245],"Anti-thyroglobulin":[246],"anti-thyroid":[248],"peroxidase":[249],"antibody":[250],"levels":[251],"were":[252],"normal.Morning":[253],"160nmol/L,":[257],"range.The":[262]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2023-05-07T00:00:00"}
