{"id":"https://openalex.org/W43698706","doi":null,"title":"Duodopa infusion treatment: a point of view from the gastroenterologist.","display_name":"Duodopa infusion treatment: a point of view from the gastroenterologist.","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W43698706","mag":"43698706","pmid":"https://pubmed.ncbi.nlm.nih.gov/21961105"},"language":"en","primary_location":{"id":"pmid:21961105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21961105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033846896","display_name":"Lucian M Negreanu","orcid":"https://orcid.org/0000-0003-3042-0754","observed_orcids":["https://orcid.org/0000-0003-3042-0754"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]},{"id":"https://openalex.org/I4388891865","display_name":"Bucharest Emergency University Hospital","ror":"https://ror.org/051v1dy68","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4388891865"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Lucian Negreanu","raw_affiliation_strings":["Department of Gastroenterology, Emergency University Hospital Bucharest, Carol Davila University Bucharest, Romania. negreanu_99@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Emergency University Hospital Bucharest, Carol Davila University Bucharest, Romania. negreanu_99@yahoo.com","institution_ids":["https://openalex.org/I162051807","https://openalex.org/I4388891865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035504241","display_name":"Bogdan Ovidiu Popescu","orcid":"https://orcid.org/0000-0003-4826-2598","observed_orcids":["https://orcid.org/0000-0003-4826-2598"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Bogdan Ovidiu Popescu","raw_affiliation_strings":["Department of Neurology, \u2018Carol Davila\u2019 University, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, \u2018Carol Davila\u2019 University, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020860676","display_name":"Ruxandra Doina Babiuc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ruxandra Doina Babiuc","raw_affiliation_strings":["Department of Gastroenterology, \u2018Carol Davila\u2019 University, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, \u2018Carol Davila\u2019 University, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065172389","display_name":"Amalia Ene","orcid":"https://orcid.org/0000-0002-9419-9967","observed_orcids":["https://orcid.org/0000-0002-9419-9967"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Amalia Ene","raw_affiliation_strings":["Department of Neurology, \u2018Carol Davila\u2019 University, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, \u2018Carol Davila\u2019 University, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112868960","display_name":"Ovidiu Alexandru Bajenaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ovidiu Alexandru Bajenaru","raw_affiliation_strings":["Department of Neurology, \u2018Carol Davila\u2019 University, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, \u2018Carol Davila\u2019 University, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"last","author":{"id":null,"display_name":"Gabriel C Smarandache","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]},{"id":"https://openalex.org/I4388891865","display_name":"Bucharest Emergency University Hospital","ror":"https://ror.org/051v1dy68","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4388891865"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Gabriel C Smarandache","raw_affiliation_strings":["Department of Digestive Surgery, Emergency University Hospital Bucharest, \u2018Carol Davila\u2019 University, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Digestive Surgery, Emergency University Hospital Bucharest, \u2018Carol Davila\u2019 University, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807","https://openalex.org/I4388891865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3881,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61744982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"20","issue":"3","first_page":"325","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duodopa","display_name":"Duodopa","score":0.9829999804496765},{"id":"https://openalex.org/keywords/levodopa-carbidopa","display_name":"levodopa/carbidopa","score":0.8320000171661377},{"id":"https://openalex.org/keywords/advanced-parkinson-s-disease","display_name":"advanced Parkinson's disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/motor-fluctuations","display_name":"motor fluctuations","score":0.5950000286102295},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.9480000138282776},{"id":"https://openalex.org/keywords/interprofessional-collaboration","display_name":"interprofessional collaboration","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gastroenterology","display_name":"gastroenterology","score":0.5709999799728394},{"id":"https://openalex.org/keywords/aspiration-pneumonia","display_name":"aspiration pneumonia","score":0.4090000092983246}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9327391386032104},{"id":"https://openalex.org/C2781338923","wikidata":"https://www.wikidata.org/wiki/Q677449","display_name":"Aspiration pneumonia","level":3,"score":0.7072641253471375},{"id":"https://openalex.org/C44315111","wikidata":"https://www.wikidata.org/wiki/Q1344580","display_name":"Enteral administration","level":3,"score":0.7056787014007568},{"id":"https://openalex.org/C2778045676","wikidata":"https://www.wikidata.org/wiki/Q1087035","display_name":"Feeding tube","level":2,"score":0.6602275371551514},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.591499924659729},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.5803984999656677},{"id":"https://openalex.org/C2777014482","wikidata":"https://www.wikidata.org/wiki/Q1495687","display_name":"Gastrostomy","level":2,"score":0.5427520275115967},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.48661288619041443},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.4449985921382904},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4364017844200134},{"id":"https://openalex.org/C78722104","wikidata":"https://www.wikidata.org/wiki/Q21653202","display_name":"Parenteral nutrition","level":2,"score":0.4330146908760071},{"id":"https://openalex.org/C3018112808","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Continuous infusion","level":2,"score":0.431166410446167},{"id":"https://openalex.org/C2776754145","wikidata":"https://www.wikidata.org/wiki/Q71133637","display_name":"Carbidopa","level":5,"score":0.4309746026992798},{"id":"https://openalex.org/C2781267111","wikidata":"https://www.wikidata.org/wiki/Q652297","display_name":"Catheter","level":2,"score":0.42685163021087646},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.4090237021446228},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.39525294303894043},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30708444118499756},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2440108358860016},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19747453927993774}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000978","descriptor_name":"Antiparkinson Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002230","descriptor_name":"Carbidopa","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005762","descriptor_name":"Gastroenterology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21961105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21961105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Case Reports"},{"id":"mag:43698706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21961105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1966681262","https://openalex.org/W2026629519","https://openalex.org/W2071991657","https://openalex.org/W2139669271","https://openalex.org/W2160721784","https://openalex.org/W2170827198"],"related_works":["https://openalex.org/W1966681262","https://openalex.org/W2101091627","https://openalex.org/W2317758991","https://openalex.org/W2587787801","https://openalex.org/W2405523852","https://openalex.org/W2495486423","https://openalex.org/W2066793310","https://openalex.org/W2077249921","https://openalex.org/W2612989369","https://openalex.org/W170256281"],"abstract_inverted_index":{"In":[0],"patients":[1,155],"with":[2,47,66,128],"advanced":[3],"Parkinson's":[4],"disease,":[5],"the":[6,10,59,62,89,100,148,158,162,167,172],"continuous":[7,31],"delivery":[8],"to":[9,106,139,147,171],"small":[11],"intestine":[12],"via":[13,110],"a":[14,21,26,54,77,92,107,111,129],"jejunal":[15],"tube":[16],"of":[17,91,119,132],"levodopa/carbidopa,":[18],"formulated":[19],"as":[20],"gel":[22],"suspension":[23],"(Duodopa)":[24],"represents":[25],"new":[27],"treatment":[28],"method.":[29],"The":[30,50],"release":[32],"results":[33],"in":[34,37,69,73,99],"less":[35],"variability":[36],"levodopa":[38],"concentrations":[39],"and":[40,44,61,102,142,166],"fewer":[41],"motor":[42],"fluctuations":[43],"dyskinesias":[45],"than":[46],"oral":[48],"administration.":[49],"method":[51],"which":[52,96],"requires":[53],"very":[55],"good":[56],"collaboration":[57],"between":[58],"neurologist":[60],"gastroenterologist":[63],"is":[64,82,97,104],"used":[65],"increasing":[67],"frequency":[68],"selected":[70],"centres":[71],"especially":[72],"severe":[74],"patients.":[75],"First,":[76],"classic":[78],"PEG":[79],"gastrostomy":[80],"kit":[81],"placed":[83],"under":[84],"propofol":[85],"sedation.":[86],"This":[87],"allows":[88],"passage":[90],"pig":[93],"tail":[94],"catheter":[95],"deployed":[98],"jejunum":[101],"it":[103],"attached":[105],"portable":[108],"pump":[109],"special":[112],"tubing":[113],"system.":[114,175],"We":[115],"present":[116],"our":[117],"experience":[118],"seven":[120],"cases":[121],"(5":[122],"males,":[123],"mean":[124],"age":[125],"60":[126],"years)":[127],"follow":[130],"up":[131],"one":[133,152],"year.":[134],"One":[135],"patient":[136],"died":[137],"due":[138],"respiratory":[140],"failure":[141],"aspiration":[143],"pneumonia":[144],"probably":[145],"related":[146,164,170],"endoscopic":[149],"procedure.":[150],"At":[151],"year,":[153],"all":[154],"agreed":[156],"that":[157],"neurological":[159],"benefit":[160],"offsets":[161],"procedure":[163],"problems":[165],"technical":[168],"issues":[169],"enteral":[173],"infusion":[174]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}