{"id":"https://openalex.org/W4368368296","doi":"https://doi.org/10.1186/s13046-023-02671-8","title":"Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis","display_name":"Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis","publication_year":2023,"publication_date":"2023-05-04","ids":{"openalex":"https://openalex.org/W4368368296","doi":"https://doi.org/10.1186/s13046-023-02671-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37143164","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10157938"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-023-02671-8","doi":"https://doi.org/10.1186/s13046-023-02671-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-023-02671-8","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02671-8","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02671-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112877053","display_name":"Tianxing Zhou","orcid":"https://orcid.org/0009-0006-0150-1343","observed_orcids":["https://orcid.org/0009-0006-0150-1343"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianxing Zhou","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032050651","display_name":"Yongjie Xie","orcid":"https://orcid.org/0009-0003-3595-0866","observed_orcids":["https://orcid.org/0009-0003-3595-0866"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjie Xie","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048252551","display_name":"Xupeng Hou","orcid":"https://orcid.org/0009-0000-6330-1773","observed_orcids":["https://orcid.org/0009-0000-6330-1773"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xupeng Hou","raw_affiliation_strings":["Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088255503","display_name":"Weiwei Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwei Bai","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101458731","display_name":"Xueyang Li","orcid":"https://orcid.org/0000-0001-8161-4781","observed_orcids":["https://orcid.org/0000-0001-8161-4781"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueyang Li","raw_affiliation_strings":["Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101893454","display_name":"Ziyun Liu","orcid":"https://orcid.org/0000-0003-2992-7590","observed_orcids":["https://orcid.org/0000-0003-2992-7590"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyun Liu","raw_affiliation_strings":["Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029788983","display_name":"Quan Man","orcid":"https://orcid.org/0000-0001-8152-7477","observed_orcids":["https://orcid.org/0000-0001-8152-7477"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Man","raw_affiliation_strings":["Department of Hepatopancreatobiliary Surgery, Tongliao City Hospital, Tongliao, 028000, Inner Mongolia, China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatopancreatobiliary Surgery, Tongliao City Hospital, Tongliao, 028000, Inner Mongolia, China","institution_ids":[]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102170560","display_name":"Jingyan Sun","orcid":"https://orcid.org/0009-0008-9619-5477","observed_orcids":["https://orcid.org/0009-0008-9619-5477"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyan Sun","raw_affiliation_strings":["Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028325387","display_name":"Danqi Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danqi Fu","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070016518","display_name":"Jingrui Yan","orcid":"https://orcid.org/0009-0006-5928-4169","observed_orcids":["https://orcid.org/0009-0006-5928-4169"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingrui Yan","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101669139","display_name":"Zhaoyu Zhang","orcid":"https://orcid.org/0000-0003-0844-264X","observed_orcids":["https://orcid.org/0000-0003-0844-264X"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoyu Zhang","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365580","display_name":"Yifei Wang","orcid":"https://orcid.org/0000-0002-2073-2837","observed_orcids":["https://orcid.org/0000-0002-2073-2837"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifei Wang","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357152","display_name":"Hongwei Wang","orcid":"https://orcid.org/0000-0003-2868-5112","observed_orcids":["https://orcid.org/0000-0003-2868-5112"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongwei Wang","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104099349","display_name":"Wenna Jiang","orcid":"https://orcid.org/0009-0000-1209-7872","observed_orcids":["https://orcid.org/0009-0000-1209-7872"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenna Jiang","raw_affiliation_strings":["Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Song Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Gao","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013680661","display_name":"Tiansuo Zhao","orcid":"https://orcid.org/0000-0003-1631-6299","observed_orcids":["https://orcid.org/0000-0003-1631-6299"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tiansuo Zhao","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077930203","display_name":"Antao Chang","orcid":"https://orcid.org/0000-0001-9442-619X","observed_orcids":["https://orcid.org/0000-0001-9442-619X"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Antao Chang","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050510042","display_name":"Xiuchao Wang","orcid":"https://orcid.org/0000-0002-3205-8544","observed_orcids":["https://orcid.org/0000-0002-3205-8544"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuchao Wang","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100552395","display_name":"Hongxia Sun","orcid":"https://orcid.org/0000-0003-3229-4173","observed_orcids":["https://orcid.org/0000-0003-3229-4173"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210116048","display_name":"Beijing National Laboratory for Molecular Sciences","ror":"https://ror.org/02601yx74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210116048"]},{"id":"https://openalex.org/I4210155088","display_name":"Institute of Chemistry","ror":"https://ror.org/048y1rc66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088"]},{"id":"https://openalex.org/I4391768210","display_name":"State Key Laboratory for Structural Chemistry of Unstable and Stable Species","ror":"https://ror.org/03mw4pt79","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210155088","https://openalex.org/I4391768210"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxia Sun","raw_affiliation_strings":["Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190, P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210116048","https://openalex.org/I4210155088","https://openalex.org/I4391768210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077986501","display_name":"Xiufeng Zhang","orcid":"https://orcid.org/0000-0001-6707-3958","observed_orcids":["https://orcid.org/0000-0001-6707-3958"]},"institutions":[{"id":"https://openalex.org/I137506752","display_name":"North China University of Science and Technology","ror":"https://ror.org/04z4wmb81","country_code":"CN","type":"education","lineage":["https://openalex.org/I137506752"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiufeng Zhang","raw_affiliation_strings":["College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063210, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063210, China","institution_ids":["https://openalex.org/I137506752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044453840","display_name":"Shengyu Yang","orcid":"https://orcid.org/0000-0001-7154-6850","observed_orcids":["https://orcid.org/0000-0001-7154-6850"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shengyu Yang","raw_affiliation_strings":["Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001077325","display_name":"Chongbiao Huang","orcid":"https://orcid.org/0000-0001-9468-9168","observed_orcids":["https://orcid.org/0000-0001-9468-9168"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chongbiao Huang","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China. chhuang@tmu.edu.cn","Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, PR China. chhuang@tmu.edu.cn","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China. chhuang@tmu.edu.cn","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, PR China. chhuang@tmu.edu.cn","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079537374","display_name":"Jihui Hao","orcid":"https://orcid.org/0000-0002-1607-1730","observed_orcids":["https://orcid.org/0000-0002-1607-1730"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jihui Hao","raw_affiliation_strings":["Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China. haojihui@tjmuch.com","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China. haojihui@tjmuch.com","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101446656","display_name":"Jing Liu","orcid":"https://orcid.org/0000-0002-8181-8159","observed_orcids":["https://orcid.org/0000-0002-8181-8159"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China. piano_solo@163.com","Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China. piano_solo@163.com","Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China. piano_solo@163.com","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]},{"raw_affiliation_string":"Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, PR China. piano_solo@163.com","institution_ids":["https://openalex.org/I2802573037"]},{"raw_affiliation_string":"Department of Breast Oncoplastic Surgery and Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, 300060, PR China","institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5001077325","https://openalex.org/A5079537374","https://openalex.org/A5101446656"],"corresponding_institution_ids":["https://openalex.org/I2802573037","https://openalex.org/I5740404"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":10.4679,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.9897702,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"42","issue":"1","first_page":"111","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irbesartan","display_name":"irbesartan","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.972000002861023},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8500000238418579},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8149999976158142},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.9850000143051147},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.7599999904632568},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.777999997138977},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9169999957084656},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.5609999895095825},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fth1","display_name":"FTH1","score":0.703000009059906},{"id":"https://openalex.org/keywords/ftl","display_name":"FTL","score":0.7289999723434448},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.9779999852180481}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6688734889030457},{"id":"https://openalex.org/C2780259554","wikidata":"https://www.wikidata.org/wiki/Q947266","display_name":"Irbesartan","level":3,"score":0.6350371837615967},{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.5916517972946167},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.5177692174911499},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.5055224895477295},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43613627552986145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43455129861831665},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3616727292537689},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3080318570137024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2577851414680481},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1027238667011261},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077405","descriptor_name":"Irbesartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13046-023-02671-8","doi":"https://doi.org/10.1186/s13046-023-02671-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-023-02671-8","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02671-8","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10157938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10157938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmid:37143164","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37143164","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e32ae4b592a7470e8dd8678ad54192c9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e32ae4b592a7470e8dd8678ad54192c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-27 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-023-02671-8","doi":"https://doi.org/10.1186/s13046-023-02671-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-023-02671-8","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02671-8","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1062725160","display_name":null,"funder_award_id":"82072657","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1505001405","display_name":null,"funder_award_id":"81720108028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1972369620","display_name":null,"funder_award_id":"2021YJSB262","funder_id":"https://openalex.org/F4320336754","funder_display_name":"Tianjin Research Innovation Project for Postgraduate Students"},{"id":"https://openalex.org/G2023121719","display_name":null,"funder_award_id":"81802433","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3479693419","display_name":null,"funder_award_id":"20JCQNJC01330","funder_id":"https://openalex.org/F4320323993","funder_display_name":"Natural Science Foundation of Tianjin City"},{"id":"https://openalex.org/G4680876834","display_name":null,"funder_award_id":"82072659","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G500261112","display_name":null,"funder_award_id":"2021YFA1201100","funder_id":"https://openalex.org/F4320335774","funder_display_name":"Key Technologies Research and Development Program"},{"id":"https://openalex.org/G5096117073","display_name":null,"funder_award_id":"82030092","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5115973257","display_name":null,"funder_award_id":"81871978","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5558984614","display_name":null,"funder_award_id":"81871968","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6574293074","display_name":null,"funder_award_id":"82103006","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7572379857","display_name":null,"funder_award_id":"82173295","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7605681664","display_name":"A novel role of fascin in cancer metastasis","funder_award_id":"R01CA233844","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8056590651","display_name":null,"funder_award_id":"82072716","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000902574","display_name":"Mitochondrial calcium signaling in pancreatic cancer metastasis and progression","funder_award_id":"R01CA256911","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null},{"id":"https://openalex.org/F4320335774","display_name":"Key Technologies Research and Development Program","ror":null},{"id":"https://openalex.org/F4320336754","display_name":"Tianjin Research Innovation Project for Postgraduate Students","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4368368296.pdf"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W810966027","https://openalex.org/W1497915798","https://openalex.org/W1603491949","https://openalex.org/W1992146834","https://openalex.org/W1998149120","https://openalex.org/W2008099498","https://openalex.org/W2010916968","https://openalex.org/W2026548544","https://openalex.org/W2039551265","https://openalex.org/W2053911973","https://openalex.org/W2068387209","https://openalex.org/W2090002737","https://openalex.org/W2109838283","https://openalex.org/W2122306081","https://openalex.org/W2125987139","https://openalex.org/W2131170195","https://openalex.org/W2141915435","https://openalex.org/W2144564695","https://openalex.org/W2146177965","https://openalex.org/W2149165326","https://openalex.org/W2154790710","https://openalex.org/W2158134441","https://openalex.org/W2160778199","https://openalex.org/W2169471480","https://openalex.org/W2170202192","https://openalex.org/W2237293117","https://openalex.org/W2411298426","https://openalex.org/W2415557067","https://openalex.org/W2419145061","https://openalex.org/W2605336808","https://openalex.org/W2801831925","https://openalex.org/W2807088563","https://openalex.org/W2807833090","https://openalex.org/W2883953721","https://openalex.org/W2889176487","https://openalex.org/W2889433609","https://openalex.org/W2911953597","https://openalex.org/W2948937390","https://openalex.org/W2950430797","https://openalex.org/W2953395929","https://openalex.org/W2969252393","https://openalex.org/W2974998460","https://openalex.org/W2999027176","https://openalex.org/W3014482292","https://openalex.org/W3015020891","https://openalex.org/W3025063128","https://openalex.org/W3034089705","https://openalex.org/W3134169653","https://openalex.org/W3176719936","https://openalex.org/W3178141356","https://openalex.org/W3184820957","https://openalex.org/W3192369129","https://openalex.org/W3202669141","https://openalex.org/W3204478270","https://openalex.org/W3205638508","https://openalex.org/W3210499119","https://openalex.org/W3214546142","https://openalex.org/W4210900517","https://openalex.org/W4213053456","https://openalex.org/W4213167486","https://openalex.org/W4224233887","https://openalex.org/W4295923048"],"related_works":["https://openalex.org/W6940100996","https://openalex.org/W4400734832","https://openalex.org/W2022442325","https://openalex.org/W4393071688","https://openalex.org/W4362543488","https://openalex.org/W4414397416","https://openalex.org/W4297515874","https://openalex.org/W4402551481","https://openalex.org/W2994630960","https://openalex.org/W2971763520"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Chemoresistance":[2],"is":[3,18],"the":[4,8,69,117,140,180,203,234,288,307,325,337],"main":[5],"reason":[6],"for":[7],"poor":[9,231],"prognosis":[10],"of":[11,38,47,55,68,123,142,197,205,227,297,329,339],"pancreatic":[12],"ductal":[13],"adenocarcinoma":[14],"(PDAC).":[15],"Thus,":[16],"there":[17],"an":[19,128,318],"urgent":[20],"need":[21],"to":[22,29,59,115,144,168,233,274,286],"screen":[23],"out":[24],"new":[25],"targets":[26],"and":[27,80,89,110,150,157,183,213,264,327,346],"compounds":[28,58,70],"reverse":[30],"chemotherapeutic":[31],"resistance.":[32,65],"Methods":[33],"We":[34,51,190],"established":[35],"a":[36,44,53,74,194,255,271,332],"bio-bank":[37],"human":[39],"PDAC":[40,48,146,166,222,245,292,345],"organoid":[41,77,87],"models,":[42],"covering":[43],"representative":[45],"range":[46],"tumor":[49],"subtypes.":[50],"screened":[52],"library":[54],"1304":[56],"FDA-approved":[57],"identify":[60],"candidates":[61],"efficiently":[62,164],"overcoming":[63],"chemotherapy":[64,143,186,237,257,285,303],"The":[66],"effects":[67],"were":[71,113],"evaluated":[72],"with":[73,224,244,252,266,284,294,341],"CellTiter-Glo-3D":[75],"assay,":[76],"apoptosis":[78],"assay":[79],"in":[81,151,188,209,259,282,291,336],"vivo":[82,152],"patient-derived":[83,86],"xenograft":[84],"(PDX),":[85],"(PDO)":[88],"LSL-Kras":[90],"G12D/+":[91],";":[92,95],"LSL-Trp53":[93],"R172H/+":[94],"Pdx1-Cre":[96],"(KPC)":[97],"genetically":[98],"engineered":[99],"mouse":[100,159],"models.":[101],"RNA-sequencing,":[102],"genome":[103],"editing,":[104],"sphere":[105],"formation":[106],"assays,":[107],"iron":[108,214],"assays":[109,112],"luciferase":[111],"conducted":[114],"elucidate":[116],"mechanism.":[118],"Results":[119],"High-throughput":[120],"drug":[121],"screening":[122],"chemotherapy-resistant":[124],"PDOs":[125],"identified":[126],"irbesartan,":[127,198],"angiotensin":[129],"\u2016":[130],"type":[131],"1":[132],"(AT1)":[133],"receptor":[134],"antagonist,":[135],"which":[136,199],"could":[137,279],"synergistically":[138],"enhance":[139],"ability":[141],"kill":[145],"cells.":[147],"In":[148],"vitro":[149],"validation":[153],"using":[154],"PDO,":[155],"PDX":[156],"KPC":[158],"models":[160],"showed":[161],"that":[162,173,221,349],"irbesartan":[163,174,253,330],"sensitized":[165],"tumors":[167],"chemotherapy.":[169,276],"Mechanistically,":[170],"we":[171,219,315,350],"found":[172],"decreased":[175],"c-Jun":[176,228,268,298],"expression":[177,204,229,269],"by":[178,305],"inhibiting":[179],"Hippo/YAP1":[181],"pathway":[182],"further":[184],"overcame":[185],"resistance":[187,304],"PDAC.":[189],"also":[191],"explored":[192],"c-Jun,":[193],"potential":[195],"target":[196],"can":[200],"transcriptionally":[201],"upregulate":[202],"key":[206],"genes":[207],"involved":[208],"stemness":[210],"maintenance":[211],"(SOX9/SOX2/OCT4)":[212],"metabolism":[215,309],"(FTH1/FTL/TFRC).":[216],"More":[217],"importantly,":[218],"observed":[220],"patients":[223,243,265,293,340],"high":[225,267,295],"levels":[226,296],"demonstrated":[230],"responses":[232],"current":[235],"standard":[236,256,333],"regimen":[238,258,335],"(gemcitabine":[239],"plus":[240,254,331],"nab-paclitaxel).":[241],"Moreover,":[242],"had":[246],"significant":[247],"survival":[248],"benefits":[249],"from":[250],"treatment":[251,338],"two-center":[260],"retrospective":[261],"clinical":[262,322],"cohorts":[263],"exhibited":[270],"better":[272],"response":[273],"combination":[275,283],"Conclusions":[277],"Irbesartan":[278,300],"be":[280],"used":[281],"improve":[287],"therapeutic":[289],"efficacy":[290,326],"expression.":[299],"effectively":[301],"inhibited":[302],"suppressing":[306],"Hippo/YAP1/c-Jun/stemness/iron":[308],"axis.":[310],"Based":[311],"on":[312,324],"our":[313],"findings,":[314],"are":[316,347],"designing":[317],"investigator-initiated":[319],"phase":[320],"II":[321],"trial":[323],"safety":[328],"gemcitabine/nab-paclitaxel":[334],"advanced":[342],"III/IV":[343],"staged":[344],"hopeful":[348],"will":[351],"observe":[352],"patient":[353],"benefits.":[354]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":20}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-05-05T00:00:00"}