{"id":"https://openalex.org/W4367845154","doi":"https://doi.org/10.3389/fcimb.2023.1178788","title":"CD4+ T cell counts and soluble programmed death-1 at baseline correlated with hepatitis B surface antigen decline in HIV/HBV coinfection during combined antiretroviral therapy","display_name":"CD4+ T cell counts and soluble programmed death-1 at baseline correlated with hepatitis B surface antigen decline in HIV/HBV coinfection during combined antiretroviral therapy","publication_year":2023,"publication_date":"2023-05-03","ids":{"openalex":"https://openalex.org/W4367845154","doi":"https://doi.org/10.3389/fcimb.2023.1178788","pmid":"https://pubmed.ncbi.nlm.nih.gov/37207191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10189149"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2023.1178788","doi":"https://doi.org/10.3389/fcimb.2023.1178788","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2023.1178788","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178788/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178788/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100755101","display_name":"Xiaodi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodi Li","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117387359","display_name":"Ling Xu","orcid":"https://orcid.org/0000-0002-5097-8256","observed_orcids":["https://orcid.org/0000-0002-5097-8256"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I2800232565","display_name":"Beijing Chao-Yang Hospital, Capital Medical University","ror":"https://ror.org/01eff5662","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800232565","https://openalex.org/I4210110145","https://openalex.org/I4210135108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Xu","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I2800232565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001819052","display_name":"Lianfeng Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianfeng Lu","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050745421","display_name":"Xiaosheng Liu","orcid":"https://orcid.org/0000-0003-4282-5740","observed_orcids":["https://orcid.org/0000-0003-4282-5740"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaosheng Liu","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","Tsinghua-Peking Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Tsinghua-Peking Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397738","display_name":"Yang\ufffd Yang","orcid":"https://orcid.org/0000-0003-1222-1209","observed_orcids":["https://orcid.org/0000-0003-1222-1209","https://orcid.org/0009-0008-3480-189X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009696416","display_name":"Yuanni Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanni Wu","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616247","display_name":"Yang Han","orcid":"https://orcid.org/0000-0003-0529-6085","observed_orcids":["https://orcid.org/0000-0003-0529-6085"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Han","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348756","display_name":"Xiaoxia Li","orcid":"https://orcid.org/0000-0002-4872-9525","observed_orcids":["https://orcid.org/0000-0002-4872-9525"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Li","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363314","display_name":"Yanling Li","orcid":"https://orcid.org/0009-0006-2328-3666","observed_orcids":["https://orcid.org/0009-0006-2328-3666"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanling Li","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115591531","display_name":"Xiaojing Song","orcid":"https://orcid.org/0009-0004-8458-5612","observed_orcids":["https://orcid.org/0009-0004-8458-5612"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Song","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100625025","display_name":"Wei Cao","orcid":"https://orcid.org/0009-0002-4291-4970","observed_orcids":["https://orcid.org/0009-0002-4291-4970"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Cao","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044459845","display_name":"Taisheng Li","orcid":"https://orcid.org/0000-0002-7050-5675","observed_orcids":["https://orcid.org/0000-0002-7050-5675","https://orcid.org/0000-0002-4575-2404","https://orcid.org/0000-0003-0993-6780"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Taisheng Li","raw_affiliation_strings":["Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China","Tsinghua-Peking Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Tsinghua-Peking Center for Life Sciences, Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044459845"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662","https://openalex.org/I4210160507","https://openalex.org/I99065089"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":1.5902,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82671906,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"1178788","last_page":"1178788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-hbv-coinfection","display_name":"HIV/HBV coinfection","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hepatitis-b-surface-antigen","display_name":"hepatitis B surface antigen","score":0.859000027179718},{"id":"https://openalex.org/keywords/hbsag-loss","display_name":"HBsAg loss","score":0.878000020980835},{"id":"https://openalex.org/keywords/hbsag-kinetics","display_name":"HBsAg kinetics","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.7059999704360962},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.9357839822769165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7788732647895813},{"id":"https://openalex.org/C2777813720","wikidata":"https://www.wikidata.org/wiki/Q1243018","display_name":"Coinfection","level":3,"score":0.7773637771606445},{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.7116992473602295},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.6137937307357788},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.5240000486373901},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5238406658172607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5130635499954224},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40789276361465454},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3290621340274811},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.21072885394096375},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.17275163531303406},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006509","descriptor_name":"Hepatitis B","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006514","descriptor_name":"Hepatitis B Surface Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fcimb.2023.1178788","doi":"https://doi.org/10.3389/fcimb.2023.1178788","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2023.1178788","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178788/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10189149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10189149","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10189149/pdf/fcimb-13-1178788.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:37207191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37207191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:50eabef1e7c545fda34e6e3bb260565f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/50eabef1e7c545fda34e6e3bb260565f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2023.1178788","doi":"https://doi.org/10.3389/fcimb.2023.1178788","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2023.1178788","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcimb.2023.1178788/pdf","source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3592520282","display_name":null,"funder_award_id":"2021\u2010I2M\u20101\u2010037","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G643743048","display_name":null,"funder_award_id":"2017ZX10202101","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G885406935","display_name":null,"funder_award_id":"2022-","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320324962","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367845154.pdf","grobid_xml":"https://content.openalex.org/works/W4367845154.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1894153170","https://openalex.org/W1978436252","https://openalex.org/W2005593266","https://openalex.org/W2014116920","https://openalex.org/W2033837061","https://openalex.org/W2063139303","https://openalex.org/W2081260856","https://openalex.org/W2092651879","https://openalex.org/W2117947644","https://openalex.org/W2128166983","https://openalex.org/W2152095262","https://openalex.org/W2157039129","https://openalex.org/W2172066280","https://openalex.org/W2173698250","https://openalex.org/W2177785621","https://openalex.org/W2288679785","https://openalex.org/W2294752065","https://openalex.org/W2507136820","https://openalex.org/W2519555875","https://openalex.org/W2535076955","https://openalex.org/W2739640246","https://openalex.org/W2790860083","https://openalex.org/W2902775411","https://openalex.org/W2906267046","https://openalex.org/W2912069976","https://openalex.org/W2962219096","https://openalex.org/W2967770094","https://openalex.org/W2971814824","https://openalex.org/W2977375198","https://openalex.org/W2980684990","https://openalex.org/W2984221112","https://openalex.org/W2995907925","https://openalex.org/W3006006446","https://openalex.org/W3020957886","https://openalex.org/W3023526733","https://openalex.org/W3045446056","https://openalex.org/W3087512461","https://openalex.org/W3091285831","https://openalex.org/W3092739720","https://openalex.org/W3161955043","https://openalex.org/W3181656942","https://openalex.org/W4205448607","https://openalex.org/W4224237532","https://openalex.org/W4283156757","https://openalex.org/W4293530565","https://openalex.org/W4294921615","https://openalex.org/W4312017187","https://openalex.org/W4317402183"],"related_works":["https://openalex.org/W4403132657","https://openalex.org/W2044734839","https://openalex.org/W1988979100","https://openalex.org/W4407757101","https://openalex.org/W2515895706","https://openalex.org/W2053759074","https://openalex.org/W2140765034","https://openalex.org/W2128166983","https://openalex.org/W143018193","https://openalex.org/W4319602560"],"abstract_inverted_index":{"Background":[0],"Several":[1],"studies":[2],"have":[3],"described":[4],"the":[5,42,53,57,153,167,195,222,296],"rapid":[6,288],"decline":[7,32,62,142,187,290,320],"and":[8,56,87,101,120,125,132,171,231,250,281],"clearance":[9,208],"of":[10,33,44,59,73,92,109,143,157,175,188,199,202,212,298],"hepatitis":[11],"B":[12,21],"surface":[13],"antigen":[14],"(HBsAg)":[15],"in":[16,41,63,166,256,263,291,321],"human":[17],"immunodeficiency":[18],"virus":[19,22],"(HIV)/hepatitis":[20],"(HBV)":[23],"coinfection":[24,67,78],"after":[25,95,155,179,242,271,295],"initiating":[26],"combined":[27],"antiretroviral":[28],"therapy":[29],"(cART).":[30],"Early":[31],"HBsAg":[34,39,54,61,110,136,160,207,240,260,269,289,322],"levels":[35,119,228,323],"is":[36],"associated":[37,238],"with":[38,65,76,239,293],"seroclearance":[40],"treatment":[43],"chronic":[45],"HBV":[46],"infection.":[47],"This":[48],"study":[49],"aims":[50],"to":[51,286,314,317],"evaluate":[52],"kinetics":[55,108],"determinants":[58],"early":[60],"patients":[64,75,205,257,292],"HIV/HBV":[66,77],"during":[68,111,134,324],"cART.":[69,158,299],"Methods":[70],"A":[71],"total":[72],"51":[74],"were":[79,104,113,127,236,253,284],"enrolled":[80],"from":[81,152],"a":[82,90,141,173,186,210,287,318],"previously":[83],"established":[84],"HIV/AIDS":[85],"cohort":[86],"followed":[88],"for":[89],"median":[91,211],"59.5":[93],"months":[94,151,170,198,214],"cART":[96,112,243,272],"initiation.":[97,244,273],"Biochemical":[98],"tests,":[99],"virology":[100],"immunology":[102],"assessments":[103],"measured":[105,128],"longitudinally.":[106],"The":[107,245],"analyzed.":[114],"Soluble":[115],"programmed":[116],"death-1":[117],"(sPD-1)":[118],"immune":[121,282,304,312],"activation":[122,283],"markers":[123],"(CD38":[124],"HLA-DR)":[126],"at":[129,149,194,209],"baseline,":[130],"1-year":[131],"3-year":[133],"treatment.":[135],"response":[137,241,261,270],"was":[138],"defined":[139],"as":[140],"more":[144,189],"than":[145,190,262],"0.5":[146,191],"log10":[147,164,177,192],"IU/ml":[148,193],"6":[150,197],"baseline":[154,224],"initiation":[156,297],"Results":[159],"declined":[161],"faster":[162,319],"(0.47":[163],"IU/mL)":[165],"first":[168,196],"six":[169],"attained":[172],"decrease":[174],"1.39":[176],"IU/mL":[178],"5-year":[180],"therapy.":[181],"Seventeen":[182],"(33.3%)":[183],"participants":[184],"achieved":[185,206,259],"cART(HBsAg":[200],"response)":[201],"which":[203],"five":[204],"11":[213],"(range:":[215],"6-51":[216],"months).":[217],"Multivariate":[218],"logistic":[219],"analysis":[220],"showed":[221],"lower":[223],"CD4+":[225],"T":[226,278],"cell":[227],"(OR=6.633,":[229],"P=0.012)":[230],"sPD-1":[232],"level":[233],"(OR=5.389,":[234],"P=0.038)":[235],"independently":[237],"alanine":[246],"aminotransferase":[247],"abnormality":[248],"rate":[249],"HLA-DR":[251],"expression":[252],"significantly":[254],"higher":[255],"who":[258,265],"those":[264],"did":[266],"not":[267],"achieve":[268],"Conclusion":[274],"Lower":[275],"CD4":[276],"+":[277],"cells,":[279],"sPD-1,":[280],"related":[285],"HIV/HBV-coinfection":[294],"These":[300],"findings":[301],"imply":[302],"that":[303],"disorders":[305],"induced":[306],"by":[307],"HIV":[308],"infection":[309],"may":[310],"disrupt":[311],"tolerance":[313],"HBV,":[315],"leading":[316],"coinfection.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-04T00:00:00"}