{"id":"https://openalex.org/W4367842813","doi":"https://doi.org/10.3892/ol.2023.13851","title":"Metabolic biomarkers in lung cancer screening and early diagnosis (Review)","display_name":"Metabolic biomarkers in lung cancer screening and early diagnosis (Review)","publication_year":2023,"publication_date":"2023-05-03","ids":{"openalex":"https://openalex.org/W4367842813","doi":"https://doi.org/10.3892/ol.2023.13851","pmid":"https://pubmed.ncbi.nlm.nih.gov/37216157","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10193366"},"language":"en","primary_location":{"id":"doi:10.3892/ol.2023.13851","doi":"https://doi.org/10.3892/ol.2023.13851","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2023.13851","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2023.13851/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/ol.2023.13851/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100780662","display_name":"Yongjie Xu","orcid":"https://orcid.org/0000-0002-6815-9312","observed_orcids":["https://orcid.org/0000-0002-6815-9312"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjie Xu","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084851606","display_name":"Xuesi Dong","orcid":"https://orcid.org/0000-0003-2986-7866","observed_orcids":["https://orcid.org/0000-0003-2986-7866"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuesi Dong","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014900922","display_name":"Chao Qin","orcid":"https://orcid.org/0000-0002-3766-771X","observed_orcids":["https://orcid.org/0000-0002-3766-771X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Qin","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455725","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0001-6767-3283","observed_orcids":["https://orcid.org/0000-0001-6767-3283"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Cao","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392349","display_name":"Jiang Li","orcid":"https://orcid.org/0000-0001-5596-9159","observed_orcids":["https://orcid.org/0000-0001-5596-9159"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Li","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021828098","display_name":"Yiwen Yu","orcid":"https://orcid.org/0000-0002-3935-846X","observed_orcids":["https://orcid.org/0000-0002-3935-846X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Yu","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101929503","display_name":"Liang Zhao","orcid":"https://orcid.org/0000-0001-8841-351X","observed_orcids":["https://orcid.org/0000-0001-8841-351X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Zhao","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071213444","display_name":"Fengwei Tan","orcid":"https://orcid.org/0000-0002-8210-684X","observed_orcids":["https://orcid.org/0000-0002-8210-684X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengwei Tan","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083719308","display_name":"Wanqing Chen","orcid":"https://orcid.org/0000-0002-1159-1884","observed_orcids":["https://orcid.org/0000-0002-1159-1884"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanqing Chen","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035433129","display_name":"Ni Li","orcid":"https://orcid.org/0000-0001-5530-7745","observed_orcids":["https://orcid.org/0000-0001-5530-7745","https://orcid.org/0000-0001-9351-7823","https://orcid.org/0009-0005-5122-9272","https://orcid.org/0009-0006-4752-4604"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ni Li","raw_affiliation_strings":["Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057297599","display_name":"Jie He","orcid":"https://orcid.org/0000-0003-4454-1784","observed_orcids":["https://orcid.org/0000-0003-4454-1784"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie He","raw_affiliation_strings":["Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R.\u00a0China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035433129","https://openalex.org/A5057297599"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"],"apc_list":null,"apc_paid":null,"fwci":0.4015,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.37150797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"25","issue":"6","first_page":"265","last_page":"265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8208000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.7940000295639038},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/low-dose-ct-screening","display_name":"low-dose CT screening","score":0.8100000023841858},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.9369999766349792},{"id":"https://openalex.org/keywords/false-positive-results","display_name":"false positives","score":0.6389999985694885},{"id":"https://openalex.org/keywords/radiation-exposure","display_name":"radiation exposure","score":0.6710000038146973},{"id":"https://openalex.org/keywords/molecular-signatures","display_name":"molecular signatures","score":0.5210000276565552},{"id":"https://openalex.org/keywords/tumor-screening","display_name":"cancer screening","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.781260073184967},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6356428265571594},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6054773926734924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5750041007995605},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5430786609649658},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4877522587776184},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.44155871868133545},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39772000908851624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37987565994262695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3661571741104126}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/ol.2023.13851","doi":"https://doi.org/10.3892/ol.2023.13851","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2023.13851","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2023.13851/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10193366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10193366","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10193366/pdf/ol-25-06-13851.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncol Lett","raw_type":"Text"},{"id":"pmid:37216157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37216157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology letters","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ol.2023.13851","doi":"https://doi.org/10.3892/ol.2023.13851","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ol.2023.13851","pdf_url":"http://www.spandidos-publications.com/10.3892/ol.2023.13851/download","source":{"id":"https://openalex.org/S58832373","display_name":"Oncology Letters","issn_l":"1792-1074","issn":["1792-1074","1792-1082"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Letters","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3418187937","display_name":null,"funder_award_id":"2018YFC1315000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4132055748","display_name":null,"funder_award_id":"82273722","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367842813.pdf","grobid_xml":"https://content.openalex.org/works/W4367842813.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W44319099","https://openalex.org/W130099911","https://openalex.org/W1522130221","https://openalex.org/W1771103014","https://openalex.org/W2004732365","https://openalex.org/W2007646009","https://openalex.org/W2021415101","https://openalex.org/W2035641101","https://openalex.org/W2036103055","https://openalex.org/W2038989299","https://openalex.org/W2039638713","https://openalex.org/W2055277627","https://openalex.org/W2057340974","https://openalex.org/W2062833528","https://openalex.org/W2063821826","https://openalex.org/W2065021234","https://openalex.org/W2068167333","https://openalex.org/W2071534982","https://openalex.org/W2072451938","https://openalex.org/W2082117719","https://openalex.org/W2083843824","https://openalex.org/W2085578084","https://openalex.org/W2102788947","https://openalex.org/W2105665764","https://openalex.org/W2107363389","https://openalex.org/W2107869090","https://openalex.org/W2113315423","https://openalex.org/W2126925889","https://openalex.org/W2130784515","https://openalex.org/W2137585293","https://openalex.org/W2137960344","https://openalex.org/W2146964349","https://openalex.org/W2149443601","https://openalex.org/W2166153631","https://openalex.org/W2185440705","https://openalex.org/W2194890007","https://openalex.org/W2207019263","https://openalex.org/W2223583769","https://openalex.org/W2232253350","https://openalex.org/W2281516445","https://openalex.org/W2291060931","https://openalex.org/W2295182096","https://openalex.org/W2304746941","https://openalex.org/W2322044910","https://openalex.org/W2325296863","https://openalex.org/W2345968351","https://openalex.org/W2586564307","https://openalex.org/W2587034866","https://openalex.org/W2587333480","https://openalex.org/W2605041950","https://openalex.org/W2734815827","https://openalex.org/W2741452529","https://openalex.org/W2742380636","https://openalex.org/W2752625590","https://openalex.org/W2753124759","https://openalex.org/W2770892030","https://openalex.org/W2788703461","https://openalex.org/W2807914299","https://openalex.org/W2904549627","https://openalex.org/W2913982013","https://openalex.org/W2916376502","https://openalex.org/W2928271642","https://openalex.org/W2954801519","https://openalex.org/W2971041600","https://openalex.org/W2978688180","https://openalex.org/W3003415550","https://openalex.org/W3010004695","https://openalex.org/W3014729519","https://openalex.org/W3042614271","https://openalex.org/W3087365107","https://openalex.org/W3119002141","https://openalex.org/W3128646645","https://openalex.org/W3129373151","https://openalex.org/W3136238717","https://openalex.org/W3136705452","https://openalex.org/W3162293114","https://openalex.org/W3164256537","https://openalex.org/W3192767557","https://openalex.org/W3193024485","https://openalex.org/W4210418780","https://openalex.org/W4230805301","https://openalex.org/W4232719563","https://openalex.org/W4239112734","https://openalex.org/W4239778289","https://openalex.org/W4241804209","https://openalex.org/W4297224520","https://openalex.org/W4308389606","https://openalex.org/W4308512276","https://openalex.org/W4308772076"],"related_works":["https://openalex.org/W2898508647","https://openalex.org/W3031711280","https://openalex.org/W4207022089","https://openalex.org/W3158484933","https://openalex.org/W4388095060","https://openalex.org/W4229378985","https://openalex.org/W2788703461","https://openalex.org/W2796527341","https://openalex.org/W4388944547","https://openalex.org/W4388699881"],"abstract_inverted_index":{"Late":[0],"diagnosis":[1],"is":[2,18,42,50],"one":[3],"of":[4,14,23,46,83,98,113,122],"the":[5,10,20,34,47,51,111,123,141,146],"major":[6],"contributing":[7],"factors":[8],"to":[9,92,107],"high":[11,70],"mortality":[12,25,62],"rate":[13],"lung":[15,39,60,132,166],"cancer,":[16],"which":[17,38],"now":[19],"leading":[21],"cause":[22],"cancer-associated":[24],"worldwide.":[26],"At":[27],"present,":[28],"low-dose":[29],"CT":[30],"(LDCT)":[31],"screening":[32,68,100,168],"in":[33,37,63,74,150,154,165],"high-risk":[35],"population,":[36],"cancer":[40,61,133,167],"incidence":[41],"higher":[43],"than":[44],"that":[45,126],"low-risk":[48,108],"population":[49],"predominant":[52],"diagnostic":[53],"strategy.":[54],"Although":[55],"this":[56,96],"has":[57,69,89],"efficiently":[58],"reduced":[59],"large":[64],"randomized":[65],"trials,":[66],"LDCT":[67,84],"false-positive":[71],"rates,":[72],"resulting":[73],"excessive":[75],"subsequent":[76],"follow-up":[77],"procedures":[78],"and":[79,95,110,169],"radiation":[80],"exposure.":[81],"Complementation":[82],"examination":[85],"with":[86,131,158],"biofluid-based":[87],"biomarkers":[88],"been":[90,138],"documented":[91],"increase":[93],"efficacy,":[94],"type":[97],"preliminary":[99],"can":[101,127],"potentially":[102],"reduce":[103],"potential":[104],"radioactive":[105],"damage":[106],"populations":[109],"burden":[112],"hospital":[114],"resources.":[115],"Several":[116],"molecular":[117],"signatures":[118],"based":[119],"on":[120,161],"components":[121],"biofluid":[124],"metabolome":[125],"possibly":[128],"discriminate":[129],"patients":[130],"from":[134],"healthy":[135],"individuals":[136],"have":[137],"proposed":[139],"over":[140],"past":[142],"two":[143],"decades.":[144],"In":[145],"present":[147],"review,":[148],"advancements":[149],"currently":[151],"available":[152],"technologies":[153],"metabolomics":[155],"were":[156],"reviewed,":[157],"particular":[159],"focus":[160],"their":[162],"possible":[163],"application":[164],"early":[170],"detection.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-05-04T00:00:00"}
