{"id":"https://openalex.org/W4367693479","doi":"https://doi.org/10.1016/j.celrep.2023.112465","title":"Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters","display_name":"Functional interplay between Mediator and RSC chromatin remodeling complex controls nucleosome-depleted region maintenance at promoters","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4367693479","doi":"https://doi.org/10.1016/j.celrep.2023.112465","pmid":"https://pubmed.ncbi.nlm.nih.gov/37133993"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2023.112465","doi":"https://doi.org/10.1016/j.celrep.2023.112465","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.112465","pdf_url":"http://www.cell.com/article/S221112472300476X/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S221112472300476X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071401053","display_name":"K\u00e9vin M. Andr\u00e9","orcid":"https://orcid.org/0009-0008-4031-9848","observed_orcids":["https://orcid.org/0009-0008-4031-9848"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"K\u00e9vin M. Andr\u00e9","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114021750","display_name":"Nathalie Giordanengo Aiach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Giordanengo Aiach","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018975964","display_name":"Veronica Martinez-Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Veronica Martinez-Fernandez","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044533871","display_name":"Leo Zeitler","orcid":"https://orcid.org/0000-0001-6667-4663","observed_orcids":["https://orcid.org/0000-0001-6667-4663"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Leo Zeitler","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0001-6667-4663","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068749773","display_name":"Adriana Alberti","orcid":"https://orcid.org/0000-0003-3372-9423","observed_orcids":["https://orcid.org/0000-0003-3372-9423"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Adriana Alberti","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-3372-9423","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053305582","display_name":"Arach Goldar","orcid":"https://orcid.org/0000-0003-4139-247X","observed_orcids":["https://orcid.org/0000-0003-4139-247X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arach Goldar","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-4139-247X","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032369856","display_name":"Michel Werner","orcid":"https://orcid.org/0000-0002-2965-5858","observed_orcids":["https://orcid.org/0000-0002-2965-5858"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210113761","display_name":"Institut Jacques Monod","ror":"https://ror.org/02c5gc203","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210113761"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Werner","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, 75013 Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-2965-5858","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, CNRS, Institut Jacques Monod, 75013 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210113761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025174656","display_name":"Cyril Denby Wilkes","orcid":"https://orcid.org/0000-0003-3932-5294","observed_orcids":["https://orcid.org/0000-0003-3932-5294"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyril Denby Wilkes","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0003-3932-5294","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010841814","display_name":"Julie Soutourina","orcid":"https://orcid.org/0000-0001-5218-2350","observed_orcids":["https://orcid.org/0000-0001-5218-2350"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210106617","display_name":"Institut de Biologie Int\u00e9grative de la Cellule","ror":"https://ror.org/01fftxe08","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210113668"]},{"id":"https://openalex.org/I4210128565","display_name":"CEA Paris-Saclay","ror":"https://ror.org/03n15ch10","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210128565"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Julie Soutourina","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Electronic address: julie.soutourina@cea.fr","Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France"],"raw_orcid":"https://orcid.org/0000-0001-5218-2350","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Electronic address: julie.soutourina@cea.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210128565"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5010841814"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I277688954","https://openalex.org/I4210106617","https://openalex.org/I4210128565"],"apc_list":{"value":5460,"currency":"USD","value_usd":5460},"apc_paid":{"value":4500,"currency":"EUR","value_usd":4853},"fwci":0.7724,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.64526374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"42","issue":"5","first_page":"112465","last_page":"112465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mediator-complex","display_name":"Mediator complex","score":0.9509999752044678},{"id":"https://openalex.org/keywords/nucleosome-depleted-regions","display_name":"nucleosome-depleted regions","score":0.9010000228881836},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.6399999856948853},{"id":"https://openalex.org/keywords/nucleosome-eviction","display_name":"nucleosome eviction","score":0.7580000162124634},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.7689999938011169},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8539999723434448},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.6449999809265137},{"id":"https://openalex.org/keywords/nucleosome-occupancy","display_name":"nucleosome occupancy","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C14519417","wikidata":"https://www.wikidata.org/wiki/Q5113740","display_name":"Chromatin structure remodeling (RSC) complex","level":5,"score":0.944010853767395},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8640010356903076},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.8352569341659546},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.8114534616470337},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.7794056534767151},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.7310836911201477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6134973168373108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6104577779769897},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4703666865825653},{"id":"https://openalex.org/C166941617","wikidata":"https://www.wikidata.org/wiki/Q421708","display_name":"SWI/SNF","level":5,"score":0.4342173933982849},{"id":"https://openalex.org/C137338518","wikidata":"https://www.wikidata.org/wiki/Q4919210","display_name":"Bivalent chromatin","level":5,"score":0.4321708083152771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4165748357772827},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17868253588676453},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13218829035758972}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.celrep.2023.112465","doi":"https://doi.org/10.1016/j.celrep.2023.112465","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.112465","pdf_url":"http://www.cell.com/article/S221112472300476X/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2022.09.22.509083","doi":"https://doi.org/10.1101/2022.09.22.509083","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.22.509083","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/09/23/2022.09.22.509083.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37133993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37133993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f9bbea9526e54585825f206e6c20bd6d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f9bbea9526e54585825f206e6c20bd6d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 42, Iss 5, Pp 112465- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2023.112465","doi":"https://doi.org/10.1016/j.celrep.2023.112465","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.112465","pdf_url":"http://www.cell.com/article/S221112472300476X/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6007769398","display_name":null,"funder_award_id":"PGA1 RF20170205342","funder_id":"https://openalex.org/F4320322361","funder_display_name":"Fondation ARC pour la Recherche sur le Cancer"},{"id":"https://openalex.org/G8468091303","display_name":null,"funder_award_id":"800945","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320322727","display_name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","ror":"https://ror.org/03sjk9a61"},{"id":"https://openalex.org/F4320323911","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55"},{"id":"https://openalex.org/F4320326715","display_name":"Minist\u00e8re de l'Enseignement sup\u00e9rieur, de la Recherche et de l'Innovation","ror":null},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367693479.pdf","grobid_xml":"https://content.openalex.org/works/W4367693479.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1534917150","https://openalex.org/W1660678623","https://openalex.org/W1949005637","https://openalex.org/W1969228261","https://openalex.org/W1970599272","https://openalex.org/W1973785602","https://openalex.org/W1974595249","https://openalex.org/W1982128166","https://openalex.org/W2005282195","https://openalex.org/W2006277271","https://openalex.org/W2017550851","https://openalex.org/W2024645644","https://openalex.org/W2029099543","https://openalex.org/W2030542066","https://openalex.org/W2056304859","https://openalex.org/W2062669590","https://openalex.org/W2085567058","https://openalex.org/W2085694012","https://openalex.org/W2094775025","https://openalex.org/W2109426592","https://openalex.org/W2127079829","https://openalex.org/W2147793191","https://openalex.org/W2150075314","https://openalex.org/W2152937220","https://openalex.org/W2159518929","https://openalex.org/W2163232947","https://openalex.org/W2167840211","https://openalex.org/W2345982876","https://openalex.org/W2525992712","https://openalex.org/W2532816831","https://openalex.org/W2611767197","https://openalex.org/W2614855056","https://openalex.org/W2620439325","https://openalex.org/W2772832167","https://openalex.org/W2831181062","https://openalex.org/W2898224297","https://openalex.org/W2898544543","https://openalex.org/W2904555596","https://openalex.org/W2961424399","https://openalex.org/W2982561006","https://openalex.org/W2997966709","https://openalex.org/W3011035493","https://openalex.org/W3119441068","https://openalex.org/W3183548352","https://openalex.org/W3189598002","https://openalex.org/W4299503428"],"related_works":["https://openalex.org/W2515838634","https://openalex.org/W2620439325","https://openalex.org/W146087253","https://openalex.org/W7214272758","https://openalex.org/W2907318477","https://openalex.org/W3084137283","https://openalex.org/W1975123147","https://openalex.org/W2970459875","https://openalex.org/W2801514156","https://openalex.org/W6987525963"],"abstract_inverted_index":{"Chromatin":[0],"organization":[1,127],"is":[2,10,63],"crucial":[3,64],"for":[4,65,145],"transcriptional":[5,138],"regulation":[6,139],"in":[7,19,38,77,134,140],"eukaryotes.":[8],"Mediator":[9,44,89,101,115],"an":[11],"essential":[12,58],"and":[13,57,83,90,99,106,124],"conserved":[14,56],"co-activator":[15],"thought":[16],"to":[17,117,121],"act":[18],"concert":[20],"with":[21,48],"chromatin":[22,59,79,126,142],"regulators.":[23],"However,":[24],"it":[25],"remains":[26],"largely":[27],"unknown":[28],"how":[29],"their":[30,78],"functions":[31],"are":[32],"coordinated.":[33],"Here,":[34],"we":[35],"provide":[36],"evidence":[37],"the":[39,51,72,141],"yeast":[40],"Saccharomyces":[41],"cerevisiae":[42],"that":[43,62,114],"establishes":[45],"physical":[46],"contact":[47],"RSC":[49,91,118],"(Remodels":[50],"Structure":[52],"of":[53,74,96,137],"Chromatin),":[54],"a":[55,86],"remodeling":[60,119],"complex":[61],"nucleosome-depleted":[66],"region":[67],"(NDR)":[68],"formation.":[69],"We":[70],"determine":[71],"role":[73],"Mediator-RSC":[75],"interaction":[76],"binding,":[80],"nucleosome":[81,104,109],"occupancy,":[82],"transcription":[84],"on":[85,93,128],"genomic":[87],"scale.":[88],"co-localize":[92],"wide":[94],"NDRs":[95,123],"promoter":[97,129],"regions,":[98],"specific":[100],"mutations":[102],"affect":[103],"eviction":[105],"TSS-associated":[107],"+1":[108],"stability.":[110],"This":[111],"work":[112],"shows":[113],"contributes":[116],"function":[120],"shape":[122],"maintain":[125],"regions.":[130],"It":[131],"will":[132],"help":[133],"our":[135],"understanding":[136],"context":[143],"relevant":[144],"severe":[146],"diseases.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-05-03T00:00:00"}