{"id":"https://openalex.org/W4367675612","doi":"https://doi.org/10.1556/030.2023.02015","title":"Investigation of in vitro efficacy of meropenem/polymyxin B and meropenem/fosfomycin combinations against carbapenem resistant Klebsiella pneumoniae strains","display_name":"Investigation of in vitro efficacy of meropenem/polymyxin B and meropenem/fosfomycin combinations against carbapenem resistant Klebsiella pneumoniae strains","publication_year":2023,"publication_date":"2023-05-02","ids":{"openalex":"https://openalex.org/W4367675612","doi":"https://doi.org/10.1556/030.2023.02015","pmid":"https://pubmed.ncbi.nlm.nih.gov/37133999"},"language":"en","primary_location":{"id":"doi:10.1556/030.2023.02015","doi":"https://doi.org/10.1556/030.2023.02015","is_oa":true,"landing_page_url":"https://doi.org/10.1556/030.2023.02015","pdf_url":"https://akjournals.com/downloadpdf/journals/030/70/2/article-p155.pdf","source":{"id":"https://openalex.org/S4210178206","display_name":"Acta Microbiologica et Immunologica Hungarica","issn_l":"1217-8950","issn":["1217-8950","1588-2640"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320364","host_organization_name":"Akad\u00e9miai Kiad\u00f3","host_organization_lineage":["https://openalex.org/P4310320364","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Akad\u00e9miai Kiad\u00f3","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Microbiologica et Immunologica Hungarica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://akjournals.com/downloadpdf/journals/030/70/2/article-p155.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072570961","display_name":"R\u0131za Adaleti","orcid":"https://orcid.org/0000-0001-9576-6794","observed_orcids":["https://orcid.org/0000-0001-9576-6794"]},"institutions":[{"id":"https://openalex.org/I4210126306","display_name":"Haydarpa\u015fa Numune E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03pdc2j75","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210126306"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"R\u0131za Adaleti","raw_affiliation_strings":["University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Laboratory of Medical Microbiology, Istanbul, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-9576-6794","affiliations":[{"raw_affiliation_string":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Laboratory of Medical Microbiology, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210126306","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000556776","display_name":"Ya\u015far Nakipo\u011flu","orcid":"https://orcid.org/0000-0001-7979-7291","observed_orcids":["https://orcid.org/0000-0001-7979-7291"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ya\u015far Nakipo\u011flu","raw_affiliation_strings":["Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093, Capa/Istanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093, Capa/Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112853764","display_name":"\u015eeyma \u00c7al\u0131k","orcid":"https://orcid.org/0000-0002-3640-5195","observed_orcids":["https://orcid.org/0000-0002-3640-5195"]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015eeyma \u00c7al\u0131k","raw_affiliation_strings":["Ministry of Health, Directorate of Public Health, Amasya, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Health, Directorate of Public Health, Amasya, T\u00fcrkiye","institution_ids":["https://openalex.org/I1303077703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024759650","display_name":"Neslihan Ar\u0131c\u0131","orcid":"https://orcid.org/0000-0003-4788-0044","observed_orcids":["https://orcid.org/0000-0003-4788-0044"]},"institutions":[{"id":"https://openalex.org/I4210126306","display_name":"Haydarpa\u015fa Numune E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03pdc2j75","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210126306"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Neslihan Ar\u0131c\u0131","raw_affiliation_strings":["University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Laboratory of Medical Microbiology, Istanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Laboratory of Medical Microbiology, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210126306","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015581641","display_name":"Nilg\u00fcn Kansak","orcid":"https://orcid.org/0000-0002-1117-3906","observed_orcids":["https://orcid.org/0000-0002-1117-3906"]},"institutions":[{"id":"https://openalex.org/I4210126306","display_name":"Haydarpa\u015fa Numune E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/03pdc2j75","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210126306"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nilg\u00fcn Kansak","raw_affiliation_strings":["University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Laboratory of Medical Microbiology, Istanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Haydarpa\u015fa Numune Training and Research Hospital, Laboratory of Medical Microbiology, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210126306","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032353857","display_name":"Seniha \u015eenbayrak","orcid":"https://orcid.org/0000-0002-4983-6613","observed_orcids":["https://orcid.org/0000-0002-4983-6613"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seniha \u015eenbayrak","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210128276"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049394497","display_name":"Sebahat Aksaray","orcid":"https://orcid.org/0000-0002-0552-1337","observed_orcids":["https://orcid.org/0000-0002-0552-1337"]},"institutions":[{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sebahat Aksaray","raw_affiliation_strings":["Department of Medical Microbiology, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, Hamidiye Medical Faculty, University of Health Sciences, Istanbul, T\u00fcrkiye","institution_ids":["https://openalex.org/I4210128276"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3643,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.46128278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"70","issue":"2","first_page":"155","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbapenem-resistant-klebsiella-pneumoniae","display_name":"carbapenem-resistant Klebsiella pneumoniae","score":0.9879999756813049},{"id":"https://openalex.org/keywords/meropenem","display_name":"meropenem","score":0.9330000281333923},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fosfomycin","display_name":"fosfomycin","score":1.0},{"id":"https://openalex.org/keywords/combination-antibiotic-therapy","display_name":"combination antibiotic therapy","score":0.6660000085830688},{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.4699999988079071},{"id":"https://openalex.org/keywords/carbapenemase-genes","display_name":"carbapenemase genes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/blakpc","display_name":"blaKPC","score":0.8629999756813049},{"id":"https://openalex.org/keywords/blaoxa-48","display_name":"blaOXA-48","score":0.9950000047683716},{"id":"https://openalex.org/keywords/blandm","display_name":"blaNDM","score":0.9120000004768372},{"id":"https://openalex.org/keywords/in-vitro-antibacterial-activity","display_name":"in vitro antibacterial activity","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2779375183","wikidata":"https://www.wikidata.org/wiki/Q421670","display_name":"Meropenem","level":4,"score":0.977878212928772},{"id":"https://openalex.org/C2778897966","wikidata":"https://www.wikidata.org/wiki/Q183554","display_name":"Fosfomycin","level":3,"score":0.9446414709091187},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.8446913361549377},{"id":"https://openalex.org/C2780026444","wikidata":"https://www.wikidata.org/wiki/Q1088175","display_name":"Polymyxin B","level":3,"score":0.8057483434677124},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7783212065696716},{"id":"https://openalex.org/C2776685102","wikidata":"https://www.wikidata.org/wiki/Q410897","display_name":"Carbapenem","level":3,"score":0.6511505842208862},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.6350376605987549},{"id":"https://openalex.org/C2780493024","wikidata":"https://www.wikidata.org/wiki/Q19903202","display_name":"Agar dilution","level":4,"score":0.5741531848907471},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.45526814460754395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3963097929954529},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.19722074270248413},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.16802248358726501},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.12993815541267395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1292034387588501},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.03518471121788025}],"mesh":[{"descriptor_ui":"D000073182","descriptor_name":"Carbapenem-Resistant Enterobacteriaceae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077731","descriptor_name":"Meropenem","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000077731","descriptor_name":"Meropenem","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005578","descriptor_name":"Fosfomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015780","descriptor_name":"Carbapenems","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1556/030.2023.02015","doi":"https://doi.org/10.1556/030.2023.02015","is_oa":true,"landing_page_url":"https://doi.org/10.1556/030.2023.02015","pdf_url":"https://akjournals.com/downloadpdf/journals/030/70/2/article-p155.pdf","source":{"id":"https://openalex.org/S4210178206","display_name":"Acta Microbiologica et Immunologica Hungarica","issn_l":"1217-8950","issn":["1217-8950","1588-2640"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320364","host_organization_name":"Akad\u00e9miai Kiad\u00f3","host_organization_lineage":["https://openalex.org/P4310320364","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Akad\u00e9miai Kiad\u00f3","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Microbiologica et Immunologica Hungarica","raw_type":"journal-article"},{"id":"pmid:37133999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37133999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta microbiologica et immunologica Hungarica","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:192590","doi":null,"is_oa":true,"landing_page_url":"https://real.mtak.hu/192590/1/030-article-p155.pdf","pdf_url":"https://real.mtak.hu/192590/1/030-article-p155.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1556/030.2023.02015","doi":"https://doi.org/10.1556/030.2023.02015","is_oa":true,"landing_page_url":"https://doi.org/10.1556/030.2023.02015","pdf_url":"https://akjournals.com/downloadpdf/journals/030/70/2/article-p155.pdf","source":{"id":"https://openalex.org/S4210178206","display_name":"Acta Microbiologica et Immunologica Hungarica","issn_l":"1217-8950","issn":["1217-8950","1588-2640"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320364","host_organization_name":"Akad\u00e9miai Kiad\u00f3","host_organization_lineage":["https://openalex.org/P4310320364","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Akad\u00e9miai Kiad\u00f3","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Microbiologica et Immunologica Hungarica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367675612.pdf","grobid_xml":"https://content.openalex.org/works/W4367675612.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W575726480","https://openalex.org/W1977371637","https://openalex.org/W2042164350","https://openalex.org/W2099140790","https://openalex.org/W2167256781","https://openalex.org/W2563455121","https://openalex.org/W2601382852","https://openalex.org/W2753535979","https://openalex.org/W2939882795","https://openalex.org/W2998629375","https://openalex.org/W3013839332","https://openalex.org/W3018744977","https://openalex.org/W3129162067","https://openalex.org/W4283789165"],"related_works":["https://openalex.org/W3006802726","https://openalex.org/W3210988981","https://openalex.org/W3107035626","https://openalex.org/W2600586474","https://openalex.org/W4311615539","https://openalex.org/W2793380213","https://openalex.org/W4409764128","https://openalex.org/W4285518683","https://openalex.org/W2397420351","https://openalex.org/W4406716447"],"abstract_inverted_index":{"The":[0,42,111],"incidence":[1],"of":[2,17,31,44,170,181,185,206],"infections":[3],"caused":[4],"by":[5,52],"carbapenem-resistant":[6],"Klebsiella":[7],"pneumoniae":[8],"(CRKP)":[9],"is":[10],"increasing":[11],"worldwide,":[12],"and":[13,34,47,55,75,79,105,128,142,152,191,198,204,216],"very":[14],"limited":[15],"number":[16],"effective":[18],"antibiotics":[19],"are":[20],"available":[21],"for":[22],"therapy.":[23],"In":[24,133],"our":[25,229],"study,":[26],"the":[27,87,91],"in":[28,97,102,107,119,125,130,149,163,166,178,230],"vitro":[29,231],"efficacy":[30],"meropenem/polymyxin":[32,45,92,140,189],"B":[33,46,93,141,190],"meropenem/fosfomycin":[35,48,112,143,192],"combinations":[36,49,144,165,193],"against":[37,61,202],"CRKP":[38,63,82,89,207],"strains":[39,64,83,135,168],"was":[40,50,95,114,176],"investigated.":[41],"efficiency":[43,162],"tested":[51],"checkerboard":[53,56],"microdilution":[54],"agar":[57],"dilution":[58],"methods,":[59],"respectively,":[60,156],"21":[62,134],"containing":[65,136],"major":[66],"carbapenem":[67,137,186],"resistant":[68],"genes":[69],"(7":[70],"blaKPC,":[71],"7":[72,76],"blaOXA-48":[73],"gene,":[74],"blaOXA-48+":[77],"blaNDM),":[78],"seven":[80,167],"additional":[81],"without":[84],"carbapenemase":[85,171],"genes.Among":[86],"28":[88],"strains,":[90,155,208],"combination":[94,113],"synergistic":[96,101,118,124,147,161,197,200],"ten":[98],"(35.7%),":[99],"partially":[100,123],"12":[103],"(42.8%),":[104],"indifferent":[106,129],"six":[108],"(21.4%)":[109],"isolates.":[110],"found":[115],"to":[116,158,221,228],"be":[117,218],"three":[120],"isolates":[121],"(10.7%),":[122],"20":[126],"(71.4%),":[127],"five":[131],"(17.8%).":[132],"resistance":[138,187],"genes,":[139,188],"exhibited":[145],"synergistic/partial":[146,160],"effects":[148,215],"15":[150],"(71.4%)":[151],"16":[153],"(76.2%)":[154],"compared":[157],"100%":[159],"both":[164,194],"free":[169],"genes.":[172],"No":[173],"antagonistic":[174,214],"effect":[175],"detected":[177],"either":[179],"combination.Regardless":[180],"presence":[182],"or":[183],"absence":[184],"demonstrated":[195],"high":[196],"partial":[199],"activity":[201],"78.4%":[203],"82.1%":[205],"respectively.":[209],"Also,":[210],"they":[211],"have":[212],"no":[213],"can":[217],"used":[219],"successfully":[220],"prevent":[222],"therapeutic":[223],"failure":[224],"with":[225],"monotherapy,":[226],"according":[227],"studies.":[232]},"counts_by_year":[{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-05-03T00:00:00"}
