{"id":"https://openalex.org/W4367674475","doi":"https://doi.org/10.1055/s-0043-1767990","title":"Once-Weekly Insulin Icodec vs Once-Daily Insulin Glargine U100 in Combination with Bolus Insulin in Individuals with Type 2 Diabetes on Basal-Bolus Regimens (ONWARDS 4)","display_name":"Once-Weekly Insulin Icodec vs Once-Daily Insulin Glargine U100 in Combination with Bolus Insulin in Individuals with Type 2 Diabetes on Basal-Bolus Regimens (ONWARDS 4)","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4367674475","doi":"https://doi.org/10.1055/s-0043-1767990"},"language":"en","primary_location":{"id":"doi:10.1055/s-0043-1767990","doi":"https://doi.org/10.1055/s-0043-1767990","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0043-1767990","pdf_url":null,"source":{"id":"https://openalex.org/S26605106","display_name":"Diabetologie und Stoffwechsel","issn_l":"1861-9002","issn":["1861-9002","1861-9010"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologie und Stoffwechsel","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031749836","display_name":"Birgit Nicola","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149061","display_name":"Novo Nordisk (Germany)","ror":"https://ror.org/03nyzw632","country_code":"DE","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210149061","https://openalex.org/I4210159963"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Birgit Nicola","raw_affiliation_strings":["Novo Nordisk Pharma GmbH, Medical Affairs, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Pharma GmbH, Medical Affairs, Mainz, Germany","institution_ids":["https://openalex.org/I4210149061"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053469409","display_name":"Chantal Mathieu","orcid":"https://orcid.org/0000-0002-4055-5233","observed_orcids":["https://orcid.org/0000-0002-4055-5233","https://orcid.org/0000-0002-6099-2406"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Chantal Mathieu","raw_affiliation_strings":["University of Leuven, -, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven, -, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071960004","display_name":"Bj\u00f6rg \u00c1sbj\u00f6rnsd\u00f3ttir","orcid":"https://orcid.org/0000-0002-0178-3663","observed_orcids":["https://orcid.org/0000-0002-0178-3663"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Bj\u00f6rg \u00c1sbj\u00f6rnsd\u00f3ttir","raw_affiliation_strings":["Novo Nordisk A/S, -, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, -, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065730535","display_name":"HARPREET SINGH BAJAJ","orcid":"https://orcid.org/0000-0002-1461-1465","observed_orcids":["https://orcid.org/0000-0002-1461-1465"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I4210112039","display_name":"LMC Diabetes & Endocrinology (Canada)","ror":"https://ror.org/01cakqh38","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210112039"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Harpreet Singh Bajaj","raw_affiliation_strings":["LMC Diabetes and Endocrinology Brampton, ON, Canada and Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada, -, Brampton, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LMC Diabetes and Endocrinology Brampton, ON, Canada and Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada, -, Brampton, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I4210112039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073112110","display_name":"Wendy S. Lane","orcid":"https://orcid.org/0000-0002-4317-9106","observed_orcids":["https://orcid.org/0000-0002-4317-9106"]},"institutions":[{"id":"https://openalex.org/I4210159096","display_name":"Mountain Diabetes and Endocrine Center","ror":"https://ror.org/04zdc2070","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Lane","raw_affiliation_strings":["Mountain Diabetes and Endocrine Center, -, Asheville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mountain Diabetes and Endocrine Center, -, Asheville, United States","institution_ids":["https://openalex.org/I4210159096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108686873","display_name":"Sreenivasa Murthy","orcid":"https://orcid.org/0000-0001-5571-7357","observed_orcids":["https://orcid.org/0000-0001-5571-7357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sreenivasa Murthy","raw_affiliation_strings":["Lifecare Hospital and Research Centre, -, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lifecare Hospital and Research Centre, -, Bangalore, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089449353","display_name":"Karolina Stachlewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Karolina Stachlewska","raw_affiliation_strings":["Novo Nordisk A/S, -, S\u00f8borg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S, -, S\u00f8borg, Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045489578","display_name":"Julio Rosenstock","orcid":"https://orcid.org/0000-0001-8324-3275","observed_orcids":["https://orcid.org/0000-0001-8324-3275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julio Rosenstock","raw_affiliation_strings":["Dallas Diabetes and Endocrine Center, -, Dallas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dallas Diabetes and Endocrine Center, -, Dallas, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07089952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"S 01","first_page":"S63","last_page":"S63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-icodec","display_name":"insulin icodec","score":0.9039999842643738},{"id":"https://openalex.org/keywords/insulin-glargine-u100","display_name":"insulin glargine U100","score":0.9399999976158142},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.925000011920929},{"id":"https://openalex.org/keywords/multiple-daily-injections","display_name":"multiple daily insulin injections","score":0.9409999847412109},{"id":"https://openalex.org/keywords/basal-insulin","display_name":"basal insulin","score":0.6010000109672546},{"id":"https://openalex.org/keywords/insulin-aspart","display_name":"insulin aspart","score":0.8349999785423279},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/insulin-dose-reduction","display_name":"insulin dose reduction","score":0.6370000243186951},{"id":"https://openalex.org/keywords/weight-change","display_name":"weight change","score":0.8220000267028809},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8209999799728394},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.5590000152587891},{"id":"https://openalex.org/keywords/insulin-dosing-frequency","display_name":"insulin dosing frequency","score":0.39399999380111694},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9025272130966187},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.8865236043930054},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.7368144989013672},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.6748252511024475},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5964799523353577},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5571985840797424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5474203824996948},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5151020884513855},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5131624341011047},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48358649015426636},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.43934962153434753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0043-1767990","doi":"https://doi.org/10.1055/s-0043-1767990","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0043-1767990","pdf_url":null,"source":{"id":"https://openalex.org/S26605106","display_name":"Diabetologie und Stoffwechsel","issn_l":"1861-9002","issn":["1861-9002","1861-9010"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetologie und Stoffwechsel","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4372214904","https://openalex.org/W4385409411","https://openalex.org/W4381852469","https://openalex.org/W4286312223","https://openalex.org/W4286309149","https://openalex.org/W3087577067","https://openalex.org/W3035367987","https://openalex.org/W7161981973","https://openalex.org/W3152666552","https://openalex.org/W4367837000"],"abstract_inverted_index":{"Objective":[0],"ONWARDS":[1],"4":[2],"was":[3,67,161,186,200],"a":[4,29,45,83,231,243],"26-week,":[5],"randomised,":[6],"treat-to-target,":[7],"phase":[8],"3":[9,122],"trial,":[10],"designed":[11],"to":[12,51,73,111,145,213],"assess":[13],"efficacy":[14],"and":[15,94,130,203],"safety":[16],"of":[17,62,86,116,136,153],"once-weekly":[18],"insulin":[19,24,31,63,156,184,228],"icodec":[20,52,100,166,218],"(icodec)":[21,93],"vs":[22,101,168,174,191,235],"once-daily":[23,236],"glargine":[25,102,170,237],"U100":[26],"(glargine)":[27,206],"in":[28,33,56,69,164,222,238],"basal-bolus":[30,46,244],"regimen":[32,47],"type":[34],"2":[35,119],"diabetes(T2D).":[36],"Method":[37],"Adults":[38],"(n=582)":[39],"with":[40,58,225,230,240],"T2D":[41,241],"(HbA1c":[42],"7.0\u201310.0%)":[43],"on":[44,242],"were":[48,91,124],"randomised":[49],"1:1":[50],"or":[53,120],"glargine,":[54],"both":[55],"combination":[57],"multiple":[59],"daily":[60],"injections":[61],"aspart.":[64],"Primary":[65],"endpoint":[66],"change":[68,199],"HbA1c":[70,89],"from":[71,82,158],"baseline":[72,85],"week":[74,80,159],"26(non-inferiority":[75],"margin":[76],"0.3%).":[77],"Result":[78],"At":[79],"26,":[81],"mean":[84,180,196],"8.3%,":[87],"estimated":[88,138],"reductions":[90],"-1.16%":[92],"-1.18%":[95],"(glargine),":[96],"confirming":[97],"non-inferiority":[98],"for":[99],"(estimated":[103],"treatment":[104],"difference":[105],"[ETD]:":[106],"0.02%":[107],"[95%":[108,142,210],"CI,":[109,143,211],"-0.11":[110],"0.15];":[112],"p<0.0001).":[113,194],"Overall":[114],"rates":[115],"combined":[117],"level":[118,121],"hypoglycaemia":[123,233],"comparable":[125,220,232],"between":[126],"treatments":[127],"(5.64":[128],"[icodec]":[129],"5.62":[131],"[glargine]":[132],"per":[133],"patient":[134],"year":[135],"exposure;":[137],"rate":[139],"ratio:":[140],"0.99":[141],"0.73":[144],"1.33];":[146],"p=0.929).":[147],"Mean":[148],"total":[149,155,181],"weekly":[150,182],"basal":[151,227],"component":[152,185],"the":[154,165,169,179],"dose":[157],"24\u201326":[160],"significantly":[162,187],"higher":[163],"arm":[167,171],"(305":[172],"U/week":[173,190],"279":[175],"U/week;":[176,193],"p=0.0286),":[177],"while":[178],"bolus":[183],"lower":[188],"(197":[189],"255":[192],"Estimated":[195],"body":[197],"weight":[198],"2.73":[201],"kg(icodec)":[202],"2.16":[204],"kg":[205,209],"(ETD:":[207],"0.57":[208],"-0.39":[212],"1.54];":[214],"p=0.2444).":[215],"Conclusion":[216],"Once-weekly":[217],"demonstrated":[219],"improvements":[221],"glycaemic":[223],"control":[224],"fewer":[226],"injections,":[229],"profile":[234],"individuals":[239],"regimen.":[245],"Publication":[246],"History":[247],"Article":[248],"published":[249],"online:":[250],"02":[251],"May":[252],"2023":[253],"\u00a9":[254],"2023.":[255],"Thieme.":[256],"All":[257],"rights":[258],"reserved.":[259],"Georg":[260],"Thieme":[261],"Verlag":[262],"R\u00fcdigerstra\u00dfe":[263],"14,":[264],"70469":[265],"Stuttgart,":[266],"Germany":[267]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-05-03T00:00:00"}
