{"id":"https://openalex.org/W4367672657","doi":"https://doi.org/10.1111/dmcn.15627","title":"Neuropsychiatric phenotypes in children with Noonan syndrome","display_name":"Neuropsychiatric phenotypes in children with Noonan syndrome","publication_year":2023,"publication_date":"2023-05-02","ids":{"openalex":"https://openalex.org/W4367672657","doi":"https://doi.org/10.1111/dmcn.15627","pmid":"https://pubmed.ncbi.nlm.nih.gov/37130201","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10592553"},"language":"en","primary_location":{"id":"doi:10.1111/dmcn.15627","doi":"https://doi.org/10.1111/dmcn.15627","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dmcn.15627","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.15627","source":{"id":"https://openalex.org/S158041768","display_name":"Developmental Medicine & Child Neurology","issn_l":"0012-1622","issn":["0012-1622","1469-8749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Medicine &amp; Child Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.15627","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026910086","display_name":"Paige E. Naylor","orcid":"https://orcid.org/0000-0003-2156-3606","observed_orcids":["https://orcid.org/0000-0003-2156-3606"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige E. Naylor","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","Equal contribution"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Equal contribution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056874261","display_name":"Jennifer L. Bruno","orcid":"https://orcid.org/0000-0001-7705-2456","observed_orcids":["https://orcid.org/0000-0001-7705-2456"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Bruno","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","Equal contribution"],"raw_orcid":"https://orcid.org/0000-0001-7705-2456","affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Equal contribution","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061182280","display_name":"Sharon Bade Shrestha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Bade Shrestha","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088576028","display_name":"Marcelle Friedman","orcid":"https://orcid.org/0000-0002-1637-1709","observed_orcids":["https://orcid.org/0000-0002-1637-1709"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcelle Friedman","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050937321","display_name":"Booil Jo","orcid":"https://orcid.org/0000-0001-8855-147X","observed_orcids":["https://orcid.org/0000-0001-8855-147X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Booil Jo","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046688401","display_name":"Allan L. Reiss","orcid":"https://orcid.org/0000-0002-1979-4942","observed_orcids":["https://orcid.org/0000-0002-1979-4942"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan L. Reiss","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1979-4942","affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054128274","display_name":"Tamar Green","orcid":"https://orcid.org/0000-0001-5661-8297","observed_orcids":["https://orcid.org/0000-0001-5661-8297"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tamar Green","raw_affiliation_strings":["Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-5661-8297","affiliations":[{"raw_affiliation_string":"Division of Interdisciplinary Brain Sciences, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054128274"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":5050,"currency":"USD","value_usd":5050},"apc_paid":null,"fwci":2.4211,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90594055,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"65","issue":"11","first_page":"1520","last_page":"1529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.11069999635219574,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0658000037074089,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noonan-syndrome","display_name":"Noonan syndrome","score":1.0},{"id":"https://openalex.org/keywords/neuropsychiatric-phenotypes","display_name":"neuropsychiatric phenotypes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9070000052452087},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9120000004768372},{"id":"https://openalex.org/keywords/oppositional-defiant-disorder","display_name":"oppositional defiant disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prepubertal-children","display_name":"prepubertal children","score":0.8920000195503235},{"id":"https://openalex.org/keywords/emotion-dysregulation","display_name":"emotional dysregulation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.6880000233650208},{"id":"https://openalex.org/keywords/behavioral-rigidity","display_name":"behavioral rigidity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/interpersonal-relationships","display_name":"interpersonal relationships","score":0.5649999976158142},{"id":"https://openalex.org/keywords/intellectual-functioning","display_name":"intellectual functioning","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2776149932","wikidata":"https://www.wikidata.org/wiki/Q1543446","display_name":"Noonan syndrome","level":2,"score":0.8831550478935242},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.6569256782531738},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.5377545356750488},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4997429847717285},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4750147759914398},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.45637214183807373},{"id":"https://openalex.org/C3020552372","wikidata":"https://www.wikidata.org/wiki/Q1079090","display_name":"Typically developing","level":3,"score":0.4375768303871155},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.42795297503471375},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.39780065417289734},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.39456450939178467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37586551904678345}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009634","descriptor_name":"Noonan Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009634","descriptor_name":"Noonan Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/dmcn.15627","doi":"https://doi.org/10.1111/dmcn.15627","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dmcn.15627","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.15627","source":{"id":"https://openalex.org/S158041768","display_name":"Developmental Medicine & Child Neurology","issn_l":"0012-1622","issn":["0012-1622","1469-8749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Medicine &amp; Child Neurology","raw_type":"journal-article"},{"id":"pmid:37130201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37130201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental medicine and child neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10592553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10592553","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10592553/pdf/nihms-1903794.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Dev Med Child Neurol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/dmcn.15627","doi":"https://doi.org/10.1111/dmcn.15627","is_oa":true,"landing_page_url":"https://doi.org/10.1111/dmcn.15627","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dmcn.15627","source":{"id":"https://openalex.org/S158041768","display_name":"Developmental Medicine & Child Neurology","issn_l":"0012-1622","issn":["0012-1622","1469-8749"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Medicine &amp; Child Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1269413713","display_name":null,"funder_award_id":"#MH099630","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1691085899","display_name":"Brain Development & Sex Chromosomes: Imaging of Turner and Klinefelter Syndromes","funder_award_id":"R21MH099630","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G322935768","display_name":null,"funder_award_id":"HD090209 K23","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5622249390","display_name":"Ras/MAPK Mutations Effects on the Developing Brain","funder_award_id":"K23HD090209","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000867383","display_name":"Research Training for Child Psychiatry and Neurodevelopment","funder_award_id":"T32MH019908","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000871762","display_name":"Gaining insights: the effects of the RMK gain-of-function mutations on brain development and neurodevelopmental disorders","funder_award_id":"R01HD108684","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320333709","display_name":"Neurofibromatosis Therapeutic Acceleration Program","ror":"https://ror.org/01359dk79"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367672657.pdf","grobid_xml":"https://content.openalex.org/works/W4367672657.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1588132147","https://openalex.org/W1968862207","https://openalex.org/W1969448637","https://openalex.org/W1983302342","https://openalex.org/W1990896826","https://openalex.org/W1998218203","https://openalex.org/W2022468474","https://openalex.org/W2023761384","https://openalex.org/W2068804834","https://openalex.org/W2076829837","https://openalex.org/W2081635903","https://openalex.org/W2098174002","https://openalex.org/W2098907329","https://openalex.org/W2137716603","https://openalex.org/W2148540129","https://openalex.org/W2160299692","https://openalex.org/W2172081237","https://openalex.org/W2345970863","https://openalex.org/W2583364382","https://openalex.org/W2619202372","https://openalex.org/W2619901591","https://openalex.org/W2757314768","https://openalex.org/W2787978396","https://openalex.org/W2808175542","https://openalex.org/W2883592784","https://openalex.org/W2887111841","https://openalex.org/W2888688605","https://openalex.org/W2909450200","https://openalex.org/W2913959566","https://openalex.org/W2917668788","https://openalex.org/W2979095943","https://openalex.org/W2995148308","https://openalex.org/W2999634066","https://openalex.org/W3044776393","https://openalex.org/W3044827191","https://openalex.org/W3080455188","https://openalex.org/W3096666145","https://openalex.org/W4206511001","https://openalex.org/W4210733870","https://openalex.org/W4250828681"],"related_works":["https://openalex.org/W2757314768","https://openalex.org/W2157906390","https://openalex.org/W2522398835","https://openalex.org/W4410514574","https://openalex.org/W2152548660","https://openalex.org/W2005090440","https://openalex.org/W2024924987","https://openalex.org/W1998218203","https://openalex.org/W1995878311","https://openalex.org/W4416815405"],"abstract_inverted_index":{"AIM:":[0],"We":[1],"investigated":[2],"neuropsychiatric":[3,28],"outcomes":[4],"in":[5,13,129,140,183,213,235,261],"children":[6,38,60,122,159,184,240],"with":[7,16,39,75,84,160,185,189,241,245,255,279],"Noonan":[8,40,85,161,190,214,242,246,256,280],"syndrome":[9,41,86,162,191,215,247,257,281],"and":[10,30,56,78,96,107,110,173,202,264,273,288],"addressed":[11],"limitations":[12],"previous":[14],"research":[15],"a":[17,197],"focus":[18],"on":[19],"prepubertal":[20],"children,":[21,26],"comparison":[22],"to":[23,119],"typically":[24,58,120],"developing":[25,59,121],"comprehensive":[27],"evaluation,":[29],"controlling":[31],"for":[32,138,165,171,196],"overall":[33,153],"cognitive":[34],"abilities.":[35],"METHOD:":[36],"Forty-five":[37],"(mean":[42,61],"=":[43,49,62,68],"8":[44,63],"years":[45,51,64],"6":[46],"months,":[47,66],"SD":[48,67],"2":[50,52,69],"months;":[53],"29":[54],"females)":[55,72],"40":[57],"9":[65],"years;":[70],"22":[71],"were":[73,134],"evaluated":[74],"objective,":[76],"parent-report,":[77],"psychiatric":[79],"interview":[80],"measures.":[81],"RESULTS:":[82],"Children":[83,188,244,254,278],"demonstrated":[87,178],"elevated":[88,284],"symptoms":[89,147,181,212],"across":[90],"attention-deficit/hyperactivity":[91],"disorder":[92,100,113],"(ADHD)":[93],"(attention,":[94],"hyperactivity,":[95,263],"inhibition),":[97],"autism":[98],"spectrum":[99],"(ASD)":[101],"(maintaining":[102],"social":[103,267,276],"relationships,":[104],"behavioral":[105,270],"rigidity,":[106,271],"sensory":[108],"sensitivity),":[109],"oppositional":[111],"defiant":[112],"(ODD)":[114],"(aggression)":[115],"symptom":[116,252],"clusters":[117],"relative":[118],"(all":[123],"p":[124],"<":[125],"0.05).":[126],"Group":[127],"differences":[128],"nearly":[130],"all":[131],"parent-report":[132],"measures":[133],"significant":[135,180,210],"after":[136],"accounting":[137],"variations":[139],"intellectual":[141],"functioning,":[142],"suggesting":[143],"that":[144,216],"increased":[145,194],"neurodevelopmental":[146,251],"are":[148,192],"not":[149,218],"simply":[150],"driven":[151],"by":[152],"intelligence.":[154],"Twenty":[155],"out":[156,168,175],"of":[157,169,176,199,239,286],"42":[158,170],"met":[163],"criteria":[164],"ADHD,":[166,200],"eight":[167],"ODD,":[172],"11":[174],"43":[177],"clinically":[179],"seen":[182],"ASD.":[186],"INTERPRETATION:":[187],"at":[193],"risk":[195],"range":[198],"ASD,":[201],"ODD":[203],"associated":[204],"symptoms.":[205],"A":[206],"dimensional":[207],"approach":[208],"reveals":[209],"ASD":[211],"do":[217],"emerge":[219],"when":[220],"using":[221],"the":[222],"currently":[223],"accepted":[224],"categorical":[225],"diagnostic":[226],"approach.":[227],"WHAT":[228],"THIS":[229],"PAPER":[230],"ADDS:":[231],"Neuropsychiatric":[232],"disorders":[233],"occur":[234],"more":[236],"than":[237],"half":[238],"syndrome.":[243],"demonstrate":[248],"highly":[249],"variable":[250,259],"profiles.":[253],"display":[258,282],"impairments":[260],"attention,":[262],"inhibition.":[265],"Specific":[266],"concerns":[268],"include":[269],"transitions,":[272],"difficulties":[274],"maintaining":[275],"relationships.":[277],"variably":[283],"levels":[285],"aggression":[287],"emotional":[289],"dysregulation.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-03T00:00:00"}