{"id":"https://openalex.org/W4367671908","doi":"https://doi.org/10.1101/2023.05.02.539090","title":"Isoform Specific Regulation of Adenylyl Cyclase 5 by G\u03b2\u03b3","display_name":"Isoform Specific Regulation of Adenylyl Cyclase 5 by G\u03b2\u03b3","publication_year":2023,"publication_date":"2023-05-02","ids":{"openalex":"https://openalex.org/W4367671908","doi":"https://doi.org/10.1101/2023.05.02.539090","pmid":"https://pubmed.ncbi.nlm.nih.gov/37205557"},"language":"en","primary_location":{"id":"doi:10.1101/2023.05.02.539090","doi":"https://doi.org/10.1101/2023.05.02.539090","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.05.02.539090","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/02/2023.05.02.539090.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/02/2023.05.02.539090.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041972612","display_name":"Yu\u2010Chen Yen","orcid":"https://orcid.org/0000-0003-4308-9167","observed_orcids":["https://orcid.org/0000-0003-4308-9167"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Chen Yen","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, IN, USA"],"raw_orcid":"https://orcid.org/0000-0003-4308-9167","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355295","display_name":"Yong Li","orcid":"https://orcid.org/0000-0001-7440-6933","observed_orcids":["https://orcid.org/0000-0001-7440-6933"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Li","raw_affiliation_strings":["Department Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002953647","display_name":"Chun-Liang Chen","orcid":"https://orcid.org/0000-0003-4625-4340","observed_orcids":["https://orcid.org/0000-0003-4625-4340"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun-Liang Chen","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, IN, USA"],"raw_orcid":"https://orcid.org/0000-0003-4625-4340","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019858699","display_name":"Thomas Klose","orcid":"https://orcid.org/0000-0002-2150-9792","observed_orcids":["https://orcid.org/0000-0002-2150-9792"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Klose","raw_affiliation_strings":["Purdue CryoEM Facility, Suite 171, Hockmeyer Hall for Structural Biology, Purdue University, West Lafayette, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue CryoEM Facility, Suite 171, Hockmeyer Hall for Structural Biology, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065145502","display_name":"Val J. Watts","orcid":"https://orcid.org/0000-0003-1581-2936","observed_orcids":["https://orcid.org/0000-0003-1581-2936"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Val J Watts","raw_affiliation_strings":["Department of Molecular Pharmacology and Medicinal Chemistry, Purdue University, West Lafayette, IN, USA"],"raw_orcid":"https://orcid.org/0000-0003-1581-2936","affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Medicinal Chemistry, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038627142","display_name":"CARMEN W. DESSAUER","orcid":"https://orcid.org/0000-0003-1210-4280","observed_orcids":["https://orcid.org/0000-0003-1210-4280"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen W Dessauer","raw_affiliation_strings":["Department Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":"https://orcid.org/0000-0003-1210-4280","affiliations":[{"raw_affiliation_string":"Department Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037144273","display_name":"John J. G. Tesmer","orcid":"https://orcid.org/0000-0003-1125-3727","observed_orcids":["https://orcid.org/0000-0003-1125-3727"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John J. G. Tesmer","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, IN, USA","Department of Molecular Pharmacology and Medicinal Chemistry, Purdue University, West Lafayette, IN, USA"],"raw_orcid":"https://orcid.org/0000-0003-1125-3727","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Medicinal Chemistry, Purdue University, West Lafayette, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037144273"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.039500001817941666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylyl-cyclase-5","display_name":"adenylyl cyclase 5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gbetagamma","display_name":"G\u03b2\u03b3","score":0.800000011920929},{"id":"https://openalex.org/keywords/isoform-specific-regulation","display_name":"isoform-specific regulation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/coiled-coil-domain","display_name":"coiled-coil domain","score":0.9049999713897705},{"id":"https://openalex.org/keywords/allosteric-modulation","display_name":"allosteric modulation","score":0.8339999914169312},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.8410000205039978},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.6480000019073486},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.8019081354141235},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.7663516998291016},{"id":"https://openalex.org/C69101867","wikidata":"https://www.wikidata.org/wiki/Q17709777","display_name":"ADCY9","level":4,"score":0.6723915338516235},{"id":"https://openalex.org/C2751546","wikidata":"https://www.wikidata.org/wiki/Q18042074","display_name":"ADCY10","level":5,"score":0.5538846850395203},{"id":"https://openalex.org/C176303035","wikidata":"https://www.wikidata.org/wiki/Q5513929","display_name":"Gs alpha subunit","level":4,"score":0.49868130683898926},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47315558791160583},{"id":"https://openalex.org/C117794106","wikidata":"https://www.wikidata.org/wiki/Q17709659","display_name":"ADCY6","level":5,"score":0.4272163212299347},{"id":"https://openalex.org/C9140185","wikidata":"https://www.wikidata.org/wiki/Q17709649","display_name":"ADCY3","level":5,"score":0.4257456064224243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34225931763648987},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19860398769378662},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08051988482475281}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2023.05.02.539090","doi":"https://doi.org/10.1101/2023.05.02.539090","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.05.02.539090","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/02/2023.05.02.539090.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37205557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37205557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:10187219","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10187219","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10187219/pdf/nihpp-2023.05.02.539090v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2023.05.02.539090","doi":"https://doi.org/10.1101/2023.05.02.539090","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.05.02.539090","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/02/2023.05.02.539090.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1649659787","display_name":"Structural and Functional Characterization of the Regulation of Adenylyl Cyclase 5 by Gbg subunits","funder_award_id":"903842","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G2499798185","display_name":null,"funder_award_id":"P30 CA023168","funder_id":"https://openalex.org/F4320309036","funder_display_name":"Purdue University"},{"id":"https://openalex.org/G3858817220","display_name":null,"funder_award_id":"GM60419","funder_id":"https://openalex.org/F4320309036","funder_display_name":"Purdue University"},{"id":"https://openalex.org/G5341518688","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA023168","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5510860277","display_name":"Regulation of Adenylyl Cyclase Signaling Pathways","funder_award_id":"R01GM060419","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000169853","display_name":null,"funder_award_id":"NS119917","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000172862","display_name":null,"funder_award_id":"CA023168","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000193054","display_name":null,"funder_award_id":"HL071818","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000221751","display_name":null,"funder_award_id":"DA051876","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000255730","display_name":null,"funder_award_id":"CA221289","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000894042","display_name":"Regulation of Adenylyl Cyclase Signaling Pathways","funder_award_id":"R35GM145291","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G91637459","display_name":"Regulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, G\u03b2\u03b3 and arrestins","funder_award_id":"R01CA254402","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320306542","display_name":"Walther Cancer Foundation","ror":"https://ror.org/02seeba69"},{"id":"https://openalex.org/F4320309036","display_name":"Purdue University","ror":"https://ror.org/02dqehb95"},{"id":"https://openalex.org/F4320309408","display_name":"Indiana Clinical and Translational Sciences Institute","ror":"https://ror.org/022t7q367"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367671908.pdf","grobid_xml":"https://content.openalex.org/works/W4367671908.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1524641925","https://openalex.org/W1586297894","https://openalex.org/W1595969520","https://openalex.org/W1864885326","https://openalex.org/W1913890558","https://openalex.org/W1965447347","https://openalex.org/W1971777722","https://openalex.org/W1972038609","https://openalex.org/W1972072010","https://openalex.org/W1980535904","https://openalex.org/W1984399239","https://openalex.org/W1988914933","https://openalex.org/W1990152357","https://openalex.org/W2000121694","https://openalex.org/W2008374286","https://openalex.org/W2017654715","https://openalex.org/W2028125482","https://openalex.org/W2029667189","https://openalex.org/W2030185192","https://openalex.org/W2045593899","https://openalex.org/W2052868677","https://openalex.org/W2057817131","https://openalex.org/W2065066076","https://openalex.org/W2072973641","https://openalex.org/W2115984118","https://openalex.org/W2124026197","https://openalex.org/W2132629607","https://openalex.org/W2135249891","https://openalex.org/W2140897490","https://openalex.org/W2141577885","https://openalex.org/W2150088795","https://openalex.org/W2150888122","https://openalex.org/W2158962985","https://openalex.org/W2160678789","https://openalex.org/W2172213037","https://openalex.org/W2301230530","https://openalex.org/W2333768344","https://openalex.org/W2401486435","https://openalex.org/W2560789061","https://openalex.org/W2587625522","https://openalex.org/W2811161567","https://openalex.org/W2899714098","https://openalex.org/W2911907665","https://openalex.org/W2913659053","https://openalex.org/W2940609599","https://openalex.org/W2944930475","https://openalex.org/W2967822738","https://openalex.org/W2972616573","https://openalex.org/W2980541278","https://openalex.org/W3131313310","https://openalex.org/W3159201785","https://openalex.org/W3177828909","https://openalex.org/W4391799731"],"related_works":["https://openalex.org/W4243372088","https://openalex.org/W2315787918","https://openalex.org/W2022672771","https://openalex.org/W1869414709","https://openalex.org/W2052586191","https://openalex.org/W2010065648","https://openalex.org/W2006726587","https://openalex.org/W2028965457","https://openalex.org/W2117514208","https://openalex.org/W4247571538"],"abstract_inverted_index":{"Abstract":[0],"The":[1,110],"nine":[2],"different":[3],"membrane-anchored":[4],"adenylyl":[5],"cyclase":[6],"isoforms":[7,169],"(AC1-9)":[8],"in":[9,45,60,123],"mammals":[10],"are":[11,118,170],"stimulated":[12],"by":[13,35],"the":[14,71,100,130,151,156],"heterotrimeric":[15],"G":[16],"protein":[17],"G\u03b1":[18],"s":[19],",":[20],"but":[21],"their":[22],"response":[23],"to":[24,65,75,82,91,120],"G\u03b2\u03b3":[25,48,63,101,113,142],"regulation":[26],"is":[27,32,89,133,159,173],"isoform-specific.":[28],"For":[29],"example,":[30],"AC5":[31,44,55,115,147],"conditionally":[33],"activated":[34],"G\u03b2\u03b3.":[36],"Here,":[37],"we":[38],"report":[39],"cryo-EM":[40],"structures":[41],"of":[42,50,54,146,165],"ligand-free":[43],"complex":[46],"with":[47,103,112,125],"and":[49,107,154],"a":[51,66,83,93],"dimeric":[52],"form":[53],"that":[56,69,88,117,129],"could":[57],"be":[58,92],"involved":[59],"its":[61,76],"regulation.":[62,97],"binds":[64],"coiled-coil":[67,152],"domain":[68],"links":[70],"AC":[72,168],"transmembrane":[73],"region":[74,84],"catalytic":[77,157],"core":[78],"as":[79,81,177],"well":[80],"(C":[85],"1b":[86],")":[87],"known":[90],"hub":[94],"for":[95,135,183],"isoform-specific":[96,184],"We":[98],"confirmed":[99],"interaction":[102,132],"both":[104],"purified":[105],"proteins":[106],"cell-based":[108],"assays.":[109],"interface":[111],"involves":[114],"residues":[116],"subject":[119],"gain-of-function":[121],"mutations":[122],"humans":[124],"familial":[126],"dyskinesia,":[127],"indicating":[128],"observed":[131],"important":[134],"motor":[136],"function.":[137],"A":[138],"molecular":[139],"mechanism":[140],"wherein":[141],"either":[143],"prevents":[144],"dimerization":[145],"or":[148],"allosterically":[149],"modulates":[150],"domain,":[153],"hence":[155],"core,":[158],"proposed.":[160],"Because":[161],"our":[162],"mechanistic":[163],"understanding":[164],"how":[166],"individual":[167],"uniquely":[171],"regulated":[172],"limited,":[174],"studies":[175],"such":[176],"this":[178],"may":[179],"provide":[180],"new":[181],"avenues":[182],"drug":[185],"development.":[186]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
