{"id":"https://openalex.org/W4367669014","doi":null,"title":"AANet: Attentive All-level Fusion Deep Neural Network Approach for Multi-modality Early Alzheimer's Disease Diagnosis.","display_name":"AANet: Attentive All-level Fusion Deep Neural Network Approach for Multi-modality Early Alzheimer's Disease Diagnosis.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4367669014","pmid":"https://pubmed.ncbi.nlm.nih.gov/37128453","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10148311"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10148311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10148311","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10148311/pdf/1055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA Annu Symp Proc","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10148311/pdf/1055.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Qinyong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinyong Wang","raw_affiliation_strings":["Center of Artificial Intelligence for Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Artificial Intelligence for Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050134236","display_name":"Rong Xu","orcid":"https://orcid.org/0000-0003-3127-4795","observed_orcids":["https://orcid.org/0000-0003-3127-4795"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Xu","raw_affiliation_strings":["Center of Artificial Intelligence for Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Artificial Intelligence for Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.4112,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59547368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2022","issue":null,"first_page":"1125","last_page":"1134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11714","display_name":"Multimodal Machine Learning Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-attention","display_name":"self-attention","score":0.953000009059906},{"id":"https://openalex.org/keywords/3d-brain-mri","display_name":"3D brain MRI","score":0.8230000138282776},{"id":"https://openalex.org/keywords/feature-pyramid-network","display_name":"feature pyramid network","score":0.7379999756813049},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.9390000104904175},{"id":"https://openalex.org/keywords/genetic-data","display_name":"genetic data","score":0.9399999976158142},{"id":"https://openalex.org/keywords/patient-demographics","display_name":"patient demographics","score":0.8730000257492065},{"id":"https://openalex.org/keywords/heterogeneous-data-integration","display_name":"heterogeneous data integration","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.7075390815734863},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6932182312011719},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6344143748283386},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5930323600769043},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5669043064117432},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4644332826137543},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4574202597141266},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.43660351634025574},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42788201570510864},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3836151659488678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3521643877029419},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3148147165775299},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2528749108314514},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19002538919448853},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.15706294775009155},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10148311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10148311","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10148311/pdf/1055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA Annu Symp Proc","raw_type":"Text"},{"id":"pmid:37128453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37128453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA ... Annual Symposium proceedings. AMIA Symposium","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10148311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10148311","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10148311/pdf/1055.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AMIA Annu Symp Proc","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3149035788","display_name":"Combine computational prediction, network analysis and genetic screening in C elegans to uncover neurodegenerative causes in Alzheimer's Disease","funder_award_id":"R01AG061388","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3851934332","display_name":"Construct large-scale phenomes of disease and drugs and develop data-driven systems approaches to understand genetic links between Alzheimer's disease and Neuropsychiatric symptoms","funder_award_id":"R56AG062272","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7260393372","display_name":"An Integrated Reverse Engineering Approach Toward Rapid drug Re positioning for Alzheimer's Disease","funder_award_id":"R01AG057557","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367669014.pdf","grobid_xml":"https://content.openalex.org/works/W4367669014.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1684991877","https://openalex.org/W1993023011","https://openalex.org/W2038003677","https://openalex.org/W2078524519","https://openalex.org/W2082429191","https://openalex.org/W2107094473","https://openalex.org/W2150456833","https://openalex.org/W2155164847","https://openalex.org/W2159285109","https://openalex.org/W2364709612","https://openalex.org/W2621028221","https://openalex.org/W2900386946","https://openalex.org/W3009441391","https://openalex.org/W3011727199","https://openalex.org/W3033107563","https://openalex.org/W3097518530","https://openalex.org/W3112990870","https://openalex.org/W3127597934","https://openalex.org/W3159492354","https://openalex.org/W3164582063"],"related_works":["https://openalex.org/W4408794060","https://openalex.org/W4394773665","https://openalex.org/W7130514187","https://openalex.org/W7164510160","https://openalex.org/W7221523335","https://openalex.org/W3196403362","https://openalex.org/W4225898646","https://openalex.org/W4393141327","https://openalex.org/W4399107575","https://openalex.org/W4404926946"],"abstract_inverted_index":{"Multi-modality":[0],"deep":[1,69],"learning":[2,70],"models":[3],"have":[4],"recently":[5],"been":[6],"used":[7],"for":[8,54,60,74,120,157],"disease":[9,55,63,137,159],"diagnosis;":[10],"however,":[11],"effectively":[12],"integrating":[13],"diverse,":[14],"complex,":[15],"and":[16,36,47,57,104,109],"heterogeneous":[17],"data":[18,113],"remains":[19],"a":[20,27,51,68,131],"challenge.":[21],"In":[22,149],"this":[23],"study,":[24],"we":[25],"propose":[26],"novel":[28],"system,":[29],"attentive":[30],"All-level":[31],"Fusion(AANet),":[32],"to":[33],"fuse":[34],"multi-level":[35],"multi-modality":[37],"patient":[38,44,100],"data,":[39],"including":[40],"3D":[41],"brain":[42,76],"images,":[43],"demographics,":[45,101],"genetics,":[46],"blood":[48,102],"biomarkers":[49],"into":[50],"deep-learning":[52],"framework":[53,156],"diagnosis,":[56],"tested":[58,110],"it":[59],"early":[61,135],"Alzheimer's":[62,116,129,136],"diagnosis.":[64,138,160],"We":[65,83,107],"first":[66],"constructed":[67],"feature":[71,81],"pyramid":[72],"network":[73],"whole-brain":[75],"magnetic":[77],"resonance":[78],"imaging":[79],"(MRI)":[80],"extraction.":[82],"then":[84],"leveraged":[85],"the":[86,115,121],"self-attention-based":[87],"all-level":[88,96],"fusion":[89],"method":[90],"by":[91],"automatically":[92],"adjusting":[93],"weights":[94],"of":[95,123,143],"MRI":[97],"image":[98],"features,":[99],"biomarkers,":[103],"genetic":[105],"data.":[106],"trained":[108],"AANet":[111,139,151],"on":[112],"from":[114,128],"Disease":[117],"Neuroimaging":[118],"Initiative":[119],"task":[122,133],"classifying":[124],"mild":[125],"cognitive":[126],"impairment":[127],"disease,":[130],"challenging":[132],"in":[134],"achieved":[140],"an":[141,153],"accuracy":[142],"90.5%,":[144],"outperformed":[145],"several":[146],"state-of-the-art":[147],"methods.":[148],"summary,":[150],"provides":[152],"advanced":[154],"methodological":[155],"multi-modality-based":[158]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-03T00:00:00"}
