{"id":"https://openalex.org/W4367668355","doi":"https://doi.org/10.1080/10826084.2023.2205492","title":"Benzodiazepine Dose Intensity among Patients Concurrently Prescribed Buprenorphine in Rhode Island","display_name":"Benzodiazepine Dose Intensity among Patients Concurrently Prescribed Buprenorphine in Rhode Island","publication_year":2023,"publication_date":"2023-05-02","ids":{"openalex":"https://openalex.org/W4367668355","doi":"https://doi.org/10.1080/10826084.2023.2205492","pmid":"https://pubmed.ncbi.nlm.nih.gov/37129006"},"language":"en","primary_location":{"id":"doi:10.1080/10826084.2023.2205492","doi":"https://doi.org/10.1080/10826084.2023.2205492","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826084.2023.2205492","pdf_url":null,"source":{"id":"https://openalex.org/S131590804","display_name":"Substance Use & Misuse","issn_l":"1082-6084","issn":["1082-6084","1532-2491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Substance Use &amp; Misuse","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003758064","display_name":"Eric P. Borrelli","orcid":"https://orcid.org/0000-0002-9941-9893","observed_orcids":["https://orcid.org/0000-0002-9941-9893"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric P. Borrelli","raw_affiliation_strings":["University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019064294","display_name":"Jeffrey P. Bratberg","orcid":"https://orcid.org/0000-0002-2240-5768","observed_orcids":["https://orcid.org/0000-0002-2240-5768"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Bratberg","raw_affiliation_strings":["University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA"],"raw_orcid":"https://orcid.org/0000-0002-2240-5768","affiliations":[{"raw_affiliation_string":"University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030428494","display_name":"Benjamin D. Hallowell","orcid":"https://orcid.org/0000-0002-6943-9615","observed_orcids":["https://orcid.org/0000-0002-6943-9615"]},"institutions":[{"id":"https://openalex.org/I1323842372","display_name":"Rhode Island Department of Health","ror":"https://ror.org/015b0dz43","country_code":"US","type":"government","lineage":["https://openalex.org/I1323842372"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D. Hallowell","raw_affiliation_strings":["Rhode Island Department of Health, Providence, Rhode Island, USA"],"raw_orcid":"https://orcid.org/0000-0002-6943-9615","affiliations":[{"raw_affiliation_string":"Rhode Island Department of Health, Providence, Rhode Island, USA","institution_ids":["https://openalex.org/I1323842372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087981760","display_name":"Stephen J Kogut","orcid":"https://orcid.org/0000-0001-8298-6245","observed_orcids":["https://orcid.org/0000-0001-8298-6245"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Kogut","raw_affiliation_strings":["University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island College of Pharmacy, Kingston, Rhode Island, USA","institution_ids":["https://openalex.org/I17626003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003758064"],"corresponding_institution_ids":["https://openalex.org/I17626003"],"apc_list":null,"apc_paid":null,"fwci":0.2548,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52668279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"58","issue":"8","first_page":"1038","last_page":"1045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9309999942779541},{"id":"https://openalex.org/keywords/buprenorphine","display_name":"buprenorphine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.781000018119812},{"id":"https://openalex.org/keywords/opioid-overdose-risk","display_name":"opioid overdose risk","score":0.5950000286102295},{"id":"https://openalex.org/keywords/prescription-drug-monitoring-programs","display_name":"prescription drug monitoring programs","score":0.8069999814033508},{"id":"https://openalex.org/keywords/opioid-use-disorder-treatment","display_name":"opioid use disorder treatment","score":0.8220000267028809},{"id":"https://openalex.org/keywords/opioid-substitution-therapy","display_name":"opioid substitution therapy","score":0.44999998807907104},{"id":"https://openalex.org/keywords/rhode-island","display_name":"Rhode Island","score":0.6430000066757202},{"id":"https://openalex.org/keywords/prescription-drug-misuse","display_name":"prescription drug misuse","score":0.4480000138282776},{"id":"https://openalex.org/keywords/treatment-retention","display_name":"treatment retention","score":0.6399999856948853},{"id":"https://openalex.org/keywords/patient-demographics","display_name":"patient demographics","score":0.39899998903274536},{"id":"https://openalex.org/keywords/county-level-variation","display_name":"county-level variation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/payment-type","display_name":"payment type","score":0.7400000095367432},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7459999918937683},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2778949969","wikidata":"https://www.wikidata.org/wiki/Q407721","display_name":"Buprenorphine","level":4,"score":0.9440773725509644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8728514313697815},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.7394670844078064},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6051372289657593},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.573556661605835},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4976849853992462},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.451777845621109},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40020325779914856},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3366726040840149},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.1352398693561554},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073958","descriptor_name":"Prescription Drug Monitoring Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002047","descriptor_name":"Buprenorphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002047","descriptor_name":"Buprenorphine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012237","descriptor_name":"Rhode Island","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/10826084.2023.2205492","doi":"https://doi.org/10.1080/10826084.2023.2205492","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10826084.2023.2205492","pdf_url":null,"source":{"id":"https://openalex.org/S131590804","display_name":"Substance Use & Misuse","issn_l":"1082-6084","issn":["1082-6084","1532-2491"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Substance Use &amp; Misuse","raw_type":"journal-article"},{"id":"pmid:37129006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37129006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Substance use & misuse","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000856905","display_name":"Advance Clinical and Translational Research (Advance-CTR)","funder_award_id":"U54GM115677","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000892276","display_name":"COBRE Center on Opioids and Overdose","funder_award_id":"P20GM125507","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W132606260","https://openalex.org/W1723129825","https://openalex.org/W1845987094","https://openalex.org/W1977378880","https://openalex.org/W1979706983","https://openalex.org/W2001464292","https://openalex.org/W2003262321","https://openalex.org/W2022774038","https://openalex.org/W2050720258","https://openalex.org/W2059057223","https://openalex.org/W2094113973","https://openalex.org/W2103647733","https://openalex.org/W2146172305","https://openalex.org/W2156886964","https://openalex.org/W2160562969","https://openalex.org/W2184235991","https://openalex.org/W2370541397","https://openalex.org/W2547178450","https://openalex.org/W2593625039","https://openalex.org/W2734369498","https://openalex.org/W2802154222","https://openalex.org/W2889861957","https://openalex.org/W2932907485","https://openalex.org/W2947319912","https://openalex.org/W2957606078","https://openalex.org/W2975621114","https://openalex.org/W2990327598","https://openalex.org/W3000666598","https://openalex.org/W3004170548","https://openalex.org/W3029708103","https://openalex.org/W3119645502","https://openalex.org/W3133562656","https://openalex.org/W4200464419","https://openalex.org/W4213270426","https://openalex.org/W4283830383","https://openalex.org/W4289257222","https://openalex.org/W4307601484"],"related_works":["https://openalex.org/W4200464419","https://openalex.org/W2810797709","https://openalex.org/W6995913743","https://openalex.org/W3006763709","https://openalex.org/W2734864535","https://openalex.org/W3000666598","https://openalex.org/W7165350060","https://openalex.org/W3093693225","https://openalex.org/W2810478373","https://openalex.org/W2809119374"],"abstract_inverted_index":{"Background:":[0],"The":[1],"concomitant":[2],"use":[3,116],"of":[4,21,52,62,108,117,172,180,232],"buprenorphine":[5,144,173,225],"and":[6,86,95,196,224,251],"benzodiazepines":[7,40,63,135,168,209,223],"has":[8],"been":[9],"linked":[10],"to":[11,88,104,132,206,241],"patient":[12,89,128],"fatalities,":[13],"with":[14,18,37,114,121,142,169],"greater":[15],"risk":[16],"occurring":[17],"higher":[19,149,178,233],"doses":[20],"benzodiazepines.":[22],"We":[23,47],"assessed":[24],"benzodiazepine":[25,110,235,246],"dose":[26,234,247],"intensity":[27],"among":[28,112,254],"patients":[29,38,54,113,122,133,207,220,255],"who":[30,41,55,136,165,215],"were":[31,42,83,102,137,166,216],"concurrently":[32,221],"prescribed":[33,39,124,134,167,208],"buprenorphine,":[34,118,125,140,219],"as":[35,119],"compared":[36,120],"not":[43,123,138,217],"receiving":[44,139,218,256],"buprenorphine.":[45,257],"Methods:":[46],"conducted":[48,103],"a":[49,59,147,176,181],"cross-sectional":[50],"analysis":[51],"adult":[53],"received":[56],"at":[57,211],"least":[58,212],"30-day":[60],"supply":[61],"during":[64],"2018,":[65],"using":[66],"data":[67],"from":[68],"the":[69,106,230,243],"Rhode":[70],"Island":[71],"(RI)":[72],"Prescription":[73],"Drug":[74],"Monitoring":[75],"Program.":[76],"Mean":[77],"daily":[78],"diazepam":[79],"milligram":[80],"equivalents":[81],"(DME)":[82],"calculated":[84],"overall":[85],"according":[87],"sex,":[90],"age":[91],"group,":[92],"payment":[93],"type,":[94],"RI":[96],"county.":[97],"Multivariable":[98],"logistic":[99],"regression":[100],"analyses":[101],"assess":[105,242],"odds":[107,179,231],"higher-dose":[109],"utilization":[111,145,171],"concurrent":[115,143,170],"adjusting":[126],"for":[127,210],"demographics.":[129],"Results:":[130],"Compared":[131,205],"those":[141],"had":[146,175,226],"significantly":[148],"mean":[150],"DME/day":[151,182,190,198],"(19.22,":[152],"95%":[153,158,186,193,201],"CI:":[154,159,187,194,202],"18.70-19.74;":[155],"vs":[156],"10.94,":[157],"10.93-10.95;":[160],"p":[161],"<":[162],"0.001).":[163],"Patients":[164],"also":[174],"comparatively":[177],"\u226515":[183],"(aOR:":[184,191,199],"2.86,":[185],"2.63-3.10),":[188],"\u226520":[189],"2.98,":[192],"2.75-3.24),":[195],"\u226525":[197],"2.99,":[200],"2.65-3.18).":[203],"Conclusion:":[204],"30":[213],"days":[214],"utilizing":[222],"more":[227],"than":[228],"twice":[229],"utilization.":[236],"Future":[237],"studies":[238],"are":[239],"needed":[240],"relationship":[244],"between":[245],"intensity,":[248],"overdose":[249],"outcomes,":[250],"treatment":[252],"retention":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-03T00:00:00"}