{"id":"https://openalex.org/W4367668321","doi":"https://doi.org/10.1182/blood.2022019340","title":"Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma: Final Analysis of KEYNOTE-170","display_name":"Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma: Final Analysis of KEYNOTE-170","publication_year":2023,"publication_date":"2023-05-02","ids":{"openalex":"https://openalex.org/W4367668321","doi":"https://doi.org/10.1182/blood.2022019340","pmid":"https://pubmed.ncbi.nlm.nih.gov/37130017"},"language":"en","primary_location":{"id":"doi:10.1182/blood.2022019340","doi":"https://doi.org/10.1182/blood.2022019340","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2022019340","pdf_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2022019340/2049815/blood.2022019340.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2022019340/2049815/blood.2022019340.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091882595","display_name":"Pier Luigi Zinzani","orcid":"https://orcid.org/0000-0002-2112-2651","observed_orcids":["https://orcid.org/0000-0002-2112-2651"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pier Luigi Zinzani","raw_affiliation_strings":["Istituto di Ematologia 'Ser\u00e0gnoli', Italy"],"raw_orcid":"https://orcid.org/0000-0002-2112-2651","affiliations":[{"raw_affiliation_string":"Istituto di Ematologia 'Ser\u00e0gnoli', Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033073385","display_name":"Catherine Thi\u00e9blemont","orcid":"https://orcid.org/0000-0002-9941-2448","observed_orcids":["https://orcid.org/0000-0002-9941-2448","https://orcid.org/0000-0002-7109-6949"]},"institutions":[{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Thieblemont","raw_affiliation_strings":["AP-HP, H\u00f4pital Saint-Louis, Hemato-oncologie, DMU DHI,F-75010 Paris, France, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP, H\u00f4pital Saint-Louis, Hemato-oncologie, DMU DHI,F-75010 Paris, France, Paris, France","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046457653","display_name":"\u0412 \u042f \u041c\u0435\u043b\u044c\u043d\u0438\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-6728-6264","observed_orcids":["https://orcid.org/0000-0002-6728-6264"]},"institutions":[{"id":"https://openalex.org/I4210113199","display_name":"National Medical and Surgical Center named after N.I. Pirogov","ror":"https://ror.org/01v2h2d39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210113199"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir Melnichenko","raw_affiliation_strings":["Pirogov National Medical Surgical Center, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pirogov National Medical Surgical Center, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210113199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068452218","display_name":"Krimo K. Bouabdallah","orcid":"https://orcid.org/0000-0002-4425-7823","observed_orcids":["https://orcid.org/0000-0002-4425-7823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krimo Bouabdallah","raw_affiliation_strings":["Service d'H\u00e9matologie clinique et Th\u00e9rapie cellulaire, PESSAC, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service d'H\u00e9matologie clinique et Th\u00e9rapie cellulaire, PESSAC, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056728544","display_name":"Jan Andrzej Walewski","orcid":"https://orcid.org/0000-0003-4247-2674","observed_orcids":["https://orcid.org/0000-0003-4247-2674"]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jan Walewski","raw_affiliation_strings":["The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warszawa, Poland"],"raw_orcid":"https://orcid.org/0000-0003-4247-2674","affiliations":[{"raw_affiliation_string":"The Maria Sklodowska-Curie Memorial Institute and Oncology Centre, Warszawa, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042798628","display_name":"Alejandro Majlis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138821","display_name":"Clinica Santa Maria","ror":"https://ror.org/04s1kgp90","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210138821"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Alejandro Majlis","raw_affiliation_strings":["Clinica Santa Maria de Santiago, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Santa Maria de Santiago, Santiago, Chile","institution_ids":["https://openalex.org/I4210138821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103052869","display_name":"Laura Maria Fogliatto","orcid":"https://orcid.org/0000-0002-0610-7971","observed_orcids":["https://orcid.org/0000-0002-0610-7971"]},"institutions":[{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laura Maria Fogliatto","raw_affiliation_strings":["Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto ALegre, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto ALegre, Brazil","institution_ids":["https://openalex.org/I4210097146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041947496","display_name":"Alejandro Mart\u0131\u0301n","orcid":"https://orcid.org/0000-0001-6330-1028","observed_orcids":["https://orcid.org/0000-0001-6330-1028","https://orcid.org/0009-0001-9445-8834"]},"institutions":[{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Martin Garcia-Sancho","raw_affiliation_strings":["Hospital Universitario de Salamanca, Salamanca, Spain"],"raw_orcid":"https://orcid.org/0000-0001-6330-1028","affiliations":[{"raw_affiliation_string":"Hospital Universitario de Salamanca, Salamanca, Spain","institution_ids":["https://openalex.org/I4210099034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104068814","display_name":"Beth A. Christian","orcid":"https://orcid.org/0009-0008-6077-3669","observed_orcids":["https://orcid.org/0009-0008-6077-3669"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth Christian","raw_affiliation_strings":["The Ohio State University, Columbus, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University, Columbus, Ohio, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058571002","display_name":"Zafer G\u00fclba\u015f","orcid":"https://orcid.org/0000-0002-4709-0627","observed_orcids":["https://orcid.org/0000-0002-4709-0627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zafer Gulbas","raw_affiliation_strings":["Anadolu Health Center, Kocaeli, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anadolu Health Center, Kocaeli, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085246270","display_name":"Muh\u0131t \u00d6zcan","orcid":"https://orcid.org/0000-0002-1326-1918","observed_orcids":["https://orcid.org/0000-0002-1326-1918"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Muhit \u00d6zcan","raw_affiliation_strings":["Ankara University School of Medicine, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1326-1918","affiliations":[{"raw_affiliation_string":"Ankara University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027294123","display_name":"Guilherme Fleury Perini","orcid":"https://orcid.org/0000-0001-7235-1334","observed_orcids":["https://orcid.org/0000-0001-7235-1334"]},"institutions":[{"id":"https://openalex.org/I2800288331","display_name":"Hospital Israelita Albert Einstein","ror":"https://ror.org/04cwrbc27","country_code":"BR","type":"funder","lineage":["https://openalex.org/I2800288331"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Guilherme Fleury Perini","raw_affiliation_strings":["Hospital Israelita Albert Einstein, Sao Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Israelita Albert Einstein, Sao Paulo, Brazil","institution_ids":["https://openalex.org/I2800288331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078342005","display_name":"Herv\u00e9 Ghesqui\u00e8res","orcid":"https://orcid.org/0000-0002-3131-3718","observed_orcids":["https://orcid.org/0000-0002-3131-3718"]},"institutions":[{"id":"https://openalex.org/I4210113288","display_name":"H\u00f4pital Lyon Sud","ror":"https://ror.org/023xgd207","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210113288"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Herve Ghesquieres","raw_affiliation_strings":["Centre Hospitalier Lyon Sud, Pierre-Benite, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier Lyon Sud, Pierre-Benite, France","institution_ids":["https://openalex.org/I4210113288"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021363179","display_name":"Margaret Ann Shipp","orcid":"https://orcid.org/0000-0002-3949-6897","observed_orcids":["https://orcid.org/0000-0002-3949-6897"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Shipp","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts, United States"],"raw_orcid":"https://orcid.org/0000-0002-3949-6897","affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109997247","display_name":"Seth Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Thompson","raw_affiliation_strings":["Merck & Co., Inc., Rahway, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, New Jersey, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005453392","display_name":"Samhita Chakraborty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samhita Chakraborty","raw_affiliation_strings":["Merck & Co., Inc., Rahway, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Rahway, New Jersey, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038208984","display_name":"Patricia Maria Marinello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Marinello","raw_affiliation_strings":["Merck & Co., Inc., Kenilworth, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck & Co., Inc., Kenilworth, New Jersey, United States","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053410437","display_name":"Philippe A. Armand","orcid":"https://orcid.org/0000-0001-6098-1603","observed_orcids":["https://orcid.org/0000-0001-6098-1603"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippe Armand","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5091882595"],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":9.7477,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98894266,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"142","issue":"2","first_page":"141","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":1.0},{"id":"https://openalex.org/keywords/primary-mediastinal-large-b-cell-lymphoma","display_name":"primary mediastinal B-cell lymphoma","score":0.9330000281333923},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.800000011920929},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9800000190734863},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.7850000262260437},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.8709999918937683},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8599228858947754},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6100231409072876},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5963440537452698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5764912366867065},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5516433119773865},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5095627307891846},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.46615585684776306},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.46571043133735657},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.4439358711242676},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4119275212287903},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4105374813079834},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.37568992376327515},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2623312771320343},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008479","descriptor_name":"Mediastinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013953","descriptor_name":"Thymus Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1182/blood.2022019340","doi":"https://doi.org/10.1182/blood.2022019340","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2022019340","pdf_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2022019340/2049815/blood.2022019340.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},{"id":"pmid:37130017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37130017","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Clinical Trial"},{"id":"pmh:oai:cris.unibo.it:11585/960033","doi":null,"is_oa":true,"landing_page_url":"https://ashpublications.org/blood/article/142/2/141/495573/Pembrolizumab-in-relapsed-or-refractory-primary","pdf_url":"https://cris.unibo.it/bitstream/11585/960033/2/blood_bld-2022-019340-main.pdf","source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10651864","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10651864","pdf_url":"https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04926252v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-04926252","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 2023, ⟨10.1182/blood.2022019340⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1182/blood.2022019340","doi":"https://doi.org/10.1182/blood.2022019340","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.2022019340","pdf_url":"https://ashpublications.org/blood/article-pdf/doi/10.1182/blood.2022019340/2049815/blood.2022019340.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320308970","display_name":"Teva Pharmaceutical Industries","ror":"https://ror.org/01wfv3m53"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320313971","display_name":"TG Therapeutics","ror":"https://ror.org/00pwykz63"},{"id":"https://openalex.org/F4320317235","display_name":"BeiGene","ror":"https://ror.org/012v2c923"},{"id":"https://openalex.org/F4320317544","display_name":"Incyte","ror":"https://ror.org/00cvzzg84"},{"id":"https://openalex.org/F4320318316","display_name":"Celltrion","ror":"https://ror.org/05k84m754"},{"id":"https://openalex.org/F4320319515","display_name":"Seagen","ror":null},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320328062","display_name":"MorphoSys","ror":"https://ror.org/00ew7rg06"},{"id":"https://openalex.org/F4320330792","display_name":"EUSA Pharma","ror":"https://ror.org/01p7jrr32"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320338413","display_name":"Cilag","ror":"https://ror.org/02fe4h741"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367668321.pdf","grobid_xml":"https://content.openalex.org/works/W4367668321.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2011228017","https://openalex.org/W2038070878","https://openalex.org/W2092347914","https://openalex.org/W2111500154","https://openalex.org/W2152006714","https://openalex.org/W2473498748","https://openalex.org/W2594602128","https://openalex.org/W2612422239","https://openalex.org/W2794872274","https://openalex.org/W2808511642","https://openalex.org/W2967569980","https://openalex.org/W2968942240","https://openalex.org/W2979952645","https://openalex.org/W4233562659","https://openalex.org/W4237955961"],"related_works":["https://openalex.org/W2344434792","https://openalex.org/W2116022383","https://openalex.org/W2072958243","https://openalex.org/W2584174693","https://openalex.org/W2771633521","https://openalex.org/W2058988606","https://openalex.org/W2406806223","https://openalex.org/W2345713706","https://openalex.org/W2416536760","https://openalex.org/W2615513935"],"abstract_inverted_index":{"Previous":[0],"analyses":[1],"of":[2,16,67,89,176,187],"the":[3,72,121,130,142,149,161,177],"phase":[4],"2":[5],"KEYNOTE-170":[6],"(NCT02576990)":[7],"study":[8],"demonstrated":[9],"effective":[10],"antitumor":[11],"activity":[12],"and":[13,65,81,167,201],"acceptable":[14,202],"safety":[15,203],"pembrolizumab":[17,189],"200":[18],"mg":[19],"given":[20],"every":[21],"3":[22],"weeks":[23],"for":[24,49,198],"up":[25],"to":[26,71,191],"35":[27],"cycles":[28],"(\u223c2":[29],"years)":[30],"in":[31,174,204],"patients":[32,113,153],"with":[33,195],"relapsed/refractory":[34],"(R/R)":[35],"primary":[36],"mediastinal":[37],"B-cell":[38],"lymphoma":[39],"(PMBCL)":[40],"whose":[41],"disease":[42],"progressed":[43,119],"after":[44],"or":[45],"who":[46,114],"were":[47,164],"ineligible":[48],"autologous":[50],"stem":[51],"cell":[52],"transplantation.":[53],"The":[54,96,106,124,136],"end":[55],"points":[56],"included":[57],"objective":[58],"response":[59,68,118],"rate":[60,133,145],"(ORR),":[61],"progression-free":[62],"survival":[63,79,200],"(PFS),":[64],"duration":[66,88],"(DOR)":[69],"according":[70],"investigator":[73],"per":[74],"2007":[75],"Response":[76],"Criteria;":[77],"overall":[78],"(OS);":[80],"safety.":[82],"In":[83],"this":[84],"final":[85],"analysis,":[86],"median":[87,107,125,137],"follow-up":[90],"was":[91,98,109,127,134,139,146],"48.7":[92],"months":[93],"(range,":[94],"41.2-56.2).":[95],"ORR":[97],"41.5%":[99],"(complete":[100],"response,":[101,104],"20.8%;":[102],"partial":[103],"20.8%).":[105],"DOR":[108],"not":[110],"reached;":[111],"no":[112,179],"achieved":[115],"a":[116],"complete":[117],"at":[120],"data":[122,150],"cutoff.":[123],"PFS":[126,132],"4.3":[128],"months;":[129,141],"4-year":[131,143],"33.0%.":[135],"OS":[138,144],"22.3":[140],"45.3%.":[147],"At":[148],"cutoff,":[151],"30":[152],"(56.6%)":[154],"had":[155],"any-grade":[156],"treatment-related":[157,171],"adverse":[158],"events":[159],"(AEs);":[160],"most":[162],"common":[163],"neutropenia,":[165],"asthenia,":[166],"hypothyroidism.":[168],"Grade":[169],"3/4":[170],"AEs":[172,182],"occurred":[173],"22.6%":[175],"patients;":[178],"grade":[180],"5":[181],"occurred.":[183],"After":[184],"4":[185],"years":[186],"follow-up,":[188],"continued":[190],"provide":[192],"durable":[193],"responses,":[194],"promising":[196],"trends":[197],"long-term":[199],"R/R":[205],"PMBCL.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":9},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}