{"id":"https://openalex.org/W4367607234","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","title":"Modelling Lung Aging in a Dish - Prolonged 3D Culture Causes Telomere Length Attrition in Induced Pluripotent Stem Cell-derived Type 2 Alveolar Epithelial Cells","display_name":"Modelling Lung Aging in a Dish - Prolonged 3D Culture Causes Telomere Length Attrition in Induced Pluripotent Stem Cell-derived Type 2 Alveolar Epithelial Cells","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4367607234","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C28. FROM OMICS TO EX VIVO MODELS: A ROAD MAP FOR NOVEL THERAPIES IN LUNG FIBROSIS","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041522170","display_name":"Anja Schweikert","orcid":"https://orcid.org/0000-0002-3187-1111","observed_orcids":["https://orcid.org/0000-0002-3187-1111"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"A. Schweikert","raw_affiliation_strings":["Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025130600","display_name":"Mari Ozaki","orcid":"https://orcid.org/0000-0003-0649-7882","observed_orcids":["https://orcid.org/0000-0003-0649-7882"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"M. Ozaki","raw_affiliation_strings":["Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087031321","display_name":"Fernanda Gutierrez\u2010Rodrigues","orcid":"https://orcid.org/0000-0003-3116-4588","observed_orcids":["https://orcid.org/0000-0003-3116-4588"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Gutierrez-Rodrigues","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052421216","display_name":"Emma M. Groarke","orcid":"https://orcid.org/0000-0002-4648-5926","observed_orcids":["https://orcid.org/0000-0002-4648-5926"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.M. Groarke","raw_affiliation_strings":["Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048751117","display_name":"Irene K. Oglesby","orcid":"https://orcid.org/0000-0002-3665-9195","observed_orcids":["https://orcid.org/0000-0002-3665-9195"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"I.K. Oglesby","raw_affiliation_strings":["Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036177862","display_name":"Killian Hurley","orcid":"https://orcid.org/0000-0003-4755-5559","observed_orcids":["https://orcid.org/0000-0003-4755-5559"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"K. Hurley","raw_affiliation_strings":["Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Royal College of Surgeons in Ireland, Dublin,  Ireland","institution_ids":["https://openalex.org/I142762351"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A4692","last_page":"A4692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-aging","display_name":"lung aging","score":0.9879999756813049},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.902999997138977},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.733826756477356},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6625376343727112},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.6023343801498413},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5450648665428162},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.501774787902832},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4936419725418091},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43454214930534363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2757140100002289},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2636393904685974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1498628854751587},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.11941927671432495},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10926753282546997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10901352763175964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06594878435134888}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4692","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"C28. FROM OMICS TO EX VIVO MODELS: A ROAD MAP FOR NOVEL THERAPIES IN LUNG FIBROSIS","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2978867854","https://openalex.org/W4391084248","https://openalex.org/W4388189711","https://openalex.org/W1967991223","https://openalex.org/W4225323918","https://openalex.org/W4234930253","https://openalex.org/W2511441887","https://openalex.org/W2970559580","https://openalex.org/W4220984151","https://openalex.org/W4225324758"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-02T00:00:00"}