{"id":"https://openalex.org/W4367606325","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","title":"Validation of A 25-Gene Blood Transcriptomic Signature Predictive of Forced Vital Capacity Decline in Patients With Idiopathic Pulmonary Fibrosis","display_name":"Validation of A 25-Gene Blood Transcriptomic Signature Predictive of Forced Vital Capacity Decline in Patients With Idiopathic Pulmonary Fibrosis","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4367606325","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D91. LOOKING FOR THE CRYSTAL BALL: BIOMARKERS TO PREDICT DISEASE PROGRESSION AND MORTALITY IN ILD","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C. Bonham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Bonham","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033011383","display_name":"Megan Lee Neely","orcid":"https://orcid.org/0000-0002-0101-1081","observed_orcids":["https://orcid.org/0000-0002-0101-1081"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4405286153","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/019mv4g96","country_code":"US","type":"facility","lineage":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.L. Neely","raw_affiliation_strings":["Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, United States","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4405286153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101831272","display_name":"Yi Huang","orcid":"https://orcid.org/0009-0003-3029-7343","observed_orcids":["https://orcid.org/0009-0003-3029-7343"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Huang","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059891831","display_name":"S.F. Ma","orcid":"https://orcid.org/0009-0000-4987-6159","observed_orcids":["https://orcid.org/0009-0000-4987-6159"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.F. Ma","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081054508","display_name":"J.S. Kim","orcid":"https://orcid.org/0009-0006-7490-6202","observed_orcids":["https://orcid.org/0009-0006-7490-6202"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.S. Kim","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066004162","display_name":"J. Oldham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.M. Oldham","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, United States","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050731274","display_name":"K. Becker","orcid":"https://orcid.org/0000-0002-7854-7925","observed_orcids":["https://orcid.org/0000-0002-7854-7925"]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Becker","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000280510","display_name":"Julia F. S\u00f6llner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330995197","display_name":"Boehringer Ingelheim (Germany)","ror":"https://ror.org/00q32j219","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330995197"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Soellner","raw_affiliation_strings":["Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany","institution_ids":["https://openalex.org/I1330995197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043961879","display_name":"Jamie L. Todd","orcid":"https://orcid.org/0000-0003-4247-3693","observed_orcids":["https://orcid.org/0000-0003-4247-3693"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I4405286153","display_name":"Duke Clinical Research Institute","ror":"https://ror.org/019mv4g96","country_code":"US","type":"facility","lineage":["https://openalex.org/I170897317","https://openalex.org/I4405286153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.L. Todd","raw_affiliation_strings":["Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, United States","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I4405286153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006650120","display_name":"Imre Noth","orcid":"https://orcid.org/0000-0001-9846-5030","observed_orcids":["https://orcid.org/0000-0001-9846-5030"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Noth","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, United States","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A6536","last_page":"A6536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fvc-decline","display_name":"forced vital capacity decline","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gene-expression-biomarkers","display_name":"gene expression biomarkers","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C55520419","wikidata":"https://www.wikidata.org/wiki/Q660995","display_name":"Vital capacity","level":5,"score":0.7365442514419556},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.72581547498703},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5899826288223267},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.5684946179389954},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.5291189551353455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5057847499847412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4850987195968628},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4286656975746155},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3511480987071991},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25959277153015137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21294498443603516},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.1608080267906189},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08324563503265381},{"id":"https://openalex.org/C165637977","wikidata":"https://www.wikidata.org/wiki/Q11067835","display_name":"Diffusing capacity","level":4,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","doi":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6536","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"D91. LOOKING FOR THE CRYSTAL BALL: BIOMARKERS TO PREDICT DISEASE PROGRESSION AND MORTALITY IN ILD","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2970893883","https://openalex.org/W2171628579","https://openalex.org/W1942856322","https://openalex.org/W3025467640","https://openalex.org/W4396515883","https://openalex.org/W2181480089","https://openalex.org/W2313591310","https://openalex.org/W2756020545","https://openalex.org/W4367599861","https://openalex.org/W4293244332"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2023-05-02T00:00:00"}