{"id":"https://openalex.org/W4367603459","doi":"https://doi.org/10.1158/2643-3249.aml23-a20","title":"Abstract A20: Inflammation remodels the immune microenvironment in acute myeloid leukemia","display_name":"Abstract A20: Inflammation remodels the immune microenvironment in acute myeloid leukemia","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4367603459","doi":"https://doi.org/10.1158/2643-3249.aml23-a20"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3249.aml23-a20","doi":"https://doi.org/10.1158/2643-3249.aml23-a20","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/2643-3249.aml23-a20","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084268353","display_name":"Audrey Lasry","orcid":"https://orcid.org/0000-0001-6588-6760","observed_orcids":["https://orcid.org/0000-0001-6588-6760"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Lasry","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055576264","display_name":"Bettina Nadorp","orcid":"https://orcid.org/0000-0003-1974-8425","observed_orcids":["https://orcid.org/0000-0003-1974-8425"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bettina Nadorp","raw_affiliation_strings":["2NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065897052","display_name":"Maarten W.J. Fornerod","orcid":"https://orcid.org/0000-0002-6166-3030","observed_orcids":["https://orcid.org/0000-0002-6166-3030"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maarten Fornerod","raw_affiliation_strings":["3Erasmus Medical Center, Rotterdam, Netherlands,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Erasmus Medical Center, Rotterdam, Netherlands,","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085998113","display_name":"Deedra Nicolet","orcid":"https://orcid.org/0000-0001-7796-0251","observed_orcids":["https://orcid.org/0000-0001-7796-0251"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deedra Nicolet","raw_affiliation_strings":["4Ohio State University, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Ohio State University, Columbus, OH,","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089702792","display_name":"Huiyun Wu","orcid":"https://orcid.org/0000-0003-2728-4608","observed_orcids":["https://orcid.org/0000-0003-2728-4608"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiyun Wu","raw_affiliation_strings":["5St. Jude, Memphis, TN,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5St. Jude, Memphis, TN,","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015187893","display_name":"Christopher James Walker","orcid":"https://orcid.org/0000-0002-1819-7388","observed_orcids":["https://orcid.org/0000-0002-1819-7388"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J Walker","raw_affiliation_strings":["4Ohio State University, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Ohio State University, Columbus, OH,","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060827293","display_name":"Zhengxi Sun","orcid":"https://orcid.org/0000-0002-1090-1609","observed_orcids":["https://orcid.org/0000-0002-1090-1609"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengxi Sun","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039371995","display_name":"Matthew T. Witkowski","orcid":"https://orcid.org/0000-0003-1434-4288","observed_orcids":["https://orcid.org/0000-0003-1434-4288"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew T Witkowski","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076989555","display_name":"Anastasia N. Tikhonova","orcid":"https://orcid.org/0000-0001-6712-1606","observed_orcids":["https://orcid.org/0000-0001-6712-1606"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anastasia N Tikhonova","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003906062","display_name":"Mar\u00eda Guillamot","orcid":"https://orcid.org/0000-0001-6970-5250","observed_orcids":["https://orcid.org/0000-0001-6970-5250"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Guillamot","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070853784","display_name":"Geraldine Cayanan","orcid":"https://orcid.org/0000-0001-5839-1428","observed_orcids":["https://orcid.org/0000-0001-5839-1428"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geraldine Cayanan","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018958246","display_name":"Anna H. Yeaton","orcid":"https://orcid.org/0000-0002-7654-371X","observed_orcids":["https://orcid.org/0000-0002-7654-371X"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Yeaton","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028885623","display_name":"Tanja Andrea Gruber","orcid":"https://orcid.org/0000-0003-1072-7257","observed_orcids":["https://orcid.org/0000-0003-1072-7257"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanja A Gruber","raw_affiliation_strings":["6Stanford University School of Medicine, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Stanford University School of Medicine, Stanford, CA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086647663","display_name":"Ann\u2010Kathrin Eisfeld","orcid":"https://orcid.org/0000-0001-6442-1419","observed_orcids":["https://orcid.org/0000-0001-6442-1419"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann-Kathrin Eisfeld","raw_affiliation_strings":["4Ohio State University, Columbus, OH,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Ohio State University, Columbus, OH,","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084923564","display_name":"Iannis Aifantis","orcid":"https://orcid.org/0000-0001-6857-1035","observed_orcids":["https://orcid.org/0000-0001-6857-1035"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iannis Aifantis","raw_affiliation_strings":["1NYU School of Medicine, New York, NY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NYU School of Medicine, New York, NY,","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"3_Supplement","first_page":"A20","last_page":"A20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-immune-microenvironment","display_name":"bone marrow immune microenvironment","score":0.875},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/atypical-b-cells","display_name":"atypical B cells","score":0.9169999957084656},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cell-clonal-expansion","display_name":"T cell clonal expansion","score":0.9940000176429749},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pediatric-acute-myeloid-leukemia","display_name":"pediatric acute myeloid leukemia","score":0.746999979019165},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6460000276565552},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7441709637641907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6763370633125305},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5960802435874939},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.58695387840271},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5123368501663208},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.49496716260910034},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4920460879802704},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.48365864157676697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4268838167190552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34678709506988525},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34374886751174927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3056080937385559}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2643-3249.aml23-a20","doi":"https://doi.org/10.1158/2643-3249.aml23-a20","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/2643-3249.aml23-a20","pdf_url":null,"source":{"id":"https://openalex.org/S4210239195","display_name":"Blood Cancer Discovery","issn_l":"2643-3230","issn":["2643-3230","2643-3249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Cancer Discovery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313313084","https://openalex.org/W4318715356","https://openalex.org/W4224247150","https://openalex.org/W4385715404","https://openalex.org/W3135631372","https://openalex.org/W4411191906","https://openalex.org/W7214759934","https://openalex.org/W4411544343","https://openalex.org/W4417002221","https://openalex.org/W2530306825"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1,207],"myeloid":[2,197],"leukemia":[3,198],"(AML)":[4],"is":[5],"a":[6,19,43,57,81,130,143],"hematopoietic":[7],"malignancy":[8],"with":[9,49,97],"poor":[10,98],"prognosis":[11],"and":[12,33,75,115,142,210],"limited":[13],"treatment":[14],"options.":[15],"Here":[16],"we":[17],"provide":[18],"comprehensive":[20],"single":[21],"cell":[22,60,85],"RNA-Sequencing":[23],"census":[24],"of":[25,45,105,119,123,147,202],"the":[26,106,148,192,203],"bone":[27],"marrow":[28],"immune":[29,140,193],"microenvironment":[30,141,194],"in":[31,42,63,72,83,101,121,151,195],"adult":[32],"pediatric":[34],"AML":[35,46,65,102,113,135],"patients.":[36,103],"We":[37,52,88],"characterize":[38],"unique":[39],"inflammation":[40],"signatures":[41],"subset":[44],"patients,":[47,66],"associated":[48],"inferior":[50],"outcomes.":[51],"identify":[53],"atypical":[54],"B":[55,59],"cells,":[56,78],"dysfunctional":[58],"subtype":[61],"enriched":[62],"high-inflammation":[64],"as":[67,69],"well":[68],"an":[70,90],"increase":[71],"CD8+":[73],"GZMK+":[74],"regulatory":[76],"T":[77,84,172],"accompanied":[79],"by":[80],"reduction":[82],"clonal":[86],"expansion.":[87],"derive":[89],"inflammation-associated":[91],"gene":[92],"score":[93],"(iScore)":[94],"that":[95],"associates":[96],"survival":[99],"outcomes":[100],"Addition":[104],"iScore":[107],"refines":[108],"current":[109],"risk":[110],"stratifications":[111],"for":[112,133,145],"patients":[114,120,136],"may":[116],"enable":[117],"identification":[118],"need":[122],"more":[124],"aggressive":[125],"treatment.":[126],"This":[127],"work":[128],"provides":[129],"first":[131],"framework":[132],"classifying":[134],"based":[137],"on":[138],"their":[139],"rationale":[144],"consideration":[146],"inflammatory":[149],"state":[150],"clinical":[152],"settings.":[153],"Citation":[154],"Format:":[155],"Audrey":[156],"Lasry,":[157],"Bettina":[158],"Nadorp,":[159],"Maarten":[160],"Fornerod,":[161],"Deedra":[162],"Nicolet,":[163],"Huiyun":[164],"Wu,":[165],"Christopher":[166],"J":[167],"Walker,":[168],"Zhengxi":[169],"Sun,":[170],"Matthew":[171],"Witkowski,":[173],"Anastasia":[174],"N":[175],"Tikhonova,":[176],"Maria":[177],"Guillamot,":[178],"Geraldine":[179],"Cayanan,":[180],"Anna":[181],"Yeaton,":[182],"Tanja":[183],"A":[184],"Gruber,":[185],"Ann-Kathrin":[186],"Eisfeld,":[187],"Iannis":[188],"Aifantis.":[189],"Inflammation":[190],"remodels":[191],"acute":[196],"[abstract].":[199],"In:":[200],"Proceedings":[201],"AACR":[204],"Special":[205],"Conference:":[206],"Myeloid":[208],"Leukemia":[209],"Myelodysplastic":[211],"Syndrome;":[212],"2023":[213],"Jan":[214],"23-25;":[215],"Austin,":[216],"TX.":[217],"Philadelphia":[218],"(PA):":[219],"AACR;":[220],"Blood":[221],"Cancer":[222],"Discov":[223],"2023;4(3_Suppl):Abstract":[224],"nr":[225],"A20.":[226]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2023-05-02T00:00:00"}