{"id":"https://openalex.org/W4367601667","doi":"https://doi.org/10.1007/s00432-023-04822-y","title":"Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells","display_name":"Impacts of potential anticancer agents based on pillar[5]arene for head and neck squamous cell carcinoma cells","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4367601667","doi":"https://doi.org/10.1007/s00432-023-04822-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/37126106","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11798307"},"language":"en","primary_location":{"id":"doi:10.1007/s00432-023-04822-y","doi":"https://doi.org/10.1007/s00432-023-04822-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00432-023-04822-y","pdf_url":null,"source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2770972/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039009469","display_name":"Serkan K\u00fc\u00e7\u00e7\u00fckt\u00fcrk","orcid":"https://orcid.org/0000-0001-8445-666X","observed_orcids":["https://orcid.org/0000-0001-8445-666X"]},"institutions":[{"id":"https://openalex.org/I46464968","display_name":"Karamano\u011flu Mehmetbey University","ror":"https://ror.org/037vvf096","country_code":"TR","type":"education","lineage":["https://openalex.org/I46464968"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serkan Kuccukturk","raw_affiliation_strings":["Medicine Faculty, Department of Medical Biology, Karamanoglu Mehmetbey University, 70100, Karaman, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Faculty, Department of Medical Biology, Karamanoglu Mehmetbey University, 70100, Karaman, Turkey","institution_ids":["https://openalex.org/I46464968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001764406","display_name":"Mehmet Ali Karaselek","orcid":"https://orcid.org/0000-0003-3201-8945","observed_orcids":["https://orcid.org/0000-0003-3201-8945"]},"institutions":[{"id":"https://openalex.org/I4210107659","display_name":"Necmettin Erbakan University","ror":"https://ror.org/013s3zh21","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210107659"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Ali Karaselek","raw_affiliation_strings":["Meram School of Medicine, Department of Internal Medicine, Necmettin Erbakan University, 42080, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meram School of Medicine, Department of Internal Medicine, Necmettin Erbakan University, 42080, Konya, Turkey","institution_ids":["https://openalex.org/I4210107659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083080384","display_name":"Tu\u011f\u00e7e Duran","orcid":"https://orcid.org/0000-0002-7353-4527","observed_orcids":["https://orcid.org/0000-0002-7353-4527"]},"institutions":[{"id":"https://openalex.org/I4210153056","display_name":"KTO Karatay University","ror":"https://ror.org/054341q84","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210153056"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tugce Duran","raw_affiliation_strings":["Medicine Faculty, Department of Medical Genetic, KTO Karatay University, 42020, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Faculty, Department of Medical Genetic, KTO Karatay University, 42020, Konya, Turkey","institution_ids":["https://openalex.org/I4210153056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024595523","display_name":"Ahmed Nuri Kur\u015funlu","orcid":"https://orcid.org/0000-0002-5490-668X","observed_orcids":["https://orcid.org/0000-0002-5490-668X"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmed Nuri Kursunlu","raw_affiliation_strings":["Science Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019141192","display_name":"Mustafa \u00d6zmen","orcid":"https://orcid.org/0000-0001-5117-9168","observed_orcids":["https://orcid.org/0000-0001-5117-9168"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mustafa Ozmen","raw_affiliation_strings":["Science Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey. musozmen@gmail.com","Science Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Science Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey. musozmen@gmail.com","institution_ids":["https://openalex.org/I137996928"]},{"raw_affiliation_string":"Science Faculty, Department of Chemistry, Selcuk University, 42250, Konya, Turkey","institution_ids":["https://openalex.org/I137996928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019141192"],"corresponding_institution_ids":["https://openalex.org/I137996928"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.3059,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.37766915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"149","issue":"11","first_page":"8711","last_page":"8718"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.6279000043869019,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.19419999420642853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pillar-5-arene","display_name":"pillar[5]arene","score":0.8949999809265137},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-pathway","display_name":"caspase pathway","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bcl-2-family-genes","display_name":"Bcl-2 family genes","score":0.7279999852180481},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6539999842643738},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.699999988079071},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C105289051","wikidata":"https://www.wikidata.org/wiki/Q1930094","display_name":"Pillar","level":2,"score":0.7646853923797607},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7520216107368469},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.720986008644104},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6867741346359253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6659833788871765},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5884870886802673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5587834119796753},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5004026889801025},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45542141795158386},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.39403265714645386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32879289984703064},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17338618636131287},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047250","descriptor_name":"Calixarenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1007/s00432-023-04822-y","doi":"https://doi.org/10.1007/s00432-023-04822-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00432-023-04822-y","pdf_url":null,"source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2770972/v1","doi":"https://doi.org/10.21203/rs.3.rs-2770972/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2770972/v1","pdf_url":"https://www.researchsquare.com/article/rs-2770972/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11798307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11798307","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11798307/pdf/432_2023_Article_4822.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"},{"id":"pmid:37126106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37126106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and clinical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.karatay.edu.tr:20.500.12498/8439","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12498/8439","pdf_url":null,"source":{"id":"https://openalex.org/S7407055354","display_name":"KTO Karatay University Institutional Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1007/s00432-023-04822-y","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:earsiv.kmu.edu.tr:11492/7236","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11492/7236","pdf_url":null,"source":{"id":"https://openalex.org/S4377196479","display_name":"eAr\u015fiv - KM\u00dc (Karamano\u011flu Mehmetbey University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46464968","host_organization_name":"Karamano\u011flu Mehmetbey University","host_organization_lineage":["https://openalex.org/I46464968"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2770972/v1","doi":"https://doi.org/10.21203/rs.3.rs-2770972/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2770972/v1","pdf_url":"https://www.researchsquare.com/article/rs-2770972/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7474615943","display_name":null,"funder_award_id":"221218015","funder_id":"https://openalex.org/F4320329599","funder_display_name":"Necmettin Erbakan \u00dcniversitesi"}],"funders":[{"id":"https://openalex.org/F4320329599","display_name":"Necmettin Erbakan \u00dcniversitesi","ror":"https://ror.org/013s3zh21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367601667.pdf","grobid_xml":"https://content.openalex.org/works/W4367601667.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1941278354","https://openalex.org/W1964184380","https://openalex.org/W2088252867","https://openalex.org/W2096482056","https://openalex.org/W2096995751","https://openalex.org/W2107277218","https://openalex.org/W2127582739","https://openalex.org/W2138779768","https://openalex.org/W2155384808","https://openalex.org/W2168042943","https://openalex.org/W2313459422","https://openalex.org/W2749596068","https://openalex.org/W2750075105","https://openalex.org/W2753844177","https://openalex.org/W2788371883","https://openalex.org/W2889646458","https://openalex.org/W2895926103","https://openalex.org/W2906189990","https://openalex.org/W2914550987","https://openalex.org/W2954123779","https://openalex.org/W2975278306","https://openalex.org/W3008362719","https://openalex.org/W3019936284","https://openalex.org/W3021916827","https://openalex.org/W3107533236","https://openalex.org/W3109082402","https://openalex.org/W3130965216","https://openalex.org/W3203513568","https://openalex.org/W3210496311","https://openalex.org/W3214917405","https://openalex.org/W4205501244","https://openalex.org/W4256088775","https://openalex.org/W4281897617","https://openalex.org/W4289913815","https://openalex.org/W4312054464","https://openalex.org/W4323921076"],"related_works":["https://openalex.org/W4323921076","https://openalex.org/W6920905005","https://openalex.org/W3019936284","https://openalex.org/W4380990616","https://openalex.org/W4223970713","https://openalex.org/W4206708516","https://openalex.org/W2792078738","https://openalex.org/W2980510112","https://openalex.org/W2326686581","https://openalex.org/W7112858941"],"abstract_inverted_index":{"Abstract":[0],"This":[1,121],"study":[2,122],"was":[3,43,73],"conducted":[4],"to":[5,45,126],"investigate":[6],"impacts":[7],"of":[8,17,22,33,50,91,132],"potential":[9,129],"anticancer":[10,130],"(associated":[11],"with":[12],"apoptosis":[13,71,142],"and":[14,27,36,56,85,102,104,113],"caspase":[15,109],"pathways)":[16],"two":[18,134],"newly":[19],"synthesized":[20],"derivatives":[21,52],"pillar[5]arene,":[23],"named":[24],"as":[25],"d-Q-P5":[26,84],"p-Q-P5,":[28],"on":[29,53,136],"Squamous":[30],"cell":[31],"carcinomas":[32],"the":[34,47,51,57,83,89,92,108,117,124,128],"head":[35],"neck":[37],"(HNSCC)":[38],"cells.":[39],"The":[40,70,79],"MTT":[41],"method":[42],"used":[44],"determine":[46],"IC50":[48],"doses":[49],"HNSCC":[54,137],"cells,":[55],"changes":[58],"in":[59,107],"gene":[60,119,143],"expression":[61],"were":[62],"analyzed":[63],"by":[64,75,94,139],"real-time":[65],"polymerase":[66],"chain":[67],"reaction":[68],"(qPCR).":[69],"change":[72],"confirmed":[74],"flow":[76],"cytometry":[77],"analysis.":[78],"results":[80],"showed":[81],"that":[82],"p-Q-P5":[86],"effectively":[87],"inhibited":[88],"proliferation":[90],"cells":[93,138],"upregulating":[95],"proapoptotic":[96],"genes":[97,105],"(Bax,":[98],"Bad,":[99],"p53,":[100],"Bak,":[101],"Apaf-1)":[103],"involved":[106],"pathway":[110],"(Casp2,":[111],"Casp3,":[112],"Casp9),":[114],"while":[115],"downregulating":[116],"antiapoptotic":[118],"(Bcl-2).":[120],"is":[123],"first":[125],"demonstrate":[127],"effects":[131],"these":[133],"agents":[135],"positively":[140],"regulating":[141],"expression.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-05-02T00:00:00"}
