{"id":"https://openalex.org/W4367601409","doi":"https://doi.org/10.1371/journal.ppat.1011352","title":"A conserved Y-shaped RNA structure in the 3\u2019UTR of chikungunya virus genome as a host-specialized element that modulates viral replication and evolution","display_name":"A conserved Y-shaped RNA structure in the 3\u2019UTR of chikungunya virus genome as a host-specialized element that modulates viral replication and evolution","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4367601409","doi":"https://doi.org/10.1371/journal.ppat.1011352","pmid":"https://pubmed.ncbi.nlm.nih.gov/37126493","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10174580"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1011352","doi":"https://doi.org/10.1371/journal.ppat.1011352","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011352","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011352&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011352&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032815050","display_name":"Eugenia S. Bardossy","orcid":"https://orcid.org/0000-0003-3255-0923","observed_orcids":["https://orcid.org/0000-0003-3255-0923"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Eugenia Soledad Bardossy","raw_affiliation_strings":["Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn-CONICET, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I228664971"]},{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn-CONICET, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032942061","display_name":"Sebastiano Volpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Sebastiano Volpe","raw_affiliation_strings":["Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I228664971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024943500","display_name":"Diego Ezequiel Alvarez","orcid":"https://orcid.org/0000-0002-4449-9670","observed_orcids":["https://orcid.org/0000-0002-4449-9670"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Diego Ezequiel Alvarez","raw_affiliation_strings":["Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn-CONICET, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I228664971"]},{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn-CONICET, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039113012","display_name":"Claudia V. Filomatori","orcid":"https://orcid.org/0000-0002-0728-5227","observed_orcids":["https://orcid.org/0000-0002-0728-5227"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Claudia Ver\u00f3nica Filomatori","raw_affiliation_strings":["Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn-CONICET, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-0728-5227","affiliations":[{"raw_affiliation_string":"Escuela de Bio y Nanotecnolog\u00eda, Universidad de San Mart\u00edn, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I228664971"]},{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad Nacional de San Mart\u00edn-CONICET, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039113012"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.1445,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.9158835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"19","issue":"5","first_page":"e1011352","last_page":"e1011352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chikungunya-virus","display_name":"chikungunya virus","score":1.0},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.9620000123977661},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mosquito-cells","display_name":"mosquito cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mammalian-cells","display_name":"mammalian cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/asian-lineage","display_name":"Asian lineage","score":0.6000000238418579},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8160197138786316},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.7171596884727478},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.6377896666526794},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5754666328430176},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5472050905227661},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.5393540263175964},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5075556039810181},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48373058438301086},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.47422099113464355},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.45785439014434814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2769085764884949}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002646","descriptor_name":"Chikungunya virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009033","descriptor_name":"Culicidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.ppat.1011352","doi":"https://doi.org/10.1371/journal.ppat.1011352","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011352","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011352&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10174580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10174580","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10174580/pdf/ppat.1011352.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmid:37126493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37126493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:345bb2f866394481af08a34c3ea26566","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/345bb2f866394481af08a34c3ea26566","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 19, Iss 5, p e1011352 (2023)","raw_type":"article"},{"id":"doi:10.60692/3763q-xmt46","doi":"https://doi.org/10.60692/3763q-xmt46","is_oa":true,"landing_page_url":"https://doi.org/10.60692/3763q-xmt46","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/h1jqe-gf567","doi":"https://doi.org/10.60692/h1jqe-gf567","is_oa":true,"landing_page_url":"https://doi.org/10.60692/h1jqe-gf567","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1011352","doi":"https://doi.org/10.1371/journal.ppat.1011352","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1011352","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011352&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1156818616","display_name":null,"funder_award_id":"PICT-2018-00561","funder_id":"https://openalex.org/F4320337954","funder_display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320337954","display_name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367601409.pdf","grobid_xml":"https://content.openalex.org/works/W4367601409.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1756899047","https://openalex.org/W1855484651","https://openalex.org/W1866111900","https://openalex.org/W1891843661","https://openalex.org/W1973053780","https://openalex.org/W1986146966","https://openalex.org/W1986946432","https://openalex.org/W1996898557","https://openalex.org/W2003574450","https://openalex.org/W2014176574","https://openalex.org/W2021982580","https://openalex.org/W2026411906","https://openalex.org/W2032928481","https://openalex.org/W2039422585","https://openalex.org/W2042895018","https://openalex.org/W2045603147","https://openalex.org/W2081157394","https://openalex.org/W2085942808","https://openalex.org/W2099378833","https://openalex.org/W2110932451","https://openalex.org/W2128535933","https://openalex.org/W2128868625","https://openalex.org/W2135074279","https://openalex.org/W2136373859","https://openalex.org/W2144408553","https://openalex.org/W2232965271","https://openalex.org/W2259471848","https://openalex.org/W2265611316","https://openalex.org/W2807620701","https://openalex.org/W2891525619","https://openalex.org/W2939726475","https://openalex.org/W2941502141","https://openalex.org/W2964881489","https://openalex.org/W2971082207","https://openalex.org/W3041363155","https://openalex.org/W3083003653","https://openalex.org/W3088933948","https://openalex.org/W3096142661","https://openalex.org/W3133865656","https://openalex.org/W3175727154","https://openalex.org/W7098469170"],"related_works":["https://openalex.org/W3088933948","https://openalex.org/W3038007602","https://openalex.org/W4399088858","https://openalex.org/W2144408553","https://openalex.org/W4401041354","https://openalex.org/W6925274020","https://openalex.org/W2941502141","https://openalex.org/W6906663066","https://openalex.org/W2049100402","https://openalex.org/W2939726475"],"abstract_inverted_index":{"RNA":[0,7,23,172],"viral":[1,32,81,89,125,146],"genomes":[2],"compact":[3],"information":[4],"into":[5],"functional":[6],"structures.":[8],"Here,":[9],"using":[10],"chikungunya":[11,179],"virus":[12,180],"as":[13],"a":[14,47],"model,":[15],"we":[16,45],"investigated":[17],"the":[18,26,56,59,65,75,96,108,115,142,155,167,176],"structural":[19,40],"requirements":[20],"of":[21,58,132,144,170,178],"conserved":[22,51],"elements":[24],"in":[25,34,64,91,99,114,127,141,175],"3'":[27],"untranslated":[28],"region":[29],"(3'UTR)":[30],"for":[31,119],"replication":[33,82,90,126],"mosquito":[35,92,128],"and":[36,42,50,83,111,123],"mammalian":[37,100,138],"cells.":[38,101,129],"Using":[39],"predictions":[41],"co-variation":[43],"analysis,":[44],"identified":[46],"highly":[48],"stable":[49],"Y-shaped":[52,109],"structure":[53,174],"(SLY)":[54],"at":[55],"end":[57],"3'UTR":[60,177],"that":[61,74,106,182],"is":[62],"duplicated":[63,135],"Asian":[66],"lineage.":[67],"Functional":[68],"studies":[69],"with":[70,134,150,154],"mutant":[71],"viruses":[72,133,159],"showed":[73,105],"SLY":[76,86,121,161],"has":[77,95],"host-specific":[78],"functions":[79],"during":[80],"evolution.":[84],"The":[85],"positively":[87],"modulates":[88],"cells":[93,139],"but":[94],"opposite":[97],"effect":[98],"Additional":[102],"structural/functional":[103],"analyses":[104],"maintaining":[107],"fold":[110],"specific":[112],"nucleotides":[113],"loop":[116],"are":[117],"critical":[118],"full":[120],"functionality":[122],"optimal":[124],"Experimental":[130],"adaptation":[131],"SLYs":[136],"to":[137],"resulted":[140],"generation":[143],"heterogeneous":[145],"populations":[147,157],"comprising":[148],"variants":[149],"diverse":[151],"3'UTRs,":[152],"contrasting":[153],"homogeneous":[156],"from":[158],"without":[160],"copies.":[162],"Altogether,":[163],"our":[164],"findings":[165],"constitute":[166],"first":[168],"evidence":[169],"an":[171],"secondary":[173],"genome":[181],"plays":[183],"host-dependent":[184],"functions.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-05-02T00:00:00"}