{"id":"https://openalex.org/W4367394559","doi":"https://doi.org/10.1002/advs.202301330","title":"Response to a Comment on \u201cScar\u2010Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis\u201d","display_name":"Response to a Comment on \u201cScar\u2010Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis\u201d","publication_year":2023,"publication_date":"2023-04-29","ids":{"openalex":"https://openalex.org/W4367394559","doi":"https://doi.org/10.1002/advs.202301330","pmid":"https://pubmed.ncbi.nlm.nih.gov/37119442","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10265037"},"language":"en","primary_location":{"id":"doi:10.1002/advs.202301330","doi":"https://doi.org/10.1002/advs.202301330","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202301330","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202301330","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202301330","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074565758","display_name":"Peng Zhao","orcid":"https://orcid.org/0000-0001-8005-0179","observed_orcids":["https://orcid.org/0000-0001-8005-0179"]},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhao","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China"],"raw_orcid":"https://orcid.org/0000-0001-8005-0179","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068596118","display_name":"Tian Sun","orcid":"https://orcid.org/0000-0002-7936-7723","observed_orcids":["https://orcid.org/0000-0002-7936-7723"]},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Sun","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035741872","display_name":"Cheng Lyu","orcid":"https://orcid.org/0000-0003-4230-5227","observed_orcids":["https://orcid.org/0000-0003-4230-5227"]},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Lyu","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China"],"raw_orcid":"https://orcid.org/0000-0003-4230-5227","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063887888","display_name":"Yanan Du","orcid":"https://orcid.org/0000-0003-2627-9727","observed_orcids":["https://orcid.org/0000-0003-2627-9727"]},"institutions":[{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanan Du","raw_affiliation_strings":["Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China"],"raw_orcid":"https://orcid.org/0000-0003-2627-9727","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China","institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063887888"],"corresponding_institution_ids":["https://openalex.org/I4210160507","https://openalex.org/I99065089"],"apc_list":{"value":5720,"currency":"USD","value_usd":5720},"apc_paid":{"value":5720,"currency":"USD","value_usd":5720},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"17","first_page":"e2301330","last_page":"e2301330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9810000061988831},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7269999980926514},{"id":"https://openalex.org/keywords/transcriptomic-profiles","display_name":"transcriptomic profiles","score":0.47200000286102295},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.8807762861251831},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7619028091430664},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6883135437965393},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.6475455164909363},{"id":"https://openalex.org/C2777642821","wikidata":"https://www.wikidata.org/wiki/Q206060","display_name":"Scars","level":2,"score":0.49161964654922485},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4887528419494629},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.46539390087127686},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4158868193626404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4120446443557739},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4036056399345398},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32389992475509644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31691592931747437},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3011898398399353},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.245965838432312},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2060529589653015}],"mesh":[{"descriptor_ui":"D002921","descriptor_name":"Cicatrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/advs.202301330","doi":"https://doi.org/10.1002/advs.202301330","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202301330","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202301330","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10265037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10265037","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10265037/pdf/ADVS-10-2301330.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Sci (Weinh)","raw_type":"Text"},{"id":"pmid:37119442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37119442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","raw_type":"Letter"},{"id":"pmh:oai:doaj.org/article:036f5225bd4140f8a4459ec20c4cfeb6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/036f5225bd4140f8a4459ec20c4cfeb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/advs.202301330","doi":"https://doi.org/10.1002/advs.202301330","is_oa":true,"landing_page_url":"https://doi.org/10.1002/advs.202301330","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202301330","source":{"id":"https://openalex.org/S2737737698","display_name":"Advanced Science","issn_l":"2198-3844","issn":["2198-3844"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367394559.pdf","grobid_xml":"https://content.openalex.org/works/W4367394559.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1834747511","https://openalex.org/W1998420703","https://openalex.org/W2000171189","https://openalex.org/W2167681436","https://openalex.org/W2307551625","https://openalex.org/W2740753576","https://openalex.org/W2751956358","https://openalex.org/W2768160230","https://openalex.org/W2789907433","https://openalex.org/W2806056821","https://openalex.org/W2951672374","https://openalex.org/W3011990411","https://openalex.org/W3203699675","https://openalex.org/W4289528645","https://openalex.org/W4301396679","https://openalex.org/W4311029040"],"related_works":["https://openalex.org/W4311029040","https://openalex.org/W4327752803","https://openalex.org/W4386314625","https://openalex.org/W4309569179","https://openalex.org/W3039317121","https://openalex.org/W2048908193","https://openalex.org/W196211339","https://openalex.org/W3061783101","https://openalex.org/W2131359209","https://openalex.org/W4409975189"],"abstract_inverted_index":{"David":[0],"Dolivo":[1],"et":[2],"al.":[3],"recently":[4],"shared":[5],"their":[6],"views":[7],"regarding":[8],"our":[9,132],"study":[10,133],"on":[11,134,303],"in":[12,82,108,111,116,203,213],"vitro":[13],"primed":[14],"endothelial":[15],"cells,":[16],"which":[17,88],"were":[18,70,158],"capable":[19],"of":[20,42,114,139,172,200,248,255,271,278,287,290],"degrading":[21,217],"scars.The":[22],"authors":[23,69],"proposed":[24],"that":[25],"the":[26,43,63,67,74,92,97,112,125,160,170,198,230,235,246,252,276,281,285,291],"current":[27],"treatment":[28,113],"strategy":[29],"for":[30,59,77,105,137,219],"fibrosis":[31,78,115,120],"should":[32,293],"be":[33,80,165,208,295],"broadened":[34],"to":[35,65,164,168,197,226,232,251],"involve":[36],"other":[37,83,148,177],"cell":[38,222,257],"types,":[39,258],"stimuli,":[40],"elements":[41],"extracellular":[44,236],"matrix":[45,237],"(ECM)":[46,238],"and":[47,155,180,191,211,265,297],"targeted":[48],"organ":[49],"types.Transcriptomic":[50],"profiles":[51,225,273],"have":[52],"been":[53],"specified":[54],"as":[55,96,152],"an":[56],"effective":[57,212],"resource":[58],"predicting":[60],"cells":[61,218,228,264,292],"with":[62,176,229],"capability":[64],"degrade":[66],"ECM.The":[68],"also":[71],"concerned":[72],"if":[73],"ECMdegradation":[75],"therapy":[76,110],"would":[79,207],"accomplished":[81],"organs":[84],"(e.g.,":[85,187],"cardiac":[86],"fibrosis),":[87],"did":[89],"not":[90],"possess":[91],"same":[93],"regenerative":[94],"capabilities":[95],"liver.Overall,":[98],"we":[99,259],"found":[100],"these":[101],"comments":[102],"quite":[103],"inspiring":[104],"future":[106],"endeavors":[107],"cell-degradation":[109],"multiple":[117,182],"organs.As":[118],"liver":[119],"advances,":[121],"collagen":[122,135,156,173],"I":[123,136],"is":[124,239],"most":[126],"prominent":[127],"ECM":[128,149,178,183,202,216,253,288],"component.[1]":[129],"We":[130],"centered":[131],"construction":[138],"a":[140,240],"cell-mediated":[141],"ECM-degradation":[142],"screening":[143,214],"system":[144],"(CEDSS),":[145],"[2]":[146],"whereas":[147],"components":[150],"such":[151],"fibronectin,":[153],"elastin,":[154],"III":[157],"absent.In":[159],"future,":[161],"CEDSS":[162],"needs":[163],"further":[166],"improved":[167],"tailor":[169],"concentration":[171],"I,":[174],"supplement":[175],"components,":[179],"include":[181],"crosslinking":[184],"schemes":[185],"[3]":[186],"lysyl":[188],"oxidases,":[189],"transglutaminases,":[190],"advanced":[192],"glycation":[193],"end":[194],"products)":[195],"according":[196],"characteristics":[199],"pathological":[201],"different":[204],"fibrotic":[205,215],"organs.This":[206],"more":[209],"bionic":[210],"specialized":[220],"organs.Utilizing":[221],"type-specific":[223],"transcriptomic":[224,272],"predict":[227],"capacity":[231],"break":[233],"down":[234],"noteworthy":[241],"concept.For":[242],"instance,":[243],"by":[244,299],"assessing":[245],"expression":[247,277],"proteases":[249,279],"related":[250,266],"degradation":[254,289],"various":[256],"can":[260],"identify":[261],"potential":[262],"ECM-degrading":[263],"regulatory":[267],"mechanisms.Nevertheless,":[268],"omics":[269],"data":[270],"only":[274],"reveal":[275],"at":[280],"gene":[282],"level,":[283],"thus":[284],"function":[286],"still":[294],"determined":[296],"validated":[298],"functional":[300],"assays":[301],"based":[302],"CEDSS.":[304]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-04-30T00:00:00"}