{"id":"https://openalex.org/W4367337263","doi":"https://doi.org/10.3802/jgo.2023.34.e58","title":"Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer","display_name":"Anti-cancer effect of fenbendazole-incorporated PLGA nanoparticles in ovarian cancer","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4367337263","doi":"https://doi.org/10.3802/jgo.2023.34.e58","pmid":"https://pubmed.ncbi.nlm.nih.gov/37170725","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10482585"},"language":"en","primary_location":{"id":"doi:10.3802/jgo.2023.34.e58","doi":"https://doi.org/10.3802/jgo.2023.34.e58","is_oa":true,"landing_page_url":"https://doi.org/10.3802/jgo.2023.34.e58","pdf_url":null,"source":{"id":"https://openalex.org/S111213320","display_name":"Journal of Gynecologic Oncology","issn_l":"2005-0380","issn":["2005-0380","2005-0399"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319472","host_organization_name":"Korean Society of Gynecologic Oncology","host_organization_lineage":["https://openalex.org/P4310319472"],"host_organization_lineage_names":["Korean Society of Gynecologic Oncology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gynecologic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.3802/jgo.2023.34.e58","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057182359","display_name":"Chi\u2010Son Chang","orcid":"https://orcid.org/0000-0002-0169-2008","observed_orcids":["https://orcid.org/0000-0002-0169-2008"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chi-Son Chang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-0169-2008","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103145541","display_name":"Ji\u2010Yoon Ryu","orcid":"https://orcid.org/0000-0002-6699-0890","observed_orcids":["https://orcid.org/0000-0002-6699-0890","https://orcid.org/0000-0002-2655-7822"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Yoon Ryu","raw_affiliation_strings":["Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-2655-7822","affiliations":[{"raw_affiliation_string":"Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090684440","display_name":"June-Kuk Choi","orcid":"https://orcid.org/0000-0003-0995-1622","observed_orcids":["https://orcid.org/0000-0003-0995-1622"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405258978","display_name":"Eulji University Uijeongbu Eulji Medical Center","ror":"https://ror.org/01ghq5e75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890","https://openalex.org/I4405258978"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"June-Kuk Choi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea","Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-0995-1622","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"]},{"raw_affiliation_string":"Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084139698","display_name":"Young-Jae Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Jae Cho","raw_affiliation_strings":["Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6181-9667","affiliations":[{"raw_affiliation_string":"Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077795933","display_name":"Jung\u2010Joo Choi","orcid":"https://orcid.org/0000-0001-8620-2129","observed_orcids":["https://orcid.org/0000-0001-8620-2129"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405258978","display_name":"Eulji University Uijeongbu Eulji Medical Center","ror":"https://ror.org/01ghq5e75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890","https://openalex.org/I4405258978"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Joo Choi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea","Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0001-8620-2129","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"]},{"raw_affiliation_string":"Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081292251","display_name":"Jae Ryoung Hwang","orcid":"https://orcid.org/0000-0003-2319-5878","observed_orcids":["https://orcid.org/0000-0003-2319-5878"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Ryoung Hwang","raw_affiliation_strings":["Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-2319-5878","affiliations":[{"raw_affiliation_string":"Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025340426","display_name":"Ju\u2010Yeon Choi","orcid":"https://orcid.org/0000-0002-9112-5436","observed_orcids":["https://orcid.org/0000-0002-9112-5436"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]},{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I4405258978","display_name":"Eulji University Uijeongbu Eulji Medical Center","ror":"https://ror.org/01ghq5e75","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210164890","https://openalex.org/I4405258978"]},{"id":"https://openalex.org/I4405260731","display_name":"Research Institute for Future Medicine","ror":"https://ror.org/046j9cm62","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831","https://openalex.org/I4405258492","https://openalex.org/I4405260731"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-Yeon Choi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea","Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-9112-5436","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea","institution_ids":["https://openalex.org/I21028721","https://openalex.org/I4405258978"]},{"raw_affiliation_string":"Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I4405260731","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091371424","display_name":"Joseph J. Noh","orcid":"https://orcid.org/0000-0002-3132-8709","observed_orcids":["https://orcid.org/0000-0002-3132-8709"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joseph J. Noh","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3132-8709","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071176469","display_name":"Chan Mi Lee","orcid":"https://orcid.org/0000-0002-3301-6733","observed_orcids":["https://orcid.org/0000-0002-3301-6733"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chan Mi Lee","raw_affiliation_strings":["Department of Immunology, School of Medicine, Konkuk University, Chungju, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3301-6733","affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Konkuk University, Chungju, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103094438","display_name":"Ji Eun Won","orcid":"https://orcid.org/0000-0003-1946-2435","observed_orcids":["https://orcid.org/0000-0003-1946-2435"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Eun Won","raw_affiliation_strings":["Department of Immunology, School of Medicine, Konkuk University, Chungju, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1946-2435","affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Konkuk University, Chungju, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043280625","display_name":"Hee Dong Han","orcid":"https://orcid.org/0000-0002-3300-5575","observed_orcids":["https://orcid.org/0000-0002-3300-5575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hee Dong Han","raw_affiliation_strings":["Innovative Discovery Center, Prestige Biopharma Korea, Busan, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3300-5575","affiliations":[{"raw_affiliation_string":"Innovative Discovery Center, Prestige Biopharma Korea, Busan, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100672939","display_name":"Jeong\u2010Won Lee","orcid":"https://orcid.org/0000-0002-6110-4909","observed_orcids":["https://orcid.org/0000-0002-6110-4909","https://orcid.org/0000-0003-0297-3116"]},"institutions":[{"id":"https://openalex.org/I2802194831","display_name":"Samsung Medical Center","ror":"https://ror.org/05a15z872","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2250650973","https://openalex.org/I2802194831"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jeong-Won Lee","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-6110-4909","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"]},{"raw_affiliation_string":"Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University School of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100672939"],"corresponding_institution_ids":["https://openalex.org/I2802194831","https://openalex.org/I848706"],"apc_list":null,"apc_paid":null,"fwci":1.1931,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.72387697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"34","issue":"5","first_page":"e58","last_page":"e58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fenbendazole","display_name":"fenbendazole","score":1.0},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.5870000123977661},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.3630000054836273},{"id":"https://openalex.org/keywords/intraperitoneal-administration","display_name":"intraperitoneal administration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/intravenous-injection","display_name":"intravenous injection","score":0.6140000224113464},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7590000033378601},{"id":"https://openalex.org/keywords/heya8-cells","display_name":"HeyA8 cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6460000276565552},{"id":"https://openalex.org/keywords/water-solubility","display_name":"water solubility","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7316057085990906},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.7080972790718079},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6992213129997253},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.653983473777771},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6378771066665649},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5119367837905884},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4919604957103729},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4882200062274933},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4665522277355194},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4664299786090851},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45409175753593445},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42543739080429077},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36029452085494995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25954514741897583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14185762405395508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08706590533256531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07102936506271362},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077216","descriptor_name":"Carcinoma, Ovarian Epithelial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005273","descriptor_name":"Fenbendazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3802/jgo.2023.34.e58","doi":"https://doi.org/10.3802/jgo.2023.34.e58","is_oa":true,"landing_page_url":"https://doi.org/10.3802/jgo.2023.34.e58","pdf_url":null,"source":{"id":"https://openalex.org/S111213320","display_name":"Journal of Gynecologic Oncology","issn_l":"2005-0380","issn":["2005-0380","2005-0399"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319472","host_organization_name":"Korean Society of Gynecologic Oncology","host_organization_lineage":["https://openalex.org/P4310319472"],"host_organization_lineage_names":["Korean Society of Gynecologic Oncology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gynecologic Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10482585","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10482585","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10482585/pdf/jgo-34-e58.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gynecol Oncol","raw_type":"Text"},{"id":"pmid:37170725","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37170725","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gynecologic oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3802/jgo.2023.34.e58","doi":"https://doi.org/10.3802/jgo.2023.34.e58","is_oa":true,"landing_page_url":"https://doi.org/10.3802/jgo.2023.34.e58","pdf_url":null,"source":{"id":"https://openalex.org/S111213320","display_name":"Journal of Gynecologic Oncology","issn_l":"2005-0380","issn":["2005-0380","2005-0399"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319472","host_organization_name":"Korean Society of Gynecologic Oncology","host_organization_lineage":["https://openalex.org/P4310319472"],"host_organization_lineage_names":["Korean Society of Gynecologic Oncology"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gynecologic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G159051455","display_name":null,"funder_award_id":"KMDF_PR_20200901_0153-2022","funder_id":"https://openalex.org/F4320318847","funder_display_name":"Korea Medical Device Development Fund"},{"id":"https://openalex.org/G6505071837","display_name":null,"funder_award_id":"2020R1C1C1007482","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G7558604506","display_name":null,"funder_award_id":"2020R1C1C1007482","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320318847","display_name":"Korea Medical Device Development Fund","ror":"https://ror.org/03g98ap29"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322014","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367337263.pdf","grobid_xml":"https://content.openalex.org/works/W4367337263.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W628741713","https://openalex.org/W1733472905","https://openalex.org/W1966354133","https://openalex.org/W1983719103","https://openalex.org/W1986826942","https://openalex.org/W1993507577","https://openalex.org/W2003474213","https://openalex.org/W2011841487","https://openalex.org/W2012812435","https://openalex.org/W2046833247","https://openalex.org/W2050564805","https://openalex.org/W2062166509","https://openalex.org/W2069439128","https://openalex.org/W2071635264","https://openalex.org/W2115847666","https://openalex.org/W2124275237","https://openalex.org/W2135103304","https://openalex.org/W2156395906","https://openalex.org/W2172019818","https://openalex.org/W2183999849","https://openalex.org/W2221428169","https://openalex.org/W2568326653","https://openalex.org/W2597015436","https://openalex.org/W2738205912","https://openalex.org/W2770841057","https://openalex.org/W2885226514","https://openalex.org/W2886834231","https://openalex.org/W2896744886","https://openalex.org/W2921927631","https://openalex.org/W2944716732","https://openalex.org/W2948115989","https://openalex.org/W2954749731","https://openalex.org/W3018023154","https://openalex.org/W3047494211","https://openalex.org/W3158883533","https://openalex.org/W3165182071","https://openalex.org/W3203845472","https://openalex.org/W4206841660","https://openalex.org/W4280531140"],"related_works":["https://openalex.org/W3021409911","https://openalex.org/W2937047141","https://openalex.org/W2966871100","https://openalex.org/W4367556603","https://openalex.org/W6964673612","https://openalex.org/W2011841487","https://openalex.org/W2017569709","https://openalex.org/W2380601641","https://openalex.org/W2103539208","https://openalex.org/W4397010906"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Fenbendazole":[1],"(FZ)":[2],"has":[3],"potential":[4],"anti-cancer":[5,24,219,232],"effects,":[6],"but":[7,170],"its":[8,13],"poor":[9],"water":[10,181],"solubility":[11,182],"limits":[12],"use":[14],"for":[15],"cancer":[16,36],"therapy.":[17],"In":[18],"this":[19],"study,":[20],"we":[21,99],"investigated":[22,108],"the":[23,78,88,109,173,214],"effect":[25,60,155],"of":[26,61,72,91,112,130,138,156,198],"FZ":[27,53,62,92,133,158,166],"with":[28,52,204],"different":[29],"drug":[30,185],"delivery":[31,79,90],"methods":[32],"on":[33,63,160],"epithelial":[34],"ovarian":[35],"(EOC)":[37],"in":[38,40,43,66,120,146,172,192,200,221,234,247],"both":[39,139],"vitro":[41],"and":[42,54,83,119,126,141,183,206,237],"vivo":[44,121],"models.":[45],"METHODS:":[46],"EOC":[47,73,143,193,235],"cell":[48,55,67,116,124,136,147,190,194],"lines":[49,125],"were":[50],"treated":[51],"proliferation":[56,137,191],"was":[57,74,153,167],"assessed.":[58],"The":[59],"tumor":[64,161,210],"growth":[65],"line":[68,148],"xenograft":[69,128,149,201,238],"mouse":[70,150,202],"model":[71,223],"examined":[75],"according":[76],"to":[77,97,179,213],"route,":[80],"including":[81,123,240],"oral":[82,157],"intraperitoneal":[84,174],"administration.":[85],"To":[86],"improve":[87],"systemic":[89],"by":[93,114],"converting":[94],"fat-soluble":[95],"drugs":[96],"hydrophilic,":[98],"prepared":[100],"FZ-encapsulated":[101],"poly(D,L-lactide-co-glycolide)":[102],"acid":[103],"(PLGA)":[104],"nanoparticles":[105,229],"(FZ-PLGA-NPs).":[106],"We":[107,176],"preclinical":[110],"efficacy":[111],"FZ-PLGA-NPs":[113,178,187,217],"analyzing":[115],"proliferation,":[117],"apoptosis,":[118],"models":[122,203,239],"patient-derived":[127],"(PDX)":[129],"EOC.":[131],"RESULTS:":[132],"significantly":[134,188,208],"decreased":[135,189],"chemosensitive":[140],"chemoresistant":[142],"cells.":[144],"However,":[145],"models,":[151],"there":[152],"no":[154],"treatment":[159],"reduction.":[162],"When":[163],"administered":[164],"intraperitoneally,":[165],"not":[168],"absorbed":[169],"aggregated":[171],"space.":[175],"synthesized":[177],"obtain":[180],"enhance":[184],"absorption.":[186],"lines.":[195],"Intravenous":[196],"injection":[197],"FZ-PLGA-NP":[199],"HeyA8":[205],"HeyA8-MDR":[207],"reduced":[209],"weight":[211],"compared":[212],"control":[215],"group.":[216],"showed":[218],"effects":[220,233],"PDX":[222],"as":[224],"well.":[225],"CONCLUSION:":[226],"FZ-incorporated":[227],"PLGA":[228],"exerted":[230],"significant":[231],"cells":[236],"PDX.":[241],"These":[242],"results":[243],"warrant":[244],"further":[245],"investigation":[246],"clinical":[248],"trials.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-04-30T00:00:00"}