{"id":"https://openalex.org/W4367316699","doi":"https://doi.org/10.1016/j.cgh.2023.04.016","title":"Bleeding and Thrombotic Complications in Patients With Cirrhosis: A State-of-the-Art Appraisal","display_name":"Bleeding and Thrombotic Complications in Patients With Cirrhosis: A State-of-the-Art Appraisal","publication_year":2023,"publication_date":"2023-04-28","ids":{"openalex":"https://openalex.org/W4367316699","doi":"https://doi.org/10.1016/j.cgh.2023.04.016","pmid":"https://pubmed.ncbi.nlm.nih.gov/37121529"},"language":"en","primary_location":{"id":"doi:10.1016/j.cgh.2023.04.016","doi":"https://doi.org/10.1016/j.cgh.2023.04.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cgh.2023.04.016","pdf_url":"http://www.cghjournal.org/article/S1542356523003166/pdf","source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.cghjournal.org/article/S1542356523003166/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044500021","display_name":"Pierre\u2010Emmanuel Rautou","orcid":"https://orcid.org/0000-0001-9567-1859","observed_orcids":["https://orcid.org/0000-0001-9567-1859"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I2799502834","display_name":"H\u00f4pital Beaujon","ror":"https://ror.org/03jyzk483","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210130096","display_name":"Centre de Recherche sur l'Inflammation","ror":"https://ror.org/02gn50d10","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210130096"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Emmanuel Rautou","raw_affiliation_strings":["Universit\u00e9 Paris-Cit\u00e9, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France; Service d'H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France","Service d'H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France","Universit\u00e9 Paris-Cit\u00e9, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-9567-1859","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Cit\u00e9, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France; Service d'H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I2799502834","https://openalex.org/I4210097159","https://openalex.org/I4210130096"]},{"raw_affiliation_string":"Service d'H\u00e9patologie, AP-HP, H\u00f4pital Beaujon, DMU DIGEST, Centre de R\u00e9f\u00e9rence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France","institution_ids":["https://openalex.org/I2799502834","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Cit\u00e9, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210130096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027753564","display_name":"Stephen Hugh Caldwell","orcid":"https://orcid.org/0000-0003-1323-4191","observed_orcids":["https://orcid.org/0000-0003-1323-4191"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen H. Caldwell","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia. Electronic address: shc5c@virginia.edu","Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia. Electronic address: shc5c@virginia.edu","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064535615","display_name":"Erica Villa","orcid":"https://orcid.org/0000-0001-6388-7022","observed_orcids":["https://orcid.org/0000-0001-6388-7022"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I4210155710","display_name":"Gastroenterology Hospital \"Saverio de Bellis\"","ror":"https://ror.org/05pfy5w65","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099368","https://openalex.org/I4210117053","https://openalex.org/I4210153126","https://openalex.org/I4210155710"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Erica Villa","raw_affiliation_strings":["Gastroenterology Unit, CHIMOMO Department, University of Modena and Reggio Emilia, Modena, Italy; IRCCS Saverio de Bellis, Castellana Grotte, Italy","Gastroenterology Unit, CHIMOMO Department, University of Modena and Reggio Emilia, Modena, Italy","IRCCS Saverio de Bellis, Castellana Grotte, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, CHIMOMO Department, University of Modena and Reggio Emilia, Modena, Italy; IRCCS Saverio de Bellis, Castellana Grotte, Italy","institution_ids":["https://openalex.org/I122346577","https://openalex.org/I4210155710"]},{"raw_affiliation_string":"Gastroenterology Unit, CHIMOMO Department, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"IRCCS Saverio de Bellis, Castellana Grotte, Italy","institution_ids":["https://openalex.org/I4210155710"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5027753564"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":2.5767,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.93428757,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"21","issue":"8","first_page":"2110","last_page":"2123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/coagulopathy","display_name":"coagulopathy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9089999794960022},{"id":"https://openalex.org/keywords/portal-hypertension","display_name":"portal hypertension","score":0.8230000138282776},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.6620000004768372},{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/procedure-related-bleeding","display_name":"procedure-related bleeding","score":0.656000018119812},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/fall-risk","display_name":"fall risk","score":0.6060000061988831},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.75},{"id":"https://openalex.org/keywords/thrombophilia","display_name":"thrombophilia","score":0.890999972820282},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9439690113067627},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.7241494059562683},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.7064383029937744},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.686219334602356},{"id":"https://openalex.org/C2778808290","wikidata":"https://www.wikidata.org/wiki/Q124604","display_name":"Portal hypertension","level":3,"score":0.6784615516662598},{"id":"https://openalex.org/C56900294","wikidata":"https://www.wikidata.org/wiki/Q7231497","display_name":"Portal venous pressure","level":4,"score":0.6389358043670654},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.5728177428245544},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.547327995300293},{"id":"https://openalex.org/C2778800853","wikidata":"https://www.wikidata.org/wiki/Q1704044","display_name":"Portal vein thrombosis","level":3,"score":0.5368216037750244},{"id":"https://openalex.org/C2780325230","wikidata":"https://www.wikidata.org/wiki/Q642548","display_name":"Hepatic encephalopathy","level":3,"score":0.4325864911079407},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.3628239035606384},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3540702760219574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17936232686042786}],"mesh":[{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cgh.2023.04.016","doi":"https://doi.org/10.1016/j.cgh.2023.04.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cgh.2023.04.016","pdf_url":"http://www.cghjournal.org/article/S1542356523003166/pdf","source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},{"id":"pmid:37121529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37121529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cgh.2023.04.016","doi":"https://doi.org/10.1016/j.cgh.2023.04.016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cgh.2023.04.016","pdf_url":"http://www.cghjournal.org/article/S1542356523003166/pdf","source":{"id":"https://openalex.org/S6642600","display_name":"Clinical Gastroenterology and Hepatology","issn_l":"1542-3565","issn":["1542-3565","1542-7714"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Gastroenterology and Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1645179935","display_name":"TimE frame ControL of Inflammation by canonical and non-canonical autophagy to Prevent fatty liver diSease progrEssion","funder_award_id":"ANR-18-CE14-0006","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4077682647","display_name":null,"funder_award_id":"FRM EQU 202303016287","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G5186833093","display_name":null,"funder_award_id":"847949","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G5604978010","display_name":"Deciphering HEArt-liVEr commuNication in nonalcohoLic fattY liver disease","funder_award_id":"ANR-22-CE14-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8538166538","display_name":"Universit\u00e9 de Paris","funder_award_id":"ANR-18-IDEX-0001","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320310441","display_name":"Boehringer Ingelheim","ror":"https://ror.org/00q32j219"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322361","display_name":"Fondation ARC pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320327535","display_name":"Tillotts Pharma","ror":"https://ror.org/02kejw255"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367316699.pdf","grobid_xml":"https://content.openalex.org/works/W4367316699.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1782727592","https://openalex.org/W1965119961","https://openalex.org/W1968641413","https://openalex.org/W1969353335","https://openalex.org/W1986644481","https://openalex.org/W1987880263","https://openalex.org/W1993340951","https://openalex.org/W2012122289","https://openalex.org/W2014780671","https://openalex.org/W2050003837","https://openalex.org/W2051639931","https://openalex.org/W2074933913","https://openalex.org/W2087915723","https://openalex.org/W2091908750","https://openalex.org/W2094486696","https://openalex.org/W2096334834","https://openalex.org/W2113917646","https://openalex.org/W2121888044","https://openalex.org/W2123328697","https://openalex.org/W2137727365","https://openalex.org/W2144703570","https://openalex.org/W2151557563","https://openalex.org/W2156365358","https://openalex.org/W2166018647","https://openalex.org/W2171993752","https://openalex.org/W2211816300","https://openalex.org/W2344515048","https://openalex.org/W2399856285","https://openalex.org/W2610258648","https://openalex.org/W2766125910","https://openalex.org/W2790069035","https://openalex.org/W2791662285","https://openalex.org/W2885107848","https://openalex.org/W2887459943","https://openalex.org/W2888122474","https://openalex.org/W2900355193","https://openalex.org/W2901884599","https://openalex.org/W2914415918","https://openalex.org/W2928291443","https://openalex.org/W2986445322","https://openalex.org/W2987948403","https://openalex.org/W2994970955","https://openalex.org/W2998487497","https://openalex.org/W3005644445","https://openalex.org/W3017543896","https://openalex.org/W3032764835","https://openalex.org/W3035440630","https://openalex.org/W3036528941","https://openalex.org/W3040316445","https://openalex.org/W3048691935","https://openalex.org/W3081186914","https://openalex.org/W3084700078","https://openalex.org/W3094935851","https://openalex.org/W3103618496","https://openalex.org/W3119444489","https://openalex.org/W3126981220","https://openalex.org/W3127108727","https://openalex.org/W3132262747","https://openalex.org/W3158507545","https://openalex.org/W3161717020","https://openalex.org/W3170961433","https://openalex.org/W3173541123","https://openalex.org/W3178740353","https://openalex.org/W3194373099","https://openalex.org/W3194453575","https://openalex.org/W3198296366","https://openalex.org/W3198714598","https://openalex.org/W3202859222","https://openalex.org/W3204551114","https://openalex.org/W3206885572","https://openalex.org/W4200092076","https://openalex.org/W4200451508","https://openalex.org/W4200473175","https://openalex.org/W4206378166","https://openalex.org/W4220963560","https://openalex.org/W4224216090","https://openalex.org/W4224436906","https://openalex.org/W4280645451","https://openalex.org/W4281556916","https://openalex.org/W4281716085","https://openalex.org/W4282938203","https://openalex.org/W4287219056","https://openalex.org/W4290972991","https://openalex.org/W4296707503","https://openalex.org/W4306181823","https://openalex.org/W4309690724","https://openalex.org/W4313530897","https://openalex.org/W4322487920","https://openalex.org/W4379376076"],"related_works":["https://openalex.org/W4407809127","https://openalex.org/W3204551114","https://openalex.org/W2596888165","https://openalex.org/W4412589617","https://openalex.org/W3196689567","https://openalex.org/W2811442223","https://openalex.org/W1923113404","https://openalex.org/W2884391724","https://openalex.org/W7118019145","https://openalex.org/W4412636775"],"abstract_inverted_index":{"Much":[0],"has":[1,47,193],"evolved":[2],"over":[3],"the":[4,12,26,60,102,115,200,225,233],"past":[5],"25":[6],"years":[7],"regarding":[8,150],"our":[9],"understanding":[10],"of":[11,14,20,30,104,117,129,138,146,165,202,222,227],"coagulopathy":[13,21],"liver":[15,237],"disease.":[16],"Paradoxically,":[17],"this":[18,69,122],"form":[19],"is":[22,36,186],"relatively":[23],"hypercoagulability":[24],"despite":[25],"common":[27,127],"clinical":[28],"impression":[29],"a":[31,65,109,160],"hemorrhagic":[32],"tendency.":[33],"The":[34,126,148],"latter":[35],"largely":[37],"driven":[38,156],"by":[39,159,171,190],"portal-mesenteric":[40],"venous":[41,130],"pressure":[42,86],"(ie,":[43],"portal":[44,85],"hypertension)":[45],"and":[46,71,87,107,141,144,207,212],"little":[48],"to":[49,74,93,154,183,195,236],"do":[50,230],"with":[51],"hemostatic":[52,119,139],"pathways.":[53],"It":[54],"cannot":[55],"be":[56,155,196,216],"emphasized":[57],"enough":[58],"that":[59,81],"INR":[61],"does":[62],"not":[63,157,231],"offer":[64],"meaningful":[66],"measure":[67],"in":[68,101,132,177,180,224],"situation":[70],"may":[72],"lead":[73],"interventions":[75],"such":[76],"as":[77],"fresh":[78],"frozen":[79],"plasma":[80],"can":[82,175],"actually":[83],"worsen":[84],"hence":[88],"pressure-driven":[89],"bleeding.":[90],"With":[91],"regard":[92],"procedure-related":[94],"bleeding,":[95,168],"we":[96],"point":[97],"out":[98],"substantial":[99],"differences":[100],"definition":[103,112],"high-risk":[105],"procedures":[106],"propose":[108],"new":[110],"operational":[111],"dependent":[113],"on":[114],"applicability":[116],"local":[118],"measures,":[120],"although":[121],"requires":[123,135],"further":[124,241],"investigation.":[125],"occurrence":[128],"thrombosis":[131],"these":[133,203],"patients":[134,181],"careful":[136],"consideration":[137],"pathways":[140],"overall":[142],"risk":[143,173],"benefit":[145],"intervention.":[147],"decision":[149],"anticoagulation":[151],"therapy":[152],"needs":[153],"only":[158],"global":[161],"assessment":[162],"including":[163,210],"history":[164],"non-portal":[166],"hypertensive-related":[167],"but":[169,192,239],"also":[170],"fall":[172],"which":[174],"result":[176],"head":[178],"trauma":[179],"prone":[182],"encephalopathy.":[184],"This":[185],"probably":[187],"best":[188],"estimated":[189],"frailty":[191],"yet":[194],"adequately":[197],"investigated.":[198],"In":[199],"background":[201],"concerns,":[204],"several":[205],"superimposed":[206],"complex":[208],"conditions":[209],"infections":[211],"renal":[213],"dysfunction":[214],"should":[215],"taken":[217],"into":[218],"account.":[219],"Inherited":[220],"forms":[221],"thrombophilia":[223,234],"setting":[226],"cirrhosis":[228],"perhaps":[229],"outweigh":[232],"inherent":[235],"disease":[238],"warrant":[240],"consideration.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-29T00:00:00"}
