{"id":"https://openalex.org/W4367309177","doi":"https://doi.org/10.47360/1995-4484-2023-188-198","title":"Efficacy of olokizumab against comorbid depressive disorder in patients with rheumatoid arthritis: Preliminary results of the study","display_name":"Efficacy of olokizumab against comorbid depressive disorder in patients with rheumatoid arthritis: Preliminary results of the study","publication_year":2023,"publication_date":"2023-04-28","ids":{"openalex":"https://openalex.org/W4367309177","doi":"https://doi.org/10.47360/1995-4484-2023-188-198"},"language":"en","primary_location":{"id":"doi:10.47360/1995-4484-2023-188-198","doi":"https://doi.org/10.47360/1995-4484-2023-188-198","is_oa":true,"landing_page_url":"https://doi.org/10.47360/1995-4484-2023-188-198","pdf_url":"https://rsp.mediar-press.net/rsp/article/download/3321/2274","source":{"id":"https://openalex.org/S4210206766","display_name":"Rheumatology Science and Practice","issn_l":"1995-4484","issn":["1995-4484","1995-4492"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology Science and Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rsp.mediar-press.net/rsp/article/download/3321/2274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034760786","display_name":"Tatyana Andreyevna Lisitsyna","orcid":"https://orcid.org/0000-0001-9437-406X","observed_orcids":["https://orcid.org/0000-0001-9437-406X"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. A. Lisitsyna","raw_affiliation_strings":["V.A. Nasonova Research Institute of Rheumatology"],"raw_orcid":"https://orcid.org/0000-0001-9437-406X","affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036596091","display_name":"\u0410\u0431\u0440\u0430\u043c\u043a\u0438\u043d \u0410\u043d\u0442\u043e\u043d \u0410\u043d\u0430\u0442\u043e\u043b\u044c\u0435\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-1504-5645","observed_orcids":["https://orcid.org/0000-0002-1504-5645"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Abramkin","raw_affiliation_strings":["V.A. Nasonova Research Institute of Rheumatology"],"raw_orcid":"https://orcid.org/0000-0002-1504-5645","affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082471558","display_name":"Dmitry Yu. Veltishchev","orcid":"https://orcid.org/0000-0001-5210-2605","observed_orcids":["https://orcid.org/0000-0001-5210-2605"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. Yu. Veltishchev","raw_affiliation_strings":["Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation; N.I. Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0001-5210-2605","affiliations":[{"raw_affiliation_string":"Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation; N.I. Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028988337","display_name":"O. Seravina","orcid":"https://orcid.org/0000-0001-5839-4637","observed_orcids":["https://orcid.org/0000-0001-5839-4637"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210145664","display_name":"Federal Medical Research Centre for Psychiatry and Narcology","ror":"https://ror.org/046wkw610","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210145664"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. F. Seravina","raw_affiliation_strings":["Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-5839-4637","affiliations":[{"raw_affiliation_string":"Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210145664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108812645","display_name":"Oksana B. Kovalevskaya","orcid":"https://orcid.org/0000-0001-6573-4337","observed_orcids":["https://orcid.org/0000-0001-6573-4337"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210145664","display_name":"Federal Medical Research Centre for Psychiatry and Narcology","ror":"https://ror.org/046wkw610","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210145664"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. B. Kovalevskaya","raw_affiliation_strings":["Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-6573-4337","affiliations":[{"raw_affiliation_string":"Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210145664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101747850","display_name":"A. B. Borisova","orcid":"https://orcid.org/0000-0001-6802-0268","observed_orcids":["https://orcid.org/0000-0001-6802-0268"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]},{"id":"https://openalex.org/I4210145664","display_name":"Federal Medical Research Centre for Psychiatry and Narcology","ror":"https://ror.org/046wkw610","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210117042","https://openalex.org/I4210145664"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. B. Borisova","raw_affiliation_strings":["V.A. Nasonova Research Institute of Rheumatology; Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-6802-0268","affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology; Moscow Research Institute of Psychiatry \u2013 the Branch of the \u00abNational Medical Research Center for Psychiatry and Narcology\u00bb of the Ministry of Health of the Russian Federation","institution_ids":["https://openalex.org/I4210117042","https://openalex.org/I4210121474","https://openalex.org/I4210145664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088449102","display_name":"V. G. Ignatiev","orcid":"https://orcid.org/0000-0003-2818-6583","observed_orcids":["https://orcid.org/0000-0003-2818-6583"]},"institutions":[{"id":"https://openalex.org/I4210097816","display_name":"R-Pharm (Russia)","ror":"https://ror.org/00veetk09","country_code":"RU","type":"company","lineage":["https://openalex.org/I4210097816"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. G. Ignatiev","raw_affiliation_strings":["AO \u00abR-Pharm\u00bb"],"raw_orcid":"https://orcid.org/0000-0003-2818-6583","affiliations":[{"raw_affiliation_string":"AO \u00abR-Pharm\u00bb","institution_ids":["https://openalex.org/I4210097816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022097092","display_name":"Evgeny Lvovich Nasonov","orcid":"https://orcid.org/0000-0002-1598-8360","observed_orcids":["https://orcid.org/0000-0002-1598-8360"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. L. Nasonov","raw_affiliation_strings":["V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)"],"raw_orcid":"https://orcid.org/0000-0002-1598-8360","affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)","institution_ids":["https://openalex.org/I17877952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8794,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.84850282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"61","issue":"2","first_page":"188","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olokizumab","display_name":"olokizumab","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.47099998593330383},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6499999761581421},{"id":"https://openalex.org/keywords/il-6-inhibitors","display_name":"IL-6 inhibitors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.7770000100135803},{"id":"https://openalex.org/keywords/psychiatric-pharmacotherapy","display_name":"psychopharmacological treatment","score":0.8690000176429749},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.8259999752044678},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.4259999990463257},{"id":"https://openalex.org/keywords/phq-9","display_name":"PHQ-9","score":0.5759999752044678},{"id":"https://openalex.org/keywords/montgomery-asberg-depression-rating-scale","display_name":"Montgomery-Asberg Depression Rating Scale","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hamilton-anxiety-rating-scale","display_name":"Hamilton Anxiety Rating Scale","score":0.9869999885559082},{"id":"https://openalex.org/keywords/das28","display_name":"DAS28","score":0.6019999980926514},{"id":"https://openalex.org/keywords/crohn-s-disease-activity-index","display_name":"CDAI","score":0.5989999771118164},{"id":"https://openalex.org/keywords/sdai","display_name":"SDAI","score":0.7910000085830688},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8491136431694031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7364190816879272},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6859414577484131},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6809799671173096},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.4258764088153839},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.41385072469711304},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4037505090236664},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3302229046821594},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19097378849983215},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.47360/1995-4484-2023-188-198","doi":"https://doi.org/10.47360/1995-4484-2023-188-198","is_oa":true,"landing_page_url":"https://doi.org/10.47360/1995-4484-2023-188-198","pdf_url":"https://rsp.mediar-press.net/rsp/article/download/3321/2274","source":{"id":"https://openalex.org/S4210206766","display_name":"Rheumatology Science and Practice","issn_l":"1995-4484","issn":["1995-4484","1995-4492"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology Science and Practice","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:21f9c854dca64839a7b03985a510c0d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/21f9c854dca64839a7b03985a510c0d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041d\u0430\u0443\u0447\u043d\u043e-\u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f, Vol 61, Iss 2, Pp 188-198 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.47360/1995-4484-2023-188-198","doi":"https://doi.org/10.47360/1995-4484-2023-188-198","is_oa":true,"landing_page_url":"https://doi.org/10.47360/1995-4484-2023-188-198","pdf_url":"https://rsp.mediar-press.net/rsp/article/download/3321/2274","source":{"id":"https://openalex.org/S4210206766","display_name":"Rheumatology Science and Practice","issn_l":"1995-4484","issn":["1995-4484","1995-4492"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology Science and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367309177.pdf","grobid_xml":"https://content.openalex.org/works/W4367309177.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1990166011","https://openalex.org/W2102746921","https://openalex.org/W2131823335","https://openalex.org/W2151628746","https://openalex.org/W2160070901","https://openalex.org/W2315394641","https://openalex.org/W2399060753","https://openalex.org/W2502812021","https://openalex.org/W2606383554","https://openalex.org/W2765982672","https://openalex.org/W2766457141","https://openalex.org/W2901491657","https://openalex.org/W2954339234","https://openalex.org/W2958651069","https://openalex.org/W2969715166","https://openalex.org/W3012729670","https://openalex.org/W3032084118","https://openalex.org/W3033489403","https://openalex.org/W3035534751","https://openalex.org/W3160028128","https://openalex.org/W3191857239","https://openalex.org/W4206213217","https://openalex.org/W4211111012","https://openalex.org/W4293105517","https://openalex.org/W4295952264","https://openalex.org/W4309004275"],"related_works":["https://openalex.org/W4415924893","https://openalex.org/W7160015687","https://openalex.org/W4390279778","https://openalex.org/W2893606592","https://openalex.org/W2610056779","https://openalex.org/W3032084118","https://openalex.org/W7171788353","https://openalex.org/W2731908664","https://openalex.org/W2755751238","https://openalex.org/W3083981335"],"abstract_inverted_index":{"Background.":[0],"Interleukin":[1],"(IL)":[2],"6":[3],"plays":[4],"an":[5,28,71,376],"important":[6],"role":[7],"in":[8,42,47,108,137,224,231,253,322,330,343,364,379,386,410,416,432],"the":[9,35,132,145,184,197,225,237,240,254,283,308,323,331,344,352,365,387,403,423,433],"pathogenesis":[10],"of":[11,37,45,64,74,82,97,101,117,134,140,144,183,191,217,227,234,245,256,310,317,325,333,346,354,369,389,396,402,405,412,426,437,442],"comorbid":[12],"rheumatoid":[13],"arthritis":[14],"(RA)":[15],"depression,":[16,427],"and":[17,54,92,95,214,229,242,270,303,335,367,429,435,444],"IL-6":[18],"inhibitors":[19],"(i)":[20],"used":[21],"to":[22,33,85,142,296,341,351,361,383],"treat":[23],"RA":[24,51,59,83,380,413],"patients":[25,48,60,128,257,311,326,417],"may":[26],"have":[27,61],"antidepressant":[29,377],"effect.":[30],"Objective":[31],"\u2013":[32,151,163,178,202,337],"evaluate":[34],"effectiveness":[36],"Russian":[38],"iIL-6":[39],"olokizumab":[40],"(OKZ)":[41],"reducing":[43],"symptoms":[44,398],"depression":[46,113,192,228,313,397],"with":[49,70,77,110,282,300,418],"moderate/high":[50],"activity.":[52],"Material":[53],"methods.":[55],"To":[56],"date,":[57],"49":[58],"been":[62],"included,":[63],"which":[65],"43":[66],"(87.7%)":[67],"are":[68],"women,":[69],"average":[72],"age":[73],"47.8\u00b112.8":[75],"years;":[76],"a":[78,106,121,138,221,297,301,362,384,393,430,440],"predominant":[79],"high":[80],"activity":[81],"according":[84],"DAS28":[86],"(CRP)":[87],"indices":[88],"(89.8%),":[89],"SDAI":[90],"(79.6%)":[91],"CDAI":[93],"(75.5%)":[94],"inefficacy":[96],"stable":[98],"12-week":[99],"therapy":[100,318,349],"\u0441DMARDs.":[102],"In":[103],"all":[104,127,232,246],"patients,":[105,381,414],"psychiatrist,":[107],"accordance":[109],"ICD-10,":[111],"diagnosed":[112],"(chronic":[114],"or":[115],"recurrent)":[116],"varying":[118],"severity":[119,193,226,368,436],"during":[120],"semi-structured":[122,298],"interview.":[123],"At":[124],"week":[125],"0,":[126],"were":[129,208],"randomized":[130],"by":[131],"method":[133],"sequential":[135],"numbers":[136],"ratio":[139],"1:1:1":[141],"one":[143],"3":[146,177],"study":[147,185],"groups:":[148],"group":[149,161,176,285,332,345],"1":[150],"cDMARDs+OKZ":[152,164,284],"64":[153,165],"mg":[154,166],"subcutaneously":[155,167],"once":[156,168],"every":[157,169],"4":[158,170],"weeks":[159,171,216,316],"(n=18);":[160],"2":[162],"+":[172],"psychopharmacotherapy":[173],"(PPT)":[174],"(n=26);":[175],"cDMARDs+PPT":[179,271],"(n=5).":[180],"The":[181,189],"duration":[182],"is":[186,399,439],"24":[187,215,315],"weeks.":[188],"dynamics":[190],"was":[194,220,248,319],"assessed":[195],"on":[196],"PHQ-9,":[198],"MADRS":[199],"scales;":[200],"anxiety":[201,230,428],"HAM-A;":[203],"experimental":[204,305],"psychological":[205,306],"projective":[206],"techniques":[207],"also":[209],"used.":[210],"Results.":[211],"After":[212],"12":[213],"therapy,":[218],"there":[219],"significant":[222],"decrease":[223,363,385,431],"groups":[233,255,324],"patients.":[235],"However,":[236],"difference":[238],"between":[239],"final":[241],"initial":[243],"values":[244],"scales":[247],"statistically":[249],"significantly":[250,320],"greater":[251],"(p<0.05)":[252],"receiving":[258,327],"PPT:":[259,328],"cDMARDs+OKZ+PPT":[260,334],"(\u0394PHQ-9":[261,272,286],"24\u20130":[262,265,273,276,287,293],"=\u20136.75\u00b13.91;":[263],"\u0394MADRS":[264,275,289],"=\u201322.5\u00b14.83;":[266],"\u0394HAM-A":[267,278,292],"24-0":[268,279,290],"=\u201314.6\u00b15.37)":[269],"=\u201315.5\u00b13.53;":[274],"=\u201325.0\u00b11.41;":[277],"=\u201318.5\u00b13.53),":[280],"compared":[281],"=\u20134.00\u00b13.89;":[288],"=\u20135.75\u00b18.29;":[291],"=\u20138.50\u00b18.21).":[294],"According":[295],"interview":[299],"psychiatrist":[302],"design":[304],"techniques,":[307],"proportion":[309],"without":[312,407],"after":[314],"higher":[321],"90%":[329],"100%":[336],"cDMARDs+PPT,":[338],"as":[339],"opposed":[340],"25%":[342,411],"cDMARDs+OKZ.":[347],"OKZ":[348,374,406,443],"contributed":[350],"normalization":[353],"night":[355],"sleep":[356,390],"but":[357,392],"did":[358],"not":[359],"lead":[360],"frequency":[366,388,434],"cognitive":[370],"disorders":[371],"(CD).":[372],"Conclusions.":[373],"has":[375],"effect":[378],"leads":[382],"disorders,":[391],"com[1]plete":[394],"regression":[395,425],"possible":[400],"because":[401],"appointment":[404],"PPT":[408],"only":[409],"mainly":[415],"mild":[419],"depression.":[420],"Optimal":[421],"for":[422],"complete":[424],"CD":[438],"combination":[441],"PPT.":[445]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-29T00:00:00"}
