{"id":"https://openalex.org/W4367302598","doi":"https://doi.org/10.1212/wnl.0000000000203911","title":"Prediction of Regional Tau Spread Using Individualized Tau Epicenters and Structural Connectomes (S39.002)","display_name":"Prediction of Regional Tau Spread Using Individualized Tau Epicenters and Structural Connectomes (S39.002)","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4367302598","doi":"https://doi.org/10.1212/wnl.0000000000203911"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000203911","doi":"https://doi.org/10.1212/wnl.0000000000203911","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000203911","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christopher Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Brown","raw_affiliation_strings":["Hospital of the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania","institution_ids":["https://openalex.org/I2799810409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047157013","display_name":"Sandhitsu R. Das","orcid":"https://orcid.org/0000-0003-0530-2887","observed_orcids":["https://orcid.org/0000-0003-0530-2887"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandhitsu Das","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010506491","display_name":"Ilya M. Nasrallah","orcid":"https://orcid.org/0000-0003-2346-7562","observed_orcids":["https://orcid.org/0000-0003-2346-7562"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilya Nasrallah","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058192322","display_name":"John A. Detre","orcid":"https://orcid.org/0000-0002-8115-6343","observed_orcids":["https://orcid.org/0000-0002-8115-6343"]},"institutions":[{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Detre","raw_affiliation_strings":["Hosp of the Univ of Penn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hosp of the Univ of Penn","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059550368","display_name":"Paul A. Yushkevich","orcid":"https://orcid.org/0000-0001-8543-4016","observed_orcids":["https://orcid.org/0000-0001-8543-4016"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Yushkevich","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037938359","display_name":"Corey T. McMillan","orcid":"https://orcid.org/0000-0002-7581-6405","observed_orcids":["https://orcid.org/0000-0002-7581-6405"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corey McMillan","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041387594","display_name":"David A. Wolk","orcid":"https://orcid.org/0000-0002-3554-3481","observed_orcids":["https://orcid.org/0000-0002-3554-3481","https://orcid.org/0000-0001-9447-5805"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Wolk","raw_affiliation_strings":["University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04046945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"17_supplement_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.5698000192642212,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.39890000224113464,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.6980000138282776},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8330000042915344},{"id":"https://openalex.org/keywords/structural-connectome","display_name":"structural connectome","score":0.7580000162124634},{"id":"https://openalex.org/keywords/probabilistic-tractography","display_name":"probabilistic tractography","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tau-pet","display_name":"tau PET","score":0.5220000147819519},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"diffusion MRI","score":0.7200000286102295},{"id":"https://openalex.org/keywords/linear-mixed-models","display_name":"linear mixed models","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.5811368823051453},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5352877378463745},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5304120182991028},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.5073449015617371},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4898166358470917},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.4841633439064026},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4788934290409088},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47253894805908203},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.4673633575439453},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.4375540614128113},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.4136529564857483},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.3231159746646881},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30233415961265564},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2927086353302002},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.27303534746170044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2723342180252075},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.26071691513061523},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.2391534149646759},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.130221426486969},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12230217456817627},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11035320162773132}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.0000000000203911","doi":"https://doi.org/10.1212/wnl.0000000000203911","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000203911","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406209880","https://openalex.org/W4417297532","https://openalex.org/W3109359388","https://openalex.org/W3111684317","https://openalex.org/W4230036965","https://openalex.org/W3142445571","https://openalex.org/W2980699203","https://openalex.org/W7163584375","https://openalex.org/W4312087812","https://openalex.org/W2980921847"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"predict":[2,236,290],"the":[3,21,33,40,73,95,108,114,205,276,329,348,378,402,421,446,489,525,556,603,621,646],"spread":[4,38,55,83],"of":[5,16,24,46,56,65,68,75,84,89,174,223,275,288,302,310,320,331,350,362,380,404,423,448,462,473,491,509,527,558,576,587,605,623,648],"tau":[6,17,25,47,217,224,251,255,280,292],"in":[7,30,44,113,159,226,231,279,304,328,347,377,401,420,445,488,524,555,602,620,645],"vivo":[8,305],"based":[9],"on":[10,384,408,495,627],"structural":[11,90,206,284],"connectivity":[12,91],"with":[13,27,170,183,220,246,536,656],"individualized":[14],"epicenters":[15,218,252,287],"pathology.":[18],"Background:":[19],"Despite":[20],"fundamental":[22],"association":[23],"pathology":[26,48,58,289,303],"functional":[28],"impairment":[29],"Alzheimer\u2019s":[31],"disease,":[32],"factors":[34],"that":[35,82,244],"drive":[36],"regional":[37,237,291],"and":[39,62,101,118,128,163,180,187,286,294],"considerable":[41],"individual":[42],"differences":[43],"patterns":[45],"remain":[49],"poorly":[50],"understood.":[51],"Prior":[52],"studies":[53],"support":[54,316,368,468,479,515,582,593],"neurodegenerative":[57],"within":[59,94],"brain":[60],"networks":[61],"provide":[63,295],"evidence":[64],"cell-to-cell":[66],"transmission":[67],"pathologic":[69],"proteins,":[70],"which":[71],"requires":[72,86],"transport":[74],"proteins":[76],"along":[77],"axons.":[78],"Therefore,":[79],"we":[80],"hypothesized":[81],"neuropathology":[85],"a":[87,148,171,232,296,336,355,385,409,496,532,610,628,653],"scaffolding":[88],"to":[92,133,168,176,191,203,235,547],"propagate":[93],"brain.":[96],"Design/Methods:":[97],"Tau":[98],"PET":[99,129],"(AV-1451)":[100],"DTI":[102,127,155],"data":[103,130,156],"from":[104,216,250,317,369,469,480,516,583,594],"29":[105],"participants":[106],"across":[107],"clinical":[109],"spectrum":[110],"were":[111,121,131,142,157,189],"included":[112],"present":[115],"study.":[116],"T1-weighted":[117],"FLAIR":[119],"images":[120],"used":[122,190,202,230],"for":[123,144,273,298,333,338,352,357,382,393,406,412,425,437,450,456,493,504,529,560,572,607,612,625,636,650],"FreeSurfer":[124,197],"cortical":[125],"segmentation.":[126],"registered":[132],"T1-space":[134],"using":[135,147],"ANTs.":[136],"Standardized":[137],"uptake":[138],"value":[139],"ratios":[140],"(SUVR)":[141],"calculated":[143],"each":[145,196,227],"region":[146],"cerebellar":[149],"gray":[150],"matter":[151],"reference":[152],"region.":[153,198],"Multi-shell":[154],"collected":[158],"113":[160],"non-collinear":[161],"directions":[162],"1.5mm":[164],"isotropic":[165],"voxels":[166],"prior":[167],"pre-processing":[169],"custom":[172],"pipeline":[173],"tools":[175],"perform":[177,192],"denoising,":[178],"bias-correction,":[179],"eddy-current/motion":[181],"correction":[182],"outlier":[184],"replacement.":[185],"BEDPOSTX":[186],"PROBTRACKX2":[188],"probabilistic":[193],"tractography":[194],"between":[195,209],"Network":[199],"analysis":[200],"was":[201,229],"calculate":[204],"connectivity-based":[207,214,248],"distance":[208,215],"all":[210],"regions.":[211],"The":[212,308,360,460,471,507,574,585],"average":[213],"(regions":[219],"top":[221],"10%":[222],"SUVR":[225],"hemisphere)":[228],"linear-mixed":[233],"model":[234,271],"SUVR.":[238,281],"Results:":[239],"A":[240],"linear":[241],"mixed-model":[242],"demonstrated":[243],"regions":[245],"shorter":[247],"distances":[249],"have":[253],"higher":[254],"burdens":[256],"(":[257],"F":[258],"1,2362.5":[259],"=":[260,266],"298.39,":[261],"p":[262],"<":[263],"0.001,":[264],"\u03b2":[265],"\u22120.022":[267],"[\u22120.0246,":[268],"\u22120.0197]).":[269],"This":[270],"accounted":[272],"40%":[274],"total":[277],"variance":[278],"Conclusions:":[282],"Individualized":[283],"connectomes":[285],"burden":[293],"tool":[297],"assessing":[299],"expected":[300],"propagation":[301],".":[306],"Disclosure:":[307],"institution":[309,361,461,472,508,575,586],"Dr.":[311,371,395,414,439,463,474,482,510,518,549,577,588,596,614,639],"Brown":[312],"has":[313,324,343,365,373,397,416,441,465,476,484,512,520,545,551,579,590,598,616,641],"received":[314,325,344,366,374,398,417,442,466,477,485,513,521,552,580,591,599,617,642],"research":[315,367,467,478,514,581,592],"National":[318],"Institute":[319],"Health.":[321],"Sandhitsu":[322,341,363],"Das":[323,342,364],"personal":[326,345,375,399,418,443,486,522,553,600,618,643],"compensation":[327,346,376,400,419,444,487,523,554,601,619,644],"range":[330,349,379,403,422,447,490,526,557,604,622,647],"$10,000-$49,999":[332,449],"serving":[334,353,383,407,426,451,494,530,561,608,626,651],"as":[335,354,427,452,531,562,609,652],"Consultant":[337,356,611],"Rancho":[339],"Biosciences.":[340],"$5,000-$9,999":[351,405,649],"Nia":[358],"Therapeutics.":[359],"NIH.":[370,470,517,595],"Nasrallah":[372,396,415,440,464,475],"$500-$4,999":[381,492,528,559,606,624],"Scientific":[386,497,629],"Advisory":[387,434,498,569,630],"or":[388,432,499,567,631],"Data":[389,500,632],"Safety":[390,501,633],"Monitoring":[391,502,634],"board":[392,503,635],"Eisai.":[394],"Speakers":[410],"Bureau":[411],"Biogen.":[413,584],"$0-$499":[424],"an":[428,453,563],"Editor,":[429,431,564,566],"Associate":[430,565],"Editorial":[433,568],"Board":[435,570],"Member":[436,571],"Springer.":[438],"Expert":[454],"Witness":[455],"Cassiday":[457],"Schade":[458],"LLP.":[459],"ASNR.":[481],"Detre":[483,511,519],"Hura":[505],"Imaging.":[506],"grant":[533],"proposal":[534],"reviewer":[535],"NIH,":[537],"VA,":[538],"European":[539],"Science":[540],"Foundation,Deutsche":[541],"Forschungsgemeinschaft.":[542],"Paul":[543],"Yushkevich":[544],"nothing":[546],"disclose.":[548],"McMillan":[550,578,589],"Elsevier.":[573],"Wolk":[597,615,640],"Neuronix.":[613],"Functional":[637],"Neuromodulation.":[638],"CME":[654],"Speaker":[655],"MJH":[657],"Life":[658],"Sciences.":[659]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-29T00:00:00"}
