{"id":"https://openalex.org/W4367180205","doi":"https://doi.org/10.1186/s13287-023-03337-0","title":"Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy","display_name":"Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy","publication_year":2023,"publication_date":"2023-04-27","ids":{"openalex":"https://openalex.org/W4367180205","doi":"https://doi.org/10.1186/s13287-023-03337-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37106393","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10142496"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-023-03337-0","doi":"https://doi.org/10.1186/s13287-023-03337-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-023-03337-0","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03337-0","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03337-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060434465","display_name":"Yuko Nitahara\u2010Kasahara","orcid":"https://orcid.org/0000-0001-7119-5894","observed_orcids":["https://orcid.org/0000-0001-7119-5894"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuko Nitahara-Kasahara","raw_affiliation_strings":["Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan. y-kasahara@ims.u-tokyo.ac.jp","Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7119-5894","affiliations":[{"raw_affiliation_string":"Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan. y-kasahara@ims.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024512014","display_name":"Soya Nakayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Soya Nakayama","raw_affiliation_strings":["Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046286062","display_name":"K\u00f4ichi Kimura","orcid":"https://orcid.org/0000-0003-4116-4135","observed_orcids":["https://orcid.org/0000-0003-4116-4135"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Kimura","raw_affiliation_strings":["Department of Laboratory Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sho Yamaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Yamaguchi","raw_affiliation_strings":["Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013099106","display_name":"Yuko Kakiuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Kakiuchi","raw_affiliation_strings":["Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074440908","display_name":"Chikako Nito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikako Nito","raw_affiliation_strings":["Laboratory for Clinical Research, Collaborative Research Center, Nippon Medical School, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical Research, Collaborative Research Center, Nippon Medical School, Tokyo, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020865626","display_name":"Masahiro Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Hayashi","raw_affiliation_strings":["Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072953900","display_name":"Tomoyuki Nakaishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Nakaishi","raw_affiliation_strings":["Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108423514","display_name":"Yasuyoshi Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyoshi Ueda","raw_affiliation_strings":["Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regenerative Medicine and Cell Therapy Laboratories, Kaneka Corporation, Kobe, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064919780","display_name":"Takashi Okada","orcid":"https://orcid.org/0000-0002-2910-3797","observed_orcids":["https://orcid.org/0000-0002-2910-3797"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Okada","raw_affiliation_strings":["Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan. t-okada@ims.u-tokyo.ac.jp","Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2910-3797","affiliations":[{"raw_affiliation_string":"Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan. t-okada@ims.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060434465","https://openalex.org/A5064919780"],"corresponding_institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.8496,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.6712913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"108","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.2485000044107437,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mdx-mice","display_name":"mdx mice","score":0.7540000081062317},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.7549999952316284},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.5559999942779541},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/cell-therapy-safety-and-efficacy","display_name":"cell therapy safety and efficacy","score":0.6159999966621399},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.5199999809265137},{"id":"https://openalex.org/keywords/running-endurance","display_name":"running endurance","score":0.8980000019073486},{"id":"https://openalex.org/keywords/myofiber-degeneration","display_name":"myofiber degeneration","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7958548069000244},{"id":"https://openalex.org/C2778943923","wikidata":"https://www.wikidata.org/wiki/Q1648484","display_name":"Duchenne muscular dystrophy","level":2,"score":0.5721579194068909},{"id":"https://openalex.org/C2778750056","wikidata":"https://www.wikidata.org/wiki/Q24976962","display_name":"mdx mouse","level":4,"score":0.5717511773109436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5354704260826111},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.45385345816612244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45053502917289734},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4437708556652069},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4227392077445984},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41568344831466675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3886137306690216},{"id":"https://openalex.org/C2780394045","wikidata":"https://www.wikidata.org/wiki/Q412285","display_name":"Dystrophin","level":3,"score":0.3461097478866577},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32996708154678345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23987308144569397},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20910733938217163},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000650","descriptor_name":"Amnion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018101","descriptor_name":"Mice, Inbred mdx","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020388","descriptor_name":"Muscular Dystrophy, Duchenne","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020388","descriptor_name":"Muscular Dystrophy, Duchenne","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13287-023-03337-0","doi":"https://doi.org/10.1186/s13287-023-03337-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-023-03337-0","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03337-0","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10142496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10142496","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10142496/pdf/13287_2023_Article_3337.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:37106393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37106393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c3f1f3dc487f4608aa4c00ce14cd3e31","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c3f1f3dc487f4608aa4c00ce14cd3e31","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-20 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-023-03337-0","doi":"https://doi.org/10.1186/s13287-023-03337-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-023-03337-0","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03337-0","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1128912987","display_name":"Development of Gene and Cell Therapeutic Technologies Using AAV Vectors and MSCs for Refractory Neurological Disorders","funder_award_id":"23K20328","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2375282852","display_name":"Multifaceted approach to supress disease progression of muscular dystrophy","funder_award_id":"23K06905","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3301098601","display_name":"Development of innovative muscular dystrophy treatment with a novel ketogenic diet","funder_award_id":"22K18345","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6410473549","display_name":null,"funder_award_id":"JSPS KAKENHI #22K06921","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6587722757","display_name":"Establishing a Novel Stroke Therapy Based on Exosomes from Amnion-Derived Mesenchymal Stem Cells","funder_award_id":"21K09163","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8053781190","display_name":"\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u306b\u5bfe\u3059\u308b\u6a5f\u80fd\u5f37\u5316\u7f8a\u819c\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u6297\u708e\u75c7\u7642\u6cd5\u3068\u8a55\u4fa1\u7cfb\u306e\u69cb\u7bc9","funder_award_id":"22K06921","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367180205.pdf","grobid_xml":"https://content.openalex.org/works/W4367180205.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W177127972","https://openalex.org/W301897234","https://openalex.org/W1535044384","https://openalex.org/W1589179725","https://openalex.org/W1888941810","https://openalex.org/W1965425745","https://openalex.org/W1981575054","https://openalex.org/W1985859986","https://openalex.org/W1986088843","https://openalex.org/W1987980762","https://openalex.org/W2008980136","https://openalex.org/W2014673628","https://openalex.org/W2015268355","https://openalex.org/W2020180085","https://openalex.org/W2023284474","https://openalex.org/W2025371271","https://openalex.org/W2029599332","https://openalex.org/W2035904396","https://openalex.org/W2041971960","https://openalex.org/W2048354593","https://openalex.org/W2048489410","https://openalex.org/W2051850871","https://openalex.org/W2067828733","https://openalex.org/W2068135722","https://openalex.org/W2070936696","https://openalex.org/W2074277664","https://openalex.org/W2079820863","https://openalex.org/W2088742404","https://openalex.org/W2088964957","https://openalex.org/W2094087897","https://openalex.org/W2095666785","https://openalex.org/W2106117542","https://openalex.org/W2111727066","https://openalex.org/W2123502833","https://openalex.org/W2139040437","https://openalex.org/W2139167732","https://openalex.org/W2143379207","https://openalex.org/W2148703658","https://openalex.org/W2149697028","https://openalex.org/W2152451347","https://openalex.org/W2153949260","https://openalex.org/W2154713489","https://openalex.org/W2157455235","https://openalex.org/W2162665146","https://openalex.org/W2165952317","https://openalex.org/W2403854759","https://openalex.org/W2464260680","https://openalex.org/W2485516716","https://openalex.org/W2558608698","https://openalex.org/W2590472825","https://openalex.org/W2619544969","https://openalex.org/W2620738021","https://openalex.org/W2735988666","https://openalex.org/W2753764215","https://openalex.org/W2766249308","https://openalex.org/W2790436657","https://openalex.org/W2893132945","https://openalex.org/W2937350297","https://openalex.org/W2966919496","https://openalex.org/W2967176962","https://openalex.org/W2986407951","https://openalex.org/W3037592572","https://openalex.org/W3122765886","https://openalex.org/W3124948419","https://openalex.org/W3126914148","https://openalex.org/W3128782885","https://openalex.org/W3175024358","https://openalex.org/W3198658136","https://openalex.org/W3212910602","https://openalex.org/W3216574014","https://openalex.org/W3217721159","https://openalex.org/W4206413682","https://openalex.org/W4223520436","https://openalex.org/W4238163958","https://openalex.org/W4292330637"],"related_works":["https://openalex.org/W6958303966","https://openalex.org/W2562001371","https://openalex.org/W4298108904","https://openalex.org/W2565608014","https://openalex.org/W4385606304","https://openalex.org/W2804295589","https://openalex.org/W2377661013","https://openalex.org/W1913981912","https://openalex.org/W3198444445","https://openalex.org/W3122765886"],"abstract_inverted_index":{"BACKGROUND:":[0],"Duchenne":[1],"muscular":[2],"dystrophy":[3],"(DMD)":[4],"is":[5],"an":[6,36,200],"incurable":[7],"genetic":[8],"disease":[9],"characterized":[10],"by":[11],"degeneration":[12],"and":[13,19,67,73,87,97,139,145,161,184,215,255,299,309],"necrosis":[14],"of":[15,70,82,95,109,141,176,188,194,204,208,224,307,323],"myofibers,":[16],"chronic":[17],"inflammation,":[18],"progressive":[20,294],"muscle":[21,207,311],"weakness":[22],"resulting":[23,302],"in":[24,221,234,238,244,277,281,290,303],"premature":[25],"mortality.":[26],"Immunosuppressive":[27],"multipotent":[28],"mesenchymal":[29,45],"stromal":[30,46],"cell":[31,52,182],"(MSC)":[32],"therapy":[33],"could":[34,264,332],"be":[35,317],"option":[37],"for":[38,91],"DMD":[39,130,278,337],"patients.":[40,338],"We":[41,75,101],"focused":[42],"on":[43,84,114],"amnion-derived":[44],"cells":[47,118],"(AMSCs),":[48],"a":[49,173,185,231],"clinically":[50],"viable":[51],"source":[53],"owing":[54],"to":[55,77,105,135,336],"their":[56,88],"unique":[57],"characteristics,":[58],"such":[59],"as":[60],"non-invasive":[61],"isolation,":[62],"mitotic":[63],"stability,":[64],"ethical":[65],"acceptability,":[66],"minimal":[68],"risk":[69],"immune":[71],"reaction":[72],"cancer.":[74],"aimed":[76],"identify":[78],"novel":[79],"immunomodulatory":[80],"effects":[81,315],"AMSCs":[83,123],"macrophage":[85,112,327],"polarization":[86],"transplantation":[89],"strategies":[90],"the":[92,107,137,205,222,235,245,261,304,320],"functional":[93],"recovery":[94],"skeletal":[96,206,308],"cardiac":[98,310],"muscles.":[99],"METHODS:":[100],"used":[102],"flow":[103],"cytometry":[104],"analyze":[106],"expression":[108],"anti-inflammatory":[110],"M2":[111,213,326],"markers":[113],"peripheral":[115],"blood":[116,152],"mononuclear":[117,181],"(PBMCs)":[119],"co-cultured":[120],"with":[121,319],"human":[122],"(hAMSCs).":[124],"hAMSCs":[125,324],"were":[126,149,192,219],"intravenously":[127],"injected":[128],"into":[129],"model":[131],"mice":[132,148,171,241,251,263,279,292],"(mdx":[133],"mice)":[134],"assess":[136],"safety":[138],"efficacy":[140],"therapeutic":[142,314,334],"interventions.":[143],"hAMSC-treated":[144,209,225,246,249,282],"untreated":[146],"mdx":[147,170,210,226,240,247,250,283,291],"monitored":[150],"using":[151],"tests,":[153],"histological":[154,202],"examinations,":[155],"spontaneous":[156],"wheel-running":[157],"activities,":[158],"grip":[159,236],"strength,":[160],"echocardiography.":[162],"RESULTS:":[163],"production.":[164],"After":[165],"repeated":[166],"systemic":[167,287],"hAMSC":[168,288],"injections,":[169],"exhibited":[172],"transient":[174],"downregulation":[175],"serum":[177],"creatin":[178],"kinase.":[179],"Limited":[180],"infiltration":[183],"decreased":[186],"number":[187],"centrally":[189],"nucleated":[190],"fibers":[191],"indicative":[193],"regenerated":[195],"myofibers":[196],"following":[197],"degeneration,":[198],"suggesting":[199],"improved":[201,243,280],"appearance":[203],"mice.":[211,227,248,284],"Upregulated":[212],"macrophages":[214],"altered":[216],"cytokine/chemokine":[217],"expressions":[218],"observed":[220],"muscles":[223],"During":[228],"long-term":[229,305],"experiments,":[230],"significant":[232],"decrease":[233],"strength":[237],"control":[239],"significantly":[242],"maintained":[252],"running":[253,258,272],"activity":[254],"enhanced":[256],"daily":[257],"distance.":[259],"Notably,":[260],"treated":[262],"run":[265],"longer":[266],"distances":[267],"per":[268],"minute,":[269],"indicating":[270],"high":[271],"endurance.":[273],"Left":[274],"ventricular":[275],"function":[276],"CONCLUSIONS:":[285],"Early":[286],"administration":[289],"ameliorated":[293],"phenotypes,":[295],"including":[296],"pathological":[297],"inflammation":[298],"motor":[300],"dysfunction,":[301],"improvement":[306],"function.":[312],"The":[313],"might":[316],"associated":[318],"immunosuppressive":[321],"properties":[322],"via":[325],"polarization.":[328],"This":[329],"treatment":[330],"strategy":[331],"provide":[333],"benefits":[335]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-04-28T00:00:00"}