{"id":"https://openalex.org/W4367179991","doi":"https://doi.org/10.1201/9781003420163-2","title":"Retrovirus-Mediated Gene Transfer","display_name":"Retrovirus-Mediated Gene Transfer","publication_year":2023,"publication_date":"2023-04-27","ids":{"openalex":"https://openalex.org/W4367179991","doi":"https://doi.org/10.1201/9781003420163-2"},"language":"en","primary_location":{"id":"doi:10.1201/9781003420163-2","doi":"https://doi.org/10.1201/9781003420163-2","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003420163-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Genome Methods","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W601314101","display_name":"Viral Genome Methods"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036869902","display_name":"Bruce Alan Bunnell","orcid":"https://orcid.org/0000-0001-6196-3722","observed_orcids":["https://orcid.org/0000-0001-6196-3722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce A. Bunnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103198733","display_name":"Richard A. Morgan","orcid":"https://orcid.org/0000-0003-0689-0916","observed_orcids":["https://orcid.org/0000-0003-0689-0916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.228,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78796729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"3","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/defective-virus","display_name":"defective virus","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.7463794946670532},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.6848896145820618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4035312831401825},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3772921860218048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3547835946083069},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29785633087158203}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1201/9781003420163-2","doi":"https://doi.org/10.1201/9781003420163-2","is_oa":false,"landing_page_url":"https://doi.org/10.1201/9781003420163-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306463075","display_name":"CRC Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320584","host_organization_name":"CRC Press","host_organization_lineage":["https://openalex.org/P4310320584","https://openalex.org/P4310320547"],"host_organization_lineage_names":["CRC Press","Taylor & Francis"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viral Genome Methods","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3021447025","https://openalex.org/W4388325063","https://openalex.org/W2051473632","https://openalex.org/W1764874870","https://openalex.org/W2396707069","https://openalex.org/W2082745512","https://openalex.org/W1576746816","https://openalex.org/W80579281","https://openalex.org/W4243110996","https://openalex.org/W2439104177"],"abstract_inverted_index":{"Retroviral-based":[0],"gene":[1,15,52],"transfer":[2,16],"vectors":[3,102],"are":[4,20,71,83],"currently":[5],"one":[6],"of":[7,23,66],"the":[8,28,45,132],"most":[9,80],"widely":[10],"used":[11,49],"and":[12,32,47,62,64,76,97],"highly":[13],"effective":[14],"systems":[17],"available.":[18],"Retroviruses":[19,70],"a":[21,35,137],"family":[22],"RNA":[24],"viruses":[25,117],"that":[26],"possess":[27],"ability":[29],"to":[30,135],"efficiently":[31],"precisely":[33],"integrate":[34],"DNA":[36],"replication":[37,122],"intermediate":[38],"into":[39,85,109],"dividing":[40],"cells.":[41],"This":[42],"chapter":[43],"describes":[44],"technology":[46],"protocols":[48],"in":[50,73],"retroviral-mediated":[51],"transfer.":[53],"It":[54],"discusses":[55],"retroviral":[56,58,101,139],"vectors,":[57],"packaging":[59,127],"cell":[60,128],"lines,":[61],"generation":[63],"characterization":[65],"high-titer":[67],"retrovirus":[68,113],"supernatants.":[69],"found":[72],"several":[74],"invertebrate":[75],"vertebrate":[77],"species,":[78],"including":[79],"mammals.":[81],"They":[82],"divided":[84],"three":[86],"subfamilies":[87],"based":[88],"primarily":[89],"on":[90],"their":[91],"association":[92],"with":[93,121],"disease:":[94],"oncovirinae,":[95],"lentivirinae,":[96],"spumavirinae.":[98],"The":[99],"first":[100],"were":[103,118],"produced":[104],"by":[105],"inserting":[106],"intact":[107],"genes":[108],"naturally":[110],"occurring,":[111],"deleted":[112],"genomes.":[114],"These":[115],"defective":[116],"then":[119],"rescued":[120],"competent":[123],"helper":[124],"virus.":[125],"Retrovirus":[126],"lines":[129],"provide":[130],"all":[131],"proteins":[133],"required":[134],"assemble":[136],"functional":[138],"vector.":[140]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2023-04-28T00:00:00"}