{"id":"https://openalex.org/W4367174176","doi":"https://doi.org/10.1007/s12010-023-04523-9","title":"Identification of Potential Insulinotropic Cytotoxins from Indian Cobra Snake Venom Using High-Resolution Mass Spectrometry and Analyzing Their Possible Interactions with Potassium Channel Receptors by In Silico Studies","display_name":"Identification of Potential Insulinotropic Cytotoxins from Indian Cobra Snake Venom Using High-Resolution Mass Spectrometry and Analyzing Their Possible Interactions with Potassium Channel Receptors by In Silico Studies","publication_year":2023,"publication_date":"2023-04-27","ids":{"openalex":"https://openalex.org/W4367174176","doi":"https://doi.org/10.1007/s12010-023-04523-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/37103736"},"language":"en","primary_location":{"id":"doi:10.1007/s12010-023-04523-9","doi":"https://doi.org/10.1007/s12010-023-04523-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12010-023-04523-9","pdf_url":null,"source":{"id":"https://openalex.org/S153285774","display_name":"Applied Biochemistry and Biotechnology","issn_l":"0273-2289","issn":["0273-2289","1559-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Biochemistry and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014319820","display_name":"Upendra Gunta","orcid":"https://orcid.org/0000-0001-8958-1494","observed_orcids":["https://orcid.org/0000-0001-8958-1494"]},"institutions":[{"id":"https://openalex.org/I288045149","display_name":"Dravidian University","ror":"https://ror.org/04zj95y60","country_code":"IN","type":"education","lineage":["https://openalex.org/I288045149"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Upendra Gunta","raw_affiliation_strings":["Department of Biotechnology, Dravidian University, Kuppam, 517426, Andhra Pradesh, India"],"raw_orcid":"https://orcid.org/0000-0001-8958-1494","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Dravidian University, Kuppam, 517426, Andhra Pradesh, India","institution_ids":["https://openalex.org/I288045149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058918776","display_name":"Gangadhara Prasadachari Vadla","orcid":"https://orcid.org/0000-0002-3492-2615","observed_orcids":["https://orcid.org/0000-0002-3492-2615","https://orcid.org/0000-0001-5248-8077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gangadhar P. Vadla","raw_affiliation_strings":["Kyntox Biotech India Pvt Ltd, Bangalore, 560032, Karnakata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyntox Biotech India Pvt Ltd, Bangalore, 560032, Karnakata, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012939065","display_name":"Kadiyala Gopi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gopi Kadiyala","raw_affiliation_strings":["Kyntox Biotech India Pvt Ltd, Bangalore, 560032, Karnakata, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyntox Biotech India Pvt Ltd, Bangalore, 560032, Karnakata, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087258010","display_name":"Dilipkumar Reddy Kandula","orcid":"https://orcid.org/0000-0002-9325-5541","observed_orcids":["https://orcid.org/0000-0002-9325-5541"]},"institutions":[{"id":"https://openalex.org/I341451707","display_name":"Shri Jagdishprasad Jhabarmal Tibrewala University","ror":"https://ror.org/03gs0q910","country_code":"IN","type":"education","lineage":["https://openalex.org/I341451707"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dilipkumar Reddy Kandula","raw_affiliation_strings":["Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, 333010, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, 333010, Rajasthan, India","institution_ids":["https://openalex.org/I341451707"]}]},{"author_position":"last","author":{"id":null,"display_name":"M. Mastan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I288045149","display_name":"Dravidian University","ror":"https://ror.org/04zj95y60","country_code":"IN","type":"education","lineage":["https://openalex.org/I288045149"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"M. Mastan","raw_affiliation_strings":["Department of Biotechnology, Dravidian University, Kuppam, 517426, Andhra Pradesh, India. gupendra80@gmail.com","Department of Biotechnology, Dravidian University, Kuppam, 517426, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Dravidian University, Kuppam, 517426, Andhra Pradesh, India. gupendra80@gmail.com","institution_ids":["https://openalex.org/I288045149"]},{"raw_affiliation_string":"Department of Biotechnology, Dravidian University, Kuppam, 517426, Andhra Pradesh, India","institution_ids":["https://openalex.org/I288045149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I288045149"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.3127,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.79554778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"196","issue":"1","first_page":"160","last_page":"181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10332","display_name":"Amphibian and Reptile Biology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.5360000133514404},{"id":"https://openalex.org/keywords/indian-cobra","display_name":"Indian cobra","score":0.7670000195503235},{"id":"https://openalex.org/keywords/naja-atra","display_name":"Naja atra","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cytotoxin","display_name":"cytotoxin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/three-finger-toxins","display_name":"three-finger toxins","score":0.8870000243186951},{"id":"https://openalex.org/keywords/insulinotropic-effect","display_name":"insulinotropic effect","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.6660000085830688},{"id":"https://openalex.org/keywords/rin-5f-cells","display_name":"RIN-5F cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.824999988079071},{"id":"https://openalex.org/keywords/bioactive-peptides","display_name":"bioactive peptides","score":0.7139999866485596},{"id":"https://openalex.org/keywords/venom-purification","display_name":"venom purification","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2779547071","wikidata":"https://www.wikidata.org/wiki/Q608565","display_name":"Cobra","level":2,"score":0.6219817996025085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5933578014373779},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.5812780261039734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5450438261032104},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5256810188293457},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5060824751853943},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.48100313544273376},{"id":"https://openalex.org/C2781281211","wikidata":"https://www.wikidata.org/wiki/Q2195995","display_name":"Repaglinide","level":4,"score":0.41948190331459045},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37490737438201904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28807422518730164},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.190189391374588},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.16488143801689148},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1459508240222931},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0842079222202301},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073176","descriptor_name":"Naja naja","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073176","descriptor_name":"Naja naja","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073176","descriptor_name":"Naja naja","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004546","descriptor_name":"Elapid Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12010-023-04523-9","doi":"https://doi.org/10.1007/s12010-023-04523-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12010-023-04523-9","pdf_url":null,"source":{"id":"https://openalex.org/S153285774","display_name":"Applied Biochemistry and Biotechnology","issn_l":"0273-2289","issn":["0273-2289","1559-0291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Biochemistry and Biotechnology","raw_type":"journal-article"},{"id":"pmid:37103736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37103736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied biochemistry and biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1887624773","https://openalex.org/W1975744071","https://openalex.org/W1986557191","https://openalex.org/W1987474460","https://openalex.org/W1991060344","https://openalex.org/W1994958220","https://openalex.org/W1998666012","https://openalex.org/W2024283409","https://openalex.org/W2045362322","https://openalex.org/W2057776973","https://openalex.org/W2060809301","https://openalex.org/W2093762253","https://openalex.org/W2096764683","https://openalex.org/W2127553917","https://openalex.org/W2134967712","https://openalex.org/W2155905771","https://openalex.org/W2177317049","https://openalex.org/W2197276814","https://openalex.org/W2337961241","https://openalex.org/W2793085160","https://openalex.org/W2804822363","https://openalex.org/W2900640955","https://openalex.org/W2946359443","https://openalex.org/W2972869264","https://openalex.org/W3025642283","https://openalex.org/W3093698663","https://openalex.org/W3165815823","https://openalex.org/W4206246887","https://openalex.org/W4210299062","https://openalex.org/W4211246989","https://openalex.org/W4225161572","https://openalex.org/W6806600338","https://openalex.org/W7073939658"],"related_works":["https://openalex.org/W4224209736","https://openalex.org/W4389950549","https://openalex.org/W4309884222","https://openalex.org/W2799402654","https://openalex.org/W4389060289","https://openalex.org/W3111792067","https://openalex.org/W2073821369","https://openalex.org/W4311446917","https://openalex.org/W2150501383","https://openalex.org/W2604218831"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}