{"id":"https://openalex.org/W4367173871","doi":"https://doi.org/10.1002/adbi.202300051","title":"The Influence of Design Modifications and Microstructured Surface Topographies on Bleb Survival after Glaucoma Tube Shunt Implantation","display_name":"The Influence of Design Modifications and Microstructured Surface Topographies on Bleb Survival after Glaucoma Tube Shunt Implantation","publication_year":2023,"publication_date":"2023-04-27","ids":{"openalex":"https://openalex.org/W4367173871","doi":"https://doi.org/10.1002/adbi.202300051","pmid":"https://pubmed.ncbi.nlm.nih.gov/37102630"},"language":"en","primary_location":{"id":"doi:10.1002/adbi.202300051","doi":"https://doi.org/10.1002/adbi.202300051","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adbi.202300051","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202300051","source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202300051","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050455819","display_name":"Ralph J. S. van Mechelen","orcid":"https://orcid.org/0000-0001-6467-0546","observed_orcids":["https://orcid.org/0000-0001-6467-0546"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Ralph J. S. van Mechelen","raw_affiliation_strings":["School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands","University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), 6202 AZ Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6467-0546","affiliations":[{"raw_affiliation_string":"School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), 6202 AZ Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006080827","display_name":"Phani Krishna Sudarsanam","orcid":"https://orcid.org/0009-0008-0182-0787","observed_orcids":["https://orcid.org/0009-0008-0182-0787"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Phani Sudarsanam","raw_affiliation_strings":["Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059861979","display_name":"Christian J.F. Bertens","orcid":"https://orcid.org/0000-0001-5710-3703","observed_orcids":["https://orcid.org/0000-0001-5710-3703"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Christian J. F. Bertens","raw_affiliation_strings":["School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands","University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), 6202 AZ Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), 6202 AZ Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mehmet O. Tas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mehmet O. Tas","raw_affiliation_strings":["Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020668415","display_name":"Marion J. Gijbels","orcid":"https://orcid.org/0000-0002-4906-0384","observed_orcids":["https://orcid.org/0000-0002-4906-0384"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4405257531","display_name":"Amsterdam Cardiovascular Sciences","ror":"https://ror.org/05c9qnd49","country_code":"NL","type":"funder","lineage":["https://openalex.org/I4405257531"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marion J. J. Gijbels","raw_affiliation_strings":["Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands","School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Experimental Vascular Biology, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4405257531"]},{"raw_affiliation_string":"School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011018910","display_name":"Leonard Pinchuk","orcid":"https://orcid.org/0000-0001-6347-6952","observed_orcids":["https://orcid.org/0000-0001-6347-6952"]},"institutions":[{"id":"https://openalex.org/I4210099140","display_name":"Santen (United States)","ror":"https://ror.org/0108v8438","country_code":"US","type":"company","lineage":["https://openalex.org/I149737975","https://openalex.org/I4210099140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard Pinchuk","raw_affiliation_strings":["InnFocus Inc. a Santen company, 12415 S.W. 136 avenue, Miami, FL, 33186 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InnFocus Inc. a Santen company, 12415 S.W. 136 avenue, Miami, FL, 33186 USA","institution_ids":["https://openalex.org/I4210099140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058224640","display_name":"Jan de Boer","orcid":"https://orcid.org/0000-0001-9188-9324","observed_orcids":["https://orcid.org/0000-0001-9188-9324","https://orcid.org/0000-0002-7748-1231"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan de Boer","raw_affiliation_strings":["Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041564002","display_name":"Henny J. M. Beckers","orcid":"https://orcid.org/0000-0001-9406-1426","observed_orcids":["https://orcid.org/0000-0001-9406-1426"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Henny J. M. Beckers","raw_affiliation_strings":["University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), 6202 AZ Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Eye Clinic Maastricht, Maastricht University Medical Center+ (MUMC+), 6202 AZ Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041564002","https://openalex.org/A5050455819"],"corresponding_institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":{"value":4020,"currency":"USD","value_usd":4020},"fwci":0.7221,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64756794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"7","issue":"7","first_page":"e2300051","last_page":"e2300051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bleb-survival","display_name":"bleb survival","score":0.8460000157356262},{"id":"https://openalex.org/keywords/microshunt","display_name":"microshunt","score":0.7630000114440918},{"id":"https://openalex.org/keywords/endplate","display_name":"endplate","score":0.7799999713897705},{"id":"https://openalex.org/keywords/antifibrotic-effect","display_name":"antifibrotic effect","score":0.777999997138977},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8629999756813049},{"id":"https://openalex.org/keywords/capsule-thickness","display_name":"capsule thickness","score":0.6140000224113464},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/implant-design-modification","display_name":"implant design modification","score":0.5509999990463257},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776228307","wikidata":"https://www.wikidata.org/wiki/Q4925763","display_name":"Bleb (medicine)","level":4,"score":0.9422981142997742},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.7073671817779541},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5658657550811768},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5030197501182556},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.500887393951416},{"id":"https://openalex.org/C2777824320","wikidata":"https://www.wikidata.org/wiki/Q3177088","display_name":"Trabeculectomy","level":3,"score":0.4737197458744049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4725232720375061},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.45938828587532043},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4592769742012024},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3633999824523926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21594291925430298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1270734667778015},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013343","descriptor_name":"Styrenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020327","descriptor_name":"Glaucoma Drainage Implants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/adbi.202300051","doi":"https://doi.org/10.1002/adbi.202300051","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adbi.202300051","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202300051","source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},{"id":"pmid:37102630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37102630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced biology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/a0381e12-7eb3-4de9-98e7-678f01c72f64","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/a0381e12-7eb3-4de9-98e7-678f01c72f64","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Mechelen, R J S, Sudarsanam, P, Bertens, C J F, Tas, M O, Gijbels, M J J, Pinchuk, L, de Boer, J & Beckers, H J M 2023, 'The Influence of Design Modifications and Microstructured Surface Topographies on Bleb Survival after Glaucoma Tube Shunt Implantation', Advanced Biology, vol. 7, no. 7, 2300051. https://doi.org/10.1002/adbi.202300051","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.tue.nl:openaire/60ebc06b-e7b2-435e-a50a-8ea642d35b84","doi":null,"is_oa":true,"landing_page_url":"https://research.tue.nl/files/305428598/Advanced_Biology_-_2023_-_Mechelen.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"van Mechelen, R J S, Sudarsanam, P, Bertens, C J F, Tas, M O, Gijbels, M J J, Pinchuk, L, de Boer, J & Beckers, H J M 2023, 'The Influence of Design Modifications and Microstructured Surface Topographies on Bleb Survival after Glaucoma Tube Shunt Implantation', Advanced Biology, vol. 7, no. 7, 2300051. https://doi.org/10.1002/adbi.202300051","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/a0381e12-7eb3-4de9-98e7-678f01c72f64","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/a0381e12-7eb3-4de9-98e7-678f01c72f64","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Biology. Wiley-VCH Verlag","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/adbi.202300051","doi":"https://doi.org/10.1002/adbi.202300051","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adbi.202300051","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adbi.202300051","source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322516","display_name":"Santen","ror":"https://ror.org/032msy923"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367173871.pdf","grobid_xml":"https://content.openalex.org/works/W4367173871.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W63668370","https://openalex.org/W1975600663","https://openalex.org/W1977890191","https://openalex.org/W1997019056","https://openalex.org/W2011143706","https://openalex.org/W2013845000","https://openalex.org/W2136515150","https://openalex.org/W2141028357","https://openalex.org/W2147370549","https://openalex.org/W2229113751","https://openalex.org/W2496950235","https://openalex.org/W2613051778","https://openalex.org/W2791640763","https://openalex.org/W2813985977","https://openalex.org/W2977710994","https://openalex.org/W3003026064","https://openalex.org/W3021709170","https://openalex.org/W3084961025","https://openalex.org/W3094796671","https://openalex.org/W3097738774","https://openalex.org/W3171806301","https://openalex.org/W3177044329","https://openalex.org/W3202260095","https://openalex.org/W4233435953","https://openalex.org/W4293124860"],"related_works":["https://openalex.org/W7127193136","https://openalex.org/W4293124860","https://openalex.org/W4317208338","https://openalex.org/W2420279577","https://openalex.org/W7165148808","https://openalex.org/W2595469781","https://openalex.org/W3046746348","https://openalex.org/W2025321240","https://openalex.org/W2009139844","https://openalex.org/W3034008384"],"abstract_inverted_index":{"Lowering":[0],"intraocular":[1],"pressure":[2],"(IOP)":[3],"by":[4],"placement":[5],"of":[6,18,32,46,77,86,104,110,142,153,156,170,181],"a":[7,43,57],"glaucoma":[8,157],"shunt":[9],"is":[10,48,70],"an":[11,34,87,105,125,143,178],"effective":[12],"treatment":[13],"for":[14,72,83],"glaucoma.":[15],"However,":[16,124],"fibrosis":[17],"the":[19,29,78,94,102,108,122,135,154,168,192],"outflow":[20],"site":[21],"can":[22],"hamper":[23],"surgical":[24],"outcome.":[25],"In":[26],"this":[27],"study,":[28],"antifibrotic":[30],"effect":[31,169],"adding":[33],"endplate":[35,88,106,144],"(with":[36],"or":[37],"without":[38],"microstructured":[39],"surface":[40,138,171],"topographies)":[41],"to":[42,121,191],"microshunt":[44],"made":[45],"poly(styrene-block-isobutylene-block-styrene)":[47],"investigated.":[49],"New":[50],"Zealand":[51],"white":[52],"rabbits":[53],"are":[54,81,132,188],"implanted":[55],"with":[56,137],"control":[58],"implant":[59],"(without":[60],"endplate)":[61],"and":[62,68,115,129,184],"modified":[63],"implants.":[64],"Afterward,":[65],"bleb":[66,90,148,161,175],"morphology":[67],"IOP":[69],"recorded":[71,96],"30":[73],"days.":[74],"After":[75],"killing":[76],"animals,":[79],"eyes":[80],"collected":[82],"histology,":[84],"Addition":[85],"extended":[89],"survival,":[91,149,176],"Topography-990":[92],"has":[93],"longest":[95],"bleb-survival":[97],"time.":[98],"Histology":[99],"reveals":[100],"that":[101,151],"addition":[103,141],"increases":[107],"presence":[109,180],"myofibroblasts,":[111],"macrophages,":[112],"polymorphonuclear":[113],"cells,":[114],"foreign":[116],"body":[117],"giant":[118],"cells":[119,183],"compared":[120,190],"control.":[123,193],"increased":[126,179,185],"capsule":[127,186],"thickness":[128,187],"inflammatory":[130],"response":[131],"observed":[133,189],"in":[134,146],"groups":[136],"topographies,":[139],"The":[140],"results":[145],"prolonged":[147],"demonstrating":[150],"engineering":[152],"shape":[155],"implants":[158],"could":[159],"prolong":[160],"functionality.":[162],"Future":[163],"research":[164],"should":[165],"further":[166],"elaborate":[167],"topographies":[172],"on":[173],"long-term":[174],"since":[177],"pro-fibrotic":[182]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-04-28T00:00:00"}
