{"id":"https://openalex.org/W4367173285","doi":"https://doi.org/10.5195/d3000.2023.483","title":"Epstein-Barr virus predominance and immunological abnormalities in oral squamous cell carcinoma","display_name":"Epstein-Barr virus predominance and immunological abnormalities in oral squamous cell carcinoma","publication_year":2023,"publication_date":"2023-04-27","ids":{"openalex":"https://openalex.org/W4367173285","doi":"https://doi.org/10.5195/d3000.2023.483"},"language":"en","primary_location":{"id":"doi:10.5195/d3000.2023.483","doi":"https://doi.org/10.5195/d3000.2023.483","is_oa":true,"landing_page_url":"http://dx.doi.org/10.5195/d3000.2023.483","pdf_url":"https://dentistry3000.pitt.edu/ojs/dentistry3000/article/download/483/181","source":{"id":"https://openalex.org/S2738238600","display_name":"Dentistry 3000","issn_l":"2167-8677","issn":["2167-8677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320335","host_organization_name":"University Library System, University of Pittsburgh","host_organization_lineage":["https://openalex.org/P4310320335","https://openalex.org/P4310316479"],"host_organization_lineage_names":["University Library System, University of Pittsburgh","University of Pittsburgh"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dentistry 3000","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dentistry3000.pitt.edu/ojs/dentistry3000/article/download/483/181","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045725443","display_name":"Ahmed Talib Ghadhban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I501048437","display_name":"Al-Muthanna University","ror":"https://ror.org/03877wr45","country_code":"IQ","type":"education","lineage":["https://openalex.org/I501048437"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ahmed Talib Ghadhban","raw_affiliation_strings":["College of Dentistry, Al-Muthanna University, Al-Muthanna, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Dentistry, Al-Muthanna University, Al-Muthanna, Iraq","institution_ids":["https://openalex.org/I501048437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072214463","display_name":"Marwa Mohammed Ali Jassim","orcid":"https://orcid.org/0000-0002-1492-5595","observed_orcids":["https://orcid.org/0000-0002-1492-5595"]},"institutions":[{"id":"https://openalex.org/I501048437","display_name":"Al-Muthanna University","ror":"https://ror.org/03877wr45","country_code":"IQ","type":"education","lineage":["https://openalex.org/I501048437"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Marwa Mohammed Ali Jassim","raw_affiliation_strings":["College of Dentistry, Al-Muthanna University, Al-Muthanna, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Dentistry, Al-Muthanna University, Al-Muthanna, Iraq","institution_ids":["https://openalex.org/I501048437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037527677","display_name":"Majid Mohammed Mahmood","orcid":"https://orcid.org/0000-0002-6887-8771","observed_orcids":["https://orcid.org/0000-0002-6887-8771"]},"institutions":[{"id":"https://openalex.org/I15873915","display_name":"Mustansiriyah University","ror":"https://ror.org/05s04wy35","country_code":"IQ","type":"education","lineage":["https://openalex.org/I15873915"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Majid Mohammed Mahmood","raw_affiliation_strings":["Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq","institution_ids":["https://openalex.org/I15873915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037527677"],"corresponding_institution_ids":["https://openalex.org/I15873915"],"apc_list":null,"apc_paid":null,"fwci":0.2406,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47422543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"11","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9760000109672546},{"id":"https://openalex.org/keywords/viral-carcinogenesis","display_name":"viral oncogenesis","score":0.5839999914169312},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/serum-cytokine-levels","display_name":"serum cytokine levels","score":0.5759999752044678},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.7120000123977661},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.7243658304214478},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.7139682769775391},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6300360560417175},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5948526263237},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.5414777398109436},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5017044544219971},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4634862244129181},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4224909245967865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26722195744514465},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26433035731315613}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5195/d3000.2023.483","doi":"https://doi.org/10.5195/d3000.2023.483","is_oa":true,"landing_page_url":"http://dx.doi.org/10.5195/d3000.2023.483","pdf_url":"https://dentistry3000.pitt.edu/ojs/dentistry3000/article/download/483/181","source":{"id":"https://openalex.org/S2738238600","display_name":"Dentistry 3000","issn_l":"2167-8677","issn":["2167-8677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320335","host_organization_name":"University Library System, University of Pittsburgh","host_organization_lineage":["https://openalex.org/P4310320335","https://openalex.org/P4310316479"],"host_organization_lineage_names":["University Library System, University of Pittsburgh","University of Pittsburgh"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dentistry 3000","raw_type":"journal-article"},{"id":"pmh:oai:ojs.dentistry3000.pitt.edu:article/483","doi":null,"is_oa":true,"landing_page_url":"https://dentistry3000.pitt.edu/ojs/dentistry3000/article/view/483","pdf_url":null,"source":{"id":"https://openalex.org/S2738238600","display_name":"Dentistry 3000","issn_l":"2167-8677","issn":["2167-8677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320335","host_organization_name":"University Library System, University of Pittsburgh","host_organization_lineage":["https://openalex.org/P4310320335","https://openalex.org/P4310316479"],"host_organization_lineage_names":["University Library System, University of Pittsburgh","University of Pittsburgh"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2167-8677","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f0f01e443d8d4080a40b68c575d1f89a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f0f01e443d8d4080a40b68c575d1f89a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dentistry 3000, Vol 11, Iss 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.5195/d3000.2023.483","doi":"https://doi.org/10.5195/d3000.2023.483","is_oa":true,"landing_page_url":"http://dx.doi.org/10.5195/d3000.2023.483","pdf_url":"https://dentistry3000.pitt.edu/ojs/dentistry3000/article/download/483/181","source":{"id":"https://openalex.org/S2738238600","display_name":"Dentistry 3000","issn_l":"2167-8677","issn":["2167-8677"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320335","host_organization_name":"University Library System, University of Pittsburgh","host_organization_lineage":["https://openalex.org/P4310320335","https://openalex.org/P4310316479"],"host_organization_lineage_names":["University Library System, University of Pittsburgh","University of Pittsburgh"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dentistry 3000","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367173285.pdf","grobid_xml":"https://content.openalex.org/works/W4367173285.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W397040656","https://openalex.org/W2027828105","https://openalex.org/W2096674277","https://openalex.org/W2461924406","https://openalex.org/W3042220057","https://openalex.org/W4281763400","https://openalex.org/W6657654058"],"related_works":["https://openalex.org/W4285739886","https://openalex.org/W2135154217","https://openalex.org/W1992576530","https://openalex.org/W4306694246","https://openalex.org/W2965179587","https://openalex.org/W4394766491","https://openalex.org/W1945246185","https://openalex.org/W4283166712","https://openalex.org/W2074864789","https://openalex.org/W2138418406"],"abstract_inverted_index":{"BACKGROUND:":[0],"Both":[1],"benign":[2],"and":[3,6,61,74,101,127,150,159],"harmful":[4],"head":[5],"neck":[7],"disorders":[8],"have":[9,19],"been":[10],"associated":[11],"with":[12,44,72,76,118,123,129],"the":[13,33,49,57,89,151,181],"Epstein-Barr":[14,52],"virus":[15],"(EBV).":[16],"Many":[17],"studies":[18],"connected":[20],"EBV":[21,60,110,169],"to":[22],"oral":[23,79,177],"squamous":[24,29],"cell":[25,30],"carcinoma":[26,31],"(OSCC).":[27],"Oral":[28],"is":[32,185],"most":[34],"prevalent":[35],"type":[36],"of":[37,51,59,91,168],"cancer.":[38],"Fresh":[39],"tissue":[40],"samples":[41],"from":[42],"patients":[43,100,158],"OSCC":[45,65,73,144,171,191],"were":[46,81,96,134],"tested":[47],"for":[48,88],"presence":[50],"virus.":[53],"OBJECTIVE:":[54],"To":[55],"determine":[56],"frequency":[58],"IL10":[62],"expression":[63,139],"in":[64,99,113,143,153,170,176,190],"patients.":[66],"MATERIALS":[67],"AND":[68],"METHODS:":[69],"Fifty":[70],"individuals":[71],"25":[75],"clinically":[77],"healthy":[78,115,148],"mucosa":[80],"studied.":[82],"In":[83],"situ":[84],"hybridization":[85],"was":[86,111,140,161],"used":[87],"detection":[90],"EBV.":[92],"Serum":[93],"IL-10":[94,106,138,155,184],"levels":[95,156,189],"also":[97],"evaluated":[98],"controls":[102,160],"using":[103],"a":[104],"human":[105],"ELISA":[107],"Kit.":[108],"RESULTS:":[109],"detected":[112],"4":[114],"patients,":[116],"6":[117],"moderately":[119],"differentiated":[120,125],"OSCC,":[121,126],"10":[122],"poorly":[124],"19":[128],"undifferentiated":[130],"OSCC.":[131],"These":[132],"differences":[133],"statistically":[135,162],"significant":[136,163],"(p<0.05).":[137],"more":[141],"common":[142],"diagnostic":[145],"groups":[146],"than":[147],"controls,":[149],"difference":[152],"blood":[154],"between":[157],"(p<0.01).":[164],"CONCLUSION:":[165],"The":[166],"prevalence":[167],"suggests":[172],"its":[173],"possible":[174],"role":[175],"cavity":[178],"malignancy.":[179],"On":[180],"other":[182],"hand,":[183],"expressed":[186],"at":[187],"higher":[188],"biopsies;":[192],"such":[193],"elevated":[194],"concentrations":[195],"may":[196],"promote":[197],"viral":[198],"spread.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-04-28T00:00:00"}