{"id":"https://openalex.org/W4367156724","doi":"https://doi.org/10.2139/ssrn.4428758","title":"Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage","display_name":"Single Cell Transcriptomics-Informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4367156724","doi":"https://doi.org/10.2139/ssrn.4428758"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.4428758","doi":"https://doi.org/10.2139/ssrn.4428758","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4428758","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.4428758","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069465755","display_name":"Angela Papalamprou","orcid":"https://orcid.org/0000-0002-0496-2501","observed_orcids":["https://orcid.org/0000-0002-0496-2501"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Papalamprou","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Victoria Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Yu","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011184040","display_name":"Wensen Jiang","orcid":"https://orcid.org/0000-0001-6985-1370","observed_orcids":["https://orcid.org/0000-0001-6985-1370"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wensen Jiang","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086934179","display_name":"Julia Sheyn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Sheyn","raw_affiliation_strings":["Cedars Sinai Medical Center - Department of Neurosurgery","Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars Sinai Medical Center - Department of Neurosurgery","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031639765","display_name":"Tina Stefanovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tina Stefanovic","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Angel Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angel Chen","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068292357","display_name":"Chloe M. Castaneda","orcid":"https://orcid.org/0000-0003-1478-6676","observed_orcids":["https://orcid.org/0000-0003-1478-6676"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chloe Castaneda","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061366417","display_name":"Melissa Chavez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Chavez","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081116926","display_name":"Dmitriy Sheyn","orcid":"https://orcid.org/0000-0002-3333-1485","observed_orcids":["https://orcid.org/0000-0002-3333-1485"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dmitriy Sheyn","raw_affiliation_strings":["Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory, Los Angeles, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Cedars-Sinai Medical Center - Orthopaedic Stem Cell Research Laboratory, Los Angeles, CA, United States","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081116926"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tendon-differentiation","display_name":"tendon differentiation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/sclerotome","display_name":"sclerotome","score":0.8149999976158142},{"id":"https://openalex.org/keywords/paraxial-mesoderm","display_name":"paraxial mesoderm","score":0.9200000166893005},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7459999918937683},{"id":"https://openalex.org/keywords/wnt-inhibitors","display_name":"Wnt inhibitors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/small-molecules","display_name":"small molecules","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tendon-tissue-engineering","display_name":"tendon tissue engineering","score":0.7250000238418579},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7715814113616943},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.7242141962051392},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6542314291000366},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.639069139957428},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5373505353927612},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.46929651498794556},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4641757011413574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42173394560813904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.235731303691864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17498889565467834},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09912613034248352}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.4428758","doi":"https://doi.org/10.2139/ssrn.4428758","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4428758","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.4428758","doi":"https://doi.org/10.2139/ssrn.4428758","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4428758","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4220816399","https://openalex.org/W4300707901","https://openalex.org/W3106810456","https://openalex.org/W3136077130","https://openalex.org/W4392767537","https://openalex.org/W4303044672","https://openalex.org/W3009498631","https://openalex.org/W3201092907","https://openalex.org/W6939542405","https://openalex.org/W2888721351"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-28T00:00:00"}
