{"id":"https://openalex.org/W4367152884","doi":"https://doi.org/10.1121/10.0018049","title":"Assessing the effects of ultrasound parameters on P-selectin expression for active targeting of nanotherapeutics","display_name":"Assessing the effects of ultrasound parameters on P-selectin expression for active targeting of nanotherapeutics","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4367152884","doi":"https://doi.org/10.1121/10.0018049"},"language":"en","primary_location":{"id":"doi:10.1121/10.0018049","doi":"https://doi.org/10.1121/10.0018049","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1121/10.0018049","pdf_url":null,"source":{"id":"https://openalex.org/S11296630","display_name":"The Journal of the Acoustical Society of America","issn_l":"0001-4966","issn":["0001-4966","1520-8524","1520-9024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","ccf-b","cwts-core","dongbi-b","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320226","host_organization_name":"Acoustical Society of America","host_organization_lineage":["https://openalex.org/P4310320226"],"host_organization_lineage_names":["Acoustical Society of America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Acoustical Society of America","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037139554","display_name":"Mark T. Burgess","orcid":"https://orcid.org/0000-0002-5312-7473","observed_orcids":["https://orcid.org/0000-0002-5312-7473"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Burgess","raw_affiliation_strings":["Dept. of Medical Phys., Memorial Sloan Kettering Cancer Ctr., 321 E 61st St., New York, NY 10065, burgesm1@mskcc.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Medical Phys., Memorial Sloan Kettering Cancer Ctr., 321 E 61st St., New York, NY 10065, burgesm1@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089413115","display_name":"Daniel E. Tylawsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Tylawsky","raw_affiliation_strings":["Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Ctr., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Ctr., New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048832074","display_name":"Quincey C. LaPlant","orcid":"https://orcid.org/0000-0002-4856-4433","observed_orcids":["https://orcid.org/0000-0002-4856-4433"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quincey LaPlant","raw_affiliation_strings":["Dept. of Radiation Oncology, Memorial Sloan Kettering Cancer Ctr., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Radiation Oncology, Memorial Sloan Kettering Cancer Ctr., New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037355958","display_name":"Daniel A. Heller","orcid":"https://orcid.org/0000-0002-6866-0000","observed_orcids":["https://orcid.org/0000-0002-6866-0000"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Heller","raw_affiliation_strings":["Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Ctr., New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Ctr., New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037139554"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"153","issue":"3_supplement","first_page":"A32","last_page":"A32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ultrasound","display_name":"ultrasound","score":0.6639999747276306},{"id":"https://openalex.org/keywords/active-targeting","display_name":"active targeting","score":0.7129999995231628},{"id":"https://openalex.org/keywords/nanotherapeutics","display_name":"nanotherapeutics","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.3970000147819519},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7379999756813049},{"id":"https://openalex.org/keywords/pulsed-ultrasound","display_name":"pulsed ultrasound","score":0.7110000252723694},{"id":"https://openalex.org/keywords/duty-cycle","display_name":"duty cycle","score":0.9319999814033508},{"id":"https://openalex.org/keywords/transcytosis","display_name":"transcytosis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vascular-barrier","display_name":"vascular barrier","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.7045031189918518},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.6458666920661926},{"id":"https://openalex.org/C199822604","wikidata":"https://www.wikidata.org/wiki/Q557120","display_name":"Duty cycle","level":3,"score":0.5757948756217957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5046643018722534},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.4389669895172119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43406370282173157},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37605974078178406},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.24148258566856384},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1979401409626007},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08842626214027405},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C163258240","wikidata":"https://www.wikidata.org/wiki/Q25342","display_name":"Power (physics)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1121/10.0018049","doi":"https://doi.org/10.1121/10.0018049","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1121/10.0018049","pdf_url":null,"source":{"id":"https://openalex.org/S11296630","display_name":"The Journal of the Acoustical Society of America","issn_l":"0001-4966","issn":["0001-4966","1520-8524","1520-9024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","ccf-b","cwts-core","dongbi-b","erih-plus","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320226","host_organization_name":"Acoustical Society of America","host_organization_lineage":["https://openalex.org/P4310320226"],"host_organization_lineage_names":["Acoustical Society of America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Acoustical Society of America","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2460304680","https://openalex.org/W2110715086","https://openalex.org/W2577184593","https://openalex.org/W2095430861","https://openalex.org/W2038869880","https://openalex.org/W2115083968","https://openalex.org/W1965861882","https://openalex.org/W2547700627","https://openalex.org/W1982619620","https://openalex.org/W1997543213"],"abstract_inverted_index":{"P-selectin":[0,92],"is":[1,179],"a":[2,48,85,96],"nanotherapeutic":[3,194],"target":[4],"for":[5,129,152,168,175,193],"enhanced":[6],"passage":[7],"of":[8,37,91,149,166],"nanoscale":[9],"drug":[10],"delivery":[11,195],"systems":[12],"across":[13],"the":[14,164],"vascular":[15],"barrier":[16],"and":[17,103,124,131,144,155,174,188],"into":[18],"tumors":[19,24,35,176],"via":[20,107],"transcytosis.":[21],"While":[22],"many":[23],"express":[25],"P-selection,":[26],"radiation":[27,178,192],"can":[28,46],"be":[29],"used":[30,74],"to":[31,42,75,116],"induce":[32],"expression":[33],"in":[34,60,84,196],"devoid":[36],"P-selectin.":[38],"This":[39],"study":[40],"aims":[41],"test":[43],"whether":[44],"ultrasound":[45,83,167,190],"elicit":[47],"similar":[49],"response":[50],"through":[51],"mechanical":[52],"or":[53],"thermal":[54],"bioeffects.":[55],"Preliminary":[56],"experiments":[57],"were":[58],"performed":[59],"vitro":[61],"using":[62,95,171],"brain":[63],"tissue":[64],"derived":[65],"mouse":[66],"endothelial":[67],"cells.":[68],"A":[69],"Vevo":[70],"SoniGene":[71],"system":[72],"was":[73,93,119],"sonicate":[76],"cells":[77,150],"with":[78,139,191],"low-intensity":[79],"(2":[80],"W/cm2)":[81],"pulsed":[82],"12-well":[86],"cell":[87],"culture":[88],"plate.":[89],"Upregulation":[90],"seen":[94],"60":[97],"second":[98],"treatment":[99],"duration":[100],"at":[101],"50%":[102,130,154],"100%":[104,132,156],"duty":[105,133,157],"cycles":[106],"flow":[108],"cytometry":[109],"analysis.":[110],"The":[111],"mean":[112],"fluorescence":[113],"intensity,":[114],"normalized":[115],"nontreated":[117],"cells,":[118],"32":[120],"+":[121,126,141,146],"/-":[122,127,142,147],"17.4":[123],"103":[125],"37.2":[128],"cycles,":[134],"respectively.":[135,160],"Viability":[136],"remained":[137],"high":[138],"72.6":[140],"14.5":[143],"77.5":[145],"8.3%":[148],"viable":[151],"both":[153],"cycle":[158],"groups,":[159],"These":[161],"results":[162],"highlight":[163],"potential":[165],"active":[169],"targeting":[170],"non-ionizing":[172],"energy":[173],"where":[177],"not":[180],"feasible.":[181],"Future":[182],"studies":[183],"will":[184],"identify":[185],"associated":[186],"bioeffects":[187],"compare":[189],"small":[197],"animal":[198],"tumor":[199],"models.":[200]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-28T00:00:00"}