{"id":"https://openalex.org/W4367055949","doi":"https://doi.org/10.18632/aging.204655","title":"lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration","display_name":"lncRNA TUSC7 sponges miR-10a-5p and inhibits BDNF/ERK pathway to suppress glioma cell proliferation and migration","publication_year":2023,"publication_date":"2023-04-14","ids":{"openalex":"https://openalex.org/W4367055949","doi":"https://doi.org/10.18632/aging.204655","pmid":"https://pubmed.ncbi.nlm.nih.gov/37100464","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10188346"},"language":"en","primary_location":{"id":"doi:10.18632/aging.204655","doi":"https://doi.org/10.18632/aging.204655","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.204655","pdf_url":"https://www.aging-us.com/article/204655/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/204655/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042205793","display_name":"Runhui Wang","orcid":"https://orcid.org/0000-0003-0823-5982","observed_orcids":["https://orcid.org/0000-0003-0823-5982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Runhui Wang","raw_affiliation_strings":["Department of Neurosurgery, Huabei Petroleum Administration Bureau General Hospital, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Huabei Petroleum Administration Bureau General Hospital, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jia Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia Wang","raw_affiliation_strings":["Department of Neurosurgery, Huabei Petroleum Administration Bureau General Hospital, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Huabei Petroleum Administration Bureau General Hospital, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017347549","display_name":"Yuanyu Wang","orcid":"https://orcid.org/0000-0001-8462-7211","observed_orcids":["https://orcid.org/0000-0001-8462-7211"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyu Wang","raw_affiliation_strings":["Department of Neurosurgery, The Second Hospital of Hebei Medical University, Renqiu, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Hospital of Hebei Medical University, Renqiu, Hebei, China","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107306704","display_name":"Liang Yang","orcid":"https://orcid.org/0000-0002-7057-649X","observed_orcids":["https://orcid.org/0000-0002-7057-649X"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Yang","raw_affiliation_strings":["Department of Neurosurgery, The Second Hospital of Hebei Medical University, Renqiu, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Second Hospital of Hebei Medical University, Renqiu, Hebei, China","institution_ids":["https://openalex.org/I4210099373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5107306704"],"corresponding_institution_ids":["https://openalex.org/I4210099373"],"apc_list":null,"apc_paid":null,"fwci":1.3949,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.80053069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"15","issue":"8","first_page":"3021","last_page":"3034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mir-10a-5p","display_name":"miR-10a-5p","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.902999997138977},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.921999990940094},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6850000023841858},{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mirna-sponge","display_name":"microRNA sponge","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7313474416732788},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6525616645812988},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6334627270698547},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6129076480865479},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5949992537498474},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5844286680221558},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5337404012680054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4873224198818207},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4433916509151459},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.434928834438324},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39413195848464966},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3888106644153595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22758749127388},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07076752185821533}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.204655","doi":"https://doi.org/10.18632/aging.204655","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.204655","pdf_url":"https://www.aging-us.com/article/204655/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10188346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10188346","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10188346/pdf/aging-15-204655.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:37100464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37100464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/aging.204655","doi":"https://doi.org/10.18632/aging.204655","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.204655","pdf_url":"https://www.aging-us.com/article/204655/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4367055949.pdf","grobid_xml":"https://content.openalex.org/works/W4367055949.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2202001486","https://openalex.org/W2303157624","https://openalex.org/W2308456509","https://openalex.org/W2560385907","https://openalex.org/W2757935580","https://openalex.org/W2793637107","https://openalex.org/W2887853695","https://openalex.org/W2903704624","https://openalex.org/W2927609087","https://openalex.org/W2929044810","https://openalex.org/W2949748204","https://openalex.org/W2967722537","https://openalex.org/W2984694031","https://openalex.org/W2998007316","https://openalex.org/W3005468192","https://openalex.org/W3006001937","https://openalex.org/W3018032433","https://openalex.org/W3089333865","https://openalex.org/W3098477215","https://openalex.org/W3121874482","https://openalex.org/W3186606102","https://openalex.org/W3196417022","https://openalex.org/W3207949416","https://openalex.org/W4210500745"],"related_works":["https://openalex.org/W2793637107","https://openalex.org/W3046660284","https://openalex.org/W3174576447","https://openalex.org/W3028533864","https://openalex.org/W3008568758","https://openalex.org/W4407306817","https://openalex.org/W2991358929","https://openalex.org/W2767259475","https://openalex.org/W1976983152","https://openalex.org/W2626794881"],"abstract_inverted_index":{"Objective:":[0],"Gliomas":[1],"as":[2,180],"primary":[3],"cerebral":[4,49],"malignancies":[5,26],"frequently":[6],"occurring":[7],"in":[8,25,47,81,185],"adults":[9],"have":[10],"relatively":[11],"high":[12],"morbidity":[13],"and":[14,54,70,85,104,117,119,123,149,156,167,173],"mortality.":[15],"The":[16,135],"underlying":[17],"role":[18],"of":[19,98,106,138],"long":[20],"non-coding":[21],"ribonucleic":[22],"acids":[23],"(lncRNAs)":[24],"has":[27],"attracted":[28],"much":[29],"attention,":[30],"among":[31],"which":[32],"tumor":[33,41,182],"suppressor":[34,42,183],"candidate":[35],"7":[36],"(TUSC7)":[37],"is":[38],"a":[39,181],"novel":[40],"gene":[43,93,184],"whose":[44],"regulatory":[45],"mechanism":[46],"human":[48,82,113,163,186],"gliomas":[50],"remains":[51],"inconclusive.":[52],"Methods":[53],"results:":[55],"In":[56],"this":[57],"study,":[58],"bioinformatics":[59],"analysis":[60],"indicated":[61],"that":[62],"TUSC7":[63,89,99,107,139,161],"could":[64],"specifically":[65],"bind":[66,101],"to":[67,72,100,102],"microRNA":[68],"(miR)-10a-5p,":[69],"according":[71],"quantitative":[73],"polymerase":[74],"chain":[75],"reaction":[76],"(q-PCR),":[77],"miR-10a-5p":[78,110,141,147,172],"was":[79,142],"up-regulated":[80],"glioma":[83,114,164],"cells":[84],"negatively":[86,170],"correlated":[87],"with":[88],"expression.":[90],"Dual-luciferase":[91],"reporter":[92],"assay":[94],"showed":[95],"the":[96,127,175],"ability":[97],"miR-10a-5p,":[103],"overexpression":[105,148],"notably":[108],"inhibited":[109],"expression,":[111],"restrained":[112],"cell":[115,121,165],"proliferation":[116,166],"migration,":[118],"regulated":[120],"cycle":[122],"cyclin":[124],"expression":[125],"via":[126],"brain-derived":[128],"neurotrophic":[129],"factor/extracellular":[130],"signal-regulated":[131],"kinase":[132],"(BDNF/ERK)":[133],"pathway.":[134],"inhibitory":[136],"effect":[137],"on":[140],"also":[143],"verified":[144],"by":[145,169],"designing":[146],"knockdown":[150],"panels":[151],"for":[152],"wound":[153],"healing,":[154],"Transwell":[155],"Western":[157],"blotting":[158],"assays.":[159],"Conclusions:":[160],"suppresses":[162],"migration":[168],"modulating":[171],"inhibiting":[174],"BDNF/ERK":[176],"pathway,":[177],"thus":[178],"acting":[179],"gliomas.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-04-27T00:00:00"}