{"id":"https://openalex.org/W4366997754","doi":"https://doi.org/10.1200/jco.22.02734","title":"The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia","display_name":"The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4366997754","doi":"https://doi.org/10.1200/jco.22.02734","pmid":"https://pubmed.ncbi.nlm.nih.gov/37098241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10306434"},"language":"en","primary_location":{"id":"doi:10.1200/jco.22.02734","doi":"https://doi.org/10.1200/jco.22.02734","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.22.02734","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.02734?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.02734?role=tab","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071044021","display_name":"David O\u2019Connor","orcid":"https://orcid.org/0000-0003-3542-5976","observed_orcids":["https://orcid.org/0000-0003-3542-5976"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I2800349819","display_name":"Great Ormond Street Hospital for Children NHS Foundation Trust","ror":"https://ror.org/03zydm450","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David O'Connor","raw_affiliation_strings":["Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom","UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-3542-5976","affiliations":[{"raw_affiliation_string":"Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021604609","display_name":"Jonas Demeulemeester","orcid":"https://orcid.org/0000-0002-2660-2478","observed_orcids":["https://orcid.org/0000-0002-2660-2478"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I4210092815","display_name":"VIB-KU Leuven Center for Cancer Biology","ror":"https://ror.org/00eyng893","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210092815","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE","GB"],"is_corresponding":false,"raw_author_name":"Jonas Demeulemeester","raw_affiliation_strings":["Department of Oncology, Laboratory for Integrative Cancer Genomics, KU Leuven, Leuven, Belgium","The Francis Crick Institute, London, United Kingdom","VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2660-2478","affiliations":[{"raw_affiliation_string":"Department of Oncology, Laboratory for Integrative Cancer Genomics, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium","institution_ids":["https://openalex.org/I4210092815"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033393201","display_name":"Luc\u00eda Conde","orcid":"https://orcid.org/0000-0001-5180-543X","observed_orcids":["https://orcid.org/0000-0001-5180-543X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucia Conde","raw_affiliation_strings":["UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5180-543X","affiliations":[{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018708168","display_name":"Amy A. Kirkwood","orcid":"https://orcid.org/0000-0003-0133-7732","observed_orcids":["https://orcid.org/0000-0003-0133-7732"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amy Kirkwood","raw_affiliation_strings":["CR UK & UCL Cancer Trials Centre, UCL Cancer Institute, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CR UK & UCL Cancer Trials Centre, UCL Cancer Institute, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055997822","display_name":"Kent T.M. Fung","orcid":"https://orcid.org/0000-0002-5797-1268","observed_orcids":["https://orcid.org/0000-0002-5797-1268"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kent Fung","raw_affiliation_strings":["UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-5797-1268","affiliations":[{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019106966","display_name":"Foteini Papaleonidopoulou","orcid":"https://orcid.org/0000-0001-9955-9477","observed_orcids":["https://orcid.org/0000-0001-9955-9477"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Foteini Papaleonidopoulou","raw_affiliation_strings":["The Francis Crick Institute, London, United Kingdom","UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-9955-9477","affiliations":[{"raw_affiliation_string":"The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]},{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038569446","display_name":"Gianna Bloye","orcid":"https://orcid.org/0009-0006-3478-9937","observed_orcids":["https://orcid.org/0009-0006-3478-9937"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gianna Bloye","raw_affiliation_strings":["UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0006-3478-9937","affiliations":[{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nadine Farah","orcid":"https://orcid.org/0000-0002-3945-9981","observed_orcids":["https://orcid.org/0000-0002-3945-9981"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nadine Farah","raw_affiliation_strings":["UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-3945-9981","affiliations":[{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058124703","display_name":"Sunniyat Rahman","orcid":"https://orcid.org/0000-0001-5374-7376","observed_orcids":["https://orcid.org/0000-0001-5374-7376"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Sunniyat Rahman","raw_affiliation_strings":["Peter MacCallum Cancer Centre, Melbourne, VIC, Australia","Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia","UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-5374-7376","affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050141938","display_name":"Jeremy P. Hancock","orcid":"https://orcid.org/0000-0001-5756-4470","observed_orcids":["https://orcid.org/0000-0001-5756-4470"]},"institutions":[{"id":"https://openalex.org/I1307034911","display_name":"North Bristol NHS Trust","ror":"https://ror.org/036x6gt55","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307034911","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeremy Hancock","raw_affiliation_strings":["South West Genomic Laboratory Hub, North Bristol NHS Trust, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South West Genomic Laboratory Hub, North Bristol NHS Trust, Bristol, United Kingdom","institution_ids":["https://openalex.org/I1307034911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011570520","display_name":"Caroline M. Bateman","orcid":"https://orcid.org/0000-0003-2759-8279","observed_orcids":["https://orcid.org/0000-0003-2759-8279"]},"institutions":[{"id":"https://openalex.org/I2802384191","display_name":"Children's Hospital at Westmead","ror":"https://ror.org/05k0s5494","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802384191"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Caroline Bateman","raw_affiliation_strings":["The Children's Hospital at Westmead, Sydney, NSW, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2759-8279","affiliations":[{"raw_affiliation_string":"The Children's Hospital at Westmead, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I2802384191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027812162","display_name":"Sarah Inglott","orcid":"https://orcid.org/0000-0003-3917-4254","observed_orcids":["https://orcid.org/0000-0003-3917-4254"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I2800349819","display_name":"Great Ormond Street Hospital for Children NHS Foundation Trust","ror":"https://ror.org/03zydm450","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Inglott","raw_affiliation_strings":["Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018894028","display_name":"Jon Mee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135017","display_name":"Cancer Research UK Clinical Trials Unit","ror":"https://ror.org/03qxptw71","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210135017","https://openalex.org/I79619799"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon Mee","raw_affiliation_strings":["Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I4210135017","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048365807","display_name":"Javier Herrero","orcid":"https://orcid.org/0000-0001-7313-717X","observed_orcids":["https://orcid.org/0000-0001-7313-717X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Javier Herrero","raw_affiliation_strings":["UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-7313-717X","affiliations":[{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079808888","display_name":"Peter Van Loo","orcid":"https://orcid.org/0000-0003-0292-1949","observed_orcids":["https://orcid.org/0000-0003-0292-1949"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Peter Van Loo","raw_affiliation_strings":["Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX","Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX","The Francis Crick Institute, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The Francis Crick Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032713965","display_name":"Anthony V. Moorman","orcid":"https://orcid.org/0000-0002-9781-6107","observed_orcids":["https://orcid.org/0000-0002-9781-6107"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony V. Moorman","raw_affiliation_strings":["Wolfson Childhood Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9781-6107","affiliations":[{"raw_affiliation_string":"Wolfson Childhood Cancer Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066319509","display_name":"Ajay J Vora","orcid":"https://orcid.org/0000-0002-2167-4368","observed_orcids":["https://orcid.org/0000-0002-2167-4368"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I2800349819","display_name":"Great Ormond Street Hospital for Children NHS Foundation Trust","ror":"https://ror.org/03zydm450","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ajay Vora","raw_affiliation_strings":["Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2167-4368","affiliations":[{"raw_affiliation_string":"Department of Haematology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074584714","display_name":"Marc R. Mansour","orcid":"https://orcid.org/0000-0001-6835-3791","observed_orcids":["https://orcid.org/0000-0001-6835-3791","https://orcid.org/0000-0002-7449-845X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc R. Mansour","raw_affiliation_strings":["Department of Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","UCL Cancer Institute, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer, UCL Great Ormond Street Institute of Child Health, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL Cancer Institute, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5071044021"],"corresponding_institution_ids":["https://openalex.org/I2800129641","https://openalex.org/I2800349819","https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":6.5243,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.97603834,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"41","issue":"19","first_page":"3545","last_page":"3556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/failed-induction","display_name":"induction failure","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6190000176429749},{"id":"https://openalex.org/keywords/young-adult-leukemia","display_name":"young adult leukemia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/noncoding-mutations","display_name":"non-coding mutations","score":0.5979999899864197},{"id":"https://openalex.org/keywords/myc-mutations","display_name":"MYC mutations","score":0.796999990940094},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.9649999737739563},{"id":"https://openalex.org/keywords/molecular-residual-disease","display_name":"molecular residual disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6119999885559082},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6909999847412109},{"id":"https://openalex.org/keywords/multi-omics-profiling","display_name":"multi-omics profiling","score":0.6399999856948853},{"id":"https://openalex.org/keywords/nelarabine","display_name":"nelarabine","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8856139183044434},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.6445522308349609},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5813769102096558},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5575279593467712},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.516258716583252},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5088215470314026},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.47161582112312317},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4283450245857239},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.414335697889328},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4091244339942932}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015452","descriptor_name":"Precursor B-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1200/jco.22.02734","doi":"https://doi.org/10.1200/jco.22.02734","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.22.02734","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.02734?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10306434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10306434","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10306434/pdf/jco-41-3545.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Oncol","raw_type":"Text"},{"id":"pmid:37098241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37098241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10169031","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10169031/","pdf_url":"https://discovery.ucl.ac.uk/id/eprint/10169031/1/jco.22.02734.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Oncology (2023)","raw_type":"Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/718932","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/718932","pdf_url":"https://lirias.kuleuven.be/retrieve/d9d34596-f901-43a4-9c18-f57047271ea0","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Of Clinical Oncology, vol. 41 (19), (3545-+)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-3181","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/2234","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"},{"id":"pmh:oai:figshare.com:article/23599407","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/The_clinicogenomic_landscape_of_induction_failure_in_childhood_and_young_adult_T-cell_acute_lymphoblastic_leukemia_/23599407","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/2be1ebee-8b0c-4bde-9b62-48767e742364","doi":null,"is_oa":true,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/2be1ebee-8b0c-4bde-9b62-48767e742364","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"O'Connor, D, Demeulemeester, J, Conde, L, Kirkwood, A, Fung, K, Papaleonidopoulou, F, Bloye, G, Farah, N, Rahman, S, Hancock, J, Bateman, C, Inglott, S, Mee, J, Herrero, J, Van Loo, P, Moorman, A V, Vora, A & Mansour, M R 2023, 'The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia', Journal of Clinical Oncology , vol. 41, no. 19, pp. 3545-3556. https://doi.org/10.1200/JCO.22.02734","raw_type":"article"},{"id":"doi:10.25418/crick.23599407","doi":"https://doi.org/10.25418/crick.23599407","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.23599407","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.25418/crick.23599407.v1","doi":"https://doi.org/10.25418/crick.23599407.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25418/crick.23599407.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407051354","display_name":"The Francis Crick Institute","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801081054","host_organization_name":"The Francis Crick Institute","host_organization_lineage":["https://openalex.org/I2801081054"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1200/jco.22.02734","doi":"https://doi.org/10.1200/jco.22.02734","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.22.02734","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.22.02734?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1185244848","display_name":null,"funder_award_id":"A27177","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G154923120","display_name":null,"funder_award_id":"FC001202","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2783693332","display_name":null,"funder_award_id":"CC2008","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G2795642262","display_name":null,"funder_award_id":"CRCPSC-Dec21\\100002","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2800982045","display_name":null,"funder_award_id":"12026","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G3088576796","display_name":null,"funder_award_id":"C416/A25145","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3377121215","display_name":null,"funder_award_id":"27177","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G3861469773","display_name":null,"funder_award_id":"2019/JGF/004","funder_id":"https://openalex.org/F4320316047","funder_display_name":"Leukaemia UK"},{"id":"https://openalex.org/G3916581401","display_name":null,"funder_award_id":"06082","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G4364247713","display_name":null,"funder_award_id":"DRCPFA-May21\\100012","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G561487881","display_name":null,"funder_award_id":"25354","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G5767515329","display_name":null,"funder_award_id":"10060","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G6447805529","display_name":null,"funder_award_id":"04076","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"},{"id":"https://openalex.org/G675373460","display_name":null,"funder_award_id":"15014","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320316047","display_name":"Leukaemia UK","ror":"https://ror.org/00xsz4758"},{"id":"https://openalex.org/F4320317235","display_name":"BeiGene","ror":"https://ror.org/012v2c923"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320319994","display_name":"Department of Health and Social Care","ror":"https://ror.org/03sbpja79"},{"id":"https://openalex.org/F4320320215","display_name":"Leukaemia and Lymphoma Research","ror":"https://ror.org/0055acf80"},{"id":"https://openalex.org/F4320320637","display_name":"Great Ormond Street Hospital Charity","ror":"https://ror.org/03vjq7x94"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366997754.pdf","grobid_xml":"https://content.openalex.org/works/W4366997754.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1525573602","https://openalex.org/W1801876107","https://openalex.org/W1970262650","https://openalex.org/W1976171159","https://openalex.org/W1976767488","https://openalex.org/W1994791278","https://openalex.org/W2002885700","https://openalex.org/W2009907103","https://openalex.org/W2028878627","https://openalex.org/W2082414039","https://openalex.org/W2104722860","https://openalex.org/W2113030986","https://openalex.org/W2143625061","https://openalex.org/W2147221248","https://openalex.org/W2148202982","https://openalex.org/W2163926478","https://openalex.org/W2166306614","https://openalex.org/W2280037895","https://openalex.org/W2419140434","https://openalex.org/W2419639370","https://openalex.org/W2500269539","https://openalex.org/W2577230177","https://openalex.org/W2606551921","https://openalex.org/W2733265822","https://openalex.org/W2787301955","https://openalex.org/W2789924919","https://openalex.org/W2795342601","https://openalex.org/W2887443702","https://openalex.org/W2909547032","https://openalex.org/W2918708984","https://openalex.org/W2986992501","https://openalex.org/W2990689630","https://openalex.org/W3063038225","https://openalex.org/W3124870698","https://openalex.org/W3135688349","https://openalex.org/W3185250096","https://openalex.org/W3209041953","https://openalex.org/W3215621251","https://openalex.org/W4200432640","https://openalex.org/W4310096200"],"related_works":["https://openalex.org/W4310102722","https://openalex.org/W2548701588","https://openalex.org/W7095691482","https://openalex.org/W2005156143","https://openalex.org/W2575579398","https://openalex.org/W2113030986","https://openalex.org/W4385220537","https://openalex.org/W2002885700","https://openalex.org/W2053908817","https://openalex.org/W4405041144"],"abstract_inverted_index":{"PURPOSE":[0],"Failure":[1],"to":[2,4,30,70,81,168,226,240],"respond":[3],"induction":[5,50],"chemotherapy":[6,133],"portends":[7],"a":[8,44,154,176,191,200,218,269],"poor":[9,262],"outcome":[10,42,157,202,256],"in":[11,21,43,89,101,117,121,139,145,153,211,259],"childhood":[12],"acute":[13],"lymphoblastic":[14],"leukemia":[15],"(ALL)":[16],"and":[17,37,68,75,93,108,119,214,245],"is":[18],"more":[19],"frequent":[20],"T-cell":[22],"ALL":[23],"(T-ALL)":[24],"than":[25],"B-cell":[26],"ALL.":[27],"We":[28,54,77],"aimed":[29],"address":[31],"the":[32,83,212],"limited":[33],"understanding":[34],"of":[35,46,58,91,103,131,194,257,268],"clinical":[36],"genetic":[38,219,271],"factors":[39],"that":[40,221],"influence":[41],"cohort":[45],"patients":[47,104,123,223],"with":[48,97,179,199,209,263],"T-ALL":[49,59,260],"failure":[51],"(IF).":[52],"METHODS":[53],"studied":[55],"all":[56],"cases":[57,92],"IF":[60,87,118,258],"on":[61,185],"two":[62],"consecutive":[63],"multinational":[64],"randomized":[65],"trials,":[66],"UKALL2003":[67],"UKALL2011,":[69,140],"define":[71],"risk":[72],"factors,":[73],"treatment,":[74],"outcomes.":[76],"performed":[78],"multiomic":[79],"profiling":[80,174],"characterize":[82],"genomic":[84],"landscape.":[85],"RESULTS":[86],"occurred":[88],"10.3%":[90],"was":[94,142,190],"significantly":[95,155],"associated":[96,198],"increasing":[98],"age,":[99],"occurring":[100],"20%":[102],"age":[105],"16":[106],"years":[107],"older.":[109],"Five-year":[110],"overall":[111],"survival":[112],"(OS)":[113],"rates":[114],"were":[115],"52.1%":[116],"90.2%":[120],"responsive":[122],"(":[124],"P":[125,170,242],"<":[126,243],".001).":[127],"Despite":[128],"increased":[129],"use":[130],"nelarabine-based":[132],"consolidated":[134],"by":[135],"hematopoietic":[136],"stem-cell":[137],"transplant":[138],"there":[141],"no":[143],"improvement":[144],"outcome.":[146],"Persistent":[147],"end-of-consolidation":[148],"molecular":[149],"residual":[150],"disease":[151],"resulted":[152],"worse":[156],"(5-year":[158,203,230],"OS,":[159,204,231],"14.3%":[160],"v":[161,233],"68.5%;":[162],"HR,":[163,235],"4.10;":[164],"95%":[165,237],"CI,":[166,238],"1.35":[167],"12.45;":[169],"=":[171],".0071).":[172],"Genomic":[173],"revealed":[175],"heterogeneous":[177],"picture":[178],"25":[180],"different":[181],"initiating":[182],"lesions":[183,208],"converging":[184],"10":[186],"subtype-defining":[187],"genes.":[188],"There":[189],"remarkable":[192],"abundance":[193],"TAL1":[195,207],"noncoding":[196],"lesions,":[197],"dismal":[201],"12.5%).":[205],"Combining":[206],"mutations":[210],"MYC":[213],"RAS":[215],"pathways":[216],"produces":[217],"stratifier":[220],"identifies":[222],"highly":[224],"likely":[225],"fail":[227],"conventional":[228],"therapy":[229],"23.1%":[232],"86.4%;":[234],"6.84;":[236],"2.78":[239],"16.78;":[241],".0001)":[244],"who":[246],"should":[247],"therefore":[248],"be":[249],"considered":[250],"for":[251],"experimental":[252],"agents.":[253],"CONCLUSION":[254],"The":[255,266],"remains":[261],"current":[264],"therapy.":[265],"lack":[267],"unifying":[270],"driver":[272],"suggests":[273],"alternative":[274],"approaches,":[275],"particularly":[276],"using":[277],"immunotherapy,":[278],"are":[279],"urgently":[280],"needed.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-27T00:00:00"}
