{"id":"https://openalex.org/W4366996748","doi":"https://doi.org/10.1210/clinem/dgad223","title":"Effects of Burosumab Treatment on Mineral Metabolism in Children and Adolescents With X-linked Hypophosphatemia","display_name":"Effects of Burosumab Treatment on Mineral Metabolism in Children and Adolescents With X-linked Hypophosphatemia","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4366996748","doi":"https://doi.org/10.1210/clinem/dgad223","pmid":"https://pubmed.ncbi.nlm.nih.gov/37097907"},"language":"en","primary_location":{"id":"doi:10.1210/clinem/dgad223","doi":"https://doi.org/10.1210/clinem/dgad223","is_oa":true,"landing_page_url":"https://doi.org/10.1210/clinem/dgad223","pdf_url":"https://academic.oup.com/jcem/article-pdf/108/10/e998/51533313/dgad223.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jcem/article-pdf/108/10/e998/51533313/dgad223.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076253700","display_name":"Annika Ewert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annika Ewert","raw_affiliation_strings":["Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050789439","display_name":"Mirko Rehberg","orcid":"https://orcid.org/0000-0001-9534-4102","observed_orcids":["https://orcid.org/0000-0001-9534-4102"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirko Rehberg","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne 50937 , Germany"],"raw_orcid":"https://orcid.org/0000-0001-9534-4102","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne 50937 , Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013194806","display_name":"Karl P. Schlingmann","orcid":"https://orcid.org/0000-0002-7245-6301","observed_orcids":["https://orcid.org/0000-0002-7245-6301"]},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Peter Schlingmann","raw_affiliation_strings":["Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital , M\u00fcnster 48149 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Pediatrics, Pediatric Nephrology, University Children's Hospital , M\u00fcnster 48149 , Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018333266","display_name":"Olaf Hiort","orcid":"https://orcid.org/0000-0001-7490-4983","observed_orcids":["https://orcid.org/0000-0001-7490-4983"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Hiort","raw_affiliation_strings":["Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of L\u00fcbeck , L\u00fcbeck 23562 , Germany"],"raw_orcid":"https://orcid.org/0000-0001-7490-4983","affiliations":[{"raw_affiliation_string":"Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of L\u00fcbeck , L\u00fcbeck 23562 , Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028902419","display_name":"Ulrike John-Kroegel","orcid":"https://orcid.org/0009-0007-3575-7256","observed_orcids":["https://orcid.org/0009-0007-3575-7256"]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike John-Kroegel","raw_affiliation_strings":["University Children's Hospital , Jena 07743 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital , Jena 07743 , Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032366805","display_name":"Oliver Metzing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Metzing","raw_affiliation_strings":["University Children's Hospital , Jena 07743 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital , Jena 07743 , Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067214322","display_name":"Elke W\u00fchl","orcid":"https://orcid.org/0000-0002-1205-2620","observed_orcids":["https://orcid.org/0000-0002-1205-2620"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elke W\u00fchl","raw_affiliation_strings":["Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg , Heidelberg 69120 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg , Heidelberg 69120 , Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038547566","display_name":"Franz S. Schaefer","orcid":"https://orcid.org/0000-0001-7564-9937","observed_orcids":["https://orcid.org/0000-0001-7564-9937"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz Schaefer","raw_affiliation_strings":["Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg , Heidelberg 69120 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Nephrology, Center for Pediatric and Adolescent Medicine, University Hospital Heidelberg , Heidelberg 69120 , Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110194722","display_name":"Markus Josef Kemper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160608","display_name":"Asklepios","ror":"https://ror.org/055tk9p53","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210160608"]},{"id":"https://openalex.org/I4210162578","display_name":"Asklepios Kliniken Hamburg","ror":"https://ror.org/05f8ejd38","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus J Kemper","raw_affiliation_strings":["Asklepios Children's Hospital Hamburg-Heidberg , Hamburg-Heidberg 22417 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asklepios Children's Hospital Hamburg-Heidberg , Hamburg-Heidberg 22417 , Germany","institution_ids":["https://openalex.org/I4210160608","https://openalex.org/I4210162578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049227835","display_name":"Ute Derichs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ute Derichs","raw_affiliation_strings":["University Children's Hospital , Mainz 55131 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital , Mainz 55131 , Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049322494","display_name":"Annette Richter-Unruh","orcid":"https://orcid.org/0009-0003-9616-6178","observed_orcids":["https://orcid.org/0009-0003-9616-6178","https://orcid.org/0000-0001-6564-5027"]},"institutions":[{"id":"https://openalex.org/I2799784675","display_name":"University Hospitals of the Ruhr-University of Bochum","ror":"https://ror.org/03zcpvf19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annette Richter-Unruh","raw_affiliation_strings":["University Children's Hospital Bochum , Bochum 44892 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital Bochum , Bochum 44892 , Germany","institution_ids":["https://openalex.org/I2799784675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113094431","display_name":"Ludwig Patzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104303","display_name":"Krankenhaus St. Elisabeth und St. Barbara","ror":"https://ror.org/01ah9ym33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210104303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ludwig Patzer","raw_affiliation_strings":["St. Elisabeth and St. Barbara Children's Hospital , Halle/Saale 06110 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Elisabeth and St. Barbara Children's Hospital , Halle/Saale 06110 , Germany","institution_ids":["https://openalex.org/I4210104303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024664970","display_name":"Norbert Albers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert Albers","raw_affiliation_strings":["Christliches Kinderhospital Osnabr\u00fcck , Osnabr\u00fcck 49074 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christliches Kinderhospital Osnabr\u00fcck , Osnabr\u00fcck 49074 , Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113619184","display_name":"D\u00e9sir\u00e9e Dunstheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802007660","display_name":"University Hospital Augsburg","ror":"https://ror.org/03b0k9c14","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802007660"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Desiree Dunstheimer","raw_affiliation_strings":["University Children's Hospital Augsburg , Augsburg 86156 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital Augsburg , Augsburg 86156 , Germany","institution_ids":["https://openalex.org/I2802007660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016774355","display_name":"Holger Haberland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090017","display_name":"Sana Klinikum Lichtenberg","ror":"https://ror.org/0071tdq26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090017"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Haberland","raw_affiliation_strings":["Children's Hospital, Sana Klinikum Lichtenberg , Berlin Lichtenberg 10365 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Sana Klinikum Lichtenberg , Berlin Lichtenberg 10365 , Germany","institution_ids":["https://openalex.org/I4210090017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007470307","display_name":"Sabine Heger","orcid":"https://orcid.org/0000-0002-3501-4053","observed_orcids":["https://orcid.org/0000-0002-3501-4053"]},"institutions":[{"id":"https://openalex.org/I4210086003","display_name":"Kinderkrankenhaus auf der Bult","ror":"https://ror.org/00b06cz11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210086003"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Heger","raw_affiliation_strings":["Kinderkrankenhaus auf der Bult , Hannover 30173 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinderkrankenhaus auf der Bult , Hannover 30173 , Germany","institution_ids":["https://openalex.org/I4210086003"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Carmen Schr\u00f6der","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799318839","display_name":"Universit\u00e4tsmedizin Greifswald","ror":"https://ror.org/025vngs54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799318839"]},{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carmen Schr\u00f6der","raw_affiliation_strings":["University Children's Hospital Greifswald , Greifswald 17475 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital Greifswald , Greifswald 17475 , Germany","institution_ids":["https://openalex.org/I2799318839","https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013926334","display_name":"Norbert Jorch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104779","display_name":"Evangelisches Krankenhaus Bielefeld","ror":"https://ror.org/0162saw54","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210104779"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norbert Jorch","raw_affiliation_strings":["University Children's Hospital, Evangelisches Klinikum Bethel , Bielefeld 33617 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital, Evangelisches Klinikum Bethel , Bielefeld 33617 , Germany","institution_ids":["https://openalex.org/I4210104779"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elmar Schmid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elmar Schmid","raw_affiliation_strings":["Clinic for Pediatric Nephrology Hirschaid , Hirschaid 96114 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Pediatric Nephrology Hirschaid , Hirschaid 96114 , Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109471286","display_name":"Hagen Staude","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136182","display_name":"Universit\u00e4tsmedizin Rostock","ror":"https://ror.org/04dm1cm79","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210136182"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hagen Staude","raw_affiliation_strings":["University Children's Hospital Rostock , Rostock 18057 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Children's Hospital Rostock , Rostock 18057 , Germany","institution_ids":["https://openalex.org/I4210136182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037273436","display_name":"Marcus Weitz","orcid":"https://orcid.org/0000-0002-1696-5646","observed_orcids":["https://orcid.org/0000-0002-1696-5646"]},"institutions":[{"id":"https://openalex.org/I4210125796","display_name":"University Children's Hospital T\u00fcbingen","ror":"https://ror.org/03esvmb28","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118","https://openalex.org/I4210125796"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Weitz","raw_affiliation_strings":["Department of General Pediatrics and Hematology/Oncology, University Children's Hospital, University Hospital T\u00fcbingen , T\u00fcbingen 72076 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Pediatrics and Hematology/Oncology, University Children's Hospital, University Hospital T\u00fcbingen , T\u00fcbingen 72076 , Germany","institution_ids":["https://openalex.org/I4210125796"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065589173","display_name":"Clemens Freiberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clemens Freiberg","raw_affiliation_strings":["Department of Pediatrics and Adolescent Medicine, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37075 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Adolescent Medicine, University Medical Center G\u00f6ttingen , G\u00f6ttingen 37075 , Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039341230","display_name":"Maren Leifheit\u2010Nestler","orcid":"https://orcid.org/0000-0002-9203-7622","observed_orcids":["https://orcid.org/0000-0002-9203-7622"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maren Leifheit-Nestler","raw_affiliation_strings":["Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany"],"raw_orcid":"https://orcid.org/0000-0002-9203-7622","affiliations":[{"raw_affiliation_string":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070941082","display_name":"Miroslav \u017divi\u010dnjak","orcid":"https://orcid.org/0000-0001-9302-712X","observed_orcids":["https://orcid.org/0000-0001-9302-712X"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miroslav Zivicnjak","raw_affiliation_strings":["Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051258274","display_name":"Dirk Schnabel","orcid":"https://orcid.org/0000-0002-7944-7790","observed_orcids":["https://orcid.org/0000-0002-7944-7790"]},"institutions":[{"id":"https://openalex.org/I4392738228","display_name":"Stiftung Charit\u00e9","ror":"https://ror.org/016rf0n60","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Schnabel","raw_affiliation_strings":["Center for Chronically Sick Children, Pediatric Endocrinology, University Medicine , Charit\u00e9, Berlin 13353 , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Chronically Sick Children, Pediatric Endocrinology, University Medicine , Charit\u00e9, Berlin 13353 , Germany","institution_ids":["https://openalex.org/I4392738228","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048758841","display_name":"Dieter Haffner","orcid":"https://orcid.org/0000-0002-9601-7813","observed_orcids":["https://orcid.org/0000-0002-9601-7813"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dieter Haffner","raw_affiliation_strings":["Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany"],"raw_orcid":"https://orcid.org/0000-0002-9601-7813","affiliations":[{"raw_affiliation_string":"Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School , Hannover 30625 , Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":22,"corresponding_author_ids":["https://openalex.org/A5048758841"],"corresponding_institution_ids":["https://openalex.org/I34809795"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":4.977,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.96044149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"108","issue":"10","first_page":"e998","last_page":"e1006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burosumab","display_name":"burosumab","score":0.996999979019165},{"id":"https://openalex.org/keywords/x-linked-hypophosphatemia","display_name":"X-linked hypophosphatemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mineral-metabolism","display_name":"mineral metabolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/serum-phosphorus","display_name":"serum phosphorus","score":0.781000018119812},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/renal-phosphate-reabsorption","display_name":"renal phosphate reabsorption","score":0.8980000019073486},{"id":"https://openalex.org/keywords/rickets","display_name":"rickets","score":0.7440000176429749},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.7009999752044678},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.9010000228881836},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.625},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hypophosphatemia","display_name":"hypophosphatemia","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.938366174697876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6830054521560669},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6510869264602661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6389659643173218},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.6316595077514648},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5852741003036499},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.501702070236206},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4941861927509308},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40415143966674805},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3490240275859833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15257200598716736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10167840123176575},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07927286624908447}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008903","descriptor_name":"Minerals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017674","descriptor_name":"Hypophosphatemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/clinem/dgad223","doi":"https://doi.org/10.1210/clinem/dgad223","is_oa":true,"landing_page_url":"https://doi.org/10.1210/clinem/dgad223","pdf_url":"https://academic.oup.com/jcem/article-pdf/108/10/e998/51533313/dgad223.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:37097907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37097907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:uni-augsburg.opus-bayern.de:105734","doi":null,"is_oa":false,"landing_page_url":"https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/105734","pdf_url":null,"source":{"id":"https://openalex.org/S4306400930","display_name":"OPUS (Augsburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119916105","host_organization_name":"Augsburg University","host_organization_lineage":["https://openalex.org/I119916105"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1210/clinem/dgad223","doi":"https://doi.org/10.1210/clinem/dgad223","is_oa":true,"landing_page_url":"https://doi.org/10.1210/clinem/dgad223","pdf_url":"https://academic.oup.com/jcem/article-pdf/108/10/e998/51533313/dgad223.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366996748.pdf","grobid_xml":"https://content.openalex.org/works/W4366996748.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1920531402","https://openalex.org/W1985742682","https://openalex.org/W1986974712","https://openalex.org/W2006255463","https://openalex.org/W2041004558","https://openalex.org/W2047329464","https://openalex.org/W2050358233","https://openalex.org/W2053045761","https://openalex.org/W2059373374","https://openalex.org/W2134229251","https://openalex.org/W2140330355","https://openalex.org/W2148823426","https://openalex.org/W2398277031","https://openalex.org/W2607424800","https://openalex.org/W2626135802","https://openalex.org/W2758093717","https://openalex.org/W2762592213","https://openalex.org/W2787289798","https://openalex.org/W2803769911","https://openalex.org/W2895834598","https://openalex.org/W2909832575","https://openalex.org/W2912982118","https://openalex.org/W2920227719","https://openalex.org/W2936631172","https://openalex.org/W2943902317","https://openalex.org/W2946559089","https://openalex.org/W2954728922","https://openalex.org/W2996727365","https://openalex.org/W3006582946","https://openalex.org/W3007637288","https://openalex.org/W3049760005","https://openalex.org/W3108090184","https://openalex.org/W3112831852","https://openalex.org/W3137143935","https://openalex.org/W3148508890","https://openalex.org/W3164672781","https://openalex.org/W3190700859","https://openalex.org/W3205791899","https://openalex.org/W3217366348","https://openalex.org/W4200439366","https://openalex.org/W4214730314","https://openalex.org/W4221052332","https://openalex.org/W4229439314"],"related_works":["https://openalex.org/W4318499766","https://openalex.org/W3006582946","https://openalex.org/W4400146384","https://openalex.org/W4229439314","https://openalex.org/W4376141336","https://openalex.org/W4386725631","https://openalex.org/W4390570601","https://openalex.org/W4210994860","https://openalex.org/W6941300399","https://openalex.org/W2943973295"],"abstract_inverted_index":{"CONTEXT:":[0],"Burosumab":[1,141],"has":[2],"been":[3],"approved":[4],"for":[5,20,77,256],"the":[6,30,182],"treatment":[7,37,142,226],"of":[8,32,35,63,87,122,139,192,224,244,250,259],"children":[9,42,153,209],"and":[10,18,46,83,109,133,150,154,158,177,190,236],"adults":[11],"with":[12,51,66,130,156,198,208],"X-linked":[13],"hypophosphatemia":[14,102,241],"(XLH).":[15],"Real-world":[16],"data":[17],"evidence":[19],"its":[21],"efficacy":[22],"in":[23,41,137,144,147,152,162,186,194,205,230,234,242,261],"adolescents":[24,47,155,206,235],"are":[25],"lacking.":[26],"OBJECTIVE:":[27],"To":[28],"assess":[29],"effects":[31],"12":[33,95,172,222],"months":[34,223],"burosumab":[36,203,225,270],"on":[38],"mineral":[39],"metabolism":[40],"(aged":[43,48],"<12":[44],"years)":[45,50],"12-18":[49],"XLH.":[52],"DESIGN:":[53],"Prospective":[54],"national":[55],"registry.":[56],"SETTING:":[57],"Hospital":[58],"clinics.":[59],"PATIENTS:":[60],"A":[61],"total":[62],"93":[64],"patients":[65,100,193],"XLH":[67,157],"(65":[68],"children,":[69,237],"28":[70],"adolescents).":[71],"MAIN":[72],"OUTCOME":[73],"MEASURES:":[74],"Z":[75],"scores":[76],"serum":[78,148,163,174,232,251],"phosphate,":[79,175],"alkaline":[80],"phosphatase":[81],"(ALP),":[82],"renal":[84],"tubular":[85],"reabsorption":[86],"phosphate":[88,132,149,252],"per":[89],"glomerular":[90],"filtration":[91],"rate":[92],"(TmP/GFR)":[93],"at":[94],"months.":[96],"RESULTS:":[97],"At":[98,171],"baseline,":[99],"showed":[101],"(-4.4":[103],"SD),":[104,108],"reduced":[105],"TmP/GFR":[106,151],"(-6.5":[107],"elevated":[110],"ALP":[111,164,178,233],"(2.7":[112],"SD,":[113],"each":[114],"P":[115,166,214],"<":[116,167,215],".001":[117,168],"vs":[118,169,211],"healthy":[119],"children)":[120],"irrespective":[121],"age,":[123],"suggesting":[124,246],"active":[125,134],"rickets":[126,260],"despite":[127,238],"prior":[128],"therapy":[129],"oral":[131],"vitamin":[135],"D":[136],"88%":[138],"patients.":[140,263],"resulted":[143],"comparable":[145],"increases":[146],"a":[159,199],"steady":[160],"decline":[161],"(each":[165],"baseline).":[170],"months,":[173],"TmP/GFR,":[176],"levels":[179],"were":[180],"within":[181],"age-related":[183],"normal":[184],"range":[185],"approximately":[187],"42%,":[188],"27%,":[189],"80%":[191],"both":[195],"groups,":[196],"respectively,":[197],"lower,":[200],"weight-based":[201,269],"final":[202],"dose":[204],"compared":[207],"(0.72":[210],"1.06":[212],"mg/kg,":[213],".01).":[216],"CONCLUSIONS:":[217],"In":[218],"this":[219],"real-world":[220],"setting,":[221],"was":[227],"equally":[228],"effective":[229],"normalizing":[231],"persistent":[239],"mild":[240],"one-half":[243],"patients,":[245],"that":[247],"complete":[248],"normalization":[249],"is":[253],"not":[254],"mandatory":[255],"substantial":[257],"improvement":[258],"these":[262],"Adolescents":[264],"appear":[265],"to":[266],"require":[267],"lower":[268],"dosage":[271],"than":[272],"children.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-04-27T00:00:00"}