{"id":"https://openalex.org/W4366992864","doi":"https://doi.org/10.1530/edm-22-0412","title":"Autoimmune hypothyroidism and trastuzumab therapy: a rare association","display_name":"Autoimmune hypothyroidism and trastuzumab therapy: a rare association","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4366992864","doi":"https://doi.org/10.1530/edm-22-0412","pmid":"https://pubmed.ncbi.nlm.nih.gov/37096975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10241240"},"language":"en","primary_location":{"id":"doi:10.1530/edm-22-0412","doi":"https://doi.org/10.1530/edm-22-0412","is_oa":true,"landing_page_url":"https://doi.org/10.1530/edm-22-0412","pdf_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2023/2/EDM22-0412.pdf","source":{"id":"https://openalex.org/S2738451715","display_name":"Endocrinology Diabetes and Metabolism Case Reports","issn_l":"2052-0573","issn":["2052-0573"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2023/2/EDM22-0412.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027099688","display_name":"Valentim Lopes","orcid":"https://orcid.org/0000-0003-2835-7709","observed_orcids":["https://orcid.org/0000-0003-2835-7709"]},"institutions":[{"id":"https://openalex.org/I4210137968","display_name":"Hospital Braga","ror":"https://ror.org/04jjy0g33","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210137968"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Valentim Lopes","raw_affiliation_strings":["Hospital de Braga, EPE, Portugal","Hospital de Braga, EPE, Portugal and"],"raw_orcid":"https://orcid.org/0000-0003-2835-7709","affiliations":[{"raw_affiliation_string":"Hospital de Braga, EPE, Portugal","institution_ids":["https://openalex.org/I4210137968"]},{"raw_affiliation_string":"Hospital de Braga, EPE, Portugal and","institution_ids":["https://openalex.org/I4210137968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021420662","display_name":"Catarina Martins Machado","orcid":"https://orcid.org/0000-0003-3098-1789","observed_orcids":["https://orcid.org/0000-0003-3098-1789"]},"institutions":[{"id":"https://openalex.org/I4210137968","display_name":"Hospital Braga","ror":"https://ror.org/04jjy0g33","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210137968"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Machado","raw_affiliation_strings":["Hospital de Braga, EPE, Portugal","Hospital de Braga, EPE, Portugal and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Braga, EPE, Portugal","institution_ids":["https://openalex.org/I4210137968"]},{"raw_affiliation_string":"Hospital de Braga, EPE, Portugal and","institution_ids":["https://openalex.org/I4210137968"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040753808","display_name":"Adriana De Sousa Lages","orcid":"https://orcid.org/0000-0003-0499-9790","observed_orcids":["https://orcid.org/0000-0003-0499-9790"]},"institutions":[{"id":"https://openalex.org/I4210137968","display_name":"Hospital Braga","ror":"https://ror.org/04jjy0g33","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210137968"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Adriana De Sousa Lages","raw_affiliation_strings":["Faculdade de Medicina, Universidade de Coimbra, Portugal","Hospital de Braga, EPE, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-0499-9790","affiliations":[{"raw_affiliation_string":"Faculdade de Medicina, Universidade de Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Hospital de Braga, EPE, Portugal","institution_ids":["https://openalex.org/I4210137968"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027099688"],"corresponding_institution_ids":["https://openalex.org/I4210137968"],"apc_list":{"value":499,"currency":"GBP","value_usd":612},"apc_paid":{"value":499,"currency":"GBP","value_usd":612},"fwci":0.507,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62370381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2023","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9380000233650208},{"id":"https://openalex.org/keywords/autoimmune-hypothyroidism","display_name":"autoimmune hypothyroidism","score":0.8920000195503235},{"id":"https://openalex.org/keywords/autoimmune-thyroiditis","display_name":"autoimmune thyroiditis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/drug-induced-thyroid-dysfunction","display_name":"drug-induced thyroid dysfunction","score":0.7070000171661377},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8389999866485596},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/goiter","display_name":"goiter","score":0.7250000238418579},{"id":"https://openalex.org/keywords/thyroid-screening","display_name":"thyroid screening","score":0.8569999933242798},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.9309999942779541},{"id":"https://openalex.org/keywords/monoclonal-antibody-adverse-effects","display_name":"monoclonal antibody adverse effects","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9276089668273926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9088379740715027},{"id":"https://openalex.org/C2775883008","wikidata":"https://www.wikidata.org/wiki/Q773449","display_name":"Levothyroxine","level":3,"score":0.8301866054534912},{"id":"https://openalex.org/C2776362883","wikidata":"https://www.wikidata.org/wiki/Q187842","display_name":"Autoimmune thyroiditis","level":4,"score":0.6333385109901428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5757859945297241},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5585798025131226},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.5395611524581909},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.49773886799812317},{"id":"https://openalex.org/C2776254400","wikidata":"https://www.wikidata.org/wiki/Q165135","display_name":"Goiter","level":3,"score":0.4697100520133972},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.43494781851768494},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.39960068464279175},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3493463099002838},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3164680600166321}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1530/edm-22-0412","doi":"https://doi.org/10.1530/edm-22-0412","is_oa":true,"landing_page_url":"https://doi.org/10.1530/edm-22-0412","pdf_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2023/2/EDM22-0412.pdf","source":{"id":"https://openalex.org/S2738451715","display_name":"Endocrinology Diabetes and Metabolism Case Reports","issn_l":"2052-0573","issn":["2052-0573"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10241240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10241240","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10241240/pdf/EDM22-0412.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinol Diabetes Metab Case Rep","raw_type":"Text"},{"id":"pmid:37096975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37096975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, diabetes & metabolism case reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:42f2a4b950944190965552d496298b34","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/42f2a4b950944190965552d496298b34","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-4 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1530/edm-22-0412","doi":"https://doi.org/10.1530/edm-22-0412","is_oa":true,"landing_page_url":"https://doi.org/10.1530/edm-22-0412","pdf_url":"https://edm.bioscientifica.com/downloadpdf/journals/edm/2023/2/EDM22-0412.pdf","source":{"id":"https://openalex.org/S2738451715","display_name":"Endocrinology Diabetes and Metabolism Case Reports","issn_l":"2052-0573","issn":["2052-0573"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","norway-1","oarl","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology, Diabetes & Metabolism Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366992864.pdf","grobid_xml":"https://content.openalex.org/works/W4366992864.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1655974874","https://openalex.org/W2085833314","https://openalex.org/W2097501837","https://openalex.org/W2275306405","https://openalex.org/W2976352116","https://openalex.org/W3035498831","https://openalex.org/W4232233295"],"related_works":["https://openalex.org/W3035498831","https://openalex.org/W2275306405","https://openalex.org/W2036056529","https://openalex.org/W2095300980","https://openalex.org/W2079986094","https://openalex.org/W2914293426","https://openalex.org/W4361741383","https://openalex.org/W3081863255","https://openalex.org/W2105854193","https://openalex.org/W4415450808"],"abstract_inverted_index":{"Summary:":[0],"We":[1,197],"report":[2,61,198],"a":[3,6,9,102,149,167,173,183],"case":[4,43,50,60,201],"of":[5,11,28,58,79,87,96,124,127,135,144,175,180,185,190,202,224],"woman":[7],"with":[8,37,69,131,164,172,188],"diagnosis":[10],"breast":[12,108],"cancer":[13],"who":[14],"unintentionally":[15],"started":[16],"gaining":[17],"weight,":[18],"feeling":[19],"tired,":[20],"and":[21,47,81,92,109,170,220],"constipated":[22],"44":[23],"weeks":[24],"after":[25,93,221],"the":[26,41,48,56,65,75,84,88,94,142,191,199,215,222],"initiation":[27,95,223],"trastuzumab.":[29,97],"Hypothyroidism":[30],"secondary":[31,205],"to":[32,63,206,213],"an":[33,122,159],"autoimmune":[34,113,128,203],"thyroiditis":[35,129,204],"associated":[36,130],"trastuzumab":[38,70,132,207],"was":[39],"diagnosed,":[40],"first":[42,200],"described":[44,51],"in":[45,106,121,137,182,194,208],"Portugal":[46],"fourth":[49],"worldwide.":[52],"Our":[53],"intention":[54],"regarding":[55],"publication":[57],"this":[59,225],"is":[62,101,117,146,156,211],"alert":[64],"clinicians":[66],"treating":[67],"people":[68],"that":[71],"they":[72],"should":[73,82],"ask":[74],"patients":[76,89],"about":[77],"symptoms":[78],"hypothyroidism":[80,136],"screen":[83],"thyroid":[85,114,192,216],"function":[86,193,217],"before,":[90,218],"during,":[91,219],"Learning":[98],"points:":[99],"Trastuzumab":[100],"humanized":[103],"MAB":[104],"used":[105],"HER2-positive":[107],"gastric":[110],"cancer.":[111],"Trastuzumab-associated":[112],"disease":[115],"(AITD)":[116],"rare":[118],"(incidence":[119],"rate":[120],"RCT":[123],"0.3%).":[125],"Manifestations":[126],"resemble":[133],"those":[134],"other":[138],"clinical":[139],"contexts,":[140],"but":[141],"presence":[143],"goiter":[145],"highlighted":[147],"as":[148],"reason":[150],"for":[151],"medical":[152],"evaluation.":[153],"Biochemically,":[154],"it":[155],"characterized":[157],"by":[158],"increased":[160],"thyroid-stimulating":[161],"hormone":[162],"(TSH)":[163],"or":[165],"without":[166],"low":[168],"FT4/FT3,":[169],"sonographically":[171],"pattern":[174],"thyroiditis.":[176],"The":[177],"treatment":[178],"consists":[179],"levothyroxine,":[181],"dose":[184],"1.6-1.8":[186],"\u00b5g/kg/day,":[187],"re-evaluation":[189],"4-6":[195],"weeks.":[196],"Portugal.":[209],"It":[210],"important":[212],"evaluate":[214],"therapeutic":[226],"agent.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-04-27T00:00:00"}