{"id":"https://openalex.org/W4366992303","doi":"https://doi.org/10.1016/j.thromres.2023.04.010","title":"Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice","display_name":"Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4366992303","doi":"https://doi.org/10.1016/j.thromres.2023.04.010","pmid":"https://pubmed.ncbi.nlm.nih.gov/37331119"},"language":"en","primary_location":{"id":"doi:10.1016/j.thromres.2023.04.010","doi":"https://doi.org/10.1016/j.thromres.2023.04.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.thromres.2023.04.010","pdf_url":"http://www.thrombosisresearch.com/article/S0049384823001032/pdf","source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.thrombosisresearch.com/article/S0049384823001032/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004870743","display_name":"Nicole R. Bonetti","orcid":"https://orcid.org/0000-0002-3580-352X","observed_orcids":["https://orcid.org/0000-0002-3580-352X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nicole R. Bonetti","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","Department of Internal Medicine, Cantonal Hospital Baden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210123091"]},{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026055080","display_name":"Annukka Jouppila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Annukka S. Jouppila","raw_affiliation_strings":["Helsinki University Hospital Clinical Research Institute, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital Clinical Research Institute, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044158541","display_name":"Seyed Soheil Saeedi Saravi","orcid":"https://orcid.org/0000-0001-6227-8049","observed_orcids":["https://orcid.org/0000-0001-6227-8049"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Seyed Soheil Saeedi Saravi","raw_affiliation_strings":["Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048220764","display_name":"Brian C. Cooley","orcid":"https://orcid.org/0000-0001-5895-7508","observed_orcids":["https://orcid.org/0000-0001-5895-7508"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian C. Cooley","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Animal Surgery Core Lab, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Animal Surgery Core Lab, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088244983","display_name":"Lisa Pasterk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lisa Pasterk","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067387423","display_name":"Luca Liberale","orcid":"https://orcid.org/0000-0003-1472-7975","observed_orcids":["https://orcid.org/0000-0003-1472-7975"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Luca L. Liberale","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy","Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001500972","display_name":"Sara Gobbato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sara Gobbato","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","Department of Internal Medicine, Cantonal Hospital Baden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210123091"]},{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113435275","display_name":"Thomas Felix L\u00fcscher","orcid":"https://orcid.org/0000-0002-5259-538X","observed_orcids":["https://orcid.org/0000-0002-5259-538X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I2802782613","display_name":"Harefield Hospital","ror":"https://ror.org/04fwa4t58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I2802782613"]},{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Thomas F. L\u00fcscher","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Royal Brompton and Harefield Hospital Trusts and National Heart and Lung Institute, Imperial College, London, UK","Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","Royal Brompton and Harefield Hospital Trusts and National Heart and Lung Institute, Imperial College, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Royal Brompton and Harefield Hospital Trusts and National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I2802782613","https://openalex.org/I4210096640","https://openalex.org/I47508984"]},{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Royal Brompton and Harefield Hospital Trusts and National Heart and Lung Institute, Imperial College, London, UK","institution_ids":["https://openalex.org/I2802782613","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055832234","display_name":"Giovanni Guido Camici","orcid":"https://orcid.org/0000-0002-0523-0695","observed_orcids":["https://orcid.org/0000-0002-0523-0695"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Giovanni G. Camici","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; University Heart Center, University Hospital Zurich, Switzerland; Department of Research and Education, University Hospital Zurich, Switzerland","Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","Department of Research and Education, University Hospital Zurich, Switzerland","University Heart Center, University Hospital Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; University Heart Center, University Hospital Zurich, Switzerland; Department of Research and Education, University Hospital Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Department of Research and Education, University Hospital Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]},{"raw_affiliation_string":"University Heart Center, University Hospital Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051498958","display_name":"Riitta Lassila","orcid":"https://orcid.org/0000-0002-1911-3094","observed_orcids":["https://orcid.org/0000-0002-1911-3094"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Riitta P. Lassila","raw_affiliation_strings":["Coagulation Disorders Unit, University of Helsinki and Departments of Hematology and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland; Helsinki University, Faculty of Medicine, Research Program in Systems Oncology, Helsinki, Finland; Aplagon Ltd., Helsinki, Finland. Electronic address: riitta.lassila@kolumbus.fi","Aplagon Ltd., Helsinki, Finland","Coagulation Disorders Unit, University of Helsinki and Departments of Hematology and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland","Helsinki University, Faculty of Medicine, Research Program in Systems Oncology, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coagulation Disorders Unit, University of Helsinki and Departments of Hematology and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland; Helsinki University, Faculty of Medicine, Research Program in Systems Oncology, Helsinki, Finland; Aplagon Ltd., Helsinki, Finland. Electronic address: riitta.lassila@kolumbus.fi","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Aplagon Ltd., Helsinki, Finland","institution_ids":[]},{"raw_affiliation_string":"Coagulation Disorders Unit, University of Helsinki and Departments of Hematology and Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]},{"raw_affiliation_string":"Helsinki University, Faculty of Medicine, Research Program in Systems Oncology, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019077055","display_name":"J\u00fcrg Hans Beer","orcid":"https://orcid.org/0000-0002-7199-0406","observed_orcids":["https://orcid.org/0000-0002-7199-0406"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210123091","display_name":"Kantonsspital Baden","ror":"https://ror.org/034e48p94","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210123091"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00fcrg H. Beer","raw_affiliation_strings":["Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","Department of Internal Medicine, Cantonal Hospital Baden, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210123091"]},{"raw_affiliation_string":"Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Department of Internal Medicine, Cantonal Hospital Baden, Switzerland","institution_ids":["https://openalex.org/I4210123091"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5051498958"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":{"value":3870,"currency":"USD","value_usd":3870},"fwci":1.3125,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.79719118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"228","issue":null,"first_page":"163","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.5386000275611877,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.4392000138759613,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asia-pacific-region","display_name":"Asia-Pacific region","score":0.8809999823570251},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.6980000138282776},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/heparin-proteoglycans","display_name":"heparin proteoglycans","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/carotid-artery-injury","display_name":"carotid artery injury","score":0.6740000247955322},{"id":"https://openalex.org/keywords/platelet-deposition","display_name":"platelet deposition","score":0.6190000176429749},{"id":"https://openalex.org/keywords/antithrombotic-agents","display_name":"antithrombotic agents","score":0.7720000147819519},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.6320000290870667},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.771759033203125},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.678090512752533},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6281991004943848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5371584892272949},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5146699547767639},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4899980127811432},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.46693652868270874},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38317573070526123},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.383012592792511},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.36462730169296265},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.3532739281654358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3460695743560791}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002341","descriptor_name":"Carotid Artery Thrombosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057772","descriptor_name":"Vascular System Injuries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.thromres.2023.04.010","doi":"https://doi.org/10.1016/j.thromres.2023.04.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.thromres.2023.04.010","pdf_url":"http://www.thrombosisresearch.com/article/S0049384823001032/pdf","source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},{"id":"pmid:37331119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37331119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis research","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:253994","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/253994/1/Intravenously_administered_APAC__a_dual_AntiPlatelet_AntiCoagulant__targets_arterial_injury_site_to_inhibit_platelet_thrombus_formation_and_tissue_factor_activity_in_mice_.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/253994/1/Intravenously_administered_APAC__a_dual_AntiPlatelet_AntiCoagulant__targets_arterial_injury_site_to_inhibit_platelet_thrombus_formation_and_tissue_factor_activity_in_mice_.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bonetti, Nicole R; Jouppila, Annukka S; Saeedi Saravi, Seyed Soheil; Cooley, Brian C; Pasterk, Lisa; Liberale, Luca L; Gobbato, Sara; L\u00fcscher, Thomas F; Camici, Giovanni G; Lassila, Riitta P; Beer, J\u00fcrg H (2023). Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice. Thrombosis Research, 228:163-171.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:helda.helsinki.fi:10138/563989","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/563989","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:unige.iris.cineca.it:11567/1204355","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11567/1204355","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/214910","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/214910","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bonetti, N. R., Jouppila, A. S., Saeedi Saravi, S. S., Cooley, B. C., Pasterk, L., Liberale, L. L., Gobbato, S., L\u00fcscher, T. F., Camici, G. G., Lassila, R. P., & Beer, J. H. (2023). Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice. Thrombosis Research, 228, 163\u2013171. https://doi.org/10.1016/j.thromres.2023.04.010","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-253994","doi":"https://doi.org/10.5167/uzh-253994","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-253994","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.thromres.2023.04.010","doi":"https://doi.org/10.1016/j.thromres.2023.04.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.thromres.2023.04.010","pdf_url":"http://www.thrombosisresearch.com/article/S0049384823001032/pdf","source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7626664804","display_name":"Unveiling the molecular networks of ischemic stroke in aging: evaluation of a novel therapeutic target","funder_award_id":"175546","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320311814","display_name":"Aarne Koskelon S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03pkp5n34"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322584","display_name":"Schweizerische Herzstiftung","ror":"https://ror.org/01k789405"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366992303.pdf","grobid_xml":"https://content.openalex.org/works/W4366992303.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W112829769","https://openalex.org/W1908289777","https://openalex.org/W1973470648","https://openalex.org/W1983760732","https://openalex.org/W1985157854","https://openalex.org/W1988253673","https://openalex.org/W1998398506","https://openalex.org/W2001712168","https://openalex.org/W2004174009","https://openalex.org/W2018322817","https://openalex.org/W2019459017","https://openalex.org/W2021855865","https://openalex.org/W2025448846","https://openalex.org/W2034485512","https://openalex.org/W2035400134","https://openalex.org/W2044452035","https://openalex.org/W2066908978","https://openalex.org/W2076475457","https://openalex.org/W2082012560","https://openalex.org/W2111757938","https://openalex.org/W2115323801","https://openalex.org/W2124551895","https://openalex.org/W2129598732","https://openalex.org/W2142649232","https://openalex.org/W2146387129","https://openalex.org/W2146933358","https://openalex.org/W2147602012","https://openalex.org/W2159856986","https://openalex.org/W2168630917","https://openalex.org/W2170221270","https://openalex.org/W2213916467","https://openalex.org/W2344977044","https://openalex.org/W2418479207","https://openalex.org/W2462769979","https://openalex.org/W2528447976","https://openalex.org/W2555446110","https://openalex.org/W2621054199","https://openalex.org/W2749380187","https://openalex.org/W2771553963","https://openalex.org/W2787428677","https://openalex.org/W2791343520","https://openalex.org/W2791893455","https://openalex.org/W2884288349","https://openalex.org/W2916269561","https://openalex.org/W2984583950","https://openalex.org/W2984760140","https://openalex.org/W3111946351","https://openalex.org/W3167091496","https://openalex.org/W3175696693","https://openalex.org/W3184612351","https://openalex.org/W3212728319","https://openalex.org/W4221004643","https://openalex.org/W4302046699"],"related_works":["https://openalex.org/W7162671236","https://openalex.org/W2903817873","https://openalex.org/W2950635447","https://openalex.org/W3167091496","https://openalex.org/W4409387874","https://openalex.org/W4411037394","https://openalex.org/W2984583950","https://openalex.org/W7129059268","https://openalex.org/W2884288349","https://openalex.org/W1990339267"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Arterial":[1],"thrombosis":[2,17,73,102,230],"is":[3],"the":[4,52,75,128,148,208],"main":[5],"underlying":[6],"mechanism":[7],"of":[8,56,71,116,125,147],"acute":[9],"atherothrombosis.":[10],"Combined":[11],"antiplatelet":[12,224],"and":[13,30,35,44,74,82,89,97,132,151,165,167,170,188,195,225,228],"anticoagulant":[14,226],"regimens":[15],"prevent":[16],"but":[18],"increase":[19],"bleeding":[20],"rates.":[21],"Mast":[22],"cell-derived":[23],"heparin":[24],"proteoglycans":[25],"have":[26],"local":[27,222,239],"antithrombotic":[28,246],"properties,":[29],"their":[31],"semisynthetic":[32],"dual":[33,223],"AntiPlatelet":[34],"AntiCoagulant":[36],"(APAC)":[37],"mimetic":[38],"may":[39],"provide":[40],"a":[41,244],"new":[42],"efficacious":[43],"safe":[45],"tool":[46],"for":[47],"arterial":[48,72,101,217],"thrombosis.":[49],"We":[50],"investigated":[51],"in":[53,67,76,79,152,182,192,209,234],"vivo":[54],"impact":[55],"intravenous":[57],"APAC":[58,126,157,206,215,237,242],"(0.3-0.5":[59],"mg/kg;":[60],"doses":[61],"chosen":[62],"according":[63],"to":[64,122,127,161,180,201,220,247],"pharmacokinetic":[65],"studies)":[66],"two":[68],"mouse":[69,80],"models":[70],"vitro":[77],"actions":[78,227],"platelets":[81],"plasma.":[83,196],"MATERIALS":[84],"AND":[85],"METHODS:":[86],"Platelet":[87],"function":[88],"coagulation":[90],"were":[91,138],"studied":[92],"with":[93,184],"light":[94],"transmission":[95],"aggregometry":[96],"clotting":[98],"times.":[99],"Carotid":[100],"was":[103,154],"induced":[104],"either":[105],"by":[106,140],"photochemical":[107,174],"injury":[108,130,204,218],"or":[109,119,186],"surgically":[110],"exposing":[111],"vascular":[112,129,202],"collagen":[113],"after":[114],"infusion":[115],"APAC,":[117],"UFH":[118,185],"vehicle.":[120],"Time":[121],"occlusion,":[123],"targeting":[124],"site":[131],"platelet":[133,159,211],"deposition":[134],"on":[135],"these":[136],"sites":[137,219],"assessed":[139],"intra-vital":[141],"imaging.":[142],"Tissue":[143],"factor":[144],"activity":[145],"(TF)":[146],"carotid":[149,175,193,232],"artery":[150],"plasma":[153],"captured.":[155],"RESULTS:":[156],"inhibited":[158],"responsiveness":[160],"agonist":[162],"stimulation":[163],"(collagen":[164],"ADP)":[166],"prolonged":[168,178],"APTT":[169],"thrombin":[171],"time.":[172],"After":[173],"injury,":[176],"APAC-treatment":[177],"times":[179],"occlusion":[181],"comparison":[183],"vehicle,":[187],"decreased":[189],"TF":[190],"both":[191],"lysates":[194],"Upon":[197],"binding":[198],"from":[199],"circulation":[200],"collagen-exposing":[203],"sites,":[205],"reduced":[207],"situ":[210],"deposition.":[212],"CONCLUSIONS:":[213],"Intravenous":[214],"targets":[216],"exert":[221],"attenuates":[229],"upon":[231],"injuries":[233],"mice.":[235],"Systemic":[236],"provides":[238],"efficacy,":[240],"highlighting":[241],"as":[243],"novel":[245],"reduce":[248],"cardiovascular":[249],"complications.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-27T00:00:00"}