{"id":"https://openalex.org/W4366991371","doi":"https://doi.org/10.31288/oftalmolzh202321620","title":"Comparing the effectiveness of brolucizumab therapy alone versus that combined with subthreshold micropulse laser exposure in the treatment of diabetic macular edema","display_name":"Comparing the effectiveness of brolucizumab therapy alone versus that combined with subthreshold micropulse laser exposure in the treatment of diabetic macular edema","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4366991371","doi":"https://doi.org/10.31288/oftalmolzh202321620"},"language":"en","primary_location":{"id":"doi:10.31288/oftalmolzh202321620","doi":"https://doi.org/10.31288/oftalmolzh202321620","is_oa":true,"landing_page_url":"http://dx.doi.org/10.31288/oftalmolzh202321620","pdf_url":"https://ua.ozhurnal.com/index.php/files/article/download/21/727","source":{"id":"https://openalex.org/S4210181155","display_name":"Oftalmologicheskii Zhurnal","issn_l":"0030-0675","issn":["0030-0675","2412-8740","2413-8746"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322697703","host_organization_name":"Ukrainian Society of Ophthalmologists","host_organization_lineage":["https://openalex.org/P4322697703"],"host_organization_lineage_names":["Ukrainian Society of Ophthalmologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oftalmologicheskii Zhurnal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ua.ozhurnal.com/index.php/files/article/download/21/727","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057067871","display_name":"\u0410. \u041e. \u0413\u0438\u044f\u0441\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6217-6392","observed_orcids":["https://orcid.org/0000-0001-6217-6392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AO Giyasova","raw_affiliation_strings":["Tashkent State Dental Institute, \u201cSIHAT KO'Z\u201d LTD Joint Venture"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tashkent State Dental Institute, \u201cSIHAT KO'Z\u201d LTD Joint Venture","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062253633","display_name":"\u041d. \u0420. \u042f\u043d\u0433\u0438\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-9251-1726","observed_orcids":["https://orcid.org/0000-0002-9251-1726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NR Yangieva","raw_affiliation_strings":["Tashkent State Dental Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tashkent State Dental Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7118,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.89198361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":null,"issue":"2","first_page":"16","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":0.9580000042915344},{"id":"https://openalex.org/keywords/brolucizumab","display_name":"brolucizumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.6359999775886536},{"id":"https://openalex.org/keywords/retinal-edema","display_name":"retinal edema","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9699454307556152},{"id":"https://openalex.org/C2780699112","wikidata":"https://www.wikidata.org/wiki/Q7246796","display_name":"Pro re nata","level":5,"score":0.9037671089172363},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7150057554244995},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.6952865123748779},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6175774931907654},{"id":"https://openalex.org/C2985127711","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic macular edema","level":4,"score":0.5797480344772339},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.5481616854667664},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.509718120098114},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.4872976541519165},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.484944611787796},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.4525054693222046},{"id":"https://openalex.org/C2778903070","wikidata":"https://www.wikidata.org/wiki/Q2211240","display_name":"Triamcinolone acetonide","level":2,"score":0.4329868257045746},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3486981987953186},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.3311571478843689},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06154945492744446},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0600685179233551}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31288/oftalmolzh202321620","doi":"https://doi.org/10.31288/oftalmolzh202321620","is_oa":true,"landing_page_url":"http://dx.doi.org/10.31288/oftalmolzh202321620","pdf_url":"https://ua.ozhurnal.com/index.php/files/article/download/21/727","source":{"id":"https://openalex.org/S4210181155","display_name":"Oftalmologicheskii Zhurnal","issn_l":"0030-0675","issn":["0030-0675","2412-8740","2413-8746"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322697703","host_organization_name":"Ukrainian Society of Ophthalmologists","host_organization_lineage":["https://openalex.org/P4322697703"],"host_organization_lineage_names":["Ukrainian Society of Ophthalmologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oftalmologicheskii Zhurnal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2bb1f8a67e0147a9b0de227c9007d3e8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2bb1f8a67e0147a9b0de227c9007d3e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ukrainian Journal of Ophthalmology, Iss 2 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31288/oftalmolzh202321620","doi":"https://doi.org/10.31288/oftalmolzh202321620","is_oa":true,"landing_page_url":"http://dx.doi.org/10.31288/oftalmolzh202321620","pdf_url":"https://ua.ozhurnal.com/index.php/files/article/download/21/727","source":{"id":"https://openalex.org/S4210181155","display_name":"Oftalmologicheskii Zhurnal","issn_l":"0030-0675","issn":["0030-0675","2412-8740","2413-8746"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4322697703","host_organization_name":"Ukrainian Society of Ophthalmologists","host_organization_lineage":["https://openalex.org/P4322697703"],"host_organization_lineage_names":["Ukrainian Society of Ophthalmologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oftalmologicheskii Zhurnal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366991371.pdf","grobid_xml":"https://content.openalex.org/works/W4366991371.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1499617936","https://openalex.org/W2002190218","https://openalex.org/W2029423386","https://openalex.org/W2514781449","https://openalex.org/W2605619962","https://openalex.org/W2737633239","https://openalex.org/W2772369846","https://openalex.org/W2887191342","https://openalex.org/W3093285793","https://openalex.org/W3173926452","https://openalex.org/W4206960604","https://openalex.org/W4251623499"],"related_works":["https://openalex.org/W3139892900","https://openalex.org/W4387728199","https://openalex.org/W4401581214","https://openalex.org/W4393242970","https://openalex.org/W4220682309","https://openalex.org/W4388729251","https://openalex.org/W4313364558","https://openalex.org/W4413171972","https://openalex.org/W4387807717","https://openalex.org/W4401580112"],"abstract_inverted_index":{"Background:":[0],"Diabetic":[1],"retinopathy":[2],"(DR)":[3],"is":[4,25,223],"a":[5,26,105,123,218],"major":[6,27],"cause":[7,28],"of":[8,29,50,77,107,138,167,210,221,230],"blindness":[9],"in":[10,13,32,47,141,179,185,208],"working-age":[11],"individuals":[12],"the":[14,48,78,84,130,136,142,180,186,233],"developed":[15],"countries.":[16],"Studies":[17],"have":[18],"found":[19],"that":[20],"diabetic":[21],"macular":[22],"edema":[23,140],"(DME)":[24],"visual":[30,132],"impairment":[31],"patients":[33,56,168],"with":[34,59,75,113,169,202],"diabetes":[35],"mellitus":[36],"(DM).":[37],"Vascular":[38],"endothelial":[39],"growth":[40],"factor":[41],"(VEGF)":[42],"plays":[43],"an":[44],"important":[45],"role":[46],"pathogenesis":[49],"DME.":[51],"Material":[52],"and":[53,120,135,159,227,232],"Methods:":[54],"Eighty-two":[55],"(153":[57],"eyes)":[58,72,103],"DME":[60,205,222],"were":[61,153],"divided":[62],"into":[63],"two":[64],"treatment":[65,198],"groups.":[66],"Group":[67],"1":[68],"(37":[69],"patients,":[70,101],"68":[71],"was":[73,127,176,206],"treated":[74],"injections":[76,175],"anti-VEGF":[79,174],"agent":[80],"brolucizumab":[81,111,200,231],"according":[82],"to":[83],"one":[85],"plus":[86,93,109],"pro":[87],"re":[88],"nata":[89],"(PRN)":[90],"regimen":[91],"(once":[92],"as":[94,145],"needed)":[95],"only,":[96],"whereas":[97],"group":[98,183,188],"2":[99],"(45":[100],"85":[102],"received":[104],"combination":[106,197],"\u201cone":[108],"PRN\u201d":[110],"therapy":[112,182],"subthreshold":[114],"micropulse":[115],"laser":[116],"exposure":[117],"(SMPLE).":[118],"Before":[119],"after":[121,162],"treatment,":[122],"comprehensive":[124],"ophthalmological":[125],"examination":[126],"performed,":[128],"including":[129],"best-corrected":[131],"acuity":[133],"(BCVA)":[134],"height":[137],"retinal":[139],"central":[143],"fovea":[144],"assessed":[146,154],"by":[147],"optical":[148],"coherence":[149],"tomography.":[150],"The":[151,165,196],"parameters":[152],"at":[155],"1,":[156],"3,":[157],"6":[158],"12":[160,213],"months":[161],"treatment.":[163],"Results:":[164],"percentage":[166],"no":[170],"need":[171],"for":[172,204],"additional":[173],"substantially":[177],"higher":[178],"combined":[181,201],"than":[184],"monotherapy":[187],"(68.5%":[189],"versus":[190],"12%,":[191],"respectively,":[192],"p":[193],"<0.001).":[194],"Conclusion:":[195],"(intravitreal":[199],"SMPLE)":[203],"effective":[207],"68.5%":[209],"cases":[211],"within":[212],"months.":[214],"In":[215],"this":[216],"way,":[217],"steady":[219],"resorption":[220],"accomplished":[224],"through":[225],"antivasoproliferative":[226],"prolonged":[228],"effects":[229],"SMPLE":[234],"session.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-27T00:00:00"}
