{"id":"https://openalex.org/W4366988409","doi":"https://doi.org/10.1007/s12031-023-02119-w","title":"Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121","display_name":"Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4366988409","doi":"https://doi.org/10.1007/s12031-023-02119-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37097512","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10200781"},"language":"en","primary_location":{"id":"doi:10.1007/s12031-023-02119-w","doi":"https://doi.org/10.1007/s12031-023-02119-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12031-023-02119-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12031-023-02119-w.pdf","source":{"id":"https://openalex.org/S133939727","display_name":"Journal of Molecular Neuroscience","issn_l":"0895-8696","issn":["0895-8696","1559-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12031-023-02119-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109422696","display_name":"Tammy B. Pham","orcid":"https://orcid.org/0000-0002-4875-7673","observed_orcids":["https://orcid.org/0000-0002-4875-7673"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tammy B. Pham","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064662616","display_name":"Ely Cheikh Boussaty","orcid":"https://orcid.org/0000-0003-3146-8821","observed_orcids":["https://orcid.org/0000-0003-3146-8821"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ely Cheikh Boussaty","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090113190","display_name":"Antonio Jose Martins Currais","orcid":"https://orcid.org/0000-0003-4142-7054","observed_orcids":["https://orcid.org/0000-0003-4142-7054"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Currais","raw_affiliation_strings":["Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013055662","display_name":"Pamela A Maher","orcid":"https://orcid.org/0000-0003-0694-0610","observed_orcids":["https://orcid.org/0000-0003-0694-0610"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela Maher","raw_affiliation_strings":["Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103537467","display_name":"David R. Schubert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Schubert","raw_affiliation_strings":["Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070633413","display_name":"Uri Manor","orcid":"https://orcid.org/0000-0002-9802-1955","observed_orcids":["https://orcid.org/0000-0002-9802-1955"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uri Manor","raw_affiliation_strings":["Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111987614","display_name":"Rick Adam Friedman","orcid":"https://orcid.org/0000-0002-5490-8562","observed_orcids":["https://orcid.org/0000-0002-5490-8562","https://orcid.org/0000-0001-8921-4459"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rick A. Friedman","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA. rafriedman@health.ucsd.edu","Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA. rafriedman@health.ucsd.edu","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111987614"],"corresponding_institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.6989,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.8090566,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"73","issue":"4-5","first_page":"307","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":0.906000018119812},{"id":"https://openalex.org/keywords/fatty-acid-synthase-inhibitors","display_name":"fatty acid synthase inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/samp8-mice","display_name":"SAMP8 mice","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7919999957084656},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/auditory-brainstem-response","display_name":"auditory brainstem response","score":0.7440000176429749},{"id":"https://openalex.org/keywords/hearing-threshold","display_name":"hearing threshold","score":0.5669999718666077},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6258301138877869},{"id":"https://openalex.org/C43791021","wikidata":"https://www.wikidata.org/wiki/Q608256","display_name":"Auditory brainstem response","level":3,"score":0.5919927358627319},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5738183259963989},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5440127849578857},{"id":"https://openalex.org/C38120836","wikidata":"https://www.wikidata.org/wiki/Q7322268","display_name":"Ribbon synapse","level":5,"score":0.48864561319351196},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.4866279065608978},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4578416049480438},{"id":"https://openalex.org/C122247490","wikidata":"https://www.wikidata.org/wiki/Q1504201","display_name":"Absolute threshold of hearing","level":3,"score":0.44280943274497986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42446303367614746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4224857985973358},{"id":"https://openalex.org/C2779912225","wikidata":"https://www.wikidata.org/wiki/Q1756133","display_name":"Presbycusis","level":3,"score":0.4100436866283417},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3496294617652893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34569695591926575},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.3319556713104248},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15989163517951965},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.0},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006199","descriptor_name":"Hair Cells, Auditory, Inner","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011304","descriptor_name":"Presbycusis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064429","descriptor_name":"Fatty Acid Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s12031-023-02119-w","doi":"https://doi.org/10.1007/s12031-023-02119-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12031-023-02119-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12031-023-02119-w.pdf","source":{"id":"https://openalex.org/S133939727","display_name":"Journal of Molecular Neuroscience","issn_l":"0895-8696","issn":["0895-8696","1559-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10200781","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10200781","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10200781/pdf/12031_2023_Article_2119.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Mol Neurosci","raw_type":"Text"},{"id":"pmid:37097512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37097512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular neuroscience : MN","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7sg4r5jz","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7sg4r5jz","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Neuroscience, vol 73, iss 4-5","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s12031-023-02119-w","doi":"https://doi.org/10.1007/s12031-023-02119-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12031-023-02119-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12031-023-02119-w.pdf","source":{"id":"https://openalex.org/S133939727","display_name":"Journal of Molecular Neuroscience","issn_l":"0895-8696","issn":["0895-8696","1559-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1749200221","display_name":null,"funder_award_id":"RF1-AG061296","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1958163345","display_name":"The Contribution of Kidney Disease to Age-Associated Cognitive Decline","funder_award_id":"RF1AG061296","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3250964000","display_name":"A Novel Model System for Restoring Hearing in vivo","funder_award_id":"R21DC018237","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G3983460365","display_name":"Lowering Mitochondrial ATP Synthase Activity Slows Aging and Alzheimer's Disease","funder_award_id":"R01AG067331","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4179704951","display_name":"The Contribution of Old Age-Associated Proteotoxicity to Inflammation and Dementia","funder_award_id":"RF1AG054714","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5774287953","display_name":"Modulation of the Innate Immune System by Fisetin for the Treatment of AD","funder_award_id":"R41AI104034","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6684247801","display_name":"Modulation of the Innate Immune Response by Fisetin Derivatives for the Treatment of AD","funder_award_id":"R44AI104034","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8145547626","display_name":"The genetic basis for age-related hearing loss in outbred mice","funder_award_id":"R01DC018566","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G8924997427","display_name":"Modulation of the Innate Immune Response by Fisetin Derivatives for the Treatment of AD","funder_award_id":"R42AI104034","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000212349","display_name":null,"funder_award_id":"AI104034","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880274","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014195","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310124","display_name":"Waitt Foundation","ror":"https://ror.org/00zf1g010"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366988409.pdf","grobid_xml":"https://content.openalex.org/works/W4366988409.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W91173676","https://openalex.org/W136988321","https://openalex.org/W1965478553","https://openalex.org/W1995454209","https://openalex.org/W1996428411","https://openalex.org/W2005110735","https://openalex.org/W2012717802","https://openalex.org/W2013496968","https://openalex.org/W2019909669","https://openalex.org/W2027029724","https://openalex.org/W2042887543","https://openalex.org/W2057663429","https://openalex.org/W2057725339","https://openalex.org/W2088038548","https://openalex.org/W2093970469","https://openalex.org/W2109634566","https://openalex.org/W2113747279","https://openalex.org/W2121393149","https://openalex.org/W2133971230","https://openalex.org/W2156291679","https://openalex.org/W2163350197","https://openalex.org/W2171600170","https://openalex.org/W2340007753","https://openalex.org/W2524232599","https://openalex.org/W2535589380","https://openalex.org/W2567954113","https://openalex.org/W2621143613","https://openalex.org/W2626395940","https://openalex.org/W2736307756","https://openalex.org/W2738123573","https://openalex.org/W2764428680","https://openalex.org/W2783050637","https://openalex.org/W2802800214","https://openalex.org/W2887949401","https://openalex.org/W2894917382","https://openalex.org/W2911800904","https://openalex.org/W2991485014","https://openalex.org/W3007918082","https://openalex.org/W3044319907","https://openalex.org/W3047422367","https://openalex.org/W3105907500","https://openalex.org/W3113581092","https://openalex.org/W3194863898"],"related_works":["https://openalex.org/W2738123573","https://openalex.org/W2293500366","https://openalex.org/W2887949401","https://openalex.org/W1996428411","https://openalex.org/W2357171214","https://openalex.org/W7204435604","https://openalex.org/W2350015537","https://openalex.org/W2034574969","https://openalex.org/W3015487523","https://openalex.org/W3194863898"],"abstract_inverted_index":{"In":[0],"the":[1,76,99,131,142,151,159,187,200,206,231],"senescence-accelerated":[2],"mouse":[3,7],"prone":[4],"8":[5],"(SAMP8)":[6],"model,":[8],"oxidative":[9],"stress":[10],"leads":[11],"to":[12,34,51,97,122,148,186,205,240],"premature":[13],"senescence":[14],"and":[15,126,176,223],"age-related":[16],"hearing":[17,54,124,139,165],"impairment":[18],"(ARHI).":[19],"CMS121":[20,37,152,188,207,238],"inhibits":[21],"oxytosis/ferroptosis":[22],"by":[23],"targeting":[24],"fatty":[25],"acid":[26],"synthase.":[27],"The":[28,67],"aim":[29],"of":[30,91,101,150,157,226],"our":[31],"study":[32,214],"was":[33,70,79,95],"determine":[35],"whether":[36],"is":[38],"protective":[39],"against":[40],"ARHI":[41],"in":[42,55,141,199,219,230],"SAMP8":[43,59],"mice.":[44,242],"Auditory":[45],"brainstem":[46],"responses":[47],"(ABRs)":[48],"were":[49,62,86,120,145],"used":[50],"assess":[52],"baseline":[53],"sixteen":[56],"4-week-old":[57],"female":[58],"mice,":[60],"which":[61],"divided":[63],"into":[64],"two":[65,132],"cohorts.":[66],"control":[68,143,160,201],"group":[69,78,144,161,202,208],"fed":[71,80],"a":[72,81,192,216],"vehicle":[73],"diet,":[74],"while":[75],"experimental":[77],"diet":[82],"containing":[83],"CMS121.":[84],"ABRs":[85],"measured":[87],"until":[88],"13":[89,155],"weeks":[90,156],"age.":[92],"Cochlear":[93],"immunohistochemistry":[94],"performed":[96,121],"analyze":[98],"number":[100],"paired":[102,127],"ribbon-receptor":[103],"synapses":[104,229],"per":[105,197],"inner":[106],"hair":[107],"cell":[108],"(IHC).":[109],"Descriptive":[110],"statistics":[111],"are":[112],"provided":[113],"with":[114,134,237],"mean":[115],"\u00b1":[116],"SEM.":[117],"Two-sample":[118],"t-tests":[119],"compare":[123],"thresholds":[125,140,166],"synapse":[128,195],"count":[129,196],"across":[130],"groups,":[133],"alpha":[135],"=":[136,174,183,211],"0.05.":[137],"Baseline":[138],"statistically":[146],"similar":[147],"those":[149],"group.":[153,189],"At":[154],"age,":[158],"had":[162],"significantly":[163,193],"worse":[164],"at":[167],"12":[168],"kHz":[169,178],"(56.5":[170],"vs.":[171,180],"39.8,":[172],"p":[173,182,210],"0.044)":[175],"16":[177],"(64.8":[179],"43.8,":[181],"0.040)":[184],"compared":[185,204,239],"Immunohistochemistry":[190],"showed":[191],"lower":[194],"IHC":[198,227],"(15.7)":[203],"(18.4),":[209],"0.014.":[212],"Our":[213],"shows":[215],"significant":[217],"reduction":[218],"ABR":[220],"threshold":[221],"shifts":[222],"increased":[224],"preservation":[225],"ribbon":[228],"mid-range":[232],"frequencies":[233],"among":[234],"mice":[235],"treated":[236],"untreated":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-04-27T00:00:00"}