{"id":"https://openalex.org/W4366978070","doi":"https://doi.org/10.1016/j.omtn.2023.04.017","title":"Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy","display_name":"Novel Fas-TNFR chimeras that prevent Fas ligand-mediated kill and signal synergistically to enhance CAR T cell efficacy","publication_year":2023,"publication_date":"2023-04-25","ids":{"openalex":"https://openalex.org/W4366978070","doi":"https://doi.org/10.1016/j.omtn.2023.04.017","pmid":"https://pubmed.ncbi.nlm.nih.gov/37200859","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10185706"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2023.04.017","doi":"https://doi.org/10.1016/j.omtn.2023.04.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.04.017","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omtn.2023.04.017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074831273","display_name":"Callum McKenzie","orcid":"https://orcid.org/0000-0002-2397-3441","observed_orcids":["https://orcid.org/0000-0002-2397-3441"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Callum McKenzie","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":"https://orcid.org/0000-0002-2397-3441","affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mohamed El-Kholy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohamed El-Kholy","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026322414","display_name":"Farhaan Parekh","orcid":"https://orcid.org/0000-0002-3652-0855","observed_orcids":["https://orcid.org/0000-0002-3652-0855"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Farhaan Parekh","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089386486","display_name":"Mathew P. Robson","orcid":"https://orcid.org/0000-0002-7498-8387","observed_orcids":["https://orcid.org/0000-0002-7498-8387"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mathew Robson","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053506686","display_name":"Katarina Lamb","orcid":"https://orcid.org/0000-0002-5155-069X","observed_orcids":["https://orcid.org/0000-0002-5155-069X"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katarina Lamb","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004138779","display_name":"Christopher G. Allen","orcid":"https://orcid.org/0000-0002-5310-0529","observed_orcids":["https://orcid.org/0000-0002-5310-0529"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Allen","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024862429","display_name":"James Sillibourne","orcid":"https://orcid.org/0000-0001-6755-3644","observed_orcids":["https://orcid.org/0000-0001-6755-3644"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Sillibourne","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074398233","display_name":"Shaun P Cordoba","orcid":"https://orcid.org/0009-0001-1519-3349","observed_orcids":["https://orcid.org/0009-0001-1519-3349"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shaun Cordoba","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057490890","display_name":"Simon Thomas","orcid":"https://orcid.org/0000-0003-3410-5698","observed_orcids":["https://orcid.org/0000-0003-3410-5698","https://orcid.org/0000-0001-7119-9545"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Thomas","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022750427","display_name":"Martin A. Pul\u00e8","orcid":"https://orcid.org/0000-0002-8347-9867","observed_orcids":["https://orcid.org/0000-0002-8347-9867"]},"institutions":[{"id":"https://openalex.org/I4210136142","display_name":"Autolus (United Kingdom)","ror":"https://ror.org/03945f733","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210136142"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Martin Pule","raw_affiliation_strings":["Autolus Therapeutics, London W12 7FP, UK","Department of Haematology, UCL Cancer Institute, University College, 72 Huntley Street, London WC1E 6DD, UK"],"raw_orcid":"https://orcid.org/0000-0002-8347-9867","affiliations":[{"raw_affiliation_string":"Autolus Therapeutics, London W12 7FP, UK","institution_ids":["https://openalex.org/I4210136142"]},{"raw_affiliation_string":"Department of Haematology, UCL Cancer Institute, University College, 72 Huntley Street, London WC1E 6DD, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022750427"],"corresponding_institution_ids":["https://openalex.org/I4210136142","https://openalex.org/I45129253"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":1.9251,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.87321445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"32","issue":null,"first_page":"603","last_page":"621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8479999899864197},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.675000011920929},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8500000238418579},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5529999732971191},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.7975291013717651},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.6772822737693787},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5591920018196106},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5293931365013123},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5135100483894348},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4911162555217743},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4594700038433075},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45677652955055237},{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.44760507345199585},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.421691358089447},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.41995179653167725},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.4112505614757538},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4042556881904602},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3527076244354248},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2886251211166382},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15962764620780945},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.09429940581321716},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.omtn.2023.04.017","doi":"https://doi.org/10.1016/j.omtn.2023.04.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.04.017","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},{"id":"doi:10.1101/2023.02.22.529492","doi":"https://doi.org/10.1101/2023.02.22.529492","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.02.22.529492","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/02/22/2023.02.22.529492.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37200859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37200859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10185706","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10185706/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10169885","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10169885/","pdf_url":"https://discovery.ucl.ac.uk/id/eprint/10169885/1/1-s2.0-S2162253123001038-main.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy - Nucleic Acids , 32 pp. 603-621. (2023)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:3161044ecdb64eac92495eea73fe8a62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3161044ecdb64eac92495eea73fe8a62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 603-621 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2023.04.017","doi":"https://doi.org/10.1016/j.omtn.2023.04.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.04.017","pdf_url":null,"source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366978070.pdf","grobid_xml":"https://content.openalex.org/works/W4366978070.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1499206957","https://openalex.org/W1614729903","https://openalex.org/W1619537825","https://openalex.org/W1650001464","https://openalex.org/W1656255119","https://openalex.org/W1711013043","https://openalex.org/W1968783338","https://openalex.org/W1969179435","https://openalex.org/W1983918344","https://openalex.org/W2003494920","https://openalex.org/W2003539449","https://openalex.org/W2016345107","https://openalex.org/W2017390384","https://openalex.org/W2023245305","https://openalex.org/W2026252733","https://openalex.org/W2039492531","https://openalex.org/W2041525823","https://openalex.org/W2076169910","https://openalex.org/W2077793109","https://openalex.org/W2091116942","https://openalex.org/W2110002127","https://openalex.org/W2129971278","https://openalex.org/W2132892038","https://openalex.org/W2144420689","https://openalex.org/W2154060541","https://openalex.org/W2155763709","https://openalex.org/W2163062545","https://openalex.org/W2252441686","https://openalex.org/W2330978427","https://openalex.org/W2588571054","https://openalex.org/W2651055861","https://openalex.org/W2766762285","https://openalex.org/W2767225644","https://openalex.org/W2773804840","https://openalex.org/W2809843782","https://openalex.org/W2883797118","https://openalex.org/W2900048176","https://openalex.org/W2901641193","https://openalex.org/W2913630852","https://openalex.org/W2916957847","https://openalex.org/W2922124059","https://openalex.org/W3017040524","https://openalex.org/W3025076282","https://openalex.org/W3081862669","https://openalex.org/W3082381897","https://openalex.org/W3096010551","https://openalex.org/W3096511289","https://openalex.org/W3104033768","https://openalex.org/W3120272235","https://openalex.org/W3120355176","https://openalex.org/W3124957342","https://openalex.org/W3159623678","https://openalex.org/W3160736060","https://openalex.org/W3166719742","https://openalex.org/W3201226829","https://openalex.org/W4210396037","https://openalex.org/W4214554658","https://openalex.org/W4220656215","https://openalex.org/W4220946188","https://openalex.org/W4281398912","https://openalex.org/W4282976776","https://openalex.org/W4297996721","https://openalex.org/W4308623157","https://openalex.org/W4311887602"],"related_works":["https://openalex.org/W4393085683","https://openalex.org/W4407977058","https://openalex.org/W2883797118","https://openalex.org/W4313359623","https://openalex.org/W2913245587","https://openalex.org/W3082381897","https://openalex.org/W4393085611","https://openalex.org/W2806519959","https://openalex.org/W2913630852","https://openalex.org/W3112128554"],"abstract_inverted_index":{"The":[0],"hostile":[1],"tumor":[2,124],"microenvironment":[3],"limits":[4],"the":[5,13,61,69,92,136,141,145,190],"efficacy":[6,56,111],"of":[7,12,36,79,100,135,177],"adoptive":[8],"cell":[9,30,55,93,116,183,202],"therapies.":[10],"Activation":[11],"Fas":[14,47,65,170,195],"death":[15],"receptor":[16],"initiates":[17],"apoptosis":[18],"and":[19,75,96,118,122,126,198],"disrupting":[20],"these":[21],"receptors":[22],"could":[23],"be":[24],"key":[25],"to":[26,91],"increasing":[27],"CAR":[28,53,114,164,181,200],"T":[29,54,115,165,182,201],"efficacy.":[31,203],"We":[32,185],"screened":[33],"a":[34,156,174],"library":[35],"Fas-TNFR":[37,160],"proteins":[38],"identifying":[39],"several":[40],"novel":[41],"chimeras":[42],"that":[43,155],"not":[44],"only":[45],"prevented":[46],"ligand-mediated":[48,196],"kill,":[49],"but":[50],"also":[51],"enhanced":[52,123],"by":[57,112],"signaling":[58,150],"synergistically":[59],"with":[60,102],"CAR.":[62],"Upon":[63],"binding":[64],"ligand,":[66],"Fas-CD40":[67,83,101,188],"activated":[68],"NF-\u03baB":[70],"pathway,":[71],"inducing":[72],"greatest":[73],"proliferation":[74,117],"IFN-\u03b3":[76],"release":[77],"out":[78],"all":[80],"Fas-TNFRs":[81,137,178],"tested.":[82],"induced":[84],"profound":[85],"transcriptional":[86],"modifications,":[87],"particularly":[88],"genes":[89],"relating":[90],"cycle,":[94],"metabolism,":[95],"chemokine":[97],"signaling.":[98],"Co-expression":[99],"either":[103],"4-1BB-":[104],"or":[105],"CD28-containing":[106],"CARs":[107],"increased":[108],"in":[109,130,179],"vitro":[110],"augmenting":[113,180],"cancer":[119],"target":[120],"cytotoxicity,":[121],"killing":[125],"overall":[127],"mouse":[128],"survival":[129],"vivo":[131],".":[132],"Functional":[133],"activity":[134],"were":[138],"dependent":[139],"on":[140],"co-stimulatory":[142],"domain":[143],"within":[144],"CAR,":[146],"highlighting":[147,173],"crosstalk":[148],"between":[149],"pathways.":[151],"Furthermore,":[152],"we":[153],"show":[154],"major":[157],"source":[158],"for":[159,193],"activation":[161],"derives":[162],"from":[163],"cells":[166],"themselves":[167],"via":[168],"activation-induced":[169],"ligand":[171],"upregulation,":[172],"universal":[175],"role":[176],"responses.":[184],"have":[186],"identified":[187],"as":[189],"optimal":[191],"chimera":[192],"overcoming":[194],"kill":[197],"enhancing":[199]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-04-27T00:00:00"}
