{"id":"https://openalex.org/W4366830696","doi":"https://doi.org/10.1017/cts.2023.410","title":"372 HMGB1 Localization as a Driver of Carcinogenesis in RDEB-Associated Squamous Cell Carcinoma","display_name":"372 HMGB1 Localization as a Driver of Carcinogenesis in RDEB-Associated Squamous Cell Carcinoma","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4366830696","doi":"https://doi.org/10.1017/cts.2023.410"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2023.410","doi":"https://doi.org/10.1017/cts.2023.410","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2023.410","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/83A396DAC878B7C03C8352E27F53ADB3/S2059866123004107a.pdf/div-class-title-372-hmgb1-localization-as-a-driver-of-carcinogenesis-in-rdeb-associated-squamous-cell-carcinoma-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/83A396DAC878B7C03C8352E27F53ADB3/S2059866123004107a.pdf/div-class-title-372-hmgb1-localization-as-a-driver-of-carcinogenesis-in-rdeb-associated-squamous-cell-carcinoma-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011685745","display_name":"Kacey Guenther Bui","orcid":"https://orcid.org/0000-0002-7384-8286","observed_orcids":["https://orcid.org/0000-0002-7384-8286"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kacey Guenther Bui","raw_affiliation_strings":["University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050487618","display_name":"Anja\u2010Katrin Bielinsky","orcid":"https://orcid.org/0000-0003-1783-619X","observed_orcids":["https://orcid.org/0000-0003-1783-619X"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anja Bielinsky","raw_affiliation_strings":["University of Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065318155","display_name":"Hai Dang Nguyen","orcid":"https://orcid.org/0000-0002-4200-8778","observed_orcids":["https://orcid.org/0000-0002-4200-8778"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Dang Nguyen","raw_affiliation_strings":["University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060519108","display_name":"Jakub Tolar","orcid":"https://orcid.org/0000-0002-0957-4380","observed_orcids":["https://orcid.org/0000-0002-0957-4380"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jakub Tolar","raw_affiliation_strings":["University of Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06528036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"s1","first_page":"110","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.2761000096797943,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.1412000060081482,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.996999979019165},{"id":"https://openalex.org/keywords/recessive-dystrophic-epidermolysis-bullosa","display_name":"recessive dystrophic epidermolysis bullosa","score":0.9940000176429749},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8889999985694885},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/inflammatory-signaling-pathways","display_name":"inflammatory signaling","score":0.6359999775886536},{"id":"https://openalex.org/keywords/genotoxic-sensitivity","display_name":"genotoxic sensitivity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.6930649280548096},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6565103530883789},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5965391993522644},{"id":"https://openalex.org/C29906990","wikidata":"https://www.wikidata.org/wiki/Q1440688","display_name":"Frameshift mutation","level":4,"score":0.584089994430542},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5147645473480225},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5116310715675354},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48008066415786743},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4539584219455719},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45317891240119934},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4167175889015198},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.39922961592674255},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28865858912467957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24155157804489136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2075032889842987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09873506426811218},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1017/cts.2023.410","doi":"https://doi.org/10.1017/cts.2023.410","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2023.410","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/83A396DAC878B7C03C8352E27F53ADB3/S2059866123004107a.pdf/div-class-title-372-hmgb1-localization-as-a-driver-of-carcinogenesis-in-rdeb-associated-squamous-cell-carcinoma-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10129564","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10129564","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10129564/pdf/S2059866123004107a.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9683d19d7f5e43abb1a0e8f9fa063b35","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9683d19d7f5e43abb1a0e8f9fa063b35","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 7, Pp 110-111 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1017/cts.2023.410","doi":"https://doi.org/10.1017/cts.2023.410","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2023.410","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/83A396DAC878B7C03C8352E27F53ADB3/S2059866123004107a.pdf/div-class-title-372-hmgb1-localization-as-a-driver-of-carcinogenesis-in-rdeb-associated-squamous-cell-carcinoma-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366830696.pdf","grobid_xml":"https://content.openalex.org/works/W4366830696.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4285992272","https://openalex.org/W7119492404","https://openalex.org/W7064829045","https://openalex.org/W7134235098","https://openalex.org/W4413149892","https://openalex.org/W3080129155","https://openalex.org/W2810167428","https://openalex.org/W1969305254","https://openalex.org/W2891517627","https://openalex.org/W4416057895"],"abstract_inverted_index":{"OBJECTIVES/GOALS:":[0],"This":[1],"study":[2],"investigates":[3],"whether":[4,298],"localization":[5],"of":[6,25,89,133,151,186,199,282,309],"high":[7,203],"mobility":[8],"group":[9],"box":[10],"1":[11],"(HMGB1)":[12],"controls":[13],"inflammatory":[14,213],"signaling":[15],"and":[16,40,114,162,175,268],"DNA":[17,127,163,206,235,254,311],"damage":[18,128,164,236,255,269,312],"response":[19],"in":[20,36,41,59,99,130,182,212,277,304],"human":[21,188],"keratinocytes,":[22],"the":[23,131,156,227,248,310],"cell":[24,29,104,291],"origin":[26],"for":[27,80,106,116,126],"squamous":[28,290],"carcinoma":[30],"(SCC).":[31],"SCC":[32],"is":[33,179,264,274],"especially":[34],"metastatic":[35,289],"chronic":[37],"wounds,":[38],"burns,":[39],"patients":[42,278],"with":[43,195,279],"recessive":[44],"dystrophic":[45],"epidermolysis":[46],"bullosa":[47],"(RDEB).":[48],"METHODS/STUDY":[49],"POPULATION:":[50],"We":[51,169,191,215],"used":[52,123,146],"CRISPR/Cas9":[53],"gene-editing":[54],"to":[55,93,124,147,155,205,226,234,238,247,259,287],"knock":[56],"out":[57,181],"HMGB1":[58,117,152,178,200,222,243,263,299],"a":[60,100,183,196,265,301],"keratinocyte":[61,76,189],"line,":[62],"p16INK4a-negative":[63],"keratinocytes":[64],"immortalized":[65],"by":[66,82,85,91,112,172,257],"ectopic":[67],"hTERT":[68],"expression":[69],"(N/TERT-2G":[70],"[46,XY]).":[71],"Following":[72],"gene":[73],"editing,":[74],"clonal":[75,108,184],"populations":[77],"were":[78,110],"screened":[79],"knockout":[81],"PCR":[83],"followed":[84],"TIDE":[86],"analysis":[87],"(Tracking":[88],"Indels":[90],"Decomposition)":[92],"identify":[94],"indels":[95],"that":[96,153,177,193,218,223,244,273],"would":[97],"result":[98],"frameshift":[101],"mutation.":[102],"Total":[103],"lysates":[105],"each":[107],"population":[109,185],"analyzed":[111],"immunoblot":[113],"immunofluorescence":[115,176],"protein.":[118],"These":[119],"cells":[120,194,219],"will":[121,143,201,229,250,284],"be":[122,145,251],"assay":[125],"sensitivity":[129,204,233],"presence":[132],"genotoxic":[134,260],"agents":[135],"(etoposide,":[136],"ultraviolet":[137],"radiation,":[138],"\u03b3-irradiation).":[139],"A":[140],"lentiviral":[141],"vector":[142],"then":[144],"express":[148],"mutant":[149,221,242],"forms":[150],"localize":[154],"nucleus":[157,249],"(C23/45S)":[158],"or":[159],"cytoplasm":[160,228],"(C106S)":[161],"assays":[165],"repeated.":[166],"RESULTS/ANTICIPATED":[167],"RESULTS:":[168],"have":[170,202],"confirmed":[171],"sequencing,":[173],"immunoblot,":[174],"knocked":[180],"N/TERT-2G":[187],"cells.":[190],"anticipate":[192],"complete":[197],"absence":[198],"damaging":[207],"agents,":[208],"but":[209],"little":[210],"change":[211],"signaling.":[214],"also":[216],"expect":[217],"expressing":[220],"localizes":[224,245],"exclusively":[225,246],"demonstrate":[230],"an":[231],"increased":[232],"relative":[237],"wild-type":[239],"controls,":[240],"while":[241],"protected":[252],"from":[253],"caused":[256],"exposure":[258],"agents.":[261],"DISCUSSION/SIGNIFICANCE:":[262],"nuclear":[266],"protein":[267],"associated":[270],"molecular":[271],"pattern":[272],"elevated":[275],"systemically":[276],"RDEB,":[280],"many":[281],"whom":[283],"go":[285],"on":[286],"develop":[288],"carcinoma.":[292],"The":[293],"experiments":[294],"described":[295],"here":[296],"investigate":[297],"plays":[300],"mechanistic":[302],"role":[303],"skin":[305],"carcinogenesis":[306],"via":[307],"regulation":[308],"response.":[313]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-04-25T00:00:00"}