{"id":"https://openalex.org/W4366830678","doi":"https://doi.org/10.1017/cts.2023.122","title":"25 In-hospital Change in Lung Ultrasound Congestion Score Predicts Heart Failure Rehospitalization and Death: Implications for Clinical Trials","display_name":"25 In-hospital Change in Lung Ultrasound Congestion Score Predicts Heart Failure Rehospitalization and Death: Implications for Clinical Trials","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4366830678","doi":"https://doi.org/10.1017/cts.2023.122"},"language":"en","primary_location":{"id":"doi:10.1017/cts.2023.122","doi":"https://doi.org/10.1017/cts.2023.122","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2023.122","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6BEA63BCAE294A5A906223C481CD878F/S205986612300122Xa.pdf/div-class-title-25-in-hospital-change-in-lung-ultrasound-congestion-score-predicts-heart-failure-rehospitalization-and-death-implications-for-clinical-trials-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6BEA63BCAE294A5A906223C481CD878F/S205986612300122Xa.pdf/div-class-title-25-in-hospital-change-in-lung-ultrasound-congestion-score-predicts-heart-failure-rehospitalization-and-death-implications-for-clinical-trials-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056425209","display_name":"Nicholas Eric Harrison","orcid":"https://orcid.org/0000-0002-8331-7833","observed_orcids":["https://orcid.org/0000-0002-8331-7833"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Eric Harrison","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078896449","display_name":"Ankit A. Desai","orcid":"https://orcid.org/0000-0001-6427-616X","observed_orcids":["https://orcid.org/0000-0001-6427-616X"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit Desai","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054668121","display_name":"Peter S. Pang","orcid":"https://orcid.org/0000-0003-3444-2811","observed_orcids":["https://orcid.org/0000-0003-3444-2811"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Pang","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06027717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"s1","first_page":"7","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.9179999828338623,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.07720000296831131,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-heart-failure","display_name":"acute heart failure","score":0.9959999918937683},{"id":"https://openalex.org/keywords/heart-failure-readmission","display_name":"heart failure readmission","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6549999713897705},{"id":"https://openalex.org/keywords/emergency-department","display_name":"emergency department","score":0.5529999732971191},{"id":"https://openalex.org/keywords/change-from-baseline","display_name":"change from baseline","score":0.6079999804496765},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.5419999957084656},{"id":"https://openalex.org/keywords/trial-design","display_name":"trial design","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8129642009735107},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.75642991065979},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.5848261117935181},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5570820569992065},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5364376306533813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4881058633327484},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.46107223629951477},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4586716592311859},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4275192618370056},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42127466201782227},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.4017554223537445},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3643706440925598},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.12329542636871338},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1017/cts.2023.122","doi":"https://doi.org/10.1017/cts.2023.122","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2023.122","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6BEA63BCAE294A5A906223C481CD878F/S205986612300122Xa.pdf/div-class-title-25-in-hospital-change-in-lung-ultrasound-congestion-score-predicts-heart-failure-rehospitalization-and-death-implications-for-clinical-trials-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10129485","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10129485","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10129485/pdf/S205986612300122Xa.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/37454","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/37454","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/5b45a499-5ee9-474c-9b5a-4b149ae20e17/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Abstract"},{"id":"pmh:oai:doaj.org/article:de07dcfcb53f4f4b8c22d43e778fc226","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/de07dcfcb53f4f4b8c22d43e778fc226","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical and Translational Science, Vol 7, Pp 7-7 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1017/cts.2023.122","doi":"https://doi.org/10.1017/cts.2023.122","is_oa":true,"landing_page_url":"https://doi.org/10.1017/cts.2023.122","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/6BEA63BCAE294A5A906223C481CD878F/S205986612300122Xa.pdf/div-class-title-25-in-hospital-change-in-lung-ultrasound-congestion-score-predicts-heart-failure-rehospitalization-and-death-implications-for-clinical-trials-div.pdf","source":{"id":"https://openalex.org/S4210205013","display_name":"Journal of Clinical and Translational Science","issn_l":"2059-8661","issn":["2059-8661"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366830678.pdf","grobid_xml":"https://content.openalex.org/works/W4366830678.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385779390","https://openalex.org/W4393163922","https://openalex.org/W7203949979","https://openalex.org/W2921438360","https://openalex.org/W4406413490","https://openalex.org/W4400470093","https://openalex.org/W4292687553","https://openalex.org/W2996021393","https://openalex.org/W4415567724","https://openalex.org/W2900794242"],"abstract_inverted_index":{"OBJECTIVES/GOALS:":[0],"Lung":[1],"Ultrasound":[2],"Congestion":[3],"Score":[4],"(LUS-CS)":[5],"is":[6],"a":[7,57,67,77,123,128,211],"proposed":[8],"measure":[9],"for":[10,40,101,127,150,189,247],"guiding":[11],"treatment":[12],"in":[13,47,70,84,115,143,170,176,194,216,233,241],"acute":[14],"heart":[15,153],"failure":[16,154],"(AHF).":[17],"An":[18],"emergency":[19],"department":[20],"(ED)":[21],"pilot":[22,68],"trial":[23,69],"of":[24,61,108,131,238],"LUS-guided":[25,78,234],"diuresis":[26,79],"showed":[27],"reduced":[28],"LUS-CS":[29,48,109,116,144,177,217,223],"at":[30,36],"48":[31],"hours":[32],"but":[33],"no":[34],"difference":[35],"hospital":[37,181,256],"discharge":[38,182],"or":[39,133,206],"clinical":[41,248],"outcomes.":[42,52],"We":[43,121],"hypothesized":[44],"total":[45,137,224],"change":[46,114,142,215,259],"would":[49],"predict":[50,230],"adverse":[51,231],"METHODS/STUDY":[53],"POPULATION:":[54],"This":[55,198],"was":[56,66,89,99,210],"post-hoc":[58],"secondary":[59],"analysis":[60],"the":[62,85,92,102,146,151,239,254],"BLUSHED-AHF":[63,65,98,171,242],"trial.":[64],"which":[71],"AHF":[72,134,267],"patients":[73,169],"were":[74,160,172],"randomized":[75],"to":[76,104,139,180],"strategy":[80],"vs.":[81],"usual":[82],"care":[83],"ED.":[86],"The":[87],"intervention":[88,103,240],"stopped":[90],"after":[91],"ED":[93,179,207],"course":[94],"(i.e.":[95],"during":[96],"hospitalization).":[97],"designed":[100],"target":[105,258],"absolute":[106,228],"values":[107],"over":[110],"time,":[111],"rather":[112],"than":[113],"from":[117,178,260],"each":[118,190],"patient\u2019s":[119],"baseline.":[120],"fit":[122],"cox":[124],"regression":[125],"model":[126],"primary":[129,147],"outcome":[130],"death":[132],"rehospitalization,":[135],"with":[136],"(ED":[138],"Hospital":[140],"Discharge)":[141],"as":[145],"predictor,":[148],"adjusted":[149],"Get-With-The-Guidelines":[152],"risk":[155],"score":[156,220],"(GWTG).":[157],"Survival":[158],"curves":[159],"plotted,":[161],"and":[162,218,226,262,269],"hazard":[163],"ratios":[164],"calculated.":[165],"RESULTS/ANTICIPATED":[166],"RESULTS:":[167],"128":[168],"analyzed.":[173],"Greater":[174],"reduction":[175,193],"predicted":[183],"event-free":[184],"survival":[185],"(HR":[186],"=":[187],"0.74":[188],"20":[191],"unit":[192],"LUS-CS,":[195],"95%CI":[196],"0.56-0.99).":[197],"effect":[199],"did":[200],"not":[201,227],"vary":[202],"by":[203,266],"hospitalization":[204],"length":[205],"disposition.":[208],"There":[209],"significant":[212],"interaction":[213],"between":[214],"GWTG":[219],"(p":[221],"DISCUSSION/SIGNIFICANCE:":[222],"change,":[225],"values,":[229],"events":[232],"diuresis.":[235],"Post-ED":[236],"cessation":[237],"may":[243],"have":[244],"precluded":[245],"opportunity":[246],"benefit.":[249],"Future":[250],"trials":[251],"should":[252],"run":[253],"entire":[255],"course,":[257],"baseline,":[261],"consider":[263],"patient":[264],"selection":[265],"severity":[268],"initial":[270],"LUS-CS.":[271]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-04-25T00:00:00"}