{"id":"https://openalex.org/W4366758709","doi":"https://doi.org/10.31234/osf.io/sre8p","title":"Epigenetic and chronological age: Associations with cognitive performance in daily life","display_name":"Epigenetic and chronological age: Associations with cognitive performance in daily life","publication_year":2023,"publication_date":"2023-04-21","ids":{"openalex":"https://openalex.org/W4366758709","doi":"https://doi.org/10.31234/osf.io/sre8p"},"language":"en","primary_location":{"id":"doi:10.31234/osf.io/sre8p","doi":"https://doi.org/10.31234/osf.io/sre8p","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/sre8p","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.31234/osf.io/sre8p","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124390677","display_name":"Daisy V Zavala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisy V Zavala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091602953","display_name":"Natalie Dzikowski","orcid":"https://orcid.org/0009-0000-2747-6445","observed_orcids":["https://orcid.org/0009-0000-2747-6445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natali Dzikowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023253169","display_name":"Shyamalika Gopalan","orcid":"https://orcid.org/0000-0002-2608-8472","observed_orcids":["https://orcid.org/0000-0002-2608-8472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shyamalika Gopalan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063088763","display_name":"Karra Harrington","orcid":"https://orcid.org/0000-0001-9230-2978","observed_orcids":["https://orcid.org/0000-0001-9230-2978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karra Harrington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040795118","display_name":"Giancarlo Pasquini","orcid":"https://orcid.org/0000-0002-0647-1415","observed_orcids":["https://orcid.org/0000-0002-0647-1415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giancarlo Pasquini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011211755","display_name":"Jacqueline A. Mogle","orcid":"https://orcid.org/0000-0002-6082-228X","observed_orcids":["https://orcid.org/0000-0002-6082-228X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline Mogle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6082-228X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016983065","display_name":"Kerry Reid","orcid":"https://orcid.org/0000-0001-5653-9935","observed_orcids":["https://orcid.org/0000-0001-5653-9935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerry Reid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075873735","display_name":"Martin J. Sliwinski","orcid":"https://orcid.org/0000-0002-9611-7558","observed_orcids":["https://orcid.org/0000-0002-9611-7558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Sliwinski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039035377","display_name":"Jennifer E. Graham\u2010Engeland","orcid":"https://orcid.org/0000-0002-9940-2856","observed_orcids":["https://orcid.org/0000-0002-9940-2856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Graham-Engeland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104112758","display_name":"Christopher Gerald Engeland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Gerald Engeland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077002680","display_name":"Kristin Bernard","orcid":"https://orcid.org/0000-0003-2421-8453","observed_orcids":["https://orcid.org/0000-0003-2421-8453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin Bernard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075133785","display_name":"Krishna R. Veeramah","orcid":"https://orcid.org/0000-0002-6768-4000","observed_orcids":["https://orcid.org/0000-0002-6768-4000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krishna Veeramah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048046796","display_name":"Stacey Scott","orcid":"https://orcid.org/0000-0002-7060-4964","observed_orcids":["https://orcid.org/0000-0002-7060-4964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacey Scott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7060-4964","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.07639999687671661,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.057500001043081284,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-age-acceleration","display_name":"epigenetic age acceleration","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-methylation-clocks","display_name":"DNA methylation clocks","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chronological-age","display_name":"chronological age","score":0.8560000061988831},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.7879999876022339},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":1.0},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.8109999895095825},{"id":"https://openalex.org/keywords/middle-aged-adults","display_name":"middle-aged adults","score":0.7039999961853027},{"id":"https://openalex.org/keywords/grimage","display_name":"GrimAge","score":0.5619999766349792},{"id":"https://openalex.org/keywords/phenoage","display_name":"PhenoAge","score":0.7879999876022339},{"id":"https://openalex.org/keywords/hannum-clock","display_name":"Hannum clock","score":0.7480000257492065},{"id":"https://openalex.org/keywords/horvath-clock","display_name":"Horvath clock","score":0.7760000228881836},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6460040807723999},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6343285441398621},{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.5270103216171265},{"id":"https://openalex.org/C2986811735","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Cognitive aging","level":3,"score":0.5219713449478149},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.520054042339325},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.5024092197418213},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4163810610771179},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.4121040403842926},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.36411774158477783},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.34902966022491455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2666255533695221},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.2514845132827759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22370830178260803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1120811402797699},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09538698196411133},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.31234/osf.io/sre8p","doi":"https://doi.org/10.31234/osf.io/sre8p","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/sre8p","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:share.osf.io:9ca4b063-1ee0-4acf-86bc-c614f0fa1eb4","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/sre8p","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"pmh:oai:share.osf.io:E01B1-599-4E3","doi":null,"is_oa":false,"landing_page_url":"http://osf.io/sre8p/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401687","display_name":"PsyArXiv (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"preprint"}],"best_oa_location":{"id":"doi:10.31234/osf.io/sre8p","doi":"https://doi.org/10.31234/osf.io/sre8p","is_oa":true,"landing_page_url":"https://doi.org/10.31234/osf.io/sre8p","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388014831","https://openalex.org/W4410457540","https://openalex.org/W7062716703","https://openalex.org/W4405969774","https://openalex.org/W7214430993","https://openalex.org/W4390198335","https://openalex.org/W7155095402","https://openalex.org/W7214067996","https://openalex.org/W4294692203","https://openalex.org/W2853644493"],"abstract_inverted_index":{"DNA":[0],"methylation-derived":[1],"epigenetic":[2,66,91,114,202],"clocks":[3],"offer":[4],"the":[5,14],"opportunity":[6],"to":[7,87],"examine":[8,88],"aspects":[9],"of":[10,54,65,73,90,107,210],"age":[11,20,67,92,111,115,137,152,186,198,203],"acceleration":[12,68,93,112,153,187,204],"(i.e.,":[13,113],"difference":[15],"between":[16,62],"an":[17],"individual\u2019s":[18],"biological":[19],"and":[21,28,69,76,105,129,131,146,164,212],"chronological":[22,39,81,118,136,197,219],"age),":[23],"which":[24],"vary":[25],"among":[26],"individuals":[27],"may":[29,205],"better":[30,208],"account":[31],"for":[32,80,196],"age-related":[33],"changes":[34],"in":[35,46,57,161,215],"cognitive":[36,44,108,216],"function":[37],"than":[38,117,218],"age.":[40,220],"Leveraging":[41],"existing":[42],"ambulatory":[43],"assessments":[45],"daily":[47],"life":[48],"from":[49],"a":[50,207],"genetically":[51],"diverse":[52],"sample":[53],"142":[55],"adults":[56],"midlife,":[58],"we":[59,83],"examined":[60],"associations":[61,89],"five":[63],"measures":[64],"performance":[70,217],"on":[71],"tasks":[72],"processing":[74,125,144,165],"speed":[75,126,145,166],"working":[77,132,147,162],"memory.":[78],"Covarying":[79],"age,":[82],"used":[84],"multilevel":[85],"models":[86],"(Horvath":[94,127],"1,":[95],"Horvath":[96],"2,":[97],"Hannum,":[98],"PhenoAge,":[99],"GrimAge":[100],"clocks)":[101],"with":[102,122,141,157,174],"both":[103],"average-level":[104],"variability":[106,160],"performance.":[109,149],"Positive":[110],"greater":[116,158,192],"age)":[119],"was":[120,138,154,172],"associated":[121,140,156,173],"poorer":[123,142],"mean":[124,143],"1":[128],"2)":[130],"memory":[133,148,163],"(GrimAge).":[134],"Higher":[135],"also":[139],"Further,":[150],"positive":[151],"generally":[155],"intraindividual":[159,176],"tasks,":[167],"whereas":[168],"being":[169],"chronologically":[170],"older":[171],"less":[175],"variability.":[177],"Although":[178],"further":[179],"work":[180],"is":[181],"needed,":[182],"our":[183],"results":[184],"indicate":[185],"effects":[188],"have":[189],"comparable":[190],"or":[191],"size":[193],"as":[194],"those":[195],"differences,":[199],"suggesting":[200],"that":[201],"be":[206],"marker":[209],"risk":[211],"interindividual":[213],"variation":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2023-04-24T00:00:00"}