{"id":"https://openalex.org/W4366609288","doi":"https://doi.org/10.1097/mpg.0000000000003796","title":"An Open Label, Randomized, Multicenter Study of Elafibranor in Children With Nonalcoholic Steatohepatitis","display_name":"An Open Label, Randomized, Multicenter Study of Elafibranor in Children With Nonalcoholic Steatohepatitis","publication_year":2023,"publication_date":"2023-04-21","ids":{"openalex":"https://openalex.org/W4366609288","doi":"https://doi.org/10.1097/mpg.0000000000003796","pmid":"https://pubmed.ncbi.nlm.nih.gov/37084342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523882"},"language":"en","primary_location":{"id":"doi:10.1097/mpg.0000000000003796","doi":"https://doi.org/10.1097/mpg.0000000000003796","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0000000000003796","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523882/pdf/nihms-1892779.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068620258","display_name":"Nidhi P. Goyal","orcid":"https://orcid.org/0000-0002-2022-0073","observed_orcids":["https://orcid.org/0000-0002-2022-0073","https://orcid.org/0009-0005-9884-1178"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nidhi P. Goyal","raw_affiliation_strings":["Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA","institution_ids":["https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023967261","display_name":"Ali Mencin","orcid":"https://orcid.org/0000-0002-8971-993X","observed_orcids":["https://orcid.org/0000-0002-8971-993X"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Mencin","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University, New York, NY","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039047714","display_name":"Kimberly P. Newton","orcid":"https://orcid.org/0009-0000-9533-8685","observed_orcids":["https://orcid.org/0009-0000-9533-8685"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kimberly P. Newton","raw_affiliation_strings":["Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA","institution_ids":["https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005537189","display_name":"Janis Durelle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janis Durelle","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007584499","display_name":"Carissa Carrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carissa Carrier","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015216068","display_name":"Patricia Ugalde\u2010Nicalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia Ugalde\u2010Nicalo","raw_affiliation_strings":["Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Benoit Noel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210110047","display_name":"Genfit (France)","ror":"https://ror.org/01zd9gz71","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210110047"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Benoit Noel","raw_affiliation_strings":["GENFIT SA, Loos, France","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT SA, Loos, France","institution_ids":["https://openalex.org/I4210110047"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010592319","display_name":"Julie Mouton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210110047","display_name":"Genfit (France)","ror":"https://ror.org/01zd9gz71","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210110047"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Julie Mouton","raw_affiliation_strings":["GENFIT SA, Loos, France","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT SA, Loos, France","institution_ids":["https://openalex.org/I4210110047"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089063566","display_name":"Dawn Vargas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dawn Vargas","raw_affiliation_strings":["GENFIT Corp., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT Corp., Cambridge, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017689340","display_name":"David Magrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210110047","display_name":"Genfit (France)","ror":"https://ror.org/01zd9gz71","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210110047"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"David Magrez","raw_affiliation_strings":["GENFIT SA, Loos, France","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT SA, Loos, France","institution_ids":["https://openalex.org/I4210110047"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025085004","display_name":"Bachirou Tadd\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210110047","display_name":"Genfit (France)","ror":"https://ror.org/01zd9gz71","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210110047"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Bachirou Tadde","raw_affiliation_strings":["GENFIT SA, Loos, France","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT SA, Loos, France","institution_ids":["https://openalex.org/I4210110047"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071117674","display_name":"PASCAL BIRMAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210110047","display_name":"Genfit (France)","ror":"https://ror.org/01zd9gz71","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210110047"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Pascal Birman","raw_affiliation_strings":["GENFIT SA, Loos, France","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT SA, Loos, France","institution_ids":["https://openalex.org/I4210110047"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081233385","display_name":"Brookie M. Best","orcid":"https://orcid.org/0000-0001-8569-2293","observed_orcids":["https://orcid.org/0000-0001-8569-2293"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brookie M. Best","raw_affiliation_strings":["Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089852008","display_name":"Carol Addy","orcid":"https://orcid.org/0000-0003-1028-2649","observed_orcids":["https://orcid.org/0000-0003-1028-2649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol Addy","raw_affiliation_strings":["GENFIT Corp., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GENFIT Corp., Cambridge, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078577867","display_name":"Jeffrey B. Schwimmer","orcid":"https://orcid.org/0000-0001-8538-2877","observed_orcids":["https://orcid.org/0000-0001-8538-2877"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210087384","display_name":"Rady Children's Hospital-San Diego","ror":"https://ror.org/00414dg76","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087384"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey B. Schwimmer","raw_affiliation_strings":["Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA","Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA","institution_ids":["https://openalex.org/I4210087384"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, UC San Diego, School of Medicine, La Jolla, CA","institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005537189","https://openalex.org/A5007584499","https://openalex.org/A5015216068","https://openalex.org/A5039047714","https://openalex.org/A5068620258","https://openalex.org/A5078577867"],"corresponding_institution_ids":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210087384"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":2.7808,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.9173883,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"77","issue":"2","first_page":"160","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elafibranor","display_name":"elafibranor","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pediatric-nonalcoholic-fatty-liver-disease","display_name":"pediatric nonalcoholic fatty liver disease","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7900000214576721},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9039620161056519},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.711017370223999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6572157740592957},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5944061875343323},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.5474881529808044},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5081198215484619},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.4959450662136078},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.48153072595596313},{"id":"https://openalex.org/C3018708256","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic steatohepatitis","level":5,"score":0.4766060709953308},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.4612179696559906},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3163451552391052},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.27577799558639526},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0775960385799408},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.056065142154693604}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011422","descriptor_name":"Propionates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/mpg.0000000000003796","doi":"https://doi.org/10.1097/mpg.0000000000003796","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mpg.0000000000003796","pdf_url":null,"source":{"id":"https://openalex.org/S197964821","display_name":"Journal of Pediatric Gastroenterology and Nutrition","issn_l":"0277-2116","issn":["0277-2116","1536-4801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition","raw_type":"journal-article"},{"id":"pmid:37084342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37084342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric gastroenterology and nutrition","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:10523882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523882","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523882/pdf/nihms-1892779.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Pediatr Gastroenterol Nutr","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0s3550hz","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0s3550hz","pdf_url":"https://escholarship.org/content/qt0s3550hz/qt0s3550hz.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pediatric Gastroenterology and Nutrition, vol 77, iss 2","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10523882","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10523882","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10523882/pdf/nihms-1892779.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Pediatr Gastroenterol Nutr","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8021374757","display_name":null,"funder_award_id":"UL1TR001442","funder_id":"https://openalex.org/F4320332603","funder_display_name":"University of California, San Diego"},{"id":"https://openalex.org/G8769330356","display_name":"UC San Diego Clinical and Translational Research Institute","funder_award_id":"UL1TR001442","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000857426","display_name":"Clinical and Translational Science Award","funder_award_id":"UL1TR001873","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366609288.pdf","grobid_xml":"https://content.openalex.org/works/W4366609288.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1966224744","https://openalex.org/W1978125779","https://openalex.org/W2066841620","https://openalex.org/W2072362233","https://openalex.org/W2075094829","https://openalex.org/W2078391210","https://openalex.org/W2092700213","https://openalex.org/W2149342673","https://openalex.org/W2169848635","https://openalex.org/W2171697576","https://openalex.org/W2253420963","https://openalex.org/W2493440403","https://openalex.org/W2510312151","https://openalex.org/W2558403761","https://openalex.org/W2612581702","https://openalex.org/W2797947316","https://openalex.org/W2883371150","https://openalex.org/W2911795662","https://openalex.org/W2973202887","https://openalex.org/W2988970608","https://openalex.org/W3024480438","https://openalex.org/W3094033262","https://openalex.org/W3176502621","https://openalex.org/W4206293601"],"related_works":["https://openalex.org/W4229506137","https://openalex.org/W1975929271","https://openalex.org/W2253420963","https://openalex.org/W3187467316","https://openalex.org/W2157671355","https://openalex.org/W2003403665","https://openalex.org/W4210925833","https://openalex.org/W2362766956","https://openalex.org/W2806788063","https://openalex.org/W6981443010"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Nonalcoholic":[1],"fatty":[2],"liver":[3,10,249],"disease":[4,11],"is":[5],"the":[6,162,194,237],"most":[7],"common":[8],"chronic":[9],"in":[12,53,61,175,222,236,248,259,271],"children.":[13],"Elafibranor,":[14],"a":[15,26,170,199,228,255],"dual":[16],"peroxisome":[17],"proliferator-activated":[18],"receptor":[19],"\u03b1/\u03b4":[20],"agonist,":[21],"has":[22],"been":[23],"proposed":[24],"as":[25],"treatment":[27,185],"for":[28,78,142,193,257],"nonalcoholic":[29],"steatohepatitis":[30],"(NASH).":[31],"The":[32,81],"aims":[33],"were":[34,67,99,113],"to":[35,69,115],"(1)":[36],"describe":[37],"pharmacokinetics":[38],"(PK),":[39],"safety,":[40],"and":[41,50,57,96,137,145,154,165,172,178],"tolerability":[42],"of":[43,184,206,217,269],"oral":[44],"elafibranor":[45,71,218,270],"at":[46,89,210],"2":[47],"doses":[48],"(80":[49],"120":[51,75,122,146,166,195,238],"mg)":[52],"children":[54,223,272],"8-17":[55],"years":[56],"(2)":[58],"assess":[59],"changes":[60],"aminotransferases.":[62],"METHODS:":[63],"Children":[64],"with":[65,111,169,198,224,246,273],"NASH":[66,112],"randomized":[68,114],"open-label":[70],"80":[72,116,143,163],"mg":[73,76,117,123,144,147,164,167,196,239],"or":[74,121],"daily":[77,215],"12":[79,211],"weeks.":[80,212],"intent-to-treat":[82],"analysis":[83],"included":[84],"all":[85],"participants":[86],"who":[87],"received":[88],"least":[90],"1":[91],"dose.":[92],"Standard":[93],"descriptive":[94],"statistics":[95],"PK":[97],"analyses":[98],"performed.":[100],"RESULTS:":[101],"Ten":[102],"males":[103],"[mean":[104],"15.1":[105],"years,":[106],"standard":[107],"deviation":[108],"(SD)":[109],"2.2]":[110],"(n":[118,124],"=":[119,125],"5)":[120],"5).":[126],"Baseline":[127],"mean":[128,186,201,233],"alanine":[129],"aminotransferase":[130],"(ALT)":[131],"was":[132,151,188,219,227],"82":[133],"U/L":[134,139,190],"(SD":[135,140,191,208],"13)":[136],"87":[138],"20)":[141,192],"groups,":[148],"respectively.":[149,182],"Elafibranor":[150,157],"rapidly":[152],"absorbed":[153],"well":[155,220],"tolerated.":[156],"plasma":[158],"exposure":[159],"increased":[160],"between":[161],"dose":[168],"1.9-":[171],"1.3-fold":[173],"increase":[174],"median":[176],"Cmax":[177],"AUC":[179],"0-24":[180],",":[181],"End":[183],"ALT":[187,202,235,242],"52":[189],"group,":[197],"relative":[200,230],"change":[203],"from":[204,232],"baseline":[205,234],"-37.4%":[207],"23.8%)":[209],"CONCLUSIONS:":[213],"Once":[214],"dosing":[216],"tolerated":[221],"NASH.":[225,274],"There":[226],"37.4%":[229],"reduction":[231],"group.":[240],"Decreasing":[241],"may":[243,265],"be":[244,253],"associated":[245],"improvement":[247],"histology,":[250],"thus":[251],"could":[252],"considered":[254],"surrogate":[256],"histology":[258],"early":[260],"phase":[261],"trials.":[262],"These":[263],"results":[264],"support":[266],"further":[267],"exploration":[268]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-23T00:00:00"}
