{"id":"https://openalex.org/W4366609028","doi":"https://doi.org/10.1016/j.mcpro.2023.100556","title":"Germ Cell\u2013Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive Azoospermia","display_name":"Germ Cell\u2013Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive Azoospermia","publication_year":2023,"publication_date":"2023-04-21","ids":{"openalex":"https://openalex.org/W4366609028","doi":"https://doi.org/10.1016/j.mcpro.2023.100556","pmid":"https://pubmed.ncbi.nlm.nih.gov/37087050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10209038"},"language":"en","primary_location":{"id":"doi:10.1016/j.mcpro.2023.100556","doi":"https://doi.org/10.1016/j.mcpro.2023.100556","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mcpro.2023.100556","pdf_url":"http://www.mcponline.org/article/S153594762300066X/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular &amp; Cellular Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.mcponline.org/article/S153594762300066X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100606709","display_name":"Junyan Zhang","orcid":"https://orcid.org/0000-0001-8679-1373","observed_orcids":["https://orcid.org/0000-0001-8679-1373"]},"institutions":[{"id":"https://openalex.org/I4210157932","display_name":"CReATe Fertility Centre","ror":"https://ror.org/047acnh17","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210157932"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Junyan Zhang","raw_affiliation_strings":["CReATe Fertility Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CReATe Fertility Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210157932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065515462","display_name":"Mirzo Kanoatov","orcid":"https://orcid.org/0000-0002-0411-8394","observed_orcids":["https://orcid.org/0000-0002-0411-8394"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mirzo Kanoatov","raw_affiliation_strings":["Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0411-8394","affiliations":[{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046304922","display_name":"Keith Allen Jarvi","orcid":"https://orcid.org/0000-0001-6966-9114","observed_orcids":["https://orcid.org/0000-0001-6966-9114"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Keith Jarvi","raw_affiliation_strings":["Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, Ontario, Canada","Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, Ontario, Canada","Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]},{"raw_affiliation_string":"Department of Surgery, Division of Urology, Mount Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025483610","display_name":"Andr\u00e9e Gauthier-Fisher","orcid":"https://orcid.org/0000-0002-1932-4684","observed_orcids":["https://orcid.org/0000-0002-1932-4684"]},"institutions":[{"id":"https://openalex.org/I4210157932","display_name":"CReATe Fertility Centre","ror":"https://ror.org/047acnh17","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210157932"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andree Gauthier-Fisher","raw_affiliation_strings":["CReATe Fertility Centre, Toronto, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1932-4684","affiliations":[{"raw_affiliation_string":"CReATe Fertility Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210157932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073293436","display_name":"Sergey I. Moskovtsev","orcid":"https://orcid.org/0000-0003-1303-6048","observed_orcids":["https://orcid.org/0000-0003-1303-6048"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210157932","display_name":"CReATe Fertility Centre","ror":"https://ror.org/047acnh17","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210157932"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sergey I. Moskovtsev","raw_affiliation_strings":["CReATe Fertility Centre, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","CReATe Fertility Centre, Toronto, Ontario, Canada","Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CReATe Fertility Centre, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4210157932"]},{"raw_affiliation_string":"CReATe Fertility Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210157932"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005426292","display_name":"Clifford Lawrence Librach","orcid":"https://orcid.org/0000-0002-9699-4059","observed_orcids":["https://orcid.org/0000-0002-9699-4059"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4210157932","display_name":"CReATe Fertility Centre","ror":"https://ror.org/047acnh17","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210157932"]},{"id":"https://openalex.org/I4210167439","display_name":"Sunnybrook Hospital","ror":"https://ror.org/008kn1a71","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4210167439"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Clifford Librach","raw_affiliation_strings":["CReATe Fertility Centre, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Sunnybrook Research Institute, Toronto, Ontario, Canada","CReATe Fertility Centre, Toronto, Ontario, Canada","Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada","Department of Physiology, University of Toronto, Toronto, Ontario, Canada","Sunnybrook Research Institute, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CReATe Fertility Centre, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada; Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I4210157932","https://openalex.org/I4391768120"]},{"raw_affiliation_string":"CReATe Fertility Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210157932"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Sunnybrook Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I4210167439","https://openalex.org/I4391768120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056642098","display_name":"Andrei P. Drabovich","orcid":"https://orcid.org/0000-0003-3049-7145","observed_orcids":["https://orcid.org/0000-0003-3049-7145"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Andrei P. Drabovich","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada. Electronic address: andrei.drabovich@ualberta.ca","Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":"https://orcid.org/0000-0003-3049-7145","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada. Electronic address: andrei.drabovich@ualberta.ca","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5056642098"],"corresponding_institution_ids":["https://openalex.org/I154425047"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":2.985,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.91025009,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"22","issue":"6","first_page":"100556","last_page":"100556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13242","display_name":"Male Reproductive Health Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-obstructive-azoospermia","display_name":"non-obstructive azoospermia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/akap4","display_name":"AKAP4","score":0.7670000195503235},{"id":"https://openalex.org/keywords/microdissection-testicular-sperm-extraction","display_name":"microdissection testicular sperm extraction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.7519999742507935},{"id":"https://openalex.org/keywords/sperm-flagellum","display_name":"sperm flagellum","score":0.4740000069141388},{"id":"https://openalex.org/keywords/acrosome","display_name":"acrosome","score":0.984000027179718},{"id":"https://openalex.org/keywords/hoechst-staining","display_name":"Hoechst staining","score":0.796999990940094},{"id":"https://openalex.org/keywords/imaging-flow-cytometry","display_name":"imaging flow cytometry","score":0.7820000052452087},{"id":"https://openalex.org/keywords/testis-specific-proteins","display_name":"testis-specific proteins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/sperm-retrieval-prediction","display_name":"sperm retrieval prediction","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C2777420699","wikidata":"https://www.wikidata.org/wiki/Q794026","display_name":"Azoospermia","level":4,"score":0.704076886177063},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6272136569023132},{"id":"https://openalex.org/C2779122487","wikidata":"https://www.wikidata.org/wiki/Q281579","display_name":"Germ cell","level":3,"score":0.5490975975990295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4099283516407013},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.40143686532974243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3289604187011719},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32057470083236694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3028548061847687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17980843782424927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1778683066368103},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.17327138781547546},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1613137423992157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09811282157897949},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053713","descriptor_name":"Azoospermia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053713","descriptor_name":"Azoospermia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053713","descriptor_name":"Azoospermia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D054758","descriptor_name":"A Kinase Anchor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.mcpro.2023.100556","doi":"https://doi.org/10.1016/j.mcpro.2023.100556","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mcpro.2023.100556","pdf_url":"http://www.mcponline.org/article/S153594762300066X/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular &amp; Cellular Proteomics","raw_type":"journal-article"},{"id":"doi:10.1101/2022.09.15.22280011","doi":"https://doi.org/10.1101/2022.09.15.22280011","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.09.15.22280011","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2022/09/17/2022.09.15.22280011.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10209038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10209038","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10209038/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Proteomics","raw_type":"Text"},{"id":"pmid:37087050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37087050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular proteomics : MCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.mcpro.2023.100556","doi":"https://doi.org/10.1016/j.mcpro.2023.100556","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.mcpro.2023.100556","pdf_url":"http://www.mcponline.org/article/S153594762300066X/pdf","source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular &amp; Cellular Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3779483730","display_name":null,"funder_award_id":"#355146","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6418865906","display_name":null,"funder_award_id":"303100","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320310747","display_name":"Movember Foundation","ror":"https://ror.org/040eybd64"},{"id":"https://openalex.org/F4320319921","display_name":"Prostate Cancer Canada","ror":"https://ror.org/03p641z80"},{"id":"https://openalex.org/F4320319946","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320319981","display_name":"Physicians' Services Incorporated Foundation","ror":"https://ror.org/0385yzn06"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366609028.pdf","grobid_xml":"https://content.openalex.org/works/W4366609028.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W327137974","https://openalex.org/W370504484","https://openalex.org/W424077279","https://openalex.org/W1910049290","https://openalex.org/W1910732401","https://openalex.org/W1973321737","https://openalex.org/W1981294952","https://openalex.org/W1983611278","https://openalex.org/W1988324145","https://openalex.org/W1988350864","https://openalex.org/W1998765170","https://openalex.org/W2008987619","https://openalex.org/W2012034410","https://openalex.org/W2015120218","https://openalex.org/W2019044222","https://openalex.org/W2021443328","https://openalex.org/W2030592563","https://openalex.org/W2041820065","https://openalex.org/W2045140820","https://openalex.org/W2057733697","https://openalex.org/W2063063530","https://openalex.org/W2064848194","https://openalex.org/W2068459641","https://openalex.org/W2078096350","https://openalex.org/W2079216108","https://openalex.org/W2081254090","https://openalex.org/W2085077505","https://openalex.org/W2089003364","https://openalex.org/W2125026410","https://openalex.org/W2125853381","https://openalex.org/W2128564638","https://openalex.org/W2132058414","https://openalex.org/W2133069770","https://openalex.org/W2137686870","https://openalex.org/W2139681830","https://openalex.org/W2139718640","https://openalex.org/W2140145660","https://openalex.org/W2140155077","https://openalex.org/W2143025831","https://openalex.org/W2148009220","https://openalex.org/W2149620854","https://openalex.org/W2159286617","https://openalex.org/W2168108725","https://openalex.org/W2171724541","https://openalex.org/W2196510095","https://openalex.org/W2314170505","https://openalex.org/W2316954565","https://openalex.org/W2339886882","https://openalex.org/W2340317259","https://openalex.org/W2347007040","https://openalex.org/W2437524902","https://openalex.org/W2465760346","https://openalex.org/W2472989101","https://openalex.org/W2538882363","https://openalex.org/W2559347256","https://openalex.org/W2560310361","https://openalex.org/W2593621562","https://openalex.org/W2802401931","https://openalex.org/W2806261901","https://openalex.org/W2900768108","https://openalex.org/W2913732601","https://openalex.org/W2944710496","https://openalex.org/W2952831894","https://openalex.org/W2954232647","https://openalex.org/W3128222907","https://openalex.org/W3136190116","https://openalex.org/W3144587591","https://openalex.org/W3178645681","https://openalex.org/W3188375721","https://openalex.org/W3206997101","https://openalex.org/W4229590205","https://openalex.org/W4241912284","https://openalex.org/W4295309656","https://openalex.org/W6730097365"],"related_works":["https://openalex.org/W4296157783","https://openalex.org/W3196909224","https://openalex.org/W2890162763","https://openalex.org/W2041472560","https://openalex.org/W7204119376","https://openalex.org/W3214803282","https://openalex.org/W7162792769","https://openalex.org/W2233100994","https://openalex.org/W4394618965","https://openalex.org/W2063063530"],"abstract_inverted_index":{"Non-obstructive":[0],"azoospermia":[1],"(NOA),":[2],"the":[3,22,76,131,143,169],"most":[4],"severe":[5,201],"form":[6],"of":[7,41,48,70,78,111,127,149,168,189,200,203],"male":[8,204],"infertility,":[9],"could":[10],"be":[11],"treated":[12],"with":[13,21,157],"intracytoplasmic":[14],"sperm":[15,25],"injection,":[16],"providing":[17],"spermatozoa":[18,43,95,122,136,192],"were":[19],"retrieved":[20],"microdissection":[23],"testicular":[24],"extraction":[26],"(mTESE).":[27],"We":[28],"hypothesized":[29],"that":[30],"testis-specific":[31,72],"and":[32,62,66,87,97,108,147,160,165,198],"germ":[33,79,83],"cell\u2013specific":[34,84],"proteins":[35,73,85],"would":[36],"facilitate":[37],"flow":[38,103],"cytometry-assisted":[39],"identification":[40,110,167],"rare":[42,112],"in":[44,94],"semen":[45,125],"cell":[46,80],"pellets":[47,126],"NOA":[49,128],"patients,":[50],"thus":[51,195],"enabling":[52],"non-invasive":[53],"diagnostics":[54,197],"prior":[55],"to":[56,186],"mTESE.":[57],"Data":[58],"mining,":[59],"targeted":[60],"proteomics,":[61],"immunofluorescent":[63],"microscopy":[64],"identified":[65],"verified":[67],"a":[68,183],"panel":[69],"highly":[71],"expressed":[74],"at":[75],"continuum":[77],"differentiation.":[81],"Late":[82],"AKAP4_HUMAN":[86],"ASPX_HUMAN":[88],"(ACRV1":[89],"gene)":[90],"revealed":[91],"exclusive":[92],"localization":[93],"tails":[96,159],"acrosomes,":[98],"respectively.":[99],"A":[100],"multiplex":[101],"imaging":[102],"cytometry":[104],"assay":[105,179],"facilitated":[106,163],"fast":[107,164],"unambiguous":[109,166],"but":[113],"morphologically":[114,190],"intact":[115,171,191],"AKAP4":[116,150,173],"+":[117,119,121,151,153,155,174,176,178],"/ASPX":[118,152,175],"/Hoechst":[120,154,177],"within":[123],"debris-laden":[124],"patients.":[129],"While":[130],"previously":[132],"suggested":[133],"markers":[134],"for":[135],"retrieval":[137,188],"suffered":[138],"from":[139],"low":[140],"diagnostic":[141],"specificity,":[142],"multistep":[144],"gating":[145],"strategy":[146],"visualization":[148],"cells":[156],"elongated":[158],"acrosome-capped":[161],"nuclei":[162],"mature":[170],"spermatozoa.":[172],"may":[180],"emerge":[181],"as":[182],"noninvasive":[184],"test":[185],"predict":[187],"by":[193],"mTESE,":[194],"improving":[196],"treatment":[199],"forms":[202],"infertility.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-04-23T00:00:00"}
