{"id":"https://openalex.org/W4366606734","doi":"https://doi.org/10.1016/j.jbc.2023.104732","title":"Arabidopsis nicotianamine synthases comprise a common core-NAS domain fused to a variable autoinhibitory C terminus","display_name":"Arabidopsis nicotianamine synthases comprise a common core-NAS domain fused to a variable autoinhibitory C terminus","publication_year":2023,"publication_date":"2023-04-21","ids":{"openalex":"https://openalex.org/W4366606734","doi":"https://doi.org/10.1016/j.jbc.2023.104732","pmid":"https://pubmed.ncbi.nlm.nih.gov/37086785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10248798"},"language":"en","primary_location":{"id":"doi:10.1016/j.jbc.2023.104732","doi":"https://doi.org/10.1016/j.jbc.2023.104732","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2023.104732","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jbc.2023.104732","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005176271","display_name":"Hiroyuki Seebach","orcid":"https://orcid.org/0000-0003-3896-2005","observed_orcids":["https://orcid.org/0000-0003-3896-2005"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hiroyuki Seebach","raw_affiliation_strings":["Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038127081","display_name":"Gabriel Radow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gabriel Radow","raw_affiliation_strings":["Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090120043","display_name":"Michael Brunek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Brunek","raw_affiliation_strings":["Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056248008","display_name":"Frank Schulz","orcid":"https://orcid.org/0000-0003-3946-7137","observed_orcids":["https://orcid.org/0000-0003-3946-7137"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Schulz","raw_affiliation_strings":["Chemistry and Biochemistry of Natural Products Research Group, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3946-7137","affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry of Natural Products Research Group, Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022168725","display_name":"Markus Piotrowski","orcid":"https://orcid.org/0000-0002-6347-3337","observed_orcids":["https://orcid.org/0000-0002-6347-3337"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus Piotrowski","raw_affiliation_strings":["Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany. Electronic address: Markus.Piotrowski@ruhr-uni-bochum.de","Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6347-3337","affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany. Electronic address: Markus.Piotrowski@ruhr-uni-bochum.de","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111502298","display_name":"Ute Kr\u00e4mer","orcid":"https://orcid.org/0000-0001-7870-4508","observed_orcids":["https://orcid.org/0000-0001-7870-4508"]},"institutions":[{"id":"https://openalex.org/I904495901","display_name":"Ruhr University Bochum","ror":"https://ror.org/04tsk2644","country_code":"DE","type":"education","lineage":["https://openalex.org/I904495901"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ute Kr\u00e4mer","raw_affiliation_strings":["Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany. Electronic address: Ute.Kraemer@ruhr-uni-bochum.de","Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7870-4508","affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany. Electronic address: Ute.Kraemer@ruhr-uni-bochum.de","institution_ids":["https://openalex.org/I904495901"]},{"raw_affiliation_string":"Department of Molecular Genetics and Physiology of Plants, Faculty of Biology and Biotechnology, Ruhr University Bochum, Bochum, Germany","institution_ids":["https://openalex.org/I904495901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022168725","https://openalex.org/A5111502298"],"corresponding_institution_ids":["https://openalex.org/I904495901"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":2.2157,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.86368154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"299","issue":"6","first_page":"104732","last_page":"104732"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.23839999735355377,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.1404000073671341,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotianamine-synthase","display_name":"nicotianamine synthase","score":1.0},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8709999918937683},{"id":"https://openalex.org/keywords/metal-homeostasis","display_name":"metal homeostasis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.4230000078678131},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.8293049931526184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5595090985298157},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.449806809425354},{"id":"https://openalex.org/C2993829489","wikidata":"https://www.wikidata.org/wiki/Q5153317","display_name":"Common core","level":3,"score":0.4484456181526184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4466601610183716},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4368268549442291},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36342114210128784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33229053020477295},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.331673800945282},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.330363392829895},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.28742629289627075},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1441391110420227},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.11602991819381714},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11457404494285583},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001383","descriptor_name":"Azetidinecarboxylic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jbc.2023.104732","doi":"https://doi.org/10.1016/j.jbc.2023.104732","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2023.104732","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"doi:10.1101/2022.10.13.512114","doi":"https://doi.org/10.1101/2022.10.13.512114","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.10.13.512114","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/17/2022.10.13.512114.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10248798","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10248798","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10248798/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:37086785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37086785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jbc.2023.104732","doi":"https://doi.org/10.1016/j.jbc.2023.104732","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jbc.2023.104732","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7806931193","display_name":null,"funder_award_id":"RTG 2341","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323715","display_name":"Ruhr-Universit\u00e4t Bochum","ror":"https://ror.org/04tsk2644"},{"id":"https://openalex.org/F4320323911","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366606734.pdf","grobid_xml":"https://content.openalex.org/works/W4366606734.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W102715436","https://openalex.org/W1517023791","https://openalex.org/W1557895981","https://openalex.org/W1918656749","https://openalex.org/W1965058477","https://openalex.org/W1966775372","https://openalex.org/W1967493657","https://openalex.org/W1968311763","https://openalex.org/W1973649172","https://openalex.org/W1978420188","https://openalex.org/W1986063867","https://openalex.org/W1991564945","https://openalex.org/W2002244380","https://openalex.org/W2007866059","https://openalex.org/W2017519756","https://openalex.org/W2018066181","https://openalex.org/W2018229525","https://openalex.org/W2025748522","https://openalex.org/W2066619228","https://openalex.org/W2073329425","https://openalex.org/W2077757827","https://openalex.org/W2084650212","https://openalex.org/W2096724410","https://openalex.org/W2101459938","https://openalex.org/W2102189122","https://openalex.org/W2104229357","https://openalex.org/W2109579035","https://openalex.org/W2110044349","https://openalex.org/W2114325411","https://openalex.org/W2115215363","https://openalex.org/W2120007834","https://openalex.org/W2132417277","https://openalex.org/W2141292707","https://openalex.org/W2144175569","https://openalex.org/W2148698435","https://openalex.org/W2152207030","https://openalex.org/W2153488363","https://openalex.org/W2161920846","https://openalex.org/W2339050814","https://openalex.org/W2403430327","https://openalex.org/W2529599567","https://openalex.org/W2765273628","https://openalex.org/W2779207844","https://openalex.org/W2780846753","https://openalex.org/W2786774014","https://openalex.org/W2795012206","https://openalex.org/W2795909519","https://openalex.org/W2804822363","https://openalex.org/W2892589395","https://openalex.org/W2947344552","https://openalex.org/W2983750859","https://openalex.org/W3006203673","https://openalex.org/W3045227871","https://openalex.org/W3049296996","https://openalex.org/W3149897898","https://openalex.org/W3156458251","https://openalex.org/W3177828909","https://openalex.org/W4200455205","https://openalex.org/W4200583967","https://openalex.org/W4235363561","https://openalex.org/W4251751280","https://openalex.org/W4283655942"],"related_works":["https://openalex.org/W2018229525","https://openalex.org/W2066619228","https://openalex.org/W1699340875","https://openalex.org/W2110044349","https://openalex.org/W4415270083","https://openalex.org/W6964298880","https://openalex.org/W2807211567","https://openalex.org/W1999521898","https://openalex.org/W3049296996","https://openalex.org/W7203790867"],"abstract_inverted_index":{"Nicotianamine":[0],"synthase":[1],"(NAS)":[2],"catalyzes":[3],"the":[4,7,14,66,110,138,166,170,206,230],"biosynthesis":[5,194],"of":[6,17,31,37,68,101,137,160,169,173,218,232,243],"low-molecular-mass":[8],"metal":[9,26,29],"chelator":[10],"nicotianamine":[11],"(NA)":[12],"from":[13],"2-aminobutyrate":[15],"moieties":[16],"three":[18],"SAM":[19],"molecules.":[20],"NA":[21,134,193],"has":[22],"central":[23],"roles":[24],"in":[25,189,224,245],"nutrition":[27],"and":[28,48,74,95,103,108,123,214,226],"homeostasis":[30],"flowering":[32,233],"plants.":[33,234],"The":[34],"enzymatic":[35],"function":[36],"NAS":[38,88,100,125,143,201,248],"remains":[39],"poorly":[40],"understood.":[41],"Crystal":[42],"structures":[43],"are":[44],"available":[45],"for":[46,65,165],"archaeal":[47],"bacterial":[49],"NAS-like":[50],"proteins":[51,89,144,202],"that":[52,126,185,203],"carry":[53],"out":[54],"simpler":[55],"aminobutanoyl":[56],"transferase":[57],"reactions.":[58],"Here,":[59],"we":[60,85,236],"report":[61],"amino":[62,158],"acids":[63,159],"essential":[64],"activity":[67,83],"AtNAS1":[69],"based":[70],"on":[71],"structural":[72],"modeling":[73],"site-directed":[75],"mutagenesis.":[76],"Using":[77],"a":[78,116,129,182,239],"newly":[79],"developed":[80],"enzyme-coupled":[81],"continuous":[82],"assay,":[84],"compare":[86],"differing":[87],"identified":[90],"through":[91],"multiple":[92],"sequence":[93],"alignments":[94],"phylogenetic":[96],"analyses.":[97],"In":[98],"most":[99],"dicotyledonous":[102],"monocotyledonous":[104],"plants":[105],"(class":[106,132],"Ia":[107,210],"Ib),":[109],"core-NAS":[111,130],"domain":[112,131],"is":[113,186,222],"fused":[114],"to":[115,121,179],"variable":[117],"C-terminal":[118,207],"domain.":[119],"Compared":[120],"fungal":[122],"moss":[124],"comprise":[127],"merely":[128],"III),":[133],"biosynthetic":[135],"activities":[136],"four":[139],"paralogous":[140],"Arabidopsis":[141,211],"thaliana":[142],"were":[145],"far":[146],"lower.":[147],"C-terminally":[148],"trimmed":[149],"core-AtNAS":[150],"variants":[151],"exhibited":[152],"strongly":[153],"elevated":[154],"activities.":[155],"Of":[156],"320":[157],"AtNAS1,":[161],"twelve,":[162],"287-TRGCMFMPCNCS-298,":[163],"accounted":[164],"autoinhibitory":[167],"effect":[168],"C":[171],"terminus,":[172],"which":[174,221],"approximately":[175],"one-third":[176],"was":[177,195],"attributed":[178],"N296":[180],"within":[181],"CNCS":[183],"motif":[184],"fully":[187],"conserved":[188],"Arabidopsis.":[190],"No":[191],"detectable":[192],"mediated":[196],"by":[197],"two":[198],"representative":[199],"plant":[200],"naturally":[204],"lack":[205],"domain,":[208],"class":[209,219,246],"halleri":[212],"NAS5":[213],"Medicago":[215],"truncatula":[216],"NAS2":[217],"II":[220],"found":[223],"dicots":[225],"diverged":[227],"early":[228],"during":[229],"evolution":[231],"Next,":[235],"will":[237],"address":[238],"possible":[240],"posttranslational":[241],"release":[242],"autoinhibition":[244],"I":[247],"proteins.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-04-23T00:00:00"}
