{"id":"https://openalex.org/W4366603281","doi":"https://doi.org/10.1126/sciadv.adf4888","title":"BBB opening with focused ultrasound in nonhuman primates and Parkinson\u2019s disease patients: Targeted AAV vector delivery and PET imaging","display_name":"BBB opening with focused ultrasound in nonhuman primates and Parkinson\u2019s disease patients: Targeted AAV vector delivery and PET imaging","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366603281","doi":"https://doi.org/10.1126/sciadv.adf4888","pmid":"https://pubmed.ncbi.nlm.nih.gov/37075119","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10115413"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.adf4888","doi":"https://doi.org/10.1126/sciadv.adf4888","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adf4888","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082130741","display_name":"Javier Blesa","orcid":"https://orcid.org/0000-0002-4257-1325","observed_orcids":["https://orcid.org/0000-0002-4257-1325"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Blesa","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4257-1325","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023850435","display_name":"Jos\u00e9 A. Pineda\u2010Pardo","orcid":"https://orcid.org/0000-0002-8776-0031","observed_orcids":["https://orcid.org/0000-0002-8776-0031"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 A. Pineda-Pardo","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8776-0031","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059427033","display_name":"Ken\u2010ichi Inoue","orcid":"https://orcid.org/0000-0002-5683-5280","observed_orcids":["https://orcid.org/0000-0002-5683-5280"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405263942","display_name":"Institute for the Evolutionary Origins of Human Behavior, Kyoto University","ror":"https://ror.org/00fqmtc51","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405263942"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichi Inoue","raw_affiliation_strings":["Systems Neuroscience Section, Department of Neuroscience, Primate Research Institute, and Center for the Evolutionary Origins of Human Behavior, Kyoto University; Inuyama, Aichi 484-8506, Japan","Inuyama, Aichi 484-8506, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5683-5280","affiliations":[{"raw_affiliation_string":"Systems Neuroscience Section, Department of Neuroscience, Primate Research Institute, and Center for the Evolutionary Origins of Human Behavior, Kyoto University; Inuyama, Aichi 484-8506, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405263942"]},{"raw_affiliation_string":"Inuyama, Aichi 484-8506, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003035367","display_name":"Carmen Gasca\u2010Salas","orcid":"https://orcid.org/0000-0001-7411-8106","observed_orcids":["https://orcid.org/0000-0001-7411-8106"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Gasca-Salas","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","University CEU-San Pablo, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7411-8106","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"University CEU-San Pablo, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089831492","display_name":"Tiziano Balzano","orcid":"https://orcid.org/0000-0001-6523-2206","observed_orcids":["https://orcid.org/0000-0001-6523-2206"]},"institutions":[{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tiziano Balzano","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-6523-2206","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010398014","display_name":"Natalia L\u00f3pez\u2010Gonz\u00e1lez del Rey","orcid":"https://orcid.org/0000-0002-1546-1825","observed_orcids":["https://orcid.org/0000-0002-1546-1825"]},"institutions":[{"id":"https://openalex.org/I2184545","display_name":"Instituto Cajal","ror":"https://ror.org/012gwbh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I2184545"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Natalia L\u00f3pez-Gonz\u00e1lez Del Rey","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","PhD Program in Neuroscience Aut\u00f3noma de Madrid University-Cajal Institute, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-1546-1825","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"PhD Program in Neuroscience Aut\u00f3noma de Madrid University-Cajal Institute, Madrid, Spain","institution_ids":["https://openalex.org/I2184545","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029025646","display_name":"Alejandro Reinares-Sebasti\u00e1n","orcid":"https://orcid.org/0000-0003-1632-4432","observed_orcids":["https://orcid.org/0000-0003-1632-4432"]},"institutions":[{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Reinares-Sebasti\u00e1n","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1632-4432","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084740875","display_name":"Noelia Esteban-Garc\u00eda","orcid":"https://orcid.org/0000-0002-2741-3054","observed_orcids":["https://orcid.org/0000-0002-2741-3054"]},"institutions":[{"id":"https://openalex.org/I2184545","display_name":"Instituto Cajal","ror":"https://ror.org/012gwbh42","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I2184545"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Noelia Esteban-Garc\u00eda","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","PhD Program in Neuroscience Aut\u00f3noma de Madrid University-Cajal Institute, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2741-3054","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"PhD Program in Neuroscience Aut\u00f3noma de Madrid University-Cajal Institute, Madrid, Spain","institution_ids":["https://openalex.org/I2184545","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086418742","display_name":"Rafael Rodr\u00edguez\u2010Rojas","orcid":"https://orcid.org/0000-0002-2903-199X","observed_orcids":["https://orcid.org/0000-0002-2903-199X"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Rodr\u00edguez-Rojas","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2903-199X","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raquel M\u00e1rquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel M\u00e1rquez","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044133107","display_name":"Mar\u00eda Ciorraga","orcid":"https://orcid.org/0000-0001-8438-6956","observed_orcids":["https://orcid.org/0000-0001-8438-6956"]},"institutions":[{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Ciorraga","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8438-6956","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103005988","display_name":"Marta del \u00c1lamo","orcid":"https://orcid.org/0000-0002-6519-4200","observed_orcids":["https://orcid.org/0000-0002-6519-4200"]},"institutions":[{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta del \u00c1lamo","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-6519-4200","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045663725","display_name":"Lina Garc\u00eda\u2010Ca\u00f1amaque","orcid":"https://orcid.org/0000-0001-6105-5281","observed_orcids":["https://orcid.org/0000-0001-6105-5281"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lina Garc\u00eda-Ca\u00f1amaque","raw_affiliation_strings":["Department of Nuclear Medicine, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","University CEU-San Pablo, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"University CEU-San Pablo, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087070696","display_name":"Santiago Ruiz de Aguiar","orcid":"https://orcid.org/0000-0002-4175-7611","observed_orcids":["https://orcid.org/0000-0002-4175-7611"]},"institutions":[{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Santiago Ruiz de Aguiar","raw_affiliation_strings":["Medical Management, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid\u00b8Spain"],"raw_orcid":"https://orcid.org/0000-0002-4175-7611","affiliations":[{"raw_affiliation_string":"Medical Management, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid\u00b8Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060540586","display_name":"Itay Rachmilevitch","orcid":"https://orcid.org/0000-0003-4290-502X","observed_orcids":["https://orcid.org/0000-0003-4290-502X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Itay Rachmilevitch","raw_affiliation_strings":["Insightec Ltd., Haifa, Israel"],"raw_orcid":"https://orcid.org/0000-0003-4290-502X","affiliations":[{"raw_affiliation_string":"Insightec Ltd., Haifa, Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047198741","display_name":"In\u00e9s Trigo\u2010Damas","orcid":"https://orcid.org/0000-0002-7821-2973","observed_orcids":["https://orcid.org/0000-0002-7821-2973"]},"institutions":[{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"In\u00e9s Trigo-Damas","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7821-2973","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040667714","display_name":"Masahiko Takada","orcid":"https://orcid.org/0000-0003-0774-2333","observed_orcids":["https://orcid.org/0000-0003-0774-2333"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405263942","display_name":"Institute for the Evolutionary Origins of Human Behavior, Kyoto University","ror":"https://ror.org/00fqmtc51","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405263942"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Takada","raw_affiliation_strings":["Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan","Systems Neuroscience Section, Department of Neuroscience, Primate Research Institute, and Center for the Evolutionary Origins of Human Behavior, Kyoto University; Inuyama, Aichi 484-8506, Japan","Inuyama, Aichi 484-8506, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0774-2333","affiliations":[{"raw_affiliation_string":"Department of Neurology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Systems Neuroscience Section, Department of Neuroscience, Primate Research Institute, and Center for the Evolutionary Origins of Human Behavior, Kyoto University; Inuyama, Aichi 484-8506, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405263942"]},{"raw_affiliation_string":"Inuyama, Aichi 484-8506, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062838955","display_name":"Jose Angel Obeso","orcid":"https://orcid.org/0000-0002-6996-8613","observed_orcids":["https://orcid.org/0000-0002-6996-8613"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]},{"id":"https://openalex.org/I4210086696","display_name":"Biomedical Research Networking Center on Neurodegenerative Diseases","ror":"https://ror.org/00zca7903","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210086696"]},{"id":"https://openalex.org/I4210122338","display_name":"HM Hospitales","ror":"https://ror.org/01ynvwr63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122338"]},{"id":"https://openalex.org/I4210122888","display_name":"University Hospital HM Puerta del Sur","ror":"https://ror.org/03rk6g530","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210122888"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 A. Obeso","raw_affiliation_strings":["HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","University CEU-San Pablo, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-6996-8613","affiliations":[{"raw_affiliation_string":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain","institution_ids":["https://openalex.org/I4210122338","https://openalex.org/I4210122888"]},{"raw_affiliation_string":"Network Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED), Instituto Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I4210086696"]},{"raw_affiliation_string":"University CEU-San Pablo, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5023850435","https://openalex.org/A5062838955","https://openalex.org/A5082130741"],"corresponding_institution_ids":["https://openalex.org/I118091203","https://openalex.org/I4210086696","https://openalex.org/I4210122338","https://openalex.org/I4210122888"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":8.0131,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.9901449,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"16","first_page":"eadf4888","last_page":"eadf4888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.09000000357627869,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood-brain-barrier-opening","display_name":"blood-brain barrier opening","score":0.9900000095367432},{"id":"https://openalex.org/keywords/focused-ultrasound","display_name":"focused ultrasound","score":0.9459999799728394},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8320000171661377},{"id":"https://openalex.org/keywords/aav9","display_name":"AAV9","score":0.925000011920929},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.7910000085830688},{"id":"https://openalex.org/keywords/18f-choline-pet","display_name":"18F-choline PET","score":0.871999979019165},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.7329999804496765},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8119999766349792},{"id":"https://openalex.org/keywords/gfp-expression","display_name":"GFP expression","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6044057607650757},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5705404877662659},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5541104674339294},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.5517081618309021},{"id":"https://openalex.org/C2985948822","wikidata":"https://www.wikidata.org/wiki/Q564897","display_name":"Focused ultrasound","level":3,"score":0.5130888223648071},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.49900364875793457},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4942465126514435},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.4937807023525238},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4919159412384033},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.42459535598754883},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.42336490750312805},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.4169628620147705},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.3926031291484833},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.39166155457496643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.237608402967453},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1751924455165863},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1126/sciadv.adf4888","doi":"https://doi.org/10.1126/sciadv.adf4888","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adf4888","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10115413","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10115413","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10115413/pdf/sciadv.adf4888.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmid:37075119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37075119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.ucjc.edu:20.500.12020/1525","doi":null,"is_oa":true,"landing_page_url":"https://www.science.org/doi/10.1126/sciadv.adf4888?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed","pdf_url":"https://repositorio.ucjc.edu/bitstream/20.500.12020/1525/1/Blesa%202023%20Sci%20Adv.pdf","source":{"id":"https://openalex.org/S7407055232","display_name":"Dep\u00f3sito Digital e-UCJC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:digital.csic.es:10261/388587","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/388587","pdf_url":"https://digital.csic.es/bitstream/10261/388587/1/sciadv.adf4888.pdf","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0005792152","doi":null,"is_oa":true,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/a8e18895-de7f-4689-94f6-685ed49c2556/download","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/a8e18895-de7f-4689-94f6-685ed49c2556/download","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Advances","raw_type":"journal article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/281763","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/281763","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.adf4888","doi":"https://doi.org/10.1126/sciadv.adf4888","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adf4888","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adf4888?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1560111206","display_name":null,"funder_award_id":"PID2019-111045RB-I00","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G3683688024","display_name":"Elucidating the primate basis of neurobiological mechanisms underlying developmental disorders","funder_award_id":"19H05467","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3690828678","display_name":null,"funder_award_id":"PID2019","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G6052008120","display_name":"Development of a method for creating primate disease models via whole-brain gene transfer technique","funder_award_id":"22K19480","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6192562398","display_name":"\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb\u30b9\u30ad\u30eb\u3092\u652f\u3048\u308b\u5927\u8133\u76ae\u8cea\uff0d\u5927\u8133\u57fa\u5e95\u6838\u9023\u95a2\u306e\u60c5\u5831\u51e6\u7406\u69d8\u5f0f","funder_award_id":"23K27472","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6816651011","display_name":null,"funder_award_id":"22H05157","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G755031667","display_name":"Enfermedad de Parkinson: vulnerabilidad neuronal y progresi\u00f3n de la enfermedad","funder_award_id":"PI20/00496","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320309171","display_name":"Focused Ultrasound Foundation","ror":"https://ror.org/04qjbd269"},{"id":"https://openalex.org/F4320309764","display_name":"Fundaci\u00f3n BBVA","ror":"https://ror.org/01jzs3b90"},{"id":"https://openalex.org/F4320317202","display_name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales","ror":"https://ror.org/0543ma965"},{"id":"https://openalex.org/F4320321854","display_name":"Fundaci\u00f3n Mapfre","ror":"https://ror.org/0248qb926"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320323113","display_name":"Banco Bilbao Vizcaya Argentaria","ror":"https://ror.org/0537dnd74"},{"id":"https://openalex.org/F4320326658","display_name":"Fundaci\u00f3n Tatiana P\u00e9rez de Guzm\u00e1n el Bueno","ror":"https://ror.org/01mzzkz08"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366603281.pdf","grobid_xml":"https://content.openalex.org/works/W4366603281.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W244971556","https://openalex.org/W1855337837","https://openalex.org/W1924463094","https://openalex.org/W1934517153","https://openalex.org/W1963291367","https://openalex.org/W1967242914","https://openalex.org/W1978221944","https://openalex.org/W1978793506","https://openalex.org/W1994064996","https://openalex.org/W1998241928","https://openalex.org/W2011526661","https://openalex.org/W2014850190","https://openalex.org/W2044074582","https://openalex.org/W2053820810","https://openalex.org/W2082025265","https://openalex.org/W2114596635","https://openalex.org/W2123188025","https://openalex.org/W2125411036","https://openalex.org/W2148470186","https://openalex.org/W2170614901","https://openalex.org/W2484015429","https://openalex.org/W2564088374","https://openalex.org/W2708579841","https://openalex.org/W2765253110","https://openalex.org/W2769590953","https://openalex.org/W2785806346","https://openalex.org/W2789003978","https://openalex.org/W2801454635","https://openalex.org/W2803104543","https://openalex.org/W2807207060","https://openalex.org/W2904612066","https://openalex.org/W2964394566","https://openalex.org/W2965224018","https://openalex.org/W2967823583","https://openalex.org/W2976433890","https://openalex.org/W2994165627","https://openalex.org/W2997881458","https://openalex.org/W3000219265","https://openalex.org/W3015813913","https://openalex.org/W3025258324","https://openalex.org/W3091396307","https://openalex.org/W3092195828","https://openalex.org/W3102529384","https://openalex.org/W3127037572","https://openalex.org/W3186708420","https://openalex.org/W3205836348","https://openalex.org/W3207084414","https://openalex.org/W3210405129","https://openalex.org/W4200415424","https://openalex.org/W4200543263","https://openalex.org/W4220817069","https://openalex.org/W4224213022","https://openalex.org/W4224228615","https://openalex.org/W4283690139","https://openalex.org/W4293092506","https://openalex.org/W4296816530","https://openalex.org/W4298326632"],"related_works":["https://openalex.org/W4367843557","https://openalex.org/W4408111830","https://openalex.org/W7167274527","https://openalex.org/W7154954706","https://openalex.org/W6943919876","https://openalex.org/W1969401867","https://openalex.org/W4391825260","https://openalex.org/W4388363926","https://openalex.org/W2402661655","https://openalex.org/W2996597998"],"abstract_inverted_index":{"Intracerebral":[0],"vector":[1,135],"delivery":[2,19,136],"in":[3,30,37,62,76,86,98],"nonhuman":[4],"primates":[5],"has":[6],"been":[7],"a":[8],"major":[9],"challenge.":[10],"We":[11],"report":[12],"successful":[13],"blood-brain":[14,66,70,89],"barrier":[15,67,71,90],"opening":[16,91],"and":[17,85,101,112,140,144],"focal":[18,111,133],"of":[20,115,128],"adeno-associated":[21],"virus":[22],"serotype":[23],"9":[24],"vectors":[25],"into":[26],"brain":[27,123],"regions":[28,63,103],"involved":[29],"Parkinson\u2019s":[31,80],"disease":[32],"using":[33],"low-intensity":[34],"focus":[35],"ultrasound":[36],"adult":[38],"macaque":[39],"monkeys.":[40],"Openings":[41],"were":[42,73],"well":[43],"tolerated":[44],"with":[45,64,79],"generally":[46],"no":[47],"associated":[48],"abnormal":[49],"magnetic":[50],"resonance":[51],"imaging":[52],"signals.":[53],"Neuronal":[54],"green":[55],"fluorescent":[56],"protein":[57],"expression":[58],"was":[59,92],"observed":[60],"specifically":[61],"confirmed":[65],"opening.":[68],"Similar":[69],"openings":[72],"safely":[74],"demonstrated":[75],"three":[77],"patients":[78,84],"disease.":[81],"In":[82],"these":[83],"one":[87],"monkey,":[88],"followed":[93],"by":[94],"18":[95],"F-Choline":[96],"uptake":[97],"the":[99,122],"putamen":[100],"midbrain":[102],"based":[104],"on":[105],"positron":[106],"emission":[107],"tomography.":[108],"This":[109],"indicates":[110],"cellular":[113],"binding":[114],"molecules":[116],"that":[117],"otherwise":[118],"would":[119],"not":[120],"enter":[121],"parenchyma.":[124],"The":[125],"less-invasive":[126],"nature":[127],"this":[129],"methodology":[130],"could":[131],"facilitate":[132],"viral":[134],"for":[137],"gene":[138],"therapy":[139],"might":[141],"allow":[142],"early":[143],"repeated":[145],"interventions":[146],"to":[147],"treat":[148],"neurodegenerative":[149],"disorders.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":43},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-04-23T00:00:00"}