{"id":"https://openalex.org/W4366597451","doi":"https://doi.org/10.3390/biom13040695","title":"Connecting Dots between Mitochondrial Dysfunction and Depression","display_name":"Connecting Dots between Mitochondrial Dysfunction and Depression","publication_year":2023,"publication_date":"2023-04-20","ids":{"openalex":"https://openalex.org/W4366597451","doi":"https://doi.org/10.3390/biom13040695","pmid":"https://pubmed.ncbi.nlm.nih.gov/37189442","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10135685"},"language":"en","primary_location":{"id":"doi:10.3390/biom13040695","doi":"https://doi.org/10.3390/biom13040695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom13040695","pdf_url":"https://www.mdpi.com/2218-273X/13/4/695/pdf?version=1681977482","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-273X/13/4/695/pdf?version=1681977482","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103851204","display_name":"Mehtab Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154799132","display_name":"Universit\u00e9 de Moncton","ror":"https://ror.org/029tnqt29","country_code":"CA","type":"education","lineage":["https://openalex.org/I154799132"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mehtab Khan","raw_affiliation_strings":["Department of Biology, University of Moncton, Moncton, NB E1A 3E9, Canada","Mitochondrial Signaling and Pathophysiology, University of Moncton, Moncton, NB E1A 3E9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Moncton, Moncton, NB E1A 3E9, Canada","institution_ids":["https://openalex.org/I154799132"]},{"raw_affiliation_string":"Mitochondrial Signaling and Pathophysiology, University of Moncton, Moncton, NB E1A 3E9, Canada","institution_ids":["https://openalex.org/I154799132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059687202","display_name":"Yann Baussan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154799132","display_name":"Universit\u00e9 de Moncton","ror":"https://ror.org/029tnqt29","country_code":"CA","type":"education","lineage":["https://openalex.org/I154799132"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yann Baussan","raw_affiliation_strings":["Department of Biology, University of Moncton, Moncton, NB E1A 3E9, Canada","Mitochondrial Signaling and Pathophysiology, University of Moncton, Moncton, NB E1A 3E9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Moncton, Moncton, NB E1A 3E9, Canada","institution_ids":["https://openalex.org/I154799132"]},{"raw_affiliation_string":"Mitochondrial Signaling and Pathophysiology, University of Moncton, Moncton, NB E1A 3E9, Canada","institution_ids":["https://openalex.org/I154799132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070307231","display_name":"\u00c9tienne H\u00e9bert-Chatelain","orcid":"https://orcid.org/0000-0003-1480-2787","observed_orcids":["https://orcid.org/0000-0003-1480-2787"]},"institutions":[{"id":"https://openalex.org/I154799132","display_name":"Universit\u00e9 de Moncton","ror":"https://ror.org/029tnqt29","country_code":"CA","type":"education","lineage":["https://openalex.org/I154799132"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Etienne Hebert-Chatelain","raw_affiliation_strings":["Department of Biology, University of Moncton, Moncton, NB E1A 3E9, Canada","Mitochondrial Signaling and Pathophysiology, University of Moncton, Moncton, NB E1A 3E9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Moncton, Moncton, NB E1A 3E9, Canada","institution_ids":["https://openalex.org/I154799132"]},{"raw_affiliation_string":"Mitochondrial Signaling and Pathophysiology, University of Moncton, Moncton, NB E1A 3E9, Canada","institution_ids":["https://openalex.org/I154799132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070307231"],"corresponding_institution_ids":["https://openalex.org/I154799132"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2558},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2558},"fwci":2.2422,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.90168015,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"13","issue":"4","first_page":"695","last_page":"695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.6304000020027161,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.3434999883174896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pathophysiology-of-depression","display_name":"depression pathophysiology","score":0.8709999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.828000009059906},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mitochondrial-membrane-lipids","display_name":"mitochondrial membrane lipids","score":0.8130000233650208},{"id":"https://openalex.org/keywords/mitochondrial-membrane-proteins","display_name":"mitochondrial membrane proteins","score":0.7919999957084656},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6919999718666077},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.5889999866485596},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.6499999761581421},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"neurotransmission","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7394537925720215},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7286847233772278},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7043619155883789},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6998827457427979},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6204855442047119},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5314174294471741},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.515396237373352},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.4944424629211426},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4675378203392029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4288121461868286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4022522270679474},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3980519771575928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3677094280719757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.280426025390625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2758462429046631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11523064970970154},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/biom13040695","doi":"https://doi.org/10.3390/biom13040695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom13040695","pdf_url":"https://www.mdpi.com/2218-273X/13/4/695/pdf?version=1681977482","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10135685","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10135685","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10135685/pdf/biomolecules-13-00695.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:37189442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37189442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:be40a37303554279a26c72a56101d8f7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/be40a37303554279a26c72a56101d8f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 13, Iss 4, p 695 (2023)","raw_type":"article"},{"id":"pmh:oai:umoncton.scholaris.ca:20.500.14658/6221","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85156175639&amp;doi=10.3390%2fbiom13040695&amp;partnerID=40&amp;md5=e5c464f156831be1e0b4d85f9a3da6cd","pdf_url":null,"source":{"id":"https://openalex.org/S7407064436","display_name":"ScriptoriUM","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I154799132","host_organization_name":"Universit\u00e9 de Moncton","host_organization_lineage":["https://openalex.org/I154799132"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/biom13040695","doi":"https://doi.org/10.3390/biom13040695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom13040695","pdf_url":"https://www.mdpi.com/2218-273X/13/4/695/pdf?version=1681977482","source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G560051739","display_name":null,"funder_award_id":"RGPIN-2015","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G6402380596","display_name":"Exploring the mitochondrial phosphoproteome during metabolic stress","funder_award_id":"rgpin-2015-05880","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8545781331","display_name":"Cell type-specific role of Src kinase in brain mitochondrial metabolism and behavior","funder_award_id":"rgpin-2022-03945","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320314075","display_name":"Fondation de la recherche en sant\u00e9 du Nouveau-Brunswick","ror":"https://ror.org/00hg4tf86"},{"id":"https://openalex.org/F4320319980","display_name":"New Brunswick Innovation Foundation","ror":"https://ror.org/02rbgnh75"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4366597451.pdf","grobid_xml":"https://content.openalex.org/works/W4366597451.grobid-xml"},"referenced_works_count":199,"referenced_works":["https://openalex.org/W19743964","https://openalex.org/W63230440","https://openalex.org/W406960581","https://openalex.org/W1165140024","https://openalex.org/W1509868652","https://openalex.org/W1512847190","https://openalex.org/W1516644432","https://openalex.org/W1523213544","https://openalex.org/W1576524074","https://openalex.org/W1597889448","https://openalex.org/W1648000881","https://openalex.org/W1692117202","https://openalex.org/W1918135542","https://openalex.org/W1938596530","https://openalex.org/W1963757288","https://openalex.org/W1965385703","https://openalex.org/W1969709153","https://openalex.org/W1970168377","https://openalex.org/W1970945239","https://openalex.org/W1971250103","https://openalex.org/W1972777532","https://openalex.org/W1973929801","https://openalex.org/W1977822710","https://openalex.org/W1977886842","https://openalex.org/W1981515582","https://openalex.org/W1981789613","https://openalex.org/W1982313674","https://openalex.org/W1982803259","https://openalex.org/W1983617759","https://openalex.org/W1985118878","https://openalex.org/W1985438873","https://openalex.org/W1985924246","https://openalex.org/W1986618045","https://openalex.org/W1987130185","https://openalex.org/W1987491785","https://openalex.org/W1988733243","https://openalex.org/W1988806196","https://openalex.org/W1992144053","https://openalex.org/W1992949421","https://openalex.org/W1993476794","https://openalex.org/W1996092905","https://openalex.org/W1996264709","https://openalex.org/W1996454121","https://openalex.org/W1996940510","https://openalex.org/W1996982207","https://openalex.org/W1997177617","https://openalex.org/W2000875771","https://openalex.org/W2001819241","https://openalex.org/W2003982930","https://openalex.org/W2005594217","https://openalex.org/W2006218562","https://openalex.org/W2006696253","https://openalex.org/W2007609810","https://openalex.org/W2007816528","https://openalex.org/W2008246214","https://openalex.org/W2008971294","https://openalex.org/W2010179451","https://openalex.org/W2011110465","https://openalex.org/W2011854518","https://openalex.org/W2012305261","https://openalex.org/W2014099101","https://openalex.org/W2014559245","https://openalex.org/W2018608345","https://openalex.org/W2018799265","https://openalex.org/W2018933100","https://openalex.org/W2025564422","https://openalex.org/W2025887442","https://openalex.org/W2030772288","https://openalex.org/W2034330364","https://openalex.org/W2036878177","https://openalex.org/W2038183514","https://openalex.org/W2039022088","https://openalex.org/W2039954704","https://openalex.org/W2040064764","https://openalex.org/W2040856926","https://openalex.org/W2042771415","https://openalex.org/W2045928883","https://openalex.org/W2057613044","https://openalex.org/W2057932313","https://openalex.org/W2060018802","https://openalex.org/W2060190753","https://openalex.org/W2061863029","https://openalex.org/W2064408093","https://openalex.org/W2066184233","https://openalex.org/W2067197999","https://openalex.org/W2067412138","https://openalex.org/W2074851919","https://openalex.org/W2076229820","https://openalex.org/W2077024758","https://openalex.org/W2079446507","https://openalex.org/W2082023836","https://openalex.org/W2085229930","https://openalex.org/W2085692486","https://openalex.org/W2087094704","https://openalex.org/W2088150719","https://openalex.org/W2089879888","https://openalex.org/W2092499931","https://openalex.org/W2093484024","https://openalex.org/W2094422818","https://openalex.org/W2094908805","https://openalex.org/W2097086441","https://openalex.org/W2099201877","https://openalex.org/W2100637353","https://openalex.org/W2103254333","https://openalex.org/W2105160377","https://openalex.org/W2106106014","https://openalex.org/W2111006129","https://openalex.org/W2111428173","https://openalex.org/W2114111268","https://openalex.org/W2120423982","https://openalex.org/W2125530468","https://openalex.org/W2131434664","https://openalex.org/W2133518193","https://openalex.org/W2134489176","https://openalex.org/W2135156135","https://openalex.org/W2136801447","https://openalex.org/W2139852368","https://openalex.org/W2140126848","https://openalex.org/W2140505555","https://openalex.org/W2145533693","https://openalex.org/W2147649093","https://openalex.org/W2148239264","https://openalex.org/W2148535867","https://openalex.org/W2149375666","https://openalex.org/W2149402043","https://openalex.org/W2149857357","https://openalex.org/W2158019450","https://openalex.org/W2159061031","https://openalex.org/W2162821981","https://openalex.org/W2165689677","https://openalex.org/W2180760460","https://openalex.org/W2181017482","https://openalex.org/W2197078876","https://openalex.org/W2279194165","https://openalex.org/W2328048826","https://openalex.org/W2386367594","https://openalex.org/W2410887937","https://openalex.org/W2414467028","https://openalex.org/W2418148234","https://openalex.org/W2461445906","https://openalex.org/W2512818135","https://openalex.org/W2560159796","https://openalex.org/W2580279138","https://openalex.org/W2589554496","https://openalex.org/W2595401536","https://openalex.org/W2606075895","https://openalex.org/W2606415818","https://openalex.org/W2611710834","https://openalex.org/W2734391724","https://openalex.org/W2755558750","https://openalex.org/W2760581048","https://openalex.org/W2760643559","https://openalex.org/W2761172596","https://openalex.org/W2766558591","https://openalex.org/W2766723179","https://openalex.org/W2767078779","https://openalex.org/W2768375420","https://openalex.org/W2769622412","https://openalex.org/W2791861226","https://openalex.org/W2794098750","https://openalex.org/W2794318060","https://openalex.org/W2794704746","https://openalex.org/W2799318245","https://openalex.org/W2799838034","https://openalex.org/W2807237913","https://openalex.org/W2807334958","https://openalex.org/W2883195085","https://openalex.org/W2885386535","https://openalex.org/W2888403478","https://openalex.org/W2896387873","https://openalex.org/W2923007378","https://openalex.org/W2947449955","https://openalex.org/W2950437836","https://openalex.org/W2966182111","https://openalex.org/W2980746109","https://openalex.org/W2999878740","https://openalex.org/W3004054511","https://openalex.org/W3009850388","https://openalex.org/W3011930227","https://openalex.org/W3022748539","https://openalex.org/W3025068857","https://openalex.org/W3042125784","https://openalex.org/W3045729221","https://openalex.org/W3088455857","https://openalex.org/W3092003534","https://openalex.org/W3112636500","https://openalex.org/W3119355212","https://openalex.org/W3130188116","https://openalex.org/W3173026910","https://openalex.org/W3189904176","https://openalex.org/W3196617255","https://openalex.org/W3197736307","https://openalex.org/W4200625146","https://openalex.org/W4210273716","https://openalex.org/W4210476933","https://openalex.org/W4243230704","https://openalex.org/W4302293782","https://openalex.org/W4315433619","https://openalex.org/W4323915035"],"related_works":["https://openalex.org/W4395687990","https://openalex.org/W2807334958","https://openalex.org/W7162212387","https://openalex.org/W2038183514","https://openalex.org/W4387387491","https://openalex.org/W2386367594","https://openalex.org/W7099361066","https://openalex.org/W2911491741","https://openalex.org/W4414159017","https://openalex.org/W4391681024"],"abstract_inverted_index":{"homeostasis.":[0],"Depression":[1],"is":[2],"a":[3],"psychiatric":[4],"disease":[5],"characterized":[6],"by":[7],"alteration":[8],"in":[9,58,71],"the":[10,20,27,45,72,82,86,104],"metabolism,":[11],"neurotransmission":[12],"and":[13,41,53,63,85,90,103],"neuroplasticity.":[14],"In":[15],"this":[16,111],"manuscript,":[17],"we":[18],"summarize":[19],"recent":[21],"evidence":[22],"linking":[23],"mitochondrial":[24,38,95],"dysfunction":[25,96],"to":[26,37,94,99],"pathophysiology":[28,84],"of":[29,33,44,61,65,74,81,88,106],"depression.":[30,77],"Impaired":[31],"expression":[32],"mitochondria-related":[34],"genes,":[35],"damage":[36],"membrane":[39],"proteins":[40],"lipids,":[42],"disruption":[43],"electron":[46],"transport":[47],"chain,":[48],"higher":[49],"oxidative":[50],"stress,":[51],"neuroinflammation":[52],"apoptosis":[54],"are":[55,97],"all":[56],"observed":[57],"preclinical":[59],"models":[60],"depression":[62,83],"most":[64],"these":[66],"parameters":[67],"can":[68],"be":[69],"altered":[70],"brain":[73],"patients":[75],"with":[76,92],"A":[78],"deeper":[79],"knowledge":[80],"identification":[87],"phenotypes":[89],"biomarkers":[91],"respect":[93],"needed":[98],"help":[100],"early":[101],"diagnosis":[102],"development":[105],"new":[107],"treatment":[108],"strategies":[109],"for":[110],"devastating":[112],"disorder.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-04-23T00:00:00"}
