{"id":"https://openalex.org/W4366404014","doi":"https://doi.org/10.1158/1541-7786.c.6606916.v1","title":"Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia","display_name":"Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia","publication_year":2023,"publication_date":"2023-04-19","ids":{"openalex":"https://openalex.org/W4366404014","doi":"https://doi.org/10.1158/1541-7786.c.6606916.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.6606916.v1","doi":"https://doi.org/10.1158/1541-7786.c.6606916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6606916.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.6606916.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028626481","display_name":"William M. Yashar","orcid":"https://orcid.org/0000-0002-8850-9850","observed_orcids":["https://orcid.org/0000-0002-8850-9850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William M. Yashar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8850-9850","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060581274","display_name":"Brittany M. Curtiss","orcid":"https://orcid.org/0000-0002-5274-8323","observed_orcids":["https://orcid.org/0000-0002-5274-8323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brittany M. Curtiss","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5274-8323","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068010590","display_name":"Daniel J. Coleman","orcid":"https://orcid.org/0000-0002-3414-3160","observed_orcids":["https://orcid.org/0000-0002-3414-3160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Coleman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3414-3160","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032148008","display_name":"Jake VanCampen","orcid":"https://orcid.org/0000-0003-1361-0927","observed_orcids":["https://orcid.org/0000-0003-1361-0927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jake VanCampen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1361-0927","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025186197","display_name":"Garth Kong","orcid":"https://orcid.org/0000-0001-5262-5406","observed_orcids":["https://orcid.org/0000-0001-5262-5406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garth Kong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5262-5406","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029691160","display_name":"Jommel Macaraeg","orcid":"https://orcid.org/0000-0002-6307-5056","observed_orcids":["https://orcid.org/0000-0002-6307-5056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jommel Macaraeg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6307-5056","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069454150","display_name":"Joseph Estabrook","orcid":"https://orcid.org/0000-0002-1027-3315","observed_orcids":["https://orcid.org/0000-0002-1027-3315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Estabrook","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1027-3315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037803004","display_name":"Emek Demir","orcid":"https://orcid.org/0000-0002-3663-7113","observed_orcids":["https://orcid.org/0000-0002-3663-7113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emek Demir","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3663-7113","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046733014","display_name":"Nicola Long","orcid":"https://orcid.org/0000-0002-9010-8167","observed_orcids":["https://orcid.org/0000-0002-9010-8167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Long","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9010-8167","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061516412","display_name":"Daniel Bottomly","orcid":"https://orcid.org/0000-0001-7191-0990","observed_orcids":["https://orcid.org/0000-0001-7191-0990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Bottomly","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7191-0990","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066373576","display_name":"Shannon K. McWeeney","orcid":"https://orcid.org/0000-0001-8333-6607","observed_orcids":["https://orcid.org/0000-0001-8333-6607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon K. McWeeney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8333-6607","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134831711","display_name":"Jeffrey W Tyner","orcid":"https://orcid.org/0000-0002-2133-0960","observed_orcids":["https://orcid.org/0000-0002-2133-0960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey W. Tyner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2133-0960","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125591963","display_name":"Brian J. Druker","orcid":"https://orcid.org/0000-0001-8331-8206","observed_orcids":["https://orcid.org/0000-0001-8331-8206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian J. Druker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8331-8206","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073522080","display_name":"Julia E. Maxson","orcid":"https://orcid.org/0000-0002-3871-7221","observed_orcids":["https://orcid.org/0000-0002-3871-7221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia E. Maxson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3871-7221","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032381895","display_name":"Theodore P. Braun","orcid":"https://orcid.org/0000-0002-6248-2143","observed_orcids":["https://orcid.org/0000-0002-6248-2143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore P. Braun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6248-2143","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.7110000252723694},{"id":"https://openalex.org/keywords/lsd1-inhibition","display_name":"LSD1 inhibition","score":0.8009999990463257},{"id":"https://openalex.org/keywords/flt3-inhibitors","display_name":"FLT3 inhibitors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/myc-super-enhancer","display_name":"MYC superenhancer","score":0.878000020980835},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gfi1","display_name":"GFI1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/h3k9me1","display_name":"H3K9me1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5889999866485596},{"id":"https://openalex.org/keywords/myc-expression","display_name":"MYC expression","score":0.5419999957084656},{"id":"https://openalex.org/keywords/kinase-inhibitor-resistance","display_name":"kinase inhibitor resistance","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7947365045547485},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.637795627117157},{"id":"https://openalex.org/C2910954276","wikidata":"https://www.wikidata.org/wiki/Q14912399","display_name":"Fms-Like Tyrosine Kinase 3","level":4,"score":0.5131869912147522},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.46442142128944397},{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.4557856619358063},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.43923404812812805},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4234503507614136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39303597807884216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36619746685028076},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3447995185852051},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2528715133666992},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19101417064666748},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15679913759231567},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.148646742105484},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.14512068033218384}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.6606916.v1","doi":"https://doi.org/10.1158/1541-7786.c.6606916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6606916.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.6606916.v1","doi":"https://doi.org/10.1158/1541-7786.c.6606916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.6606916.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361190333","https://openalex.org/W4282933356","https://openalex.org/W3097226213"],"abstract_inverted_index":{"Abstract":[0],"Mutations":[1],"in":[2,11,39,54,90,108,138,157],"Fms-like":[3],"tyrosine":[4],"kinase":[5,36,136],"3":[6],"(FLT3)":[7],"are":[8],"common":[9],"drivers":[10],"acute":[12],"myeloid":[13],"leukemia":[14],"(AML)":[15],"yet":[16],"FLT3":[17,48,153],"inhibitors":[18,29,137],"only":[19],"provide":[20],"modest":[21],"clinical":[22],"benefit.":[23],"Prior":[24],"work":[25,146],"has":[26],"shown":[27],"that":[28,44,60],"of":[30,93,135,151],"lysine-specific":[31],"demethylase":[32],"1":[33],"(LSD1)":[34],"enhance":[35],"inhibitor":[37],"activity":[38,134],"AML.":[40,56,143],"Here":[41],"we":[42],"show":[43],"combined":[45,152],"LSD1":[46,98,155],"and":[47,67,83,154,163],"inhibition":[49,156],"induces":[50],"synergistic":[51,119,149],"cell":[52],"death":[53],"FLT3-mutant":[55],"Multi-omic":[57],"profiling":[58],"revealed":[59],"the":[61,71,91,114,122,133,148,167],"drug":[62,86,123],"combination":[63,87],"disrupts":[64],"STAT5,":[65],"LSD1,":[66],"GFI1":[68,164],"binding":[69,165],"at":[70,100,166],"MYC":[72,81,101,168],"blood":[73],"superenhancer,":[74],"suppressing":[75],"superenhancer":[76,170],"accessibility":[77],"as":[78,80],"well":[79],"expression":[82],"activity.":[84],"The":[85],"simultaneously":[88],"results":[89],"accumulation":[92],"repressive":[94],"H3K9me1":[95],"methylation,":[96],"an":[97],"substrate,":[99],"target":[102],"genes.":[103],"We":[104],"validated":[105],"these":[106,126],"findings":[107],"72":[109],"primary":[110],"AML":[111,159],"samples":[112],"with":[113],"nearly":[115],"every":[116],"sample":[117],"demonstrating":[118],"responses":[120],"to":[121],"combination.":[124],"Collectively,":[125],"studies":[127],"reveal":[128],"how":[129],"epigenetic":[130],"therapies":[131],"augment":[132],"FLT3-ITD":[139,158],"(internal":[140],"tandem":[141],"duplication)":[142],"Implications:":[144],"This":[145],"establishes":[147],"efficacy":[150],"by":[160],"disrupting":[161],"STAT5":[162],"blood-specific":[169],"complex.":[171]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-21T00:00:00"}
